JP5159638B2 - 材料とその利用 - Google Patents
材料とその利用 Download PDFInfo
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- JP5159638B2 JP5159638B2 JP2008552890A JP2008552890A JP5159638B2 JP 5159638 B2 JP5159638 B2 JP 5159638B2 JP 2008552890 A JP2008552890 A JP 2008552890A JP 2008552890 A JP2008552890 A JP 2008552890A JP 5159638 B2 JP5159638 B2 JP 5159638B2
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- Prior art keywords
- sensitizer
- polymer
- porphyrin
- hema
- charged
- Prior art date
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000011037 discontinuous sequential dilution Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- ISVXIZFUEUVXPG-UHFFFAOYSA-N etiopurpurin Chemical compound CC1C2(CC)C(C(=O)OCC)=CC(C3=NC(C(=C3C)CC)=C3)=C2N=C1C=C(N1)C(CC)=C(C)C1=CC1=C(CC)C(C)=C3N1 ISVXIZFUEUVXPG-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000003473 flash photolysis reaction Methods 0.000 description 1
- 238000012921 fluorescence analysis Methods 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 238000001506 fluorescence spectroscopy Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- UACSZOWTRIJIFU-UHFFFAOYSA-N hydroxymethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCO UACSZOWTRIJIFU-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
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- 125000003010 ionic group Chemical group 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 229910052751 metal Chemical class 0.000 description 1
- 239000002184 metal Chemical class 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
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- 229920006280 packaging film Polymers 0.000 description 1
- 239000012785 packaging film Substances 0.000 description 1
- 235000016236 parenteral nutrition Nutrition 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 238000002428 photodynamic therapy Methods 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- NUSQOFAKCBLANB-UHFFFAOYSA-N phthalocyanine tetrasulfonic acid Chemical class C12=CC(S(=O)(=O)O)=CC=C2C(N=C2NC(C3=CC=C(C=C32)S(O)(=O)=O)=N2)=NC1=NC([C]1C=CC(=CC1=1)S(O)(=O)=O)=NC=1N=C1[C]3C=CC(S(O)(=O)=O)=CC3=C2N1 NUSQOFAKCBLANB-UHFFFAOYSA-N 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 239000002745 poly(ortho ester) Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001843 polymethylhydrosiloxane Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920005591 polysilicon Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
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- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- AZJPTIGZZTZIDR-UHFFFAOYSA-L rose bengal Chemical compound [K+].[K+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 AZJPTIGZZTZIDR-UHFFFAOYSA-L 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000001235 sensitizing effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000002210 silicon-based material Substances 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000004528 spin coating Methods 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- ZQZCOBSUOFHDEE-UHFFFAOYSA-N tetrapropyl silicate Chemical compound CCCO[Si](OCCC)(OCCC)OCCC ZQZCOBSUOFHDEE-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- ZNEOHLHCKGUAEB-UHFFFAOYSA-N trimethylphenylammonium Chemical compound C[N+](C)(C)C1=CC=CC=C1 ZNEOHLHCKGUAEB-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 238000002371 ultraviolet--visible spectrum Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 229920006163 vinyl copolymer Polymers 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0091—Complexes with metal-heteroatom-bonds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B47/00—Porphines; Azaporphines
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B47/00—Porphines; Azaporphines
- C09B47/04—Phthalocyanines abbreviation: Pc
- C09B47/045—Special non-pigmentary uses, e.g. catalyst, photosensitisers of phthalocyanine dyes or pigments
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B67/00—Influencing the physical, e.g. the dyeing or printing properties of dyestuffs without chemical reactions, e.g. by treating with solvents grinding or grinding assistants, coating of pigments or dyes; Process features in the making of dyestuff preparations; Dyestuff preparations of a special physical nature, e.g. tablets, films
- C09B67/0097—Dye preparations of special physical nature; Tablets, films, extrusion, microcapsules, sheets, pads, bags with dyes
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
- C09B69/108—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing a phthalocyanine dye
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
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- C09B69/00—Dyes not provided for by a single group of this subclass
- C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
- C09B69/109—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing other specific dyes
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- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/10—Optical coatings produced by application to, or surface treatment of, optical elements
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
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- G02B1/18—Coatings for keeping optical surfaces clean, e.g. hydrophobic or photo-catalytic films
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Description
ポリマー(ポリマーには、ポリマーの混合物を含み得る)を含む材料は様々な産生物、例えば液体および固体の保存、食物の準備および保存、健康管理器具、医療用具など、様々な産物を与えるのに広く利用されている。細菌類の材料表面への付着およびそれに続く前記細菌の増殖は感染の危険を与える。
発明の最初の態様は、少なくとも1つのポリマーを含み、増感剤を少なくとも1つ含む材料であり、前記増感剤が材料表面に局在化され、増感剤の電磁放射への曝露によって抗菌性および/または抗ウィルス性活性が増大されるものの提供である。
‐本発明の最初の態様による材料の提供、および
‐材料に高活性の一重項酸素を産生させる原因となる適切な波長の電磁放射の提供
を含む、処置領域の細菌またはウィルスのコロニー形成を減少させる方法を提供する。
‐ポリマーを含む材料の荷電表面への荷電増感剤の提供
‐増感剤および材料表面の静電相互作用を起こすために適した状況の提供、および
‐荷電表面への増感剤の結合
というステップを含む。
‐少なくとも1つの増感剤および増感剤が結合できるポリマーを含む材料の表面の機能化、
‐材料表面への増感剤の提供、および
‐材料表面への増感剤の結合
のステップを含む。
‐中性の増感剤の、工程を進行するのに十分な量の増感剤が溶解可能な溶媒への溶解
‐中性の増感剤が溶解した溶媒への中性ポリマーの浸漬、および
‐少なくとも1つの増感剤が少なくとも1つのポリマーに結合するといった反応条件の提供
のステップを含む。
研究はポルフィリン溶液の、菌を感染性眼内炎の培養陽性患者から単離したスタフィロコッカス・エピデルミディス(Staphylococcus epidermidis)、シュードモナス・エルギノーサ(Pseudomonas aeruginosa)、プロテウス・ミラビリス(Proteus mirabilis)に対する感光活性について行われた。研究はポルフィリン水溶液を試験菌のカルチャーに添加し、混合物に日光または4×250Wハロゲン電球を含むより強い光源に曝露し、その後1mLのサンプルを、生菌数を測定するためにある時間ごとに採取した。
約1×105cfu/mLの接種材料がポルフィリン溶液の細菌研究を通して利用された。活性は通常の日光条件および4×250Wハロゲン電球を含むより強い光源を使用し、温度を32℃付近に冷却した。
TMPyPは日光中では感光活性はなかった。TMAPは24時間で1ログサイクルの増殖が減少した。しかしながら、より強い光源を使用した場合、光不活性化に成功し、1時間以内に完全に死滅させた。TPPSについては、より強力な光源での5時間の照射によって、生菌数計測において1ログサイクルの減少があった。
TMPyPおよびTMAPでは、日光で光不活性化に成功し、1時間以内に完全に死滅させたが、TPPSでは光不活性化の成功に24時間の照射が必要だった。より強い光源を使用すると、全ての菌は光不活性化され、1時間以内に完全に死滅した。
日光条件を使用すると、TMPyPで24時間後に1ログサイクルの増殖の減少があった。TMAPも似たような結果を得たが、TPPSでは24時間の生菌数計測での減少は見られなかった。より強力な光では、TMPyPは5時間の生菌数計測で3ログサイクルの減少があったが、TMAPでは3時間で3ログサイクルの減少があった。TPPSは5時間以内の照射では感光活性は見られなかった。
24時間の研究において1時間で完全な光不活性を見せ、完全な死滅をもたらしたどのポルフィリン‐菌の組合せについても、サンプルを10、20,30,40,50および60分で採取することでさらなる研究が行われた。非濾過および2度濾過滅菌の10mcg/mL溶液が、2度濾過が活性に与える効果を分析するために使用された。
図1に示したように、図1のタイプ(a)の系は、全体で+4電荷の陽イオン性テトラ‐4‐N‐メチルピリジニウムポルフィリン(TMPyP)および陰イオン性コポリマーであるポリ(アクリル酸/メタクリル酸ヒドロキシメチル)の間の、または全体で−4電荷の陰イオン性テトラ‐4‐スルフォナト‐フェニルポルフィリン(TPPS)と陽イオン性コポリマーであるポリ(メタクリル酸ジメチルアミノエチル/メタクリル酸ヒドロキシエチル)の間の静電的相互作用に基づいている。双方の場合で、ポルフィリンおよびヒドロゲル間の強い結合が、ヒドロゲルをポルフィリンの水溶液に浸漬した場合に提供され得、ポルフィリンはヒドロゲルト接触した最初の点(つまり表面)のみで結合し、したがってヒドロゲルの内部に深く進入しない。
図1bを参照すると、バイオマテリアルは、一般的なモノマーである2‐メタクリル酸ヒドロキシエチル(HEMA、眼内バイオマテリアルとして広く利用されていることが見出される生体適合性ヒドロゲル)とビニル基を有するポルフィリンとのコポリマーで被膜されたヒドロゲルを利用して形成され得る。
ポルフィリン含浸材料の微生物学的活性が研究された。
コントロール材料、日光条件=1.13±1.02×105cfu/cm2
コントロール材料、強い光装置条件=1.14±0.42×104cfu/cm2
ポルフィリン含浸材料=5.33±0.21×103cfu/cm2
日光に曝露したコントロール材料に対して95.3%の死滅が示された。
同じ材料、同じポルフィリンおよびおなじ内蔵条件を利用し、しかしより低い接種量5.05×103cfu/mLのS.エピデルミディスに対する調査で、暗闇を保ったポルフィリンを含むサンプルの付着細菌が、日光に曝露したコントロールサンプルに対して97.0%の減少を見せ、ポルフィリンを含み強い光に曝露したサンプルはコントロールと比較して100%の減少(つまり完全な死滅が達成された)を見せた。
荷電モノマーの含有比率の増加がポルフィリン結合に顕著な効果を有するのかを究明するために、コポリマーの構成の範囲が詳細に調べられた。
全てのポルフィリン取り込みフィルムの紫外可視波長はポルフィリン含有量に特色付けられ、総ポルフィリン取り込み量をμgcm−2(表面からの距離によって変化する局所的な濃度の計測)で究明する有用な手法を提供する。MAA:HEMAコポリマーを使用した最初の実験が0:100/MAA:HEMAおよび100:0/MAA:HEMAの間で行われた。しかしながら、発明者は30%以上のMAAがあるサンプルは濁っていると究明した。以降の研究は0,10,20および30%のMAAがある透明なポリマーに限定された。
過渡吸収差分(ΔA)計測は、20分間窒素で泡立てて脱気した後、酸素で泡立てた条件下で行われた。窒素による泡立ては、凍結‐吸引‐解凍(freeze-pump-thaw)サイクルの繰り返しよりも酸素の除去には効果がない。しかしながら、凍結‐吸引‐解凍がポリマーサンプルには適さないため、本研究では窒素の泡立てを利用した。全体的なMAA:HEMAポリマー中のTMPyPの光物理的特性はその単純水溶液と似ており、脱酸素ポリマー中では約1msの寿命である三重項が、O2飽和状態下では約3μsに落ちる。発明者によって計測された溶液相値は、N2泡立て状態では161μs、酸素下では436nsに落ちる。
放出動態は緩衝液にポルフィリンドープされたポリマーサンプルを浸漬することで記録され、1週間間隔で、1ml単位で引き出された。単位中のポルフィリン濃度が蛍光光度法(MAA:HEMA系ではλex=413nm、λem=685nm、DEAEMA:HEMA系ではλex=413nm、λem=645nm)で計測された。
Claims (14)
- 少なくとも1つのポリマー及び少なくとも1つの増感剤を含む材料であって、
増感剤が、該増感剤の電磁放射への曝露に続き、高い反応性の一重項酸素1O2を産生し、
増大した抗細菌および/または抗ウィルス活性を提供するもので、
材料の表面や当該部位のポリマーには化学的な修飾はなされずに、増感剤が帯電し、かつポリマーが反対電荷に帯電していることにより、または、増感剤が中性であり、かつポリマーが中性であることにより、
ポリマーを含む材料の表面に増感剤を適用することで、増感剤とポリマーとが、静電結合、水素結合またはファンデルワールス力によって結合し、増感剤が材料表面に局在化している、前記材料。 - 増感剤が、10nmから1mmの範囲の厚さの表面層に局在化している、請求項1に記載の材料。
- 増感剤が、フタロシアニン、メタロフタロシアニン、スルホン化フタロシアニン、スルホン化メタロシアニン、クロリン、テキサフィリン、サフィリン、プルプリン、ポルフィリン、メチレンブルー、またはローズベンガルから少なくともから1つ選択されている、請求項1または2に記載の材料。
- 増感剤がポルフィリンである、請求項1〜3のいずれかに記載の材料。
- ポルフィリンが、プロトポルフィリンIX、テトラ‐4‐N‐メチルピリジニウムポルフィリン(TMPyP)、テトラ‐4‐スルホナト‐フェニル‐ポルフィリン(TPPS)、テトラ(4N,N,N‐トリメチル‐アニリニウム)ポルフィンテトラクロリド(TMAP)、ヘマトポルフィリン誘導体(HpD)およびその精製画分、および「フォトフリン」の少なくとも1つから選択されている、請求項4に記載の材料。
- 少なくとも1つのポリマーが、ヒドロゲルである請求項1〜5に記載の材料。
- ヒドロゲルが、ポリ(メタクリル酸コメタクリル酸ヒドロキシエチル)、ポリ(メタクリル酸ジエチルアミノエチルコメタクリル酸ヒドロキシエチル)、またはポリ(メタクリル酸ヒドロキシエチルコプロトポルフィリン)から少なくとも1つ選択されている、請求項6に記載の材料。
- 増感剤が、材料内の層として材料表面に局在化されている、請求項1〜7のいずれかに記載の材料。
- 請求項1〜8のいずれかに記載の材料を含む医療デバイス。
- 医療デバイスが人工器官である、請求項9に記載の医療デバイス。
- 人工器官が、人工水晶体もしくはコンタクトレンズから選択されている、請求項10に記載の医療デバイス。
- 少なくとも1つのポリマーおよび少なくとも1つの増感剤を含む請求項1〜8のいずれかに記載の材料を製造する方法であって、
‐帯電した増感剤を、ポリマー含有材料の反対電荷の帯電表面に適用する工程、および
‐ポリマー含有材料の帯電表面に対して、帯電した増感剤を静電結合させる工程を含む、前記方法。 - 少なくとも1つのポリマーおよび少なくとも1つの増感剤を含む請求項1〜8のいずれかに記載の材料を製造する方法であって、
‐増感剤を結合するための増感剤または材料表面を機能化する工程
‐増感剤を材料表面に適用する工程、および
‐増感剤の材料表面への結合工程を含む、前記方法。 - 少なくとも1つのポリマーおよび少なくとも1つの増感剤を含む請求項1〜8のいずれかに記載の材料を製造する方法であって、
‐中性増感剤の溶媒への溶解工程、および
‐中性増感剤を溶解した溶媒溶液に中性ポリマー含有材料を浸漬して材料表面に中性増感剤を適用する工程を含む、前記方法。
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101793832B1 (ko) * | 2016-08-02 | 2017-11-03 | 연세대학교 산학협력단 | 광에너지 유도 활성산소종을 이용한 줄기세포 분화유도장치 및 방법 |
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AU2007210947B2 (en) | 2012-12-13 |
US8450359B2 (en) | 2013-05-28 |
CA2641895C (en) | 2014-08-26 |
CA2641895A1 (en) | 2007-08-09 |
US20090292357A1 (en) | 2009-11-26 |
AU2007210947A1 (en) | 2007-08-09 |
GB0602125D0 (en) | 2006-03-15 |
JP2009525108A (ja) | 2009-07-09 |
WO2007088392A1 (en) | 2007-08-09 |
EP1984439A1 (en) | 2008-10-29 |
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