JP6026753B2 - Automatic analyzer - Google Patents

Description

  The present invention relates to an automatic analyzer that performs qualitative and quantitative analysis of samples such as blood and urine.

  As an automatic analyzer that performs qualitative and quantitative analysis of a sample such as blood or urine (hereinafter referred to as a specimen), for example, Patent Document 1 (Japanese Patent Laid-Open No. 2011-127916) contains a specimen such as a biological sample. Sample container, sample disk holding the sample container, reaction container containing the sample, reaction disk holding the reaction container, and pipette attached to the operating arm for dispensing the sample from the sample container to the reaction container A nozzle, a reaction container held on the reaction disk, a liquid storage part for storing a liquid for maintaining the sample in the stored reaction container at a constant temperature, and a space between the liquid storage part and the reaction container And a photometer for optically measuring a sample in a reaction vessel housed in a liquid container of the reaction tank. It discloses a technique relating to an automatic analyzer having a.

JP 2011-127916 A

  In the automatic analyzer as described above, the next sample container containing the sample to be analyzed is sequentially added to the empty area of the sample disk, and the sample container in which the dispensing of the sample into the reaction container has been completed. Sequentially replaced with the next specimen container.

  However, in the above-described prior art, when the next sample container is additionally installed following the sample being analyzed, the sample container holding unit for installing the next sample is covered with the probe guard, so that the sample being analyzed It is necessary to wait until the dispensing operation is completed, and after the dispensing operation is completed, the next specimen installation position must be manually moved to the outside of the probe guard, which may reduce operability. The

  The present invention has been made in view of the above, and an object of the present invention is to provide an automatic analyzer capable of easily performing an operation of additionally installing the next sample container following the sample being analyzed.

In order to achieve the above object, the present invention provides a plurality of specimen containers holding parts arranged side by side in the circumferential direction to arrange specimen containers containing specimens, and a plurality of emergency specimens arranged in a row in the circumferential direction. a sample disc and another sample container holder of the specimen container holder and a general sample was placed in use, the reagent disk in which a plurality of reagent container containing a reagent used for analysis of the specimen, and the specimen A reaction disk in which a plurality of reaction containers containing reaction liquids mixed with a reagent are arranged; a sample dispensing mechanism for dispensing the sample in the sample container into the reaction container; and the reaction in the reagent in the reagent container A reagent dispensing mechanism that dispenses into a container, an analyzer that analyzes the reaction solution in the reaction container to measure a component of the sample, and at least a predetermined invasion that includes an operating range of the sample dispensing mechanism. Operations to area A first cover member that covers the inaccessible area so as to prevent data access, a second cover member that covers a range including the inaccessible area and a part of the sample disk, and the second cover member. Placed on the outer side of the cover member, mounted on the sample container holding position of the sample container or provided for exchanging the sample container to be analyzed next, and mounted on or exchanged on the sample disk If the sample container is a general sample, the sample disk is rotated to move the sample container holding part for the general sample to be mounted or exchanged to the sample container handling position , In some cases, the specimen container holder for the emergency specimen is moved to the specimen container handling position, and in the case where there are more general specimens or emergency specimens to be mounted or exchanged, the specimen container is held. The specimen container holder of the handling position and that a single movement control device.

  According to the present invention, it is possible to additionally install the next sample container following the sample being analyzed.

It is a figure which shows the whole structure of the automatic analyzer which concerns on one embodiment. It is a figure which expands and shows the sample disk in an automatic analyzer with the periphery structure. It is a figure which shows an example of the operation setting screen displayed on a display apparatus at the time of general sample registration. It is a figure which shows an example of the operation setting screen displayed on a display apparatus during analysis operation | movement. It is a figure which shows an example of the operation setting screen displayed on a display apparatus at the time of additional sample registration. It is a flowchart which shows the processing content of a sample addition process.

An embodiment of the present invention will be described with reference to the drawings.
FIG. 1 is a diagram schematically showing an overall configuration of an automatic analyzer according to the present embodiment.

  In FIG. 1, the automatic analyzer is roughly composed of an analysis unit 100 and an operation unit 16. The analysis unit 100 includes a computer 14 as a control unit that controls the entire automatic analyzer, a sample disk 2, a reagent disk 4, and a reaction disk 6 that are provided so as to be intermittently rotatable, and a sample that dispenses the sample. A dispensing probe 7, a reagent dispensing probe 8 for dispensing a reagent, a measuring unit 21 for measuring a reaction solution, and an interface 15 for connecting them are provided. The operation unit 16 also displays a display device 17 for displaying information such as a setting screen and analysis results, an input device 18 for inputting settings and instructions, various programs used for analysis, settings, analysis results, and the like. A storage device 19 that stores information and an output device 19 that outputs information such as analysis results (for example, a printing device that performs printing) are provided, and are connected to the control unit 14 via an interface 15.

  The control unit 14 controls the overall operation of the automatic analyzer, and based on various settings and commands input by the input device 18, various information (measurement programs and settings, measurement results, etc.) to the storage device 19. ) And control the operation of the sample disk 2, the reagent disk 4, the reaction disk 6, the sample dispensing probe 7, the reagent dispensing probe 8, the measuring unit 21, the output device 19, and the like, and a display device 17 display contents are controlled. The operator inputs various commands and settings through the input device 18 based on the display content of the display device 17.

  FIG. 2 is an enlarged view showing the sample disk together with its peripheral configuration.

  As shown in FIGS. 1 and 2, the sample disk 2 holds a plurality of sample containers for holding a sample container 1 in which a sample such as blood or urine to be analyzed (hereinafter referred to as a sample) is stored. The parts 1a are arranged side by side in the circumferential direction, and are rotationally driven in the circumferential direction by a rotation driving mechanism (not shown). Identification numbers 1d are sequentially assigned in the circumferential direction to a plurality (for example, 35) of sample container holders 1a of the sample disk 2 (see FIG. 2). Among the plurality of sample container holding parts 1a, a plurality of (for example, five) sample container holding parts 1a in the circumferential direction are assigned to hold the sample container 1 containing the emergency sample, and other sample containers The holding unit 1a is assigned to hold the sample container 1 containing the general sample. In the present embodiment, the specimen container holding part 1a having the identification number 1d of 1 to 30 is used to hold the specimen container 1 containing the general specimen, and the specimen container holding part 1a having the identification number 1d of 31 to 35 is used to hold the emergency specimen. The case where each is assigned is shown.

  Between the sample disk 2 and the reaction disk 6, a sample dispensing probe 7 for dispensing the sample from the sample container 1 of the sample disk 2 to the reaction container 5 of the reaction disk 6 is disposed, and at least the sample dispensing probe 7 is disposed. The probe guard 7a is arranged so as to cover the upper part of the operating area. The probe guard 7a prevents the operator from entering the working area of the sample dispensing probe 7 and coming into contact with the sample dispensing probe 7. The probe guard 7a defines an invasion impossible area.

  The sample container holding unit 1a and the sample container 1 are driven by rotation of the sample disk 2 on the trajectory of the sample container 1, and at least outside the region covered by the probe guard 7a (inaccessible region), the sample container holding unit 1a A sample container handling position 1c for mounting or replacing the sample container 1 is set, and a sample container handling position mark 1b is provided at that position. The sample disk 2 is arranged on the front side of the reaction disk 6, and the operator accesses the sample container holding unit 1a moved to the sample container handling position 1c by the control unit 14 described later from the front side of the analysis unit 100. The sample container 1 is mounted on or replaced with the sample disk 2.

  On the reagent disk 4, reagent bottles 3 containing various reagents used for sample analysis are arranged side by side in the circumferential direction, and are rotationally driven in the circumferential direction by a rotation driving mechanism (not shown). A reagent dispensing probe 8 for dispensing a reagent from the reagent bottle 3 of the reagent disk 4 to the reaction container 5 of the reaction disk 6 is disposed between the reagent disk 4 and the reaction disk 6.

  On the reaction disk 6, reaction containers 5 containing reaction liquids in which a specimen to be analyzed and a reagent are mixed are arranged side by side in the circumferential direction, and are rotationally driven in the circumferential direction by a rotation driving mechanism (not shown). On the transport path of the reaction vessel 5 in the rotational drive of the reaction disk 6, the stirring device 9 for stirring the reaction solution stored in the reaction vessel 5, the measuring unit 21 for measuring the amount of light transmitted through the reaction solution, and the end of the measurement And a cleaning device 12 for cleaning the reaction vessel 5.

  The measurement unit 21 includes a light source 10 that irradiates measurement light to a reaction vessel 5 to be measured, and a multiwavelength photometer 11 that measures the luminous intensity of light that passes through the reaction vessel 5 and the reaction solution. The measurement result of the multiwavelength photometer 11 is converted into a digital signal by the A / D converter 13, sent to the storage device 20 via the interface 15, stored, and sent to the control unit (computer) 14. The absorbance is calculated. The calculation result (absorbance) in the control unit 14 is sent to and stored in the storage unit 20 via the interface 15.

  The analysis unit 100 is provided with a main body cover 100a that covers the sample disk 1, the reagent disk 2, the reaction disk 5, and the like so as to be opened and closed. A part of the sample disk 2 including the sample container handling position 1c is arranged so as to protrude to the front side of the main body cover 100a. That is, the sample container handling position 1c of the sample disk 1 is exposed on the front side of the main body cover 100a, and the operator can set the sample container 1 even when the main body cover 100a is in an open state or a closed state. It is possible to mount or replace the sample container holding unit 1a.

  3 to 5 are diagrams showing an example of an operation setting screen displayed on the display device. FIG. 3 is a general sample registration time, FIG. 4 is an analysis process, and FIG. 5 is an additional sample registration time operation setting screen. It is a figure which shows an example, respectively.

  3 to 5, an operation setting screen 170 displayed on the display device 17 is used for various settings and operations in the automatic analyzer, display of measurement results, and the like, and an operation state indicating an operation state of the automatic analyzer. Display unit 179, a plurality of switching buttons 171 for switching display contents of the operation setting screen, a switching tab 172 for switching display contents between an analysis request and a measurement result, and a plurality of operations for instructing various operations of the automatic analyzer. Button 178 is provided.

  On the screen on which the analysis request is selected on the switching tab 172, a general sample button 173a for setting whether the sample stored in the sample container 1 added to the sample disk 2 is a general sample or an emergency sample, and an emergency A sample selection unit 173 having a sample button 173b, an information display unit 174 for displaying information for assisting an operator's operation, a start button 175 for instructing start of processing, and a sample container 1 containing a sample to be measured A sample addition button 176 for instructing a sample addition process for adding a sample, and an item selection information section 177 for setting a request content of the sample to be added and registering it by a registration button 177a are provided.

  As shown in FIG. 3, at the time of registration of a general sample (during standby), the operator performs various operations according to instructions displayed on the information display unit 174. When the sample addition button 176 is selected, the sample disk 2 is rotationally driven by the control unit 14, and the sample container holding unit 1a for general samples to which the sample container 1 can be added is, for example, the position 1 (that is, the identification number). The specimen container holding part 1a) 1d is moved to the specimen container handling position 1c. In the information display unit 174, as information for assisting the operator, the loading of the sample container 1 in the position 1 and the registration of the item selection information in the item selection information unit 177 (that is, the sample type, patient ID, assumed item, etc.) Input / selection and selection of the registration button 177a) and a prompt to select the start button 175.

  As shown in FIG. 4, during analysis (during operation), when an additional sample is desired to be installed, a display prompting the user to select an additional sample button 176 is displayed. When an additional sample is installed, the operator can add a sample by selecting whether the sample to be added is a general sample or an emergency sample by using the sample selection unit 173 and selecting an additional sample button 176 (sample addition). processing).

  As shown in FIG. 5, when the additional sample is an emergency sample, when the sample selection unit 173 selects the emergency sample button 173 b and selects the sample addition button 176, the sample disk 2 is rotationally driven by the control unit 14. For example, the position 31 (that is, the sample container holding part 1a having the identification number 1d of 31) is moved to the sample container handling position 1c as the specimen container holding part 1a for the emergency specimen to which the specimen container 1 can be added. In the information display unit 174, as information for assisting the operator, mounting of the sample container 1 at the position 31 and registration of item selection information in the item selection information unit 177 (that is, sample type, patient ID, assumed item, etc.) Input / selection and selection of the registration button 177a) and a prompt to select the start button 175.

  FIG. 6 is a flowchart illustrating the procedure of the sample addition process by the control unit.

  During the analysis, the control unit 14 rotationally drives the sample disk 2 to sequentially move the sample to be dispensed and measured to the dispensing position by the sample dispensing probe 7 (Step S10). Processing is performed (step S20). Here, it is determined whether or not the sample addition button 176 is selected on the operation setting screen 170 (step S30). If the determination result is NO, it is determined whether or not the sample is the final sample (step S31). If the determination result in step S31 is NO, the processes in steps S10 to S30 are repeated, and if the determination result is YES, the sample container holding unit 1a (that is, the sample container 1 is mounted) on which the sample container 1 can be mounted. The sample container holding unit 1a) that holds the sample container 1 that has not been held or that has undergone the dispensing process is moved to the sample container handling position 1c (step S32), and the process ends.

  If the determination result in step S30 is YES, the dispensing process for the sample container 1 mounted on the sample disk 2 is temporarily suspended (step S40), and it is determined whether the sample to be added is an emergency sample. (Step S50). If the determination result in step S50 is NO, that is, if the sample to be added is a general sample, the sample container 1 of the sample container holding portions 1a having the identification numbers 1d assigned to the general samples is 1 to 30. Is moved to the sample container handling position 1c (for example, position 1) (step S51). At this time, on the information display unit 174 of the operation setting screen 170, a display prompting the loading of the sample container 1 in the position 1, registration of the item selection information in the item selection information unit 177, and selection of the start button 175 is made. (See FIG. 3).

  If the determination result in step S50 is YES, that is, if the sample to be added is an urgent sample, the sample among the sample container holding parts 1a having the identification numbers 1d assigned to the urgent sample is 31 to 35. The specimen container holding portion 1a (for example, position 31) on which the container 1 can be mounted is moved to the specimen container handling position 1c (step S60). At this time, the information display unit 174 of the operation setting screen 170 is displayed to prompt the loading of the sample container 1 at the position 31, registration of the item selection information in the item selection information unit 177, and selection of the start button 175. (See FIG. 3).

  When the processing of step S51 and step S60 ends, it is determined whether or not the registration button 177a has been selected, that is, whether or not item selection information has been registered (step S70). The position of the sample container holding unit 1a located on the container mounting unit 1c is moved by one (step S80), and if the determination result is NO, it is determined whether the start button 175 has been selected (step S90). If the determination result in step S90 is NO, the process returns to step S70.

  If the determination result in step S90 is YES, it is determined whether the additional sample is an emergency sample (step S100). If the determination result is YES, the target sample container 1, that is, added. The sample container 1 containing the urgent sample is moved to the dispensing position (step S110), and a dispensing process is performed (step S120). Subsequently, it is determined whether or not the urgent sample dispensing process has been completed (step S130). If the determination result is NO, the process of step S120 is repeated until the determination result in step S130 is YES.

  If the determination result in step S100 is NO or if the determination result in step S130 is YES, the suspension of the dispensing process performed in step S40 is released (step S140), and the process returns to step S10. .

  The effect of the present embodiment configured as described above will be described.

  In the conventional automatic analyzer, the next sample container containing the sample to be analyzed is sequentially added to the empty area of the sample disk, and the sample container in which the dispensing of the sample into the reaction container has been completed is the next sample container. Sequentially replaced with containers. However, when the next sample container is additionally installed following the sample being analyzed, the sample container holding portion for installing the next sample is covered with the probe guard, and thus the dispensing operation of the sample being analyzed is completed. After the dispensing operation is completed, the sample container holder for installing the next sample must be manually moved to the outside of the probe guard. .

  On the other hand, in the present embodiment, a plurality of sample disks in which a plurality of sample container holding parts for arranging sample containers containing samples are arranged in the circumferential direction and a plurality of samples containing reagents used for analyzing samples are stored. In an automatic analyzer equipped with a reagent disk on which a plurality of reaction containers are arranged and a reaction disk on which a plurality of reaction containers containing a reaction liquid in which a sample and a reagent are mixed are disposed, at least the sample in the sample container is divided into reaction containers. Specimen container handling position provided for loading and unloading the specimen container from the specimen container holder outside the non-intrusion area that is predetermined to include the operating range of the specimen dispensing mechanism to be poured In addition, since the sample disk holder is rotated to move the sample container holding unit to be loaded or replaced, the next sample container is additionally installed following the sample being analyzed. Rukoto is possible.

DESCRIPTION OF SYMBOLS 1 Specimen container 1a Specimen container holding part 1b Specimen container handling position mark 1c Specimen container handling position 1d Identification number 2 Specimen disk 3 Reagent bottle 4 Reagent disk 5 Reaction container 6 Reaction disk 7 Specimen dispensing probe 7a Probe guard 8 Reagent dispensing probe 9 Stirring device 10 Light source 11 Multi-wavelength photometer 12 Cleaning device 13 A / D converter 14 Computer (control unit)
15 Interface 16 Operation Unit 17 Display Device 18 Input Device 19 Output Device 20 Storage Device 21 Measuring Unit 100 Analysis Unit 100a Body Cover

Claims (4)

A plurality of specimen container holders arranged side by side in the circumferential direction for arranging specimen containers containing specimens, and a plurality of specimen container holders for emergency specimens arranged in a row in the circumferential direction, and for general specimens a sample disc and a sample container holder was placed in,
A reagent disk in which a plurality of reagent containers containing reagents used for analysis of the specimen are arranged;
A reaction disk in which a plurality of reaction containers containing a reaction liquid in which the sample and the reagent are mixed are disposed;
A sample dispensing mechanism for dispensing the sample of the sample container into the reaction container;
A reagent dispensing mechanism for dispensing the reagent of the reagent container into the reaction container;
An analyzer for analyzing the reaction solution in the reaction vessel and measuring a component of the specimen;
A first cover member that covers the inaccessible area so as to prevent an operator from accessing the inaccessible area that is predetermined to include at least the operating range of the specimen dispensing mechanism;
A second cover member covering a range including the intrusion impossible area and a part of the sample disk;
A specimen container handling position that is disposed outside the second cover member and is provided for mounting the specimen container on the specimen container holding unit or for exchanging the specimen container to be analyzed next;
It said when the specimen container to be mounted or replaced on the sample disk is generally specimen one of the sample container holder for said general analyte of interest to mount or replace the specimen container by rotating the said specimen disk When the sample is moved to a sample container handling position and is an urgent sample, one of the sample container holding parts for the urgent sample is moved to the sample container handling position, and the general sample or emergency sample to be mounted or replaced If there is further, there is provided an automatic analyzer comprising a control device that moves one specimen container holding portion at the specimen container handling position . The automatic analyzer according to claim 1, wherein
When the dispensing of all the sample containers previously mounted on the sample container holding unit of the sample disk is completed, the control device mounts the sample container in which the sample to be dispensed is stored next. An automatic analyzer which moves a container holding part to the specimen container handling position. The automatic analyzer according to claim 2,
An additional setting means for setting additional loading of the sample container different from the sample container previously mounted on the sample container holding unit of the sample disk to the plurality of sample container holding units;
The control device suspends dispensing of the sample container previously mounted on the sample container holding unit of the sample disk based on the setting of the additional setting means, and the sample container on which the sample container to be added is mounted An automatic analyzer characterized by moving a holding part to the specimen container handling position. The automatic analyzer according to any one of claims 1 to 3,
Comprising sample information setting means for setting information of the sample container mounted on the sample container holding part of the sample disk;
The control device selects one of the plurality of sample container holding units based on the setting of the sample information setting means, and moves to the sample container handling position.

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