JP5231355B2 - Automatic analyzer - Google Patents

Description

  The present invention relates to an automatic analyzer that performs qualitative and quantitative analysis of samples such as blood and urine.

  An automatic analyzer that uses a sample disk installs the sample on the sample disk when adding the sample. Since this sample disk is always operating to dispense the sample, the sample cannot be added unless the analysis is interrupted.

  For example, as described in Patent Document 1, when a sample (sample) to be measured is added during an operation and there is no remaining reagent bottle, a reagent registration interrupt request is made. In response to the reagent registration interrupt request, the apparatus is configured to temporarily stop the analysis operation and to stop the sampling of the sample.

JP-A-10-142230

  As described above, in the conventional automatic analyzer, the sample (sample) analysis can be interrupted only at the timing when the analysis interrupt button for interrupting the analysis is pressed.

  For this reason, if the sample that you want to analyze preferentially is being analyzed when you try to suspend the analysis to add a new sample, it is unavoidable that the sample that you want to analyze preferentially is unavoidable. The analysis had to be interrupted.

  In addition, it is possible to wait until the analysis of the sample to be preferentially analyzed is completed and then press the analysis interruption button. In this case, the operator observes until the analysis of the sample to be preferentially analyzed is completed. The waiting time had occurred.

  If you have to wait until the analysis of the sample you want to analyze preferentially is completed and then press the analysis stop button, it is possible that the analysis stop button will be pressed incorrectly. After resuming the start operation, it is necessary to wait for the analysis interruption timing to operate. When the analysis interruption timing is delayed, the addition of a new sample is delayed accordingly.

  An object of the present invention is to realize an automatic analyzer that can specify the timing at which an analysis is interrupted by an operator and can interrupt the analysis at an appropriate timing without interfering with the analysis of a sample to be preferentially analyzed. It is.

  In order to achieve the above object, the present invention is configured as follows.

  The automatic analyzer according to the present invention interrupts the analysis of a sample according to an analysis interruption timing designation means in which an operator designates a timing at which the analysis of the sample is suspended, and an analysis interruption timing designated by the analysis interruption timing designation means. Control means.

  According to the present invention, it is possible to realize an automatic analyzer capable of designating a timing for interrupting an analysis by an operator and capable of interrupting the analysis at an appropriate timing without interfering with the analysis of a sample to be preferentially analyzed. Can do.

It is a figure which shows the analysis interruption screen for interrupting the analysis in Example 1 of this invention. It is explanatory drawing which showed the principle whole structure outline of the automatic analyzer to which this invention is applied. It is explanatory drawing which showed the measurement sequence in a comparative example, and the measurement sequence to which this invention was applied. It is a figure which shows the analysis start screen for starting the analysis in Example 1 of this invention. It is a figure which shows the analysis interruption screen for interrupting the analysis in Example 1 of this invention. It is an operation | movement flowchart for interrupting an analysis.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

  In the following description of the examples, “interruption of analysis” mainly means stopping of the dispensing of the sample (specimen), and together with stopping of the dispensing of the sample, stopping of the dispensing of the reagent, or When the operation of the apparatus is stopped, these operations are also included.

  FIG. 1 is a diagram showing an analysis interruption screen according to the first embodiment of the present invention, and FIG. 2 is a schematic diagram showing the overall configuration of the principle of the automatic analyzer.

  In FIG. 2, 2-1 is an operation unit, and the operation unit 2-1 is a computer. The operation unit 2-1 includes a keyboard 2-2 for inputting data, a mouse 2-3, a display device 2-4 for displaying data, and a printing device 2-5 for printing data. And an interface 2-6 for connecting to an analysis unit, which will be described later, a storage order 2-7 for storing the requested item measurement order and the liquid amount of the sample to be measured, and other peripheral devices.

  Reference numeral 2-8 denotes an analysis unit, which is connected to the operation unit 2-1 through an interface 2-6.

  In the analysis unit 2-8, reference numeral 2-9 denotes a reaction disk, and a plurality of reaction vessels 2-10 are installed on the concentric circumference thereof. 2-11 is a reagent disk, and a plurality of reagent bottles 2-12 containing various reagents are installed on the concentric circle.

  A sample dispensing probe 2-13, a stirring device 2-14, a cleaning device 2-15, a light source 2-16, and a multi-wavelength photometer 2-17 are disposed around the reaction disk 2-9. A reagent dispensing probe 2-18 is disposed between the reaction disk 2-9 and the reagent disk 2-11.

  A sample disk 2-19 is installed on the rotation circumference of the sample dispensing probe 2-13 and next to the reagent disk 2-11. A plurality of sample containers 2-20 containing samples are installed in a sample disk 2-19. All of these mechanism operations are controlled by the computer 2-22 via the interface 2-21.

  The operator uses the display device 2-4 of the operation unit 2-1, the keyboard 2-2, or the mouse 2-3 to request a measurement item and give an analysis instruction to the analysis device. The analysis instruction is transmitted to the analysis unit 2-8 via the interface 2-6. The analysis unit 2-8 performs an analysis operation as follows according to the received analysis instruction.

  The sample dispensing probe 2-13 dispenses a predetermined amount of the sample contained in the sample container 2-20 to the reaction container 2-10 by the number of requested items. When the dispensing for one sample container 2-20 is completed, the sample disk 2-19 rotates so that the next sample container 2-20 is located directly below the sample dispensing probe 2-13. The reaction container 2-10 into which the sample is dispensed rotates on the reaction disk 2-9 by the rotation of the reaction disk 2-9. Meanwhile, with respect to the sample in the reaction container 2-10, the reagent in the reagent bottle 2-12 is dispensed by the reagent dispensing probe 2-18, the reaction liquid is stirred by the stirring device 2-14, the light source 2-16, And the absorbance is measured by the multiwavelength photometer 2-17. Thereafter, the reaction vessel 2-10 that has been analyzed is washed by the washing device 2-15.

  The measured absorbance signal is supplied to the computer 2-22 via the interface 2-21 via the A / D converter 2-23. From this absorbance signal, based on the analysis method set for each analysis item in advance, calibration curve data is calculated from the set concentration data in the case of standard solution samples, and measurement of standard solution samples in the case of patient samples and control samples Concentration data is calculated from the calibration curve data obtained in (1). These data are transmitted as measurement results to the operation unit 2-1 via the interface 2-6 after adding information symbolizing the type of the sample.

  The operation unit 2-1 stores the received measurement result in the storage device 2-7 and outputs it to the display device 2-4 and the printing device 2-5.

  Next, with reference to FIG. 1 and FIG. 6, an analysis interruption screen for interrupting the analysis in the first embodiment of the present invention will be described. FIG. 6 is a determination flowchart for interrupting the analysis in the first embodiment of the present invention.

  In the first embodiment of the present invention, the computer 2-22 allows the computer 2-22 to specify the timing for interrupting the analysis on the analysis interrupt screen (analysis interrupt timing specifying means) on the display device 2-4 of the computer 2-1. When the analysis is interrupted by controlling the operation, it is possible to delay the analysis until the designated timing from the screen.

  1 and 6, when the analysis interruption timing radio button 1-1 is designated and executed (step 6-1), the designated timing is determined (step 6-2), and the analysis is performed at the designated timing. It is interrupted and the sample can be added.

  When the immediate button 1-2 is designated in the analysis interruption timing 1-1, the analysis is interrupted at the shortest timing at which the analysis apparatus can interrupt the analysis (step 6-3). When the emergency sample button 1-3 is designated, it is possible to designate all the buttons 1-4 or the position button 1-5 (step 6-4).

  When all buttons 1-4 are designated, the analysis is interrupted after the analysis of all the emergency samples is completed (steps 6-6 and 6-7). If the sample is an emergency sample, this is stored in the computer 2-22 together with the position of the sample disk before the analysis is started. The computer 2-22 is also sample analysis interruption timing storage means.

  When the position button 1-5 is designated, a position can be input in the position input area 1-6, and the analysis is interrupted after the analysis of the emergency sample at the input position is completed (steps 6-5 and 6-7).

  When the general sample button 1-7 is designated, all the buttons 1-8 or the sample number button 1-9 can be designated (step 6-8).

  When all buttons 1-8 are designated, the analysis is interrupted after the analysis of all the general samples is completed (steps 6-11 and 6-10).

  When the sample number button 1-9 is designated, the sample number can be input in the sample number input area 1-10, and the analysis is interrupted after the analysis of the general sample having the input sample number is completed (steps 6-9, 6). -10).

  When the calibration button 1-11 is designated, the analysis is interrupted after the end of the calibration analysis (steps 6-12 and 6-13).

  When the control button 1-12 is designated, the analysis is interrupted after the analysis of the control sample (quality control sample) is completed (steps 6-14 and 6-15).

  Furthermore, the specification of the timing at which the analysis is interrupted is not limited to this, and it is possible to specify a bar code, a time, a sample 5-1 to interrupt the analysis as shown in FIG. It is only necessary that the timing for interrupting the analysis can be specified.

  FIG. 3 is an explanatory diagram for comparing the measurement sequence in the prior art with the measurement sequence in the case where the embodiment of the present invention is applied.

  In FIG. 3, it is assumed that analysis is performed in the order of the sample (A) 3-1, the sample (B) 3-2, the sample (C) 3-3, and the sample (D) 3-4. In this case, a case where the analysis interruption button is pressed while the sample (B) 3-2 is being dispensed in order to add the sample (E) 3-5 (operation 3-6) will be described.

  In the conventional measurement sequence 3-7, the analysis is interrupted at the shortest timing at which the analysis can be interrupted.

  In this case, even if the sample (C) 3-3 is desired to be analyzed preferentially, the analysis is interrupted at the timing when the analysis interrupt button is pressed, so the analysis of the sample (C) 3-3 is performed after the restart. The timing 3-8 for outputting the result is later than 3-9 when not interrupted.

  On the other hand, in the measurement sequence 3-10 to which the first embodiment of the present invention is applied, the sample (B) 3 is specified by designating the end of the analysis of the sample (C) 3-3 at the timing when the analysis is interrupted. Even when the analysis interruption button is pressed while -2 is being dispensed, the analysis can be interrupted after the analysis of the sample (C) 3-3 is completed.

  As a result, the result of the sample (C) 3-3 to be preferentially analyzed can be quickly known, and the sample (E) 3-5 is added immediately after the analysis of the sample (C) 3-3 is completed. Thus, the operator can add the sample in the shortest time without disturbing the analysis of the sample to be preferentially analyzed.

  In addition, when starting the analysis by designating the timing for interrupting the analysis in advance, it can be set by the screen shown in FIG.

  That is, in FIG. 4, in addition to the analysis start specimen number designation area 4-3, the analysis specimen erection position designation area 4-4, etc., an analysis interruption timing setting area 4-1 is displayed on the screen.

  If the analysis interruption no button 4-2 in the analysis interruption timing setting area 4-1 is designated, the analysis is executed without interruption of the analysis. If there is a possibility that the analysis is interrupted, the analysis interruption no button 4 -2 is not specified.

  In the analysis interruption timing setting area 4-1, the timing for interrupting the analysis is designated in advance. Analysis is started by pressing the start button on the screen.

  As described above, according to the embodiment of the present invention, when adding an analysis of a new sample during the execution of the analysis operation of the automatic analyzer, the analysis is immediately interrupted during the analysis operation, and after the urgent sample has been dispensed, the designation is made. The operator can designate after dispensing of the sample, after dispensing of the general sample, and the like.

  Therefore, when adding an analysis of a new sample while the analysis operation of the automatic analyzer is being performed, it is necessary to suspend the analysis of the sample unavoidably, even if it is a sample to be analyzed preferentially. It is possible to avoid a situation in which the analysis interruption button must be pressed after waiting for the analysis of the sample to be completed.

  That is, the analysis can be interrupted at the best timing required by the operator, and the operability of the automatic analyzer can be improved. New sample analysis can then be added.

  In the above-described embodiment, there are six types of timings at which the analysis is interrupted. However, the present invention is not limited to this, and several other types of timings can be specified if the timing at which the analysis is interrupted can be specified.

  1-1 ... Analysis interruption timing radio button, 1-2 ... Analysis interruption timing radio button, 1-3 ... Analysis interruption timing radio button, 1-4 ... Analysis interruption timing radio button, 1- 5 ... Analysis interruption timing radio button, 1-6 ... Position input area, 1-7 ... Analysis interruption timing radio button, 1-8 ... Analysis interruption timing radio button, 1-9 ... Analysis interruption timing radio button, 1-10... Sample number input area, 1-11... Analysis interruption timing radio button, 1-12... Analysis interruption timing radio button, 2-1. 2-2 ... Keyboard, 2-3 ... Mouse, 2-4 ... Display device, 2-5 ... Printing device, 2-6 ... Interface, 2-7 ... Operation unit 2-8 ... analyzing unit, 2-9 ... reaction disk, 2-10 ... reaction vessel, 2-11 ... reagent disk, 2-12 ... reagent bottle, 2-13 ... Sample dispensing probe, 2-14 ... stirring device, 2-15 ... washing device, 2-16 ... light source, 2-17 ... multi-wavelength photometer, 2-18 ... reagent Dispensing probe, 2-19 ... sample disk, 2-20 ... sample container containing sample, 2-21 ... interface, 2-22 ... computer, 2-23 ... A / D converter, 3-1 to 3-5, specimen, 3-6, dispensing stop button pressing timing, 3-7, measurement sequence of comparative example, 3-8, analysis was suspended Sample C result output, 3-9... Sample C result output when analysis is not interrupted, 3-10. Ming measurement sequence, 4-1, 4-2 ... analysis interruption timing radio buttons, specimens for instructing to suspend 5-1 ... analysis

Claims (2)

In automatic analyzers that perform qualitative and quantitative analysis of samples,
A plurality of sample containers containing a plurality of samples;
A sample disk on which the multiple sample containers are disposed;
A plurality of reaction containers for containing a sample and a reagent;
A reaction disk on which the plurality of reaction vessels are disposed;
The sample contained in the sample container disposed in the sample disk, and dispensing the sample dispensing means to the reaction vessel arranged in the reaction disc,
An analysis unit for analyzing a sample housed in a reaction vessel disposed on the reaction disk;
An input means for selecting and inputting the analysis interruption timing of the sample to select whether the analysis of all the samples is interrupted by the operator or the analysis of the other samples is interrupted after the analysis operation of the selected sample is completed ,
Control means for controlling the operation of the sample disk, the reaction disk, the sample dispensing means, and the analysis unit, and suspending the sample dispensing operation according to the analysis interruption timing of the sample input by the input means;
An automatic analyzer characterized by comprising. 2. The automatic analyzer according to claim 1, wherein the input means includes an input area for the position or sample number of the sample disk, and the selected sample is input with the position or sample number input in the input area. An automatic analyzer characterized by being a sample corresponding to the above.

Images