JP5128707B2 - 内因性伝導の追跡による動的心臓再同期療法 - Google Patents
内因性伝導の追跡による動的心臓再同期療法 Download PDFInfo
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
- A61N1/3682—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions with a variable atrioventricular delay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36507—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by gradient or slope of the heart potential
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
- A61N1/3684—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions for stimulating the heart at multiple sites of the ventricle or the atrium
- A61N1/36842—Multi-site stimulation in the same chamber
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
- A61N1/3684—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions for stimulating the heart at multiple sites of the ventricle or the atrium
- A61N1/36843—Bi-ventricular stimulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
- A61N1/3684—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions for stimulating the heart at multiple sites of the ventricle or the atrium
Description
一実施において、ペーシング補充収縮間隔は、第1の心周期の内因性房室間隔と最適化され同期された心房心室腔遅延との差に基づく。一実施において、ペーシング補充収縮間隔は、第1の心周期の内因性房室間隔と第1の心周期のA−A間隔から最適化され同期された心房心室腔遅延を差し引いた間隔との差を備える。
式中、AVDOptは一定の最適AV遅延であり、AVEAは内因性心房事象またはペーシングされた心房事象Aと心室早期興奮VEAとの間の間隔である。
AVDOpt=N2AVI+Kwide(広いQRS波を有する患者の場合)
式中、0<N1、N2<1、およびN2≦N1であり、KnarrowおよびKwideは経験的に決定された定数であってもよい。
AVDOpt=K1AVL+K2AVR+K3
後でシステムにプログラムするために、あるいは臨床医が使用するために、指定係数KnまたはNnの導出は、心臓機能を反映する別のパラメータ(たとえば、最大値dP/dt)の同時測定によって決定されるようなペーシングパラメータの最適値に対して測定された伝導パラメータの具体的な値に関係する臨床人口データを得ることに関わる。指定係数が回帰係数であるような、ペーシングパラメータを設定する式において使用される指定係数の値を導くために線形回帰分析が実施されてもよい。
式中、AVDOptは前述のように計算することができる。
ペーシング補充収縮間隔RVn-1−LVnは、第1の心周期の内因性RV脱分極を検知することに対して開始される(530)。次の心周期で、LVはRVn-1−LVn間隔の終了に対してペーシングされる(540)。AVIRn-1−AVDOptは、初期化の間に決定され周期的に再決定されうる定数である。RVn-1−LVn間隔は、A−A間隔の少なくとも部分的な変化によって心拍ごとに変化してもよい。
以下に、上記各実施形態から把握できる技術思想を記載する。
(付記1)
心臓ペーシング装置を作動させる方法であって、
心房事象と少なくとも1つの心室の心室脱分極との間の内因性房室間隔に基づいて最適なAV遅延を計算すること、
心房興奮から心室早期興奮までの間隔(AV EA )を決定すること、
前記計算された最適なAV遅延から前記AV EA を差し引くことによって、前記心室の早期興奮ペーシング間隔を計算すること、
心周期の間に前記心室の早期興奮を検知すること、
前記早期興奮を検知することに応答して、前記心周期の早期興奮ペーシング間隔を開始すること、
前記早期興奮ペーシング間隔の終了に対して、前記心周期の間に前記少なくとも1つの心室をペーシングすること、
を備える方法。
(付記2)
前記AV EA を決定することは、前記心房事象と心室脱分極Q * の開始との間の間隔を決定することを含む、付記1に記載の方法。
(付記3)
前記AV EA を決定することは、
前記ヒス束の脱分極を検知すること、
前記心房事象と前記ヒス束の脱分極との間の間隔を決定すること、
を含む、付記1に記載の方法。
(付記4)
前記少なくとも1つの心室は右心室を含む、付記1に記載の方法。
(付記5)
前記少なくとも1つの心室は左心室を含む、付記1に記載の方法。
(付記6)
前記少なくとも1つの心室は右心室と左心室とを含む、付記1に記載の方法。
(付記7)
前記心室の早期興奮を検知することに応答して前記早期興奮ペーシング間隔を開始することは、右心室または左心室の早期興奮を検知することに応答して前記早期興奮ペーシング間隔を開始することを含み、
前記早期興奮ペーシング間隔の終了に対し前記心室をペーシングすることは、前記早期興奮ペーシング間隔の終了に対し前記右心室および左心室をペーシングすることを含む、付記1に記載の方法。
(付記8)
前記右心室および左心室をペーシングすることは、右心室および左心室ペーシングを実質的に同時に行うことを含む、付記7に記載の方法。
(付記9)
前記右心室および左心室をペーシングすることは、心室間遅延によって隔てられた右心室および左心室ペーシングを順番に行うことを含む、付記7に記載の方法。
(付記10)
心調律管理装置であって、
複数の心腔に電気的に結合された電極と、
前記電極を介して心臓電気信号を検知し、心臓事象に関連する心臓信号特徴を検出するように構成された検知回路と、
前記検知回路に結合され、1つまたは複数の心拍間隔を測定するように構成された測定回路であって、前記1つまたは複数の心拍間隔が、心房事象と少なくとも1つの心室の心室脱分極との間の房室間隔(AVI)と、心房事象と前記心室の心室脱分極の早期興奮との間の心房興奮から心室早期興奮までの間隔(AV EA )とを含む、前記測定回路と、
前記測定された房室間隔に基づいて最適なAV遅延を計算し、前記計算された最適なAVDから前記測定されたAV EA を差し引くことによって、前記心室の早期興奮ペーシング間隔を計算するように構成された最適化回路と、
前記心室の早期興奮を検知することに応答して、前記早期興奮ペーシング間隔を開始するように構成されたペーシング間隔コントローラと、
前記早期興奮ペーシング間隔の終了に対して、前記心室をペーシングするように構成されたペーシング治療回路と、
を備える心調律管理装置。
(付記11)
前記心室の早期興奮の間隔は、前記心房事象と心室脱分極Q * の開始との間の間隔を含む、付記10に記載の心調律管理装置。
(付記12)
前記心室の早期興奮の間隔は、前記心房事象とヒス束脱分極との間の間隔を含む、付記10に記載の心調律管理装置。
(付記13)
心臓ペーシング装置を作動させる方法であって、
第1の心周期の心房(A−A)間隔および内因性房室間隔(AVI)を測定すること、
前記測定されたA−A間隔と前記測定されたAVIとに基づいて、同期された心室腔のペーシング補充収縮期間を計算すること、
前記第1の心周期の内因性拍動心室脱分極を検知することに応答して、前記ペーシング補充収縮期間を開始すること、
前記第1の心周期の直後に続く第2の心周期の間に、前記ペーシング補充収縮期間の終了に対して同期された心室腔をペーシングすること、
各後続の心周期に対して、直前の心周期から測定されたA−A間隔に少なくとも基づいて前記ペーシング補充収縮期間を再計算すること、
を備える方法。
(付記14)
前記拍動心室は右心室であり、前記同期心室は左心室である、付記13に記載の方法。
(付記15)
前記拍動心室は左心室であり、前記同期心室は右心室である、付記13に記載の方法。
(付記16)
前記ペーシング補充収縮間隔は、前記第1の心周期の内因性房室間隔と最適化され同期された心房心室腔遅延との間の差に基づく、付記13に記載の方法。
(付記17)
前記ペーシング補充収縮間隔は、前記第1の心周期の内因性房室間隔と、前記第1の心周期のA−A間隔から最適化され同期された心房心室腔遅延を差し引いた間隔との差よりなる、付記13に記載の方法。
(付記18)
心調律管理装置であって、
複数の心腔に電気的に結合された電極と、
前記電極を介して心臓電気信号を検知し、心臓事象に関連する心臓信号特徴を検出するように構成された検知回路と、
前記検知回路に結合され、1つまたは複数の心拍間隔を測定するように構成された測定回路であって、前記1つまたは複数の心拍間隔が、心房事象と、心房事象と心室脱分極の間の房室間隔(AVI)との間の間隔を含む、前記測定回路と、
第1の心周期の間に測定されたA−A間隔と前記第1の心周期の間に測定されたAVIとに基づいて、同期された心室腔のペーシング補充収縮間隔を計算するように構成された最適化回路と、
前記第1の心周期の内因性拍動心室脱分極を検知することに応答して、ペーシング補充収縮間隔を開始するように構成されたペーシング間隔コントローラと、
前記第1の心周期の直後に続く第2の心周期の間に前記ペーシング補充収縮間隔の終了に対して同期された心室腔をペーシングするように構成されたペーシング治療回路であって、前記最適化回路は、直前の心周期から測定されたA−A間隔に少なくとも基づいて各後続の心周期の前記ペーシング補充収縮間隔を再計算するように構成されている、前記ペーシング治療回路と、
を備える心調律管理装置。
(付記19)
前記ペーシング補充収縮間隔は、前記第1の心周期の内因性房室間隔と最適化され同期された心房心室腔遅延との間の差に基づく、付記18に記載の心調律管理装置。
(付記20)
前記ペーシング補充収縮間隔は、前記第1の心周期の内因性房室間隔と、前記第1の心周期のA−A間隔から最適化され同期された心房心室腔遅延を差し引いた間隔との差に基づく、付記18に記載の心調律管理装置。
Claims (6)
- 心調律管理装置(600,700)であって、
複数の心腔に電気的に結合された電極(641,642,651〜656,725)と、
前記電極を介して心臓電気信号を検知し、心臓事象に関連する心臓信号特徴を検出するように構成された検知回路(720)と、
前記検知回路に結合され、1つまたは複数の心拍間隔を測定するように構成された測定回路であって、前記1つまたは複数の心拍間隔が、心房事象と少なくとも1つの心室の心室脱分極との間の房室間隔(AVI)と、心房事象と前記心室の心室脱分極の早期興奮との間の心房興奮から心室早期興奮までの間隔(AVEA)とを含む、前記測定回路(720)と、
前記測定された房室間隔に基づいて最適なAV遅延を計算し、前記計算された最適なAV遅延から前記測定されたAVEAを差し引くことによって、前記心室の早期興奮ペーシング間隔を計算するように構成された最適化回路(775)と、
前記心室の早期興奮を検知することに応答して、前記早期興奮ペーシング間隔を開始するように構成されたペーシング間隔コントローラ(765)と、
前記早期興奮ペーシング間隔の終了に対して、前記心室をペーシングするように構成されたペーシング治療回路(730)と、
を備える心調律管理装置。 - 前記心室の早期興奮の間隔は、前記心房事象と心室脱分極Q*の開始との間の間隔を含む、請求項1に記載の心調律管理装置。
- 前記心室の早期興奮の間隔は、前記心房事象とヒス束脱分極との間の間隔を含む、請求項1に記載の心調律管理装置。
- 前記少なくとも1つの心室が、右心室を含むか、あるいは左心室を含むか、または右心室と左心室との双方を含む、請求項1乃至3のいずれか一項に記載の心調律管理装置。
- 前記最適化回路は、右心室または左心室の早期興奮を検知することに応答して、前記早期興奮ペーシング間隔を計算するように構成されており、
前記ペーシング治療回路は、前記早期興奮ペーシング間隔の終了に対して、前記右心室および左心室をペーシングするように構成されている、請求項1に記載の心調律管理装置。 - 前記ペーシング治療回路は、前記右心室および左心室のペーシングを実質的に同時に行うように構成されているか、または
前記ペーシング治療回路は、心室間遅延による間隔で前記右心室および左心室のペーシングを順番に行うように構成されている、請求項5に記載の心調律管理装置。
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PCT/US2009/059005 WO2010042364A2 (en) | 2008-10-06 | 2009-09-30 | Dynamic cardiac resynchronization therapy by tracking intrinsic conduction |
US12/570,167 | 2009-09-30 | ||
US12/570,167 US8321014B2 (en) | 2008-10-06 | 2009-09-30 | Dynamic cardiac resynchronization therapy by tracking intrinsic conduction |
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US9089710B2 (en) | 2012-12-28 | 2015-07-28 | Cardiac Pacemakers, Inc. | Systems and methods to optimize pacing fusion with native activation |
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EP2349467A2 (en) | 2011-08-03 |
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US20130085539A1 (en) | 2013-04-04 |
JP2012504465A (ja) | 2012-02-23 |
US8321014B2 (en) | 2012-11-27 |
WO2010042364A2 (en) | 2010-04-15 |
US8725257B2 (en) | 2014-05-13 |
WO2010042364A3 (en) | 2011-06-23 |
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