JP5203808B2 - 絡み編み構造を備えたメッシュインプラント - Google Patents
絡み編み構造を備えたメッシュインプラント Download PDFInfo
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- JP5203808B2 JP5203808B2 JP2008153433A JP2008153433A JP5203808B2 JP 5203808 B2 JP5203808 B2 JP 5203808B2 JP 2008153433 A JP2008153433 A JP 2008153433A JP 2008153433 A JP2008153433 A JP 2008153433A JP 5203808 B2 JP5203808 B2 JP 5203808B2
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- fibers
- mesh implant
- mesh
- absorbent
- implant
- Prior art date
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- 239000007943 implant Substances 0.000 title claims abstract description 105
- 239000000835 fiber Substances 0.000 claims abstract description 81
- 230000015556 catabolic process Effects 0.000 claims abstract description 12
- 238000006731 degradation reaction Methods 0.000 claims abstract description 12
- 210000004872 soft tissue Anatomy 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims description 47
- 229920000642 polymer Polymers 0.000 claims description 29
- 230000002745 absorbent Effects 0.000 claims description 27
- 239000002250 absorbent Substances 0.000 claims description 27
- 238000002513 implantation Methods 0.000 claims description 14
- 206010019909 Hernia Diseases 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 7
- 238000009940 knitting Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000001172 regenerating effect Effects 0.000 claims description 3
- 229920005594 polymer fiber Polymers 0.000 claims 2
- 239000011358 absorbing material Substances 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000007547 defect Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 31
- 210000003815 abdominal wall Anatomy 0.000 description 8
- 230000035876 healing Effects 0.000 description 8
- 230000008859 change Effects 0.000 description 7
- 238000012360 testing method Methods 0.000 description 6
- 230000029663 wound healing Effects 0.000 description 6
- 238000000354 decomposition reaction Methods 0.000 description 5
- 239000010410 layer Substances 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 230000000451 tissue damage Effects 0.000 description 4
- 231100000827 tissue damage Toxicity 0.000 description 4
- 230000017423 tissue regeneration Effects 0.000 description 4
- 238000002054 transplantation Methods 0.000 description 4
- 206010021620 Incisional hernias Diseases 0.000 description 3
- 229910000831 Steel Inorganic materials 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 238000007634 remodeling Methods 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- 210000002435 tendon Anatomy 0.000 description 3
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000013013 elastic material Substances 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 239000002346 layers by function Substances 0.000 description 2
- 210000003041 ligament Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- VPVXHAANQNHFSF-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1 VPVXHAANQNHFSF-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 208000027536 Femoral Hernia Diseases 0.000 description 1
- 208000034991 Hiatal Hernia Diseases 0.000 description 1
- 206010020028 Hiatus hernia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000029836 Inguinal Hernia Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920001710 Polyorthoester Polymers 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 238000002695 general anesthesia Methods 0.000 description 1
- 230000037313 granulation tissue formation Effects 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 230000007124 immune defense Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229920005684 linear copolymer Polymers 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003274 myotonic effect Effects 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000002745 poly(ortho ester) Substances 0.000 description 1
- 229920002627 poly(phosphazenes) Polymers 0.000 description 1
- 229920000162 poly(ureaurethane) Polymers 0.000 description 1
- 229920001692 polycarbonate urethane Polymers 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000012779 reinforcing material Substances 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 206010045458 umbilical hernia Diseases 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Knitting Of Fabric (AREA)
Description
ボールバースト試験装置のための引張強度16N/cmにおける本発明のメッシュインプラントの全体的な相対的膨張は(K. Junge et al.: Elasticity of the another abdominal wall and impact for reparation of incisional hernias using mesh implants. Hernia 2001, no. 5, pp. 113-118参照)、固定形状に関する(25.4mmの磨き鋼球、44.45mmの内部開口径)ASTM D3787−01ガイドラインにしたがって決定された。共に2種の異なるインターロックパターン、ダイヤモンドパターンおよびフルトリコット、に編まれた2つの異なるメッシュがテストされた。両メッシュとも同様の2種の繊維からなり、分解速度が速い繊維(40重量%)は、ソフトコアおよび86%のグリコリド、残りがトリメチレンカーボネイトおよびラクチドからなる結晶アームを有する3軸共重合体であり、分解速度が遅い繊維(60重量%)は、ソフトコアおよび91.5%のラクチド、残りがトリメチレンカーボネイトからなる結晶アームを有する線状共重合体であった。各メッシュの単位面積重量は約135g/m2であった。
1)試験中の最大負荷(N)
2)最大負荷における伸長(mm)
3)71Nの負荷における伸長(mm)
Claims (13)
- 損傷軟組織再生に使用するための吸収性高分子メッシュインプラントであって、
第1の吸収性材料と、
前記第1の吸収性材料よりも遅い時点で実質的に分解する第2の吸収性材料と、を有し、
前記第1の吸収性材料が前記第2の吸収性材料の開口部を横切ることにより前記第2の吸収性材料の動きを制限して移植後のメッシュインプラントの相対的膨張を前記第1の吸収性材料が実質的に分解するまで略一定に保ち、前記第1の吸収性材料が実質的に分解した後はメッシュインプラントの相対的膨張が大幅に上昇するように、前記第1の吸収性材料は前記第2の吸収性材料に接触していることを特徴とするメッシュインプラント。 - 損傷軟組織再生に使用するための吸収性高分子メッシュインプラントであって、
少なくとも第1の組の吸収性高分子繊維と第2の組の吸収性高分子繊維とを有し、
前記第1の組の繊維のフィラメントが前記第2の組の繊維のフィラメントに組み合わせられ、少なくとも部分的に前記第2の組の繊維の編みパターンを横切って、前記第1の組の繊維のフィラメントが前記第2の組の繊維により形成されたメッシュインプラントの一部の動きを制限するように、繊維が互いに編まれており、
移植後のメッシュインプラントの相対的膨張は前記第1の組の繊維が実質的に分解するまで略一定であり、
前記第2の組の繊維は前記第1の組の繊維よりも遅い時点で実質的に分解することを特徴とする請求項1に記載のメッシュインプラント。 - 前記第2の組の繊維よりも遅い時点で実質的に分解する第3の組の繊維をさらに有し、
前記第2の組の繊維が実質的に分解した後、メッシュインプラントの相対的膨張が大幅に変化することを特徴とする請求項2に記載の吸収性高分子メッシュインプラント。 - 異なる組の繊維が移植時から異なる分解時間を有する異なる材料からなることを特徴とする請求項2または3に記載の吸収性高分子メッシュインプラント。
- 前記第1の組の繊維が、移植後2日から40日の範囲内で実質的に分解することを特徴とする請求項2または3に記載の吸収性高分子メッシュインプラント。
- 最後に実質的に分解する組の繊維が、移植後3ヶ月から18ヶ月の範囲内で実質的に分解することを特徴とする請求項2または3に記載の吸収性高分子メッシュインプラント。
- 移植時から前記第1の組の繊維が実質的に分解するまでのメッシュインプラントの相対的膨張度は0%から10%であることを特徴とする請求項2または3に記載の吸収性高分子メッシュインプラント。
- 前記第1の組の繊維が実質的に分解した後のメッシュインプラントの相対的膨張度は10%より高いことを特徴とする請求項2または3に記載の吸収性高分子メッシュインプラント。
- 吸収性高分子メッシュインプラントはヘルニアメッシュインプラントであることを特徴とする請求項2または3に記載の吸収性高分子メッシュインプラント。
- メッシュインプラントの面に沿った一方向に、メッシュインプラントの面に沿った他方向よりも伸長することを特徴とする請求項2または3に記載の吸収性高分子メッシュインプラント。
- 内部身体構造を支持するために三次元形状に形成されたことを特徴とする請求項2または3に記載の吸収性高分子メッシュインプラント。
- 前記第1の組の繊維および/またその他の組の繊維が、開口寸法が0.1mmから4.0mmの範囲の編み構造を有するもしくは開口寸法が0.1mmから4.0mmの範囲の編み構造に組み込まれていることを特徴とする請求項2または3に記載の吸収性高分子メッシュインプラント。
- 伝線に耐性を有するメッシュを製造する技術により編まれたことを特徴とする請求項2または3に記載の吸収性高分子メッシュインプラント。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07109992.3 | 2007-06-11 | ||
EP07109992A EP2002800B1 (en) | 2007-06-11 | 2007-06-11 | Mesh implant with an interlocking knitted structure |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009039511A JP2009039511A (ja) | 2009-02-26 |
JP5203808B2 true JP5203808B2 (ja) | 2013-06-05 |
Family
ID=38668663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008153433A Active JP5203808B2 (ja) | 2007-06-11 | 2008-06-11 | 絡み編み構造を備えたメッシュインプラント |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2002800B1 (ja) |
JP (1) | JP5203808B2 (ja) |
CN (1) | CN101401748B (ja) |
AT (1) | ATE444031T1 (ja) |
AU (1) | AU2008202439B2 (ja) |
DE (1) | DE602007002621D1 (ja) |
ES (1) | ES2333990T3 (ja) |
PL (1) | PL2002800T3 (ja) |
Families Citing this family (31)
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US9833240B2 (en) | 2008-02-18 | 2017-12-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
US8758373B2 (en) | 2008-02-18 | 2014-06-24 | Covidien Lp | Means and method for reversibly connecting a patch to a patch deployment device |
US8808314B2 (en) | 2008-02-18 | 2014-08-19 | Covidien Lp | Device and method for deploying and attaching an implant to a biological tissue |
US9393093B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
US9393002B2 (en) | 2008-02-18 | 2016-07-19 | Covidien Lp | Clip for implant deployment device |
US9044235B2 (en) | 2008-02-18 | 2015-06-02 | Covidien Lp | Magnetic clip for implant deployment device |
US9034002B2 (en) | 2008-02-18 | 2015-05-19 | Covidien Lp | Lock bar spring and clip for implant deployment device |
US8317808B2 (en) | 2008-02-18 | 2012-11-27 | Covidien Lp | Device and method for rolling and inserting a prosthetic patch into a body cavity |
US9301826B2 (en) | 2008-02-18 | 2016-04-05 | Covidien Lp | Lock bar spring and clip for implant deployment device |
CA2730547C (en) | 2008-10-20 | 2013-08-06 | Polytouch Medical Ltd. | A device for attaching a patch to a biological tissue |
AU2010286117B9 (en) | 2009-08-17 | 2014-07-10 | Covidien Lp | Articulating patch deployment device and method of use |
US9999424B2 (en) | 2009-08-17 | 2018-06-19 | Covidien Lp | Means and method for reversibly connecting an implant to a deployment device |
JP5339649B2 (ja) * | 2010-02-26 | 2013-11-13 | 株式会社ティー・アンド・アイ | 軟部組織治療器具 |
US8911504B2 (en) | 2010-10-28 | 2014-12-16 | Novus Scientific Ab | Elastically deformable and resorbable medical mesh implant |
US9561093B2 (en) | 2010-10-28 | 2017-02-07 | Novus Scientific Ab | Elastically deformable and resorbable medical mesh implant |
SE535629C2 (sv) | 2010-10-28 | 2012-10-23 | Novus Scient Pte Ltd | Elastiskt deformerbart och resorberbart medicinskt nätimplantat |
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CN104043151B (zh) * | 2013-03-15 | 2016-03-30 | 深圳兰度生物材料有限公司 | 一种复合人工韧带及其制备方法 |
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JP2619972B2 (ja) * | 1990-06-29 | 1997-06-11 | 株式会社ニッショー | 医療用補綴材料 |
DE19613730C2 (de) * | 1996-03-26 | 2002-08-14 | Ethicon Gmbh | Flächiges Implantat zum Verstärken oder Verschließen von Körpergewebe |
US6319264B1 (en) * | 1998-04-03 | 2001-11-20 | Bionx Implants Oy | Hernia mesh |
DE10219860A1 (de) * | 2002-05-03 | 2003-11-20 | Ethicon Gmbh | Chirurgischer Faden und chirurgisches Implantat mit einem derartigen Faden |
US7008299B2 (en) * | 2002-08-29 | 2006-03-07 | Micron Technology, Inc. | Apparatus and method for mechanical and/or chemical-mechanical planarization of micro-device workpieces |
EP1674048B1 (en) * | 2004-12-23 | 2009-10-21 | Novus Scientific Pte. Ltd. | Mesh implant for use in reconstruction of soft tissue defects |
FR2898502B1 (fr) * | 2006-03-16 | 2012-06-15 | Sofradim Production | Tissu prothetique tridimensionnel a face dense resorbable |
-
2007
- 2007-06-11 AT AT07109992T patent/ATE444031T1/de not_active IP Right Cessation
- 2007-06-11 EP EP07109992A patent/EP2002800B1/en active Active
- 2007-06-11 DE DE602007002621T patent/DE602007002621D1/de active Active
- 2007-06-11 ES ES07109992T patent/ES2333990T3/es active Active
- 2007-06-11 PL PL07109992T patent/PL2002800T3/pl unknown
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2008
- 2008-06-02 AU AU2008202439A patent/AU2008202439B2/en active Active
- 2008-06-11 JP JP2008153433A patent/JP5203808B2/ja active Active
- 2008-06-11 CN CN2008101785901A patent/CN101401748B/zh active Active
Also Published As
Publication number | Publication date |
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AU2008202439A1 (en) | 2009-01-08 |
CN101401748B (zh) | 2012-08-01 |
ATE444031T1 (de) | 2009-10-15 |
PL2002800T3 (pl) | 2010-02-26 |
JP2009039511A (ja) | 2009-02-26 |
CN101401748A (zh) | 2009-04-08 |
ES2333990T3 (es) | 2010-03-03 |
DE602007002621D1 (de) | 2009-11-12 |
EP2002800A1 (en) | 2008-12-17 |
EP2002800B1 (en) | 2009-09-30 |
AU2008202439B2 (en) | 2013-01-24 |
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