JP5116916B2 - 免疫原性ｌｈｒｈ組成物およびそれに関する方法 - Google Patents

免疫原性ｌｈｒｈ組成物およびそれに関する方法 Download PDF

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Publication number
JP5116916B2
JP5116916B2 JP2000501770A JP2000501770A JP5116916B2 JP 5116916 B2 JP5116916 B2 JP 5116916B2 JP 2000501770 A JP2000501770 A JP 2000501770A JP 2000501770 A JP2000501770 A JP 2000501770A JP 5116916 B2 JP5116916 B2 JP 5116916B2
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Japan
Prior art keywords
lhrh
conjugate
dextran
diphtheria toxoid
deae
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Expired - Lifetime
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JP2000501770A
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English (en)
Japanese (ja)
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JP2001509489A (ja
Inventor
マイケル、ケリン、マクナマラ
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ファイザー・インク
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Pregnancy & Childbirth (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
JP2000501770A 1997-07-09 1998-07-09 免疫原性ｌｈｒｈ組成物およびそれに関する方法 Expired - Lifetime JP5116916B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AUPO7768A AUPO776897A0 (en) 1997-07-09 1997-07-09 A method of achieving production gains in livestock and agents useful for same
AU7768 1997-07-09
AUPO7768 1997-07-09
PCT/AU1998/000532 WO1999002180A1 (en) 1997-07-09 1998-07-09 Immunogenic lhrh compositions and methods relating thereto

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009244560A Division JP5231378B2 (ja) 1997-07-09 2009-10-23 免疫原性ｌｈｒｈ組成物およびそれに関する方法

Publications (2)

Publication Number Publication Date
JP2001509489A JP2001509489A (ja) 2001-07-24
JP5116916B2 true JP5116916B2 (ja) 2013-01-09

Family

ID=3802056

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2000501770A Expired - Lifetime JP5116916B2 (ja) 1997-07-09 1998-07-09 免疫原性ｌｈｒｈ組成物およびそれに関する方法
JP2009244560A Expired - Lifetime JP5231378B2 (ja) 1997-07-09 2009-10-23 免疫原性ｌｈｒｈ組成物およびそれに関する方法
JP2012195610A Pending JP2013006862A (ja) 1997-07-09 2012-09-05 免疫原性ｌｈｒｈ組成物およびそれに関する方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009244560A Expired - Lifetime JP5231378B2 (ja) 1997-07-09 2009-10-23 免疫原性ｌｈｒｈ組成物およびそれに関する方法
JP2012195610A Pending JP2013006862A (ja) 1997-07-09 2012-09-05 免疫原性ｌｈｒｈ組成物およびそれに関する方法

Country Status (19)

Country Link
US (6) US7534441B2 (de)
EP (4) EP2196213A1 (de)
JP (3) JP5116916B2 (de)
KR (2) KR100680631B1 (de)
AT (1) ATE458493T1 (de)
AU (2) AUPO776897A0 (de)
CA (1) CA2294865C (de)
CY (2) CY1109968T1 (de)
DE (2) DE122010000033I1 (de)
DK (1) DK1007084T3 (de)
ES (1) ES2339308T3 (de)
FR (2) FR10C0035I2 (de)
LU (1) LU91711I2 (de)
NZ (1) NZ502080A (de)
PL (1) PL200495B1 (de)
PT (1) PT1007084E (de)
TW (1) TWI235666B (de)
WO (1) WO1999002180A1 (de)
ZA (1) ZA986074B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO776897A0 (en) * 1997-07-09 1997-07-31 Csl Limited A method of achieving production gains in livestock and agents useful for same
AUPP807399A0 (en) * 1999-01-08 1999-02-04 Csl Limited Improved immunogenic lhrh composition and methods relating thereto
DK1035133T3 (da) 1999-02-17 2005-05-02 Pfizer Prod Inc Fusionsproteiner, der omfatter bærere, som kan inducere et dobbelt immunrespons
US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
CA2575997A1 (en) * 2004-08-04 2006-03-16 Cytos Biotechnology Ag Carrier conjugates of gnrh-peptides
WO2006129162A2 (en) * 2005-06-01 2006-12-07 Pfizer Products Inc. Vaccine compositions and methods for the treatment of urinary incontinence
WO2008110912A1 (en) * 2007-03-14 2008-09-18 Pfizer Inc. Fertility regulation in horses
NZ707752A (en) 2012-12-03 2020-01-31 Pfizer Novel selective androgen receptor modulators
KR101918381B1 (ko) * 2017-01-11 2018-11-13 이경민 칠보 공예품을 제조하는 방법과 이에 의하여 제조되는 칠보 공예품
KR102477054B1 (ko) * 2020-03-24 2022-12-14 주식회사 바이오앱 웅취 제거용 재조합 단백질 및 이를 포함하는 백신 조성물

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963691A (en) * 1974-10-07 1976-06-15 Merck & Co., Inc. Synthetic antigens of luteinizing hormone releasing hormone
DE3411224A1 (de) 1984-03-27 1985-10-10 Hoechst Ag, 6230 Frankfurt Verfahren zur racematarmen herstellung von peptidzwischenprodukten der gonadorelin- und gonadorelinanaloga-synthese und neue zwischenprodukte bei diesem verfahren
NZ220932A (en) * 1986-07-03 1990-05-28 Victoria State Composition comprising an antigenic substance, such as lhrh, conjugated to at least two different carriers and method of immunological castration and spaying
NZ221306A (en) 1986-08-15 1990-02-26 Commw Scient Ind Res Org 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof
WO1988005308A1 (en) * 1987-01-14 1988-07-28 Commonwealth Scientific And Industrial Research Or Anti reproductive hormone
GB2228262B (en) * 1989-01-25 1992-10-07 Nat Inst Immunology Antigenic derivative of gnrh
WO1990009799A1 (en) * 1989-02-23 1990-09-07 Colorado State University Research Foundation GnRH ANALOGS FOR DESTROYING GONADOTROPHS
NL8900726A (nl) 1989-03-23 1990-10-16 Stichting Centr Diergeneeskund Peptide, immunogene samenstelling en vaccin- of geneesmiddelpreparaat; werkwijze voor het immuniseren van een zoogdier tegen lhrh, en werkwijze voor het verbeteren van de vleeskwaliteit van varkens.
US5138034A (en) * 1989-07-12 1992-08-11 The Green Cross Corporation Method of fractionating plasma proteins
ATE140972T1 (de) 1989-08-25 1996-08-15 Biotech Australia Pty Ltd Fusionsproteine bestehend aus tratp und mindestens einem lhrh-analog
US5324512A (en) 1990-12-26 1994-06-28 The Population Council [Gln']-luteinizing hormone releasing hormone conjugate of tetanus vaccine and its uses
SK282056B6 (sk) * 1991-03-01 2001-10-08 Merial Spôsob zlepšenia organoleptických vlastností mäsa nevykastrovaných samcov domácich zvierat
EP0596959B1 (de) * 1991-07-26 2000-03-29 Commonwealth Scientific And Industrial Research Organisation System der bereitstellung eines impfstoffes auf peptidbasis, das sein eigenes adjuvans bildet, und seine herstellung
US5837268A (en) 1991-10-16 1998-11-17 University Of Saskatchewan GnRH-leukotoxin chimeras
ZA934199B (en) 1992-06-18 1994-01-10 Akzo Nv Carrier system against gnrh
US5614487A (en) 1993-05-28 1997-03-25 Genentech, Inc. Sustained release pharmaceutical composition
US5688506A (en) * 1994-01-27 1997-11-18 Aphton Corp. Immunogens against gonadotropin releasing hormone
ES2163631T3 (es) 1995-06-07 2002-02-01 Dlo Inst Voor Dierhouderij En Un peptido mejorado, composicion inmunogenica y vacuna o preparacion medica, un procedimiento para inmunizar a los animales contra la hormona lhrh, analogos del peptido lhrh repetidos en tandem y su uso como vacuna.
US5885966A (en) * 1995-06-07 1999-03-23 Dlo Instituut Voor Dierhouderij En Diergezondheid Peptide, immunogenic composition and vaccine or medical preparation, a method to immunise animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine
AU7468196A (en) 1995-10-27 1997-05-15 Merck & Co., Inc. Conjugates of gonadotropin releasing hormone
AUPO776897A0 (en) * 1997-07-09 1997-07-31 Csl Limited A method of achieving production gains in livestock and agents useful for same
US6013770A (en) 1997-07-21 2000-01-11 Washington State University Chimeric contraceptive vaccines

Also Published As

Publication number Publication date
TWI235666B (en) 2005-07-11
ATE458493T1 (de) 2010-03-15
PL338037A1 (en) 2000-09-25
AU8200198A (en) 1999-02-08
US20090226484A1 (en) 2009-09-10
EP1007084A4 (de) 2003-07-02
AU725562B2 (en) 2000-10-12
FR10C0035I1 (fr) 2010-08-27
WO1999002180A1 (en) 1999-01-21
FR10C0040I1 (fr) 2010-10-15
EP2196213A1 (de) 2010-06-16
JP2001509489A (ja) 2001-07-24
NZ502080A (en) 2001-09-28
CY1109968T1 (el) 2012-01-25
ES2339308T3 (es) 2010-05-18
US20110293647A1 (en) 2011-12-01
EP1007084A1 (de) 2000-06-14
FR10C0035I2 (fr) 2012-06-22
EP2316477A1 (de) 2011-05-04
KR20060101554A (ko) 2006-09-25
EP2191839A2 (de) 2010-06-02
EP1007084B1 (de) 2010-02-24
DE69841521D1 (de) 2010-04-08
ZA986074B (en) 1999-03-16
CY2010013I2 (el) 2012-01-25
JP2010059167A (ja) 2010-03-18
US20060024290A1 (en) 2006-02-02
US20090291098A1 (en) 2009-11-26
US7534441B2 (en) 2009-05-19
PT1007084E (pt) 2010-04-08
JP2013006862A (ja) 2013-01-10
KR100680631B1 (ko) 2007-02-09
US20140271695A1 (en) 2014-09-18
PL200495B1 (pl) 2009-01-30
DK1007084T3 (da) 2010-05-03
JP5231378B2 (ja) 2013-07-10
LU91711I2 (fr) 2010-09-28
DE122010000033I1 (de) 2011-12-01
CA2294865C (en) 2013-05-21
EP2191839A3 (de) 2010-09-08
US20120328639A1 (en) 2012-12-27
CY2010013I1 (el) 2012-01-25
US8741303B2 (en) 2014-06-03
KR20010021623A (ko) 2001-03-15
CA2294865A1 (en) 1999-01-21
AUPO776897A0 (en) 1997-07-31

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