JP5132178B2 - Nasal irrigation composition - Google Patents

Description

  The present invention relates to a composition for nasal cavity washing, which contains a fragrance.

  Mucous membranes such as the oral mucosa, nasal mucosa, and ocular mucosa are portions that are in direct contact with the outside world in the human body. However, unlike the body surface, the mucous membrane is a very delicate part because it is not covered with the epidermis. Therefore, there is a great influence from the outside world such as pollen and dust, and when such things adhere to the mucous membrane, uncomfortable discomfort (for example, itching) and disease symptoms (for example, allergic rhinitis, pollinosis, sty, conjunctivitis) , Corneal erosion, herpes, stomatitis, etc.). The nasal mucosa, in particular, is susceptible and often at risk of causing serious symptoms. Conventionally, methods for physically removing pollen and dust (for example, washing) have been applied to improve discomfort and disease symptoms due to pollen and dust adhering to the nasal mucosa.

In order to clean the nasal mucosa, it is necessary to apply a composition in consideration of cells and sensuality due to the characteristics of mucosal application. For example, when tap water or the like is used to clean the nasal mucosa, the cells may be destroyed and pain may be felt, which is difficult for the user to accept and cannot be sufficiently cleaned due to pain. Various mucosal cleaning compositions that have reduced such problems have been used in the past (see, for example, Patent Document 1), but all have room for further improvement and sufficient cleaning effect. It was hard to say.
JP 2000-109425 A

  The main object of the present invention is to provide a composition for nasal irrigation that can exert an excellent cleaning effect by expanding the nasal cavity, and also has an excellent usability in terms of taste and refreshment. To do.

  As a result of intensive studies in view of the above problems, it has been found that the nasal cavity can be expanded by applying a composition containing a predetermined fragrance ingredient to the nasal cavity. In addition, the present inventors have found that by including a predetermined fragrance component in the composition for nasal cavity washing, the nasal resistance is reduced and the washing liquid can easily pass, and therefore, an excellent nasal cavity washing effect can be exhibited. It was. Furthermore, although the fragrance components used in the nasal irrigation composition individually have a bitter taste, the nasal irrigation composition containing a combination of these fragrance components is excellent in terms of taste and coolness. It had a feeling of use. The present invention has been completed by further research based on these findings.

That is, the present invention provides the following inventions:
Item 1. A composition for nasal cavity washing containing at least one selected from the group consisting of peppermint oil and citrus essential oil, peppermint oil and l-menthol.
Item 2. Item 2. The composition for nasal cavity cleaning according to Item 1, comprising at least one selected from the group consisting of peppermint oil and citrus essential oil, peppermint oil, and l-menthol in a total amount of 0.001 to 3 wt%.
Item 3. 0.03 to 0.15 parts by weight of l-menthol, 0.017 to 0.037 parts by weight of peppermint oil and / or 0.05 to 0.3 parts by weight of citrus essential oil with respect to 1 part by weight of peppermint oil Item 3. The composition for nasal cavity washing according to Item 1 or 2, which is contained in a proportion of
Item 4. Item 4. The composition for nasal cavity cleaning according to any one of Items 1 to 3, wherein the citrus essential oil is at least one selected from the group consisting of lemon oil, lime oil, grapefruit oil, orange oil, mandarin oil, and bergamot oil. .
Item 5. Further, (A) a quaternary ammonium salt-based preservative, (B) edetic acid and / or a salt thereof, and (C) polysorbate as a base,
(A) 0.5 to 110 parts by weight of polysorbate per 1 part by weight of quaternary ammonium salt preservative, and
(C) The nasal cavity washing | cleaning in any one of Claims 1-4 which contains 0.001 to 1.5 weight part of (B) edetic acid and / or its salt with respect to 1 weight part of polysorbate. Composition.
Item 6. 1 to 60 parts by weight of (C) polysorbate with respect to 1 part by weight of (A) quaternary ammonium salt preservative, and
(C) The nasal cavity washing | cleaning in any one of Claims 1-5 containing 0.002 to 0.08 weight part of (B) edetic acid and / or its salt with respect to 1 weight part of polysorbate. Composition.
Item 7. Item 7. The composition for nasal cavity washing according to Item 5 or 6, wherein the composition for nasal cavity washing contains 0.0001 to 0.02% by weight of (A) a quaternary ammonium salt preservative.
Item 8. Nasal irrigation comprising the step of adjusting the concentration of at least one selected from the group consisting of peppermint oil and citrus essential oil, peppermint oil and l-menthol to a total amount of 0.001 to 3% by weight in the composition A method for producing a composition.
Item 9. The composition comprises 0.03 to 0.15 parts by weight of 1-menthol, 0.017 to 0.037 parts by weight of mint oil, and / or 0.05 to 0.05 parts of citrus essential oil with respect to 1 part by weight of peppermint oil. Item 9. The method for producing a composition for nasal cavity washing according to Item 8, which is contained at a rate of 0.3 part by weight.

  Hereinafter, the present invention will be described in detail.

  The composition for nasal cavity washing | cleaning of this invention contains the fragrance | flavor component prepared by the combination of a specific fragrance | flavor, It is characterized by the above-mentioned. Hereinafter, each component of the composition for nasal cavity washing | cleaning of this invention is demonstrated.

(I) Perfume component The perfume component used in the present invention is prepared by combining at least one selected from the group consisting of peppermint oil and citrus essential oil, peppermint oil, and l-menthol.

  The citrus essential oil used in the present invention can be selected from conventionally known citrus oils, and is not particularly limited. Examples thereof include lemon oil, lime oil, grapefruit oil, orange oil, mandarin oil, and bergamot oil. Of these citrus essential oils, preferred are lemon oil, lime oil, grapefruit oil and orange oil, and more preferred are lemon oil, lime oil and grapefruit oil. These citrus essential oils may be used alone or in combination of two or more.

  The citrus essential oil can be prepared by a conventionally known method using various citrus fruits as a raw material. As an example of the preparation method, a general method such as a steam distillation method or a solvent extraction method can be employed. In the present invention, so-called “essence” obtained by squeezing citrus peel can also be used.

  Moreover, as a simple method, what can be obtained commercially as citrus essential oil can be used, for example, it can obtain from Hasegawa perfume Co., Ltd., Takasago perfume industry Co., Ltd., Inabata perfume Co., Ltd., etc.

  The mint oil used in the present invention can be obtained according to the above-described essential oil preparation method. Moreover, what can be obtained commercially can also be used simply and can be obtained from the same vendor as the said citrus essential oil.

  About peppermint oil, what was obtained according to said essential oil preparation method may be used, and it can also obtain from the same vendor as the above-mentioned citrus system essential oil.

  About 1-menthol, it can be purchased from, for example, Nagaoka Jitsugyo Co., Ltd., Toyo Hakkan Kogyo Co., Ltd., Takasago International Corporation, etc.

  In the composition for cleaning nasal cavity of the present invention, at least one selected from the group consisting of peppermint oil and citrus essential oil, a perfume component consisting of peppermint oil and l-menthol in a total amount of 0.001 to 3% by weight, Preferably it contains 0.035 to 2% by weight, more preferably 0.06 to 1% by weight.

  Moreover, the said fragrance | flavor component is 0.017-0.037 weight part of peppermint oil with respect to 1 weight part of peppermint oil, Preferably it is 0.021-0.033 weight part, 0.05-0.3 citrus essential oil. Parts by weight, preferably 0.08 to 0.17; 1-menthol is contained in a proportion of 0.03 to 0.15 parts by weight, preferably 0.05 to 0.13 parts by weight. Also, mint oil and citrus essential oil can be used in combination.

  By blending the fragrance component in the above ratio, the nasal cavity can be sufficiently expanded, so that the cleaning liquid can easily flow through the nasal cavity and the cleaning effect can be further enhanced. Furthermore, the composition for nasal cavity washing | cleaning which has a favorable refreshing feeling and the bitterness reduced by mix | blending a fragrance | flavor component with the said predetermined amount can be provided. Moreover, since the composition for nasal cavity washing | cleaning of this invention has a nasal cavity expansion effect, it can improve nasal ventilation and it is useful also for elimination of uncomfortable feelings, such as a nasal congestion.

  Preferred embodiments of the present invention include, for example, 0.05 to 0.13 parts by weight of 1-menthol; 0.021 to 0.033 parts by weight of peppermint oil, or 0.1 to 0.033 parts by weight of lemon oil. The composition for nasal cavity washing | cleaning which contains the fragrance | flavor component contained in the ratio of 08-0.17 weight part or lime oil 0.08-0.17 weight part in a total amount is 0.035-2 weight%.

  In addition to the above fragrance components, other fragrances can be used in combination as long as the effects of the present invention are not impaired. Examples of fragrances other than those described above that can be used in the present invention include synthetic fragrances such as ethyl butyrate, linalool, octanal, decanal, citronellal, geranyl acetate; lavender, chamomile, clericage, cypress, sandalwood, juniper, geranium, tea tree , Marjoram, Eucalyptus, Lemongrass, Rose, Rosewood, Rosemary, Jasmine, Sage, Parsley, Thyme, Ravensara, Oregano, Basil, Fennel, Sweet Marjoram, Wintergreen, Estragon, Cypress, Immortelle, Coriander, Ginger, Caraway , Spearmint, lily of the valley, patchouli, holland sansen, bacuda, clove, turpentine, roman chamomile, thymol, cinnamon, cedar leaves, kaya Essential oils, such as tape, and the like. The blending amount in the case of using these fragrances can be appropriately set by referring to the blending amounts of various fragrances in the fragrance component so as to achieve the effects of the present invention.

  The composition for nasal cavity washing | cleaning of this invention can exhibit the effect which expands the excellent nasal cavity by containing the said fragrance | flavor component, and can be used suitably for the use of a nasal cavity washing | cleaning. It has been found for the first time by the present inventors that a nasal cavity expansion effect can be obtained by a combination of predetermined fragrances used in the present invention.

(Ii) Base As long as the composition for nasal washing of the present invention contains at least one selected from the group consisting of peppermint oil and citrus essential oil, peppermint oil, and l-menthol, Is not particularly limited, but is preferably an aqueous base from the viewpoint that it can be easily applied to mucous membranes. Further, water or physiological saline itself can be used alone as a base.

  In addition, by using a base that has little irritation to the nasal mucosa and high stability (prevents formation of precipitates), it is possible to provide a composition more suitable for nasal irrigation. From this point of view, the above fragrance component is blended with a base containing (A) a quaternary ammonium salt preservative, (B) edetic acid and / or a salt thereof, and (C) polysorbates in a predetermined ratio. It is preferable to do. Hereinafter, each component of the base will be described.

(A) Quaternary ammonium salt preservative In the present invention, the quaternary ammonium salt preservative is a quaternary ammonium salt having antiseptic and / or bactericidal action, and is a known antiseptic and / or bactericidal component. It is. Specific examples of quaternary ammonium salt preservatives include benzalkonium chloride, benzethonium chloride, decalinium chloride, cetylpyridinium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, cetyl chloride Examples include trimethylammonium, lauryltrimethylammonium chloride, and laurylpyridinium chloride. Among these, benzalkonium chloride, benzethonium chloride, and decalinium chloride are preferable because they are low in risk and odorless, have a wide antibacterial spectrum, and are excellent in safety and effectiveness. Ni. The said (A) component may be used individually by 1 type, and may be used in combination of 2 or more type.

(B) Edetic acid and / or its salt Edetic acid is also known as ethylenediaminetetraacetic acid, and is a known compound. Examples of the edetic acid salt used as the component (B) in the nasal cavity washing composition of the present invention include disodium salt, disodium calcium salt, and tetrasodium salt. These edetic acid salts may be hydrates such as dihydrate and tetrahydrate. Among these, disodium salt of edetic acid is preferable, and disodium salt of edetic acid is more preferable, because it is excellent in safety and has high solubility in water and easily acts on other components such as polysorbate. . As the component (B), one type may be used alone, or two or more types may be used in arbitrary combination.

(C) Polysorbate Polysorbate is a hydrophilic nonionic surfactant obtained by adding 20 mol of ethylene oxide to a sorbitan fatty acid ester. Specific examples of the polysorbate used in the present invention include polysorbate 80 (polyoxyethylene sorbitan oleate), polysorbate 65 (polyoxyethylene sorbitan tristearate), polysorbate 60 (polyoxyethylene sorbitan stearate), and polysorbate 40. (Polyoxyethylene sorbitan palmitate), polysorbate 20 (polyoxyethylene sorbitan laurate), polysorbate 85 (polyoxyethylene sorbitan trioleate) and the like are exemplified. Among these, polysorbate 80 and polysorbate 60 are preferable from the viewpoint of further improving the stability of the composition for nasal irrigation, particularly the solubility of (A) the quaternary ammonium salt preservative, and more preferably polysorbate. 80. As the component (C), one type may be used alone, or two or more types may be used in combination.

  From the viewpoint of further improving the stability of the composition for cleaning nasal cavity of the present invention, further reducing irritation felt during mucosal application, and improving the feeling of use, the combination of the above components (A) to (C) As an embodiment, a combination of benzalkonium chloride, a disodium salt of edetic acid, and polysorbate 80 is preferably exemplified.

  In the composition for nasal cavity washing of the present invention, the blending ratio of the component (C) to 1 part by weight of the component (A) is 0.5 to 110 parts by weight, preferably 0.7 to 100 parts by weight. More preferably, it is 1-60 weight part. When the blending ratio is less than 0.5 parts by weight or more than 110 parts by weight, the stability at low and high temperatures is lowered, and precipitates are generated or an unpleasant odor is generated.

  In the nasal cavity cleaning composition of the present invention, the blending ratio of the component (B) to 1 part by weight of the component (C) is 0.001 to 1.5 parts by weight, preferably 0.002 to 1 part by weight. Part, more preferably 0.002 to 0.08 part by weight. When the blending ratio is less than 0.001 part by weight, the stability at high temperature decreases, and when it exceeds 1.5 parts by weight, the stability at low temperature and high temperature decreases. When the stability is lowered, precipitates are generated or an unpleasant odor tends to be generated.

  By containing the components (A), (B) and (C) so as to have the above-mentioned ratio, excellent stability is obtained, and even when applied to the mucous membrane, there is no irritation and a good feeling of use is obtained. be able to.

In the composition for cleaning nasal cavity of the present invention, the concentration of the component (A) varies depending on the blending ratio of the components (A) to (C), the type of the component (A), etc. In general, it is 0.01 × 10 ^{−2 to} 0.1 wt%, preferably 0.01 × 10 ^{−1 to} 0.05 wt%, more preferably 0.02 × 10 ^{−1 to} 0.02 wt%. . By containing the component (A) within such a range, the antiseptic or bactericidal action can be effectively exhibited.

Further, the concentration of the components (B) and (C) is not particularly limited as long as it is set within a range satisfying the blending ratio of the components (A) to (C) described above, but the blending amount of these components As an example, the component (B) is usually 0.01 × 10 ^{−4 to} 1.8% by weight and the component (C) is 0.05 × 10 ^{−2 to} 2.2% by weight, based on the composition for nasal irrigation; Preferably component (B) is 0.02 × 10 ^{−4 to} 1.2 wt% and component (C) is 0.07 × 10 ⁻² to 2 wt%; more preferably component (B) is 0.02 × Examples are 10 ^{−4 to} 0.1 wt% and component (C) 0.01 × 10 ^{−1 to} 1.2 wt%.

In the composition containing the component (A) at 0.02% by weight or less, conventionally, the generation of precipitates becomes remarkable under a temperature condition of 40 ° C. or more, and there is a problem that the stability is particularly easily lost. However, when the components (A), (B), and (C) satisfy the above-described ratio, excellent stability can be provided while containing the component (A) at a low concentration. Therefore, from the viewpoint of solving the long-standing problem in the composition containing the component (A) at a low concentration, as a preferred embodiment of the composition for nasal cavity washing of the present invention, the component (A) is 0.02 It is mentioned that it is a low concentration of less than wt%. More specifically, when the component (A) is contained at a low concentration, the component (A) is 0.01 × 10 ^{−2 to} 0.02 wt%, preferably 0. Examples are concentrations of 01 × 10 ^{−1 to} 0.01% by weight, more preferably 0.02 × 10 ^{−1 to} 0.05 × 10 ⁻¹ % by weight. Use of the component (A) at such a concentration is suitable particularly for the purpose of washing the nasal mucosa.

In addition, when the component (A) is contained in an amount of 0.02% by weight or less, the concentration of the component (B) and (C) is within the range satisfying the blending ratio of the components (A) to (C) described above. The concentration of these components is 0.01 × 10 ^{−4 to} 0.1% by weight and (C) component is 0.05 × per nasal irrigation composition. 10 ^{−2 to} 1.2% by weight; preferably, component (B) is 0.02 × 10 ^{−4 to} 0.05% by weight and component (C) is 0.07 × 10 ^{−2 to} 0.12% by weight; More preferably, the component (B) is 0.02 × 10 ^{−4 to} 0.25 × 10 ⁻¹ wt% and the component (C) is 0.01 × 10 ^{−1 to} 0.06 wt%.

  As described above, the base containing the components (A) to (C) does not generate precipitates or unpleasant odors, is excellent in stability over time and temperature change, and also against mucous membranes. Low irritation and good usability. Therefore, it can be suitably used as a base for a composition for nasal cavity cleaning.

(Iii) Other components In order to improve the feeling of use, the composition for cleaning nasal cavity of the present invention should contain one or more of polyhydric alcohols and tonicity agents in combination. Is desirable. In particular, in order to make the feeling of use stable and good without being affected by long-term storage, temperature change, etc., it is desirable to contain a combination of both a polyhydric alcohol and an isotonizing agent.

  Examples of the polyhydric alcohol include glycerin (including concentrated glycerin), propylene glycol, ethylene glycol, polyethylene glycol, sorbitol, mannitol, and xylitol. These polyhydric alcohols may be used individually by 1 type, and may be used in combination of 2 or more type. Among these polyhydric alcohols, glycerin is preferable because it is excellent in terms of taste and aroma in addition to isotonicity of the composition for nasal cavity washing. When the polyhydric alcohol is blended, the blending ratio is, for example, 0.0125 to 3% by weight, preferably 0.05 to 2.5% by weight, and more preferably 0.2 to 2% by weight.

  Specific examples of the isotonic agent include sodium chloride, potassium chloride, boric acid, borax and the like. Of these, sodium chloride and potassium chloride are preferable. These isotonic agents may be used alone or in combination of two or more. When an isotonizing agent is blended, the blending ratio is appropriately set according to the blending amount of other components and the like, but is usually 0.15% to 1.5% by weight, preferably 0.3 to 1%. .2% by weight, more preferably 0.45 to 0.9% by weight.

  By using the polyhydric alcohol and the isotonic agent in combination and setting the blending amount in the above range, a composition for nasal cavity washing having a particularly excellent feeling of use can be obtained.

  In the composition for nasal cavity washing of the present invention, a particularly good usability can be imparted by containing glycerin and sodium chloride in combination. Moreover, according to the composition for nasal cavity washing | cleaning of this aspect, the favorable usability | use_condition is not impaired by long-term storage or an environmental influence.

  In addition to the above components, the nasal cavity cleaning composition of the present invention includes anti-inflammatory agents, bactericides, antibacterial agents, astringents, decongestants, antiallergic agents, antihistamines, vitamins, amino acids and other pharmacological components, An appropriate amount of additives such as a solubilizer, a thickener, a surfactant, a pH adjuster, an antioxidant, a colorant, a preservative, a buffer, and a stabilizer may be included.

  The composition for nasal irrigation of the present invention is in a liquid state, and when it is an aqueous composition, a predetermined amount of the above fragrance ingredients and base ingredients are added to sterilized water, distilled water, purified water, deep sea water, etc. It can be prepared by dissolving and subjecting to sterilization treatment as necessary.

  When using the base containing the components (A) to (C) in the above ratio, the nasal cavity cleaning composition of the present invention can be filled into a transparent container that can transmit light. Conventionally, a composition for nasal irrigation in which precipitates are likely to occur is generally filled in a container whose contents cannot be visually confirmed. Conventionally, by using such a container, it has been avoided that the occurrence of precipitates is recognized and an unpleasant psychological influence is given to the user. On the other hand, the nasal cavity cleaning composition of the present invention is suitable for filling a transparent container when a base containing the components (A) to (C) in the above proportion is used. That is, when the nasal irrigation composition of the present invention is filled in a transparent container, even if it is stored for a long period of time, it is stable without generating precipitates, so the properties of the nasal irrigation composition in the container can be visually observed. Even so, there is no inconvenience such as an unpleasant psychological influence on the user. Furthermore, filling the transparent container with the nasal cavity cleaning composition of the present invention has the advantage that the remaining amount inside the container can be easily confirmed, and its practical value is enhanced. .

  The container filled with the nasal cavity cleaning composition of the present invention may be any of glass, polyethylene terephthalate, polyethylene, polypropylene, etc. The composition for cleaning nasal cavity of the invention can more effectively exhibit stability over time and stability against temperature change.

  The composition for cleaning nasal cavity of the present invention can exhibit an excellent nasal cavity expansion effect (an effect of decreasing the nasal resistance value) by containing a predetermined fragrance component, so that the nasal cavity can be easily flowed through the nasal cavity. be able to. Therefore, pollen and dust adhering to the nasal mucosa can be sufficiently washed away, and discomfort and unpleasant symptoms such as sneezing, runny nose and itching caused by the pollen and dust adhering can be reduced. And since a nasal cavity is expanded and nasal ventilation improves, it can be used suitably also for improvement of a nasal congestion.

  In addition, the fragrance used in the present invention exhibits a bitter taste as an individual fragrance, but by using a fragrance component having a predetermined composition, it is possible to obtain a good refreshing feeling with a good taste and is comfortable. A feeling of use can be realized.

  Furthermore, by using the above-mentioned predetermined base, it is possible to provide a composition for nasal cavity washing that is less irritating to the nasal mucosa and has a better usability. The above-mentioned base suitable for the present invention contains (A) a quaternary ammonium salt-based preservative, and is excellent in stability over time and temperature change in a transparent container and applied to the mucous membrane. The feeling of use at the time is good.

  In addition, a composition containing a quaternary ammonium salt preservative at 0.02% by weight or less has become unstable under a temperature condition of 40 ° C. or higher. When exposed to the above temperature conditions due to storage, storage by the user, etc., there is a problem that the generation of precipitates becomes significant. On the other hand, in the composition for nasal cavity washing of the present invention using the base containing the components (A) to (C) in the above proportion, the quaternary ammonium salt preservative is 0.02% by weight or less. Although it is contained in, it has excellent stability, and it can be said that its usefulness is extremely high.

  In addition, by using a base containing the components (A) to (C) in the above proportions, when the nasal cavity cleaning composition of the present invention is filled in a transparent container, the internal residual amount can be easily confirmed. In addition to this advantage, there is an advantageous effect that it is stable even if it is stored for a long period of time or is affected by environmental influences such as temperature change, and its practical value is very high.

  Hereinafter, although an example and a formulation example are given and the present invention is explained, the present invention is not limited to these examples.

Test Example 1 Nasal Resistance Test A composition for cleaning the nasal cavity having the composition shown in Table 1 was prepared. Specifically, the fragrance component and polysorbate 80 were dissolved according to the formulation shown in Table 1 to prepare an admixture. On the other hand, components other than the fragrance component and polysorbate 80 were dissolved in water to prepare an aqueous solution. The prepared admixture and aqueous solution were mixed to prepare a composition for nasal irrigation.

  Panelists (12 persons) performed nasal irrigation with each prepared nasal irrigation composition (10 ml / one nose). Nasal washes were performed by pouring each composition shown in Table 1 into the nasal cavity and discharging it from the mouth.

  Using a nasal ventilation meter MPR-3100 (manufactured by Nippon Koden Kogyo Co., Ltd.), nasal ventilation was measured before nasal washing and 10 minutes after nasal washing. The measurement and evaluation methods are as follows.

The air flow rate when the subject's nasal pressure was 100 Pa was measured with a nasal air permeability meter, and the nasal air permeability was calculated by the following equation.
Nasal air permeability (l / sec / Pa) = Air velocity (l / sec) / Nasal pressure (Pa)
Here, since nasal cavity resistance value = 1 / nasal cavity air permeability, it is defined as follows.
Nasal resistance value (Pa / l / sec) = nasal pressure (Pa) / air velocity (l / sec)
For the above evaluation method, see “Application of nasal air permeability to clinical examinations-Examination of changes in nasal air permeability due to swelling and contraction of nasal mucosa” Masaya Fukami; See pages 635-658.

  Based on the nasal resistance value obtained from the above formula, the ratio of the nasal resistance value before and after nasal washing was obtained, and the average value of the panel was calculated. A composition in which the nasal resistance value after washing was improved by 20% or more compared with that before washing was confirmed to have a sufficient nasal dilation effect.

The results are shown in Table 1 below.
Abbreviations in the table are as follows.
EDTA · 2Na: Disodium edetate

  As shown in Table 1, according to the composition for cleaning nasal cavity of the present invention, a sufficient nasal cavity expansion effect was confirmed when a composition containing mint oil, peppermint oil and 1-menthol was used (implementation). Example 1). Moreover, sufficient nasal cavity expansion effect was confirmed also when the composition containing any one sort of citrus essential oil, peppermint oil, and l-menthol was used (Examples 2-4).

  On the other hand, a composition containing only peppermint oil (Comparative Example 1), a composition containing only l-menthol (Comparative Example 5), a composition containing only peppermint oil and l-menthol (Comparative Example 3), peppermint oil and mint For the composition containing only oil (Comparative Example 4), it was shown that sufficient nasal cavity expansion effect could not be obtained.

Test Example 2 The sensory evaluation panelists (8 persons) performed nasal washing and sensory evaluation. In sensory evaluation, a total score was calculated as a 5-step evaluation (minimum 1 point, maximum 5 points) for refreshing feeling and bitterness, and evaluated as shown in Table 2 below. In addition, nasal washing followed the method described in Test Example 1.

  The results are shown in Table 3-1 and Table 3-2.

  As shown in Table 3-1 and Table 3-2, 0.05 to 0.13 parts by weight of 1-menthol with respect to 1 part by weight of peppermint oil; 0.017 to 0.037 parts by weight of peppermint oil or The composition for cleaning nasal passages (Examples 1 to 3 and 7 to 18) containing citrus essential oil in a proportion of 0.05 to 0.25 parts by weight had good refreshing feeling and reduced bitterness. .

  In addition, a composition for nasal washing containing 0.08 to 0.13 parts by weight of l-menthol and 0.021 to 0.033 parts by weight of peppermint oil per 1 part by weight of peppermint oil (Example 6) 10) to 10) were further improved in refreshing feeling.

  On the other hand, with respect to Comparative Example 1 and Comparative Examples 6 to 12 in which any one of the blending ratios of l-menthol, peppermint oil or citrus essential oil to peppermint oil is outside the scope of the present invention, good refreshing feeling and bitterness As a result, it was found that the sufficient reduction effect was not recognized, and that the feeling of use was not satisfactory.

Formulation Example According to the formulation examples shown in Table 4 and Table 5, compositions for nasal cavity washing were prepared.

  The fragrance component and polysorbate 80 were dissolved in accordance with the formulation shown in the table to prepare a mixed solution. On the other hand, components other than the fragrance component and polysorbate 80 were dissolved in water to prepare an aqueous solution. The prepared mixture was mixed with an aqueous solution to prepare a solution.

Claims (6)

At least one member selected from the group consisting of peppermint oil and citrus essential oils, comprising the step of blending the peppermint oil and l- menthol, a method for producing a nasal cleaning composition that having a nasal dilating action,
0.03 to 0.15 parts by weight of l-menthol, 0.017 to 0.037 parts by weight of peppermint oil and / or 0.05 to 0.3 parts by weight of citrus essential oil with respect to 1 part by weight of peppermint oil The said manufacturing method mix | blended in the ratio of a part. The manufacturing method of the composition for nasal cavity washing | cleaning of Claim 1 which mix | blends 0.001 to 3 weight% of at least 1 sort (s) selected from the group consisting of mint oil and citrus essential oil, peppermint oil, and 1-menthol. Citrus essential oil, lemon oil, lime oil, grapefruit oil, is at least one orange oil is selected from the group consisting of mandarin oil and bergamot oil, manufacture of nasal cleaning composition according to claim 1 or 2 Way . Furthermore, as a base (A) Quaternary ammonium salt-based preservatives, blended with (B) edetate and / or its salts, and (C) polysorbate, in the group agent,
(A) 0.5 to 110 parts by weight of polysorbate per 1 part by weight of quaternary ammonium salt preservative, and
(C) For nasal irrigation according to any one of claims 1 to 3 , wherein (B) edetic acid and / or a salt thereof is blended at a ratio of 0.001 to 1.5 parts by weight with respect to 1 part by weight of polysorbate. A method for producing the composition. 1 to 60 parts by weight of (C) polysorbate with respect to 1 part by weight of (A) quaternary ammonium salt preservative, and
The nasal irrigation according to any one of claims 1 to 4 , wherein (B) edetic acid and / or a salt thereof is blended in a proportion of 0.002 to 0.08 parts by weight with respect to 1 part by weight of (C) polysorbate. A method for producing a composition. During nasal cleaning composition, preparation of nasal cleaning composition according to (A) a quaternary ammonium salt-based preservative in a proportion of 0.0001 to 0.02 wt%, claim 4 or 5 Way .