JP5219808B2 - 改良された結核ワクチン - Google Patents

改良された結核ワクチン Download PDF

Info

Publication number
JP5219808B2
JP5219808B2 JP2008517321A JP2008517321A JP5219808B2 JP 5219808 B2 JP5219808 B2 JP 5219808B2 JP 2008517321 A JP2008517321 A JP 2008517321A JP 2008517321 A JP2008517321 A JP 2008517321A JP 5219808 B2 JP5219808 B2 JP 5219808B2
Authority
JP
Japan
Prior art keywords
vaccine
polypeptide
rv2660c
ag85b
fusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008517321A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008543890A (ja
JP2008543890A5 (cg-RX-API-DMAC7.html
Inventor
クラウス・アーガード
カリナ・ヴィングスボ−ルンドベルグ
ペーター・アンデルセン
Original Assignee
ステイテンス・セラム・インスティテュート
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ステイテンス・セラム・インスティテュート filed Critical ステイテンス・セラム・インスティテュート
Publication of JP2008543890A publication Critical patent/JP2008543890A/ja
Publication of JP2008543890A5 publication Critical patent/JP2008543890A5/ja
Application granted granted Critical
Publication of JP5219808B2 publication Critical patent/JP5219808B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/04Mycobacterium, e.g. Mycobacterium tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2008517321A 2005-06-23 2006-06-20 改良された結核ワクチン Expired - Fee Related JP5219808B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200500924 2005-06-23
DKPA200500924 2005-06-23
DKPA200501393 2005-10-05
DKPA200501393 2005-10-05
PCT/DK2006/000356 WO2006136162A2 (en) 2005-06-23 2006-06-20 Tuberculosis vaccines comprising antigens expressed during the latent infection phase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013001657A Division JP2013121959A (ja) 2005-06-23 2013-01-09 改良された結核ワクチン

Publications (3)

Publication Number Publication Date
JP2008543890A JP2008543890A (ja) 2008-12-04
JP2008543890A5 JP2008543890A5 (cg-RX-API-DMAC7.html) 2009-12-24
JP5219808B2 true JP5219808B2 (ja) 2013-06-26

Family

ID=37134239

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008517321A Expired - Fee Related JP5219808B2 (ja) 2005-06-23 2006-06-20 改良された結核ワクチン
JP2013001657A Pending JP2013121959A (ja) 2005-06-23 2013-01-09 改良された結核ワクチン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013001657A Pending JP2013121959A (ja) 2005-06-23 2013-01-09 改良された結核ワクチン

Country Status (12)

Country Link
US (4) US7968105B2 (cg-RX-API-DMAC7.html)
EP (4) EP1910409A2 (cg-RX-API-DMAC7.html)
JP (2) JP5219808B2 (cg-RX-API-DMAC7.html)
KR (2) KR101035053B1 (cg-RX-API-DMAC7.html)
CN (1) CN102836425B (cg-RX-API-DMAC7.html)
AU (1) AU2006261445B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0612833A2 (cg-RX-API-DMAC7.html)
CA (2) CA2836319A1 (cg-RX-API-DMAC7.html)
ES (1) ES2647070T3 (cg-RX-API-DMAC7.html)
IL (3) IL188222A (cg-RX-API-DMAC7.html)
MX (1) MX2007016165A (cg-RX-API-DMAC7.html)
WO (1) WO2006136162A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3034957B2 (ja) 1995-08-02 2000-04-17 マンネスマン・アクチエンゲゼルシャフト 鋼から連鋳材を製造するためのプレート鋳型

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003242504A1 (en) * 2002-07-13 2004-02-02 Statens Serum Institut Therapeutic tuberculosis vaccines
PL2136836T3 (pl) * 2007-04-04 2017-07-31 Infectious Disease Research Institute Kompozycje immunogenne zawierające polipeptydy prątka gruźlicy i produkty ich fuzji
WO2008128065A2 (en) * 2007-04-12 2008-10-23 Jennifer Lighter Tuberculosis vaccine and method of using same
US8563009B2 (en) * 2007-06-29 2013-10-22 Statens Serum Institut Use of monomycolyl glycerol (MMG) as an adjuvant
EP2244720A4 (en) * 2008-01-11 2013-01-16 Us Gov Health & Human Serv POLYPEPTIDE VACCINE AND VACCINE STRATEGY AGAINST MYCOBACTERIUM
US20100015171A1 (en) * 2008-07-15 2010-01-21 Statens Serum Institute Vaccines comprising tb 10.4
HUE031044T2 (en) * 2008-07-25 2017-06-28 Glaxosmithkline Biologicals Sa Polypeptides, polynucleotides and compositions for use in the treatment of latent tuberculosis
ES2588183T3 (es) * 2009-03-31 2016-10-31 Japan As Represented By Director-General Of National Institute Of Infectious Diseases Procedimiento para la prevención de la gripe utilizando una vacuna para administración intranasal
CN102413837B (zh) * 2009-04-24 2015-11-25 国立血清研究所 预防再激活的结核病tb疫苗
CN106421743A (zh) * 2009-07-29 2017-02-22 贝恩德·赫尔穆特·阿达姆·雷姆 聚合物微粒及其用途
SG11201500171YA (en) 2012-07-10 2015-02-27 Transgene Sa Mycobacterial antigen vaccine
RU2520078C1 (ru) * 2013-04-25 2014-06-20 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации (ФГБУ "НИИЭМ им. Н.Ф. Гамалеи" Минздрава России) СПОСОБ ПОЛУЧЕНИЯ ИММУНОГЕННОЙ КОМПОЗИЦИИ НА ОСНОВЕ ГИБРИДНОГО БЕЛКА Ag85A-DBD И ДЕКСТРАНА, РЕКОМБИНАНТНАЯ ПЛАЗМИДА pAg85A-DBD, ШТАММ Escherichia coli [pREP4, pAg85A-DBD], ХИМЕРНЫЙ БЕЛОК Ag85A-DBD
RU2520737C1 (ru) * 2013-04-25 2014-06-27 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт эпидемиологии и микробиологии имени почётного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации (ФГБУ "НИИЭМ им. Н.Ф. Гамалеи" Минздрава России) СПОСОБ ПОЛУЧЕНИЯ ИММУНОГЕННОЙ КОМПОЗИЦИИ НА ОСНОВЕ ГИБРИДНОГО БЕЛКА pESAT6-DBD И ДЕКСТРАНА, РЕКОМБИНАНТНАЯ ПЛАЗМИДА pESAT6-DBD, ШТАММ Escherichia coli, ХИМЕРНЫЙ БЕЛОК ESAT6-DBD И ИХ ПРИМЕНЕНИЕ
RU2539026C1 (ru) * 2013-06-11 2015-01-10 Федеральное государственное бюджетное учреждение "Центральный научно-исследовательский институт туберкулеза" Российской академии медицинских наук РЕКОМБИНАНТНАЯ ПЛАЗМИДА pESAT6-CFP10-DBD, РЕКОМБИНАНТНЫЙ ШТАММ Escherichia coli M15 [pREP4, pESAT6-CFP10-DBD], СПОСОБ ПОЛУЧЕНИЯ, ИММОБИЛИЗАЦИИ, КОНЦЕНТРИРОВАНИЯ И ОЧИСТКИ РЕКОМБИНАНТНОГО БЕЛКА ESAT6-CFP10-DBD НА ДЕКСТРАНЕ, РЕКОМБИНАНТНЫЙ БЕЛОК ESAT6-CFP10-DBD И ИММУНОГЕННАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ БЕЛОК ESAT6-CFP10-DBD
WO2014210018A1 (en) 2013-06-25 2014-12-31 Aeras Global Tb Vaccine Foundation Tuberculosis compositions and methods of using the same
CN106103471B (zh) * 2014-01-09 2020-01-07 特兰斯吉恩股份有限公司 异源寡聚分枝杆菌抗原的融合
WO2017218867A1 (en) * 2016-06-16 2017-12-21 Aeras Tuberculosis compositions and methods of treating or preventing tuberculosis
CN107970444B (zh) * 2016-10-25 2022-03-01 中国人民解放军第三0九医院 复合佐剂及含有该复合佐剂的疫苗
PH12021553146A1 (en) * 2019-06-14 2024-04-22 Statens Seruminstitut Fusion proteins for tuberculosis vaccines
EP4217066A4 (en) * 2020-09-23 2024-10-23 The General Hospital Corporation BCG VACCINES TO PREVENT COVID-19 AND OTHER INFECTIOUS DISEASES
KR102709729B1 (ko) * 2020-12-04 2024-09-25 주식회사 제넥신 결핵의 예방 또는 치료용 약학적 조성물
CN115598041B (zh) * 2021-07-07 2025-08-19 中国科学院微生物研究所 结核鉴别诊断细胞因子及其在结核感染风险评估中的应用
KR20240153581A (ko) 2022-02-21 2024-10-23 스태튼스 세룸 인스티튜트 신규한 양이온 어주번트 조성물
CN117531001A (zh) * 2023-11-15 2024-02-09 首都医科大学附属北京胸科医院 结核分枝杆菌毒素抗毒素系统及其相关应用
CN118108815B (zh) * 2024-04-23 2024-07-23 成都康华生物制品股份有限公司 结核分枝杆菌多免疫原抗原、编码其的mRNA、应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1331C (da) 1897-11-15 Hans Daae Militær- og Skilygte.
US4599230A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4599231A (en) 1984-03-09 1986-07-08 Scripps Clinic And Research Foundation Synthetic hepatitis B virus vaccine including both T cell and B cell determinants
US4608251A (en) 1984-11-09 1986-08-26 Pitman-Moore, Inc. LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues
US4601903A (en) 1985-05-01 1986-07-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccine against Neisseria meningitidis Group B serotype 2 invasive disease
US6641814B1 (en) 1997-04-02 2003-11-04 Statens Serum Institut Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis
WO1996009320A1 (fr) * 1994-09-20 1996-03-28 Hitachi Chemical Company, Ltd. Polypeptide antigenique de chlamydia pneumoniae
EP1741718A3 (en) 1995-06-07 2007-03-28 Sanofi Pasteur Inc. Expression of lipoproteins
US20040018574A1 (en) * 1998-08-25 2004-01-29 Marcel Behr Molecular differences between species of the M. tuberculosis complex
JP2003510326A (ja) 1999-09-30 2003-03-18 ニューロジェン・コーポレーション アミノ置換ピラゾロ[1,5−a]−1,5−ピリミジン類及びピラゾロ[1,5−a]−1,3,5−トリアジン類
AU2001250294A1 (en) 2000-04-19 2001-10-30 Statens Serum Institut Tuberculosis antigens and methods of use thereof
AU2001271963A1 (en) 2000-07-10 2002-01-21 Colorado State University Research Foundation Mid-life vaccine and methods for boosting anti-mycobacterial immunity
US20030180953A1 (en) * 2000-12-29 2003-09-25 Elitra Pharmaceuticals, Inc. Gene disruption methodologies for drug target discovery
JP2005522980A (ja) * 2001-04-23 2005-08-04 エリトラ ファーマシューティカルズ,インコーポレイテッド アスペルギルス・フミガーツス(Aspergillusfumigatus)の必須遺伝子の同定および使用方法
EP1404706A2 (en) * 2001-07-04 2004-04-07 Health Protection Agency Mycobacterial antigens expressed during latency
AU2003242504A1 (en) * 2002-07-13 2004-02-02 Statens Serum Institut Therapeutic tuberculosis vaccines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3034957B2 (ja) 1995-08-02 2000-04-17 マンネスマン・アクチエンゲゼルシャフト 鋼から連鋳材を製造するためのプレート鋳型

Also Published As

Publication number Publication date
EP2380589A3 (en) 2012-09-12
IL188222A (en) 2015-11-30
AU2006261445B2 (en) 2011-03-31
CA2836319A1 (en) 2006-12-28
CN102836425B (zh) 2015-08-19
BRPI0612833A2 (pt) 2010-11-30
CA2612900C (en) 2016-08-09
US20110206713A1 (en) 2011-08-25
EP2380590A3 (en) 2012-08-22
IL188222A0 (en) 2008-03-20
HK1179855A1 (zh) 2013-10-11
EP2380590A2 (en) 2011-10-26
KR20100122130A (ko) 2010-11-19
EP2163255A1 (en) 2010-03-17
US8101193B2 (en) 2012-01-24
KR20080027877A (ko) 2008-03-28
AU2006261445A1 (en) 2006-12-28
CA2612900A1 (en) 2006-12-28
CN102836425A (zh) 2012-12-26
US20090186048A1 (en) 2009-07-23
US8293250B2 (en) 2012-10-23
US7968105B2 (en) 2011-06-28
EP2163255B1 (en) 2017-08-09
MX2007016165A (es) 2008-03-14
WO2006136162A2 (en) 2006-12-28
JP2013121959A (ja) 2013-06-20
US20120114687A1 (en) 2012-05-10
EP1910409A2 (en) 2008-04-16
KR101035053B1 (ko) 2011-05-19
WO2006136162A3 (en) 2007-11-15
IL222915A0 (en) 2012-12-31
ES2647070T3 (es) 2017-12-19
JP2008543890A (ja) 2008-12-04
US8703151B2 (en) 2014-04-22
HK1124071A1 (en) 2009-07-03
IL222914A0 (en) 2012-12-31
KR101188045B1 (ko) 2012-10-05
EP2380589A2 (en) 2011-10-26
US20130095132A1 (en) 2013-04-18

Similar Documents

Publication Publication Date Title
JP5219808B2 (ja) 改良された結核ワクチン
US10519202B2 (en) Tuberculosis TB vaccine to prevent reactivation
WO2005061534A2 (en) Improved tuberculosis vaccines
CN101248084B (zh) 包含潜伏感染阶段期间所表达的抗原的结核疫苗
AU2011203012A1 (en) Tuberculosis vaccines comprising antigens expressed during the latent infection phase
US20020172685A1 (en) Methods and compositions for therapeutic intervention in infectious disease
CIPO Prophylactic GP studies
HK1124071B (en) Tuberculosis vaccines comprising antigens expressed during the latent infection phase
HK1179855B (en) Tuberculosis vaccines comprising antigens expressed during the latent infection phase
HK1166018B (en) A tuberculosis tb vaccine to prevent reactivation

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090615

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090615

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091015

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091102

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120117

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120412

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121009

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130109

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130205

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130305

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20160315

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 5219808

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees