JP5105890B2 - VEGFC production promoter - Google Patents

Description

  The present invention relates to an agent for improving swelling, lymphedema, wrinkle, or obesity by inducing vascular endothelial growth factor C (VEGFC) expression and promoting activation of lymphatic vessel function.

  The skin vascular system exists in the dermis and is composed of blood vessels and lymphatic vessels. In order to maintain homeostasis, the tissue fluid that has moved out of the blood vessel must return to the vein again. Skin veins send blood efficiently to the center. However, the ability of the vein itself to take up tissue fluid is poor. From this, it has been understood that a tissue that takes in tissue fluid, that is, a lymphatic vessel, is an essential structure in the skin.

  Lymphatic vessels play an important role in maintaining a constant state of the microenvironment around the cells by collecting unwanted substances present in the skin, water that constantly leaks from blood vessels, and proteins. In addition, it has been considered to play a role of resisting infectious agents and external factors from the outside through the transport of T lymphocytes.

  Symptoms such as swelling and lymphedema are known as pathological conditions of lymphatic dysfunction (Non-Patent Document 1: Jussila, L. & Alitalo, K. (2002) Physiol Rev 82, 673-700). Moreover, it is known that the function of lymphatic vessels is not limited to swelling, but also plays an important role in photoaging (wrinkle formation) of the skin associated with ultraviolet rays (Non-Patent Document 2: Kajiya, K. & Detmar, M. (2006) J Invest Dermatol 126, 919-21).

  From previous studies, VEGFR-3 has been identified as a transmembrane receptor specifically present in lymphatic vessels, and VEGFC and VEGFD have been found as ligands thereof. VEGFC acts on lymphatic vessels to promote lymphatic endothelial cell proliferation, migration and lumen formation, and activates lymphatic function (Non-patent Document 1: Jussila, L. & Alitalo, K. (2002). Physiol Rev 82, 673-700). In addition, the possibility of gene therapy by introduction of VEGFC has been sought for edema as a swelling pathological condition (Non-patent Document 3: Saaristo, A., Tammela, T., Timonen, J., Yla-Herttuala, S., Tukiainen, E., Asko-Seljavaara, S. & Alitalo, K. (2004) Faseb J 18, 1707-9).

  Recently, it has been known that genetically-mutated mice that cause abnormal lymphatic function exhibit obesity when mature. Regarding the mechanism by which abnormalities in the formation and function of lymphatic vessels exhibit obesity, the knowledge that lymph fluid flowing through lymphatic vessels promotes the differentiation of progenitor mast cells into fat has been obtained (Non-Patent Document 4: Harvey, NL, etc.) Nat Genet 2005, 37, 1072-81). That is, it has been reported that lymphatic fluid leaks out of the lymphatic vessels due to abnormalities of the lymphatic vessels, which leads to fat differentiation and eventually obesity formation. Therefore, the VEGFC promoter is also expected as a therapeutic agent for obesity prevention that functionally forms lymphatic vessels.

  VEGF-A to E exist as VEGF family genes. Among them, VEGFB and VEGFE have been identified as factors that act only on blood vessels. VEGFA is known to be a factor that exists in the skin and works on lymphatic vessels but conversely deteriorates the function of the lymphatic vessels (Non-patent Document 5: Nagy, JA, Vasile, E., Feng, D.). , Sundberg, C., Brown, LF, Detmar, MJ, Lawitts, JA, Benjamin, L., Tan, X., Manseau, EJ, Dvorak, AM & Dvorak, HF (2002) J Exp Med 196, 1497-506 ).

  In skin, VEGFD has been reported to be present in trace amounts in the dermis, but VEGFD is not an essential factor for skin lymphangiogenesis because VEGFD knockout mice do not cause any abnormalities in the formation and function of skin lymphatics. (Non-Patent Document 6: Baldwin, ME, Halford, MM, Roufail, S., Williams, RA, Hibbs, ML, Grail, D., Kubo, H., Stacker, SA & Achen, MG ( 2005) Mol Cell Biol 25, 2441-9). On the other hand, VEGFC in the skin is strongly expressed in the epidermis. Mice that highly expressed VEGFC in the epidermis have an increased number of lymphatic vessels in the dermis (Non-patent Document 7: Jeltsch, M., Kaipainen, A., Joukov, V., Meng, X., Lakso). , M., Rauvala, H., Swartz, M., Fukumura, D., Jain, RK & Alitalo, K. (1997) Science 276, 1423-5), on the other hand, of VEGFC receptor VEGFR-3 When the neutralizing antibody is highly expressed in the epidermis to block the effect of VEGFC in the epidermis, it has been found that the number of lymphatic vessels in the dermis is extremely reduced and edema is formed (Non-Patent Document 8: Makinen) , T., Jussila, L., Veikkola, T., Karpanen, T., Kettunen, MI, Pulkkanen, KJ, Kauppinen, R., Jackson, DG, Kubo, H., Nishikawa, S., Yla-Herttuala, S. & Alitalo, K. (2001) Nat Med 7, 199-205). From these facts, it is known that the function of lymphatic vessels existing in the dermis of the skin is controlled by VEGFC expressed in the epidermis, and that swelling (edema) is exhibited when VEGFC stops functioning.

  Therefore, as a method of activating lymphatic vessels to eliminate swelling and the like, a crude drug that promotes the expression of VEGFC was screened.

Physiol Rev 82, 673-700 (2002). J Invest Dermatol 126, 919-21 (2006). Faseb J 18, 1707-9 (2004). Nat Genet 37,1072-81 (2005). J Exp Med 196, 1497-506 (2002). Mol Cell Biol 25, 2441-9 (2005). Science 276, 1423-5 (1997). Nat Med 7, 199-205 (2001).

  An object of the present invention is to find a drug effective in preventing or controlling new swelling, lymphedema, wrinkle formation, or obesity from the viewpoint of activation of lymphatic vessel function by induction of VEGFC expression.

  The present inventor screened a number of crude drugs and determined that the prescribed crude drugs, namely, Kyonin extract, carrot extract, valerian extract, hawthorn extract, merirot extract, licorice extract, and Iris root extract induce the expression of VEGFC. I found it. In other words, these herbal medicines that induce VEGFC expression promote the activation of lymphatic function and are extremely useful in preventing or suppressing swelling, lymphedema, wrinkle formation due to photoaging of the skin with ultraviolet rays, or obesity. I found it effective.

The configuration of the present invention is as follows.
[a] A swelling improving agent comprising one or a plurality of drugs selected from the group consisting of a ginseng extract, carrot extract, valerian extract, hawthorn extract, merirot extract, nettle extract, and iris root extract. .
[b] Improvement of lymphedema characterized by containing one or more kinds of drugs selected from the group consisting of ginseng extract, carrot extract, valerian extract, hawthorn extract, merirot extract, nettle extract, and iris root extract Agent.
[c] A wrinkle improving agent characterized by containing one or more kinds of drugs selected from the group consisting of Kyonin extract, carrot extract, valerian extract, hawthorn extract, merirot extract, nettle extract, and iris root extract. .
[d] An obesity-improving agent comprising one or more kinds of drugs selected from the group consisting of Kyonin extract, carrot extract, valerian extract, hawthorn extract, merirot extract, nettle extract, and iris root extract .
[e] Lymphangiogenesis characterized by containing one or more kinds of drugs selected from the group consisting of ginseng extract, carrot extract, valerian extract, hawthorn extract, merirot extract, nettle extract, and iris root extract And / or a function promoter.
[f] Promotion of VEGFC production characterized by containing one or more kinds of drugs selected from the group consisting of ginseng extract, carrot extract, valerian extract, hawthorn extract, merirot extract, nettle extract, and iris root extract Agent.
[g] The lymphangiogenesis and / or function promoter according to [e], which prevents or inhibits swelling.
[h] The VEGFC production promoter according to [f], which prevents or inhibits swelling.
[i] The lymphangiogenesis and / or function promoter according to [e], which prevents or suppresses lymphedema.
[j] The VEGFC production promoter according to [f], which prevents or suppresses lymphedema.
[k] The lymphangiogenesis and / or function promoter according to [e], which prevents or suppresses the formation of wrinkles.
[l] The VEGFC production promoter according to [f], which prevents or suppresses the formation of wrinkles.
[m] The lymphangiogenesis and / or function promoter according to [e], which prevents or suppresses obesity.
[n] The VEGFC production promoter according to [f], which prevents or suppresses obesity.
[o] A method for suppressing swelling, comprising applying to the skin the lymphangiogenesis and / or function promoter described in [e].
[p] A method for suppressing swelling, the method comprising applying the VEGFC production promoter according to [f] to the skin.
[q] A method for suppressing wrinkle formation, comprising applying the lymphangiogenesis and / or function promoter according to [e] to the skin.
[r] A method for suppressing wrinkle formation, comprising applying the VEGFC production promoter according to [f] to the skin.

Definition:
As used herein, the term “swelling” is used synonymously with “edema” and refers to a condition in which tissue fluid or lymph fluid accumulates in a cell, a cell gap, or a body cavity for some reason, and is found in subcutaneous tissue. . Furthermore, the term “lymphedema” in the present specification refers to a state in which tissue fluid is accumulated in a peripheral portion due to obstruction of lymphatic vessels.

  As described in detail in the Examples below, screening for drugs that induce VEGFC, which is a lymphatic activating factor, is carried out by allowing various candidate drugs to act on the HaCat cell line, which is a cultured cell derived from human epidermis. The amount of VEGFC was used as VEGFC-inducing activity, and a drug having VEGFC-inducing activity was selected as an effective drug.

As a result, the following drugs were found to induce VEGFC.
・ Kyonin extract (Apricot Kernel Extract): This product is an extract extracted from Kyonin Prunus armeniaca Linne, Prunus armeniaca Linne var. Ansu Maximowicz or other related plants (Rosaceae) in 30% ethanol solution.
-Carrot extract (Ginseng Extract): This product is made from steamed and dried roots or roots (raw) of Panax ginseng CA Meyer (Panax schinseng Nees) (Araliaceae), water, ethanol, propylene glycol, 1,3- It is an extract obtained by extracting with butylene glycol or a mixture thereof or with absolute ethanol.
-Valerian Extract: This product is extracted from the roots and rhizomes of Valeriana fauriei Briquet or other related plants (Valerianaceae) with purified water.
-Hawthorn extract (Crataegus Fruit Extract): This product is extracted from the fruits of hawthorn crataegus cuneata Siebold et Zuccarini (Rosaceae) with water, ethanol, propylene glycol, 1,3-butylene glycol, diethylene glycol ethyl ether, or a mixture of these. Extract.
・ Merilot extract: This product is extracted from flowers, leaves, or flowers and leaves of Melilotus officinalis Linne (Leguminosae) with water, ethanol, propylene glycol, 1,3-butylene glycol, or a mixture of these. It is an extract.
・ White Nettle Extract: This product is extracted from Lamium album Linne (Labiatae) flowers, stems and leaves with water, propylene glycol, 1,3-butylene glycol or a mixture of these. It is.
-Iris Root Extract (Orris Extract): This product is a liquid extracted from rhizomes of white squirrels Iris florentina Linne (Iridaceae) with water, ethanol, 1,3-butylene glycol, or a mixture thereof.

  The said extract can be obtained by a conventional method, for example, after immersing the plant used as the origin of each extract with an extraction solvent, or heating-refluxing, it can filter and concentrate and can obtain. As the extraction solvent, any solvent that is usually used for extraction can be used. For example, water, methanol, ethanol, propylene glycol, 1,3-butylene glycol, glycerin and other alcohols, hydrous alcohols, chloroform , Organic solvents such as dichloroethane, carbon tetrachloride, acetone, ethyl acetate, hexane and the like can be used alone or in combination. The extract obtained by extraction with the above solvent is used as it is, or the concentrated extract is adsorbed by an adsorption method, for example, by removing impurities using an ion exchange resin, or by a column of a porous polymer (for example, Amberlite XAD-2). Then, it can be extracted with methanol or ethanol and concentrated. In addition, a partition method, for example, an extract extracted with water / ethyl acetate can be used.

  The drug according to the present invention is extremely effective in promoting the formation and function of lymphatic vessels. Symptoms associated with lymphatic vessel dysfunction include not only swelling and lymphedema, but also photoaging of the skin (such as wrinkles) associated with ultraviolet rays, and obesity. The drug according to the present invention is effective for the prevention and suppression of skin photoaging due to ultraviolet rays and obesity as well as swelling and lymphedema. Furthermore, the above drugs are considered effective for the treatment of congenital lymphedema.

  Skin photoaging refers to changes in the appearance and function of the skin that are generally recognized as a result of repeated exposure to sunlight. Ultraviolet light (UV), which is a component of sunlight, particularly intermediate UV (wavelength 290-320 nm, called UVB) mainly causes photoaging. The amount of UVB exposure necessary to cause photoaging is currently unknown. However, repeated exposure to UVB at levels that cause erythema and sunburn usually leads to photoaging. Clinically, photoaging is rough skin, wrinkle formation, spot coloration, soil coloration, sagging formation, onset of telangiectasia, development of mole, onset of purpura, vulnerable, atrophy, fibrosis It can be specified as the occurrence of a pigment removal region, the development of a pre-malignant tumor, a malignant tumor, and the like. Photoaging usually occurs in skin that is habitually exposed to sunlight, such as the face, ears, head, neck and hands.

  The drug for inducing VEGFC in the swelling improving agent, lymphedema improving agent, wrinkle improving agent, obesity improving agent, lymphangiogenesis and / or function promoter, or VEGFC production promoter of the present invention is a dry product in the total amount of the drug. 0.1 to 0.0001%, preferably 0.01 to 0.001%.

  In addition to the above essential components, the swelling improving agent, lymphedema improving agent, wrinkle improving agent, obesity improving agent, lymphangiogenesis and / or function promoter, or VEGFC production promoter of the present invention are usually used in cosmetics and pharmaceuticals. Components used for external preparations for skin, such as whitening agents, moisturizers, antioxidants, oily components, UV absorbers, surfactants, thickeners, alcohols, powder components, colorants, aqueous components, water, various A skin nutrient or the like can be appropriately blended as necessary.

  Others, edetate disodium, edetate trisodium, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid and other metal sequestering agents, caffeine, tannin, verapamil, tranexamic acid, and derivatives thereof, licorice extract, Grab lysine, Karin fruit hot water extract, various herbal medicines, tropherol acetate, glycyrrhizic acid and its derivatives or salts thereof, vitamin C, ascorbic acid magnesium phosphate, ascorbic acid glucoside, arbutin, kojic acid, etc. Agents, sugars such as glucose, flucotose, mannose, sucrose, and trehalose, vitamin A such as retinoic acid, retinol, retinol acetate, and retinol palmitate can also be appropriately blended.

  The swelling improvement agent, lymphedema improvement agent, wrinkle improvement agent, obesity improvement agent, lymphangiogenesis and / or function promoter, or VEGFC production promoter of the present invention is, for example, for ointment, cream, emulsion, lotion, pack, bath Any agent may be used as long as it is a conventional skin external preparation, and it may be used for cosmetic purposes, and the dosage form is not particularly limited.

HaCaT cells (German Cancer Research Center, Heidelberg, Germany), which are cultured cells derived from human epidermis, were cultured in DMEM containing 10% FBS and seeded in a 24-well plate at 15 × 10 ⁴ per well. After about 24 hours, the medium was changed to serum-free DMEM and cultured for 24 hours. After that, various plant extract dried products as candidate drugs dissolved in 70% EtOH so as to be 2% by mass are added in volume amounts of 1/100, 1/1000, 1/10000 of the culture solution. Further culture was performed. 48 hours after the addition of the drug, the culture supernatant was collected, and the amount of VEGFC in the culture supernatant was quantified according to the protocol of ELISA (R & D systems). In addition, Alamar Blue (TREK Diagnostic systems) was added to the cells after collecting the culture supernatant, and the amount of cells was measured as fluorescence intensity (Ex 544 nm, Em 590 nm). By dividing the amount of VEGFC in the culture supernatant by the fluorescence value of Alamar Blue, the amount of VEGFC expressed per cell was obtained. These results are shown in FIG. A value obtained by adding 70% EtOH as a solvent instead of the drug to the cells was set as 100 as a control. Further, 5% FBS was used as a positive control.

  From the above screening results, the ginseng extract, carrot extract, valerian extract, hawthorn extract, merirot extract, licorice extract, and Iris root extract all show VEGFC-inducing activity almost exceeding control, in particular carrot extract, licorice extract, and The Iris root extract showed high VEGFC-inducing activity in a dose-dependent manner.

Formulation Example 1 O / W cream formula (wt%)
Liquid paraffin 3
Vaseline 1
Dimethylpolysiloxane 1
Stearyl alcohol 1.8
Behenyl alcohol 1.6
Macadamia nut oil 2
Palm oil 3
Squalane 6
Stearic acid 2
Cholesteryl hydroxystearate 0.5
Cetyl 2-ethylhexanoate 4
Polyoxyethylene hydrogenated castor oil 0.5
Self-emulsifying glyceryl monostearate 3
Tocopherol acetate 0.1
Retinol 0.01
(Dimethicone / Vinyl Dimethicone) Cross Polymer 3
(Product name: KSG-16, Shin-Etsu Chemical Co., Ltd.)
4-t-butyl-4′-methoxydibenzoylmethane 0.05
P-hydroxybenzoate appropriate amount diparamethoxycinnamic acid mono-2-ethylhexanoate glyceryl 0.05
Potassium hydroxide 0.15
Sodium hexametaphosphate 0.05
Trimethylglycine 2
Glycerin 8
Dipropylene glycol 5
α-tocopherol 2-L-ascorbic acid potassium phosphate diester 1
(Acroyldimethyltaurate ammonium / VP) copolymer 0.1
(Product name: Aristoflex AVC, Clariant)
Valerian extract 0.1
Biodyne EMPP 0.1
Edetate trisodium 0.05
Carboxyvinyl polymer 0.05
Scale-like inorganic composite powder 10
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Mica titanium 0.1
Colorant Appropriate amount of purified water

Formulation example 2
W / O cream formula for weight (% by weight)
Dimethylpolysiloxane 3
Decamethylcyclopentasiloxane 13
Dodecamethylcyclohexasiloxane 5
Polyoxyethylene / methylpolysiloxane copolymer 1
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 1
Dow Corning 9040 Silicone Elastomer Blend 5
(Dimethicone cross polymer decamethylcyclopentasiloxane blend, company name Dow Corning)
Retinol acetate 0.1
P-hydroxybenzoate appropriate amount L-menthol appropriate amount trimethylsiloxysilicic acid 2
Ethanol 2
Glycerin 3
Dipropylene glycol 5
Polyethylene glycol 6000 5
Sodium hexametaphosphate 0.05
Tocopherol acetate 0.1
Caffeine 0.1
Kyonin extract 0.1
Hamelis Extract 0.1
Carrot extract 0.1
Biodyne EMPP 1
Edetate trisodium 0.05
Dimorpholinopyridazinone 0.01
Methylbis (trimethylsiloxy) silylisopentyl trimethoxycinnamate 0.1
Scale-like inorganic composite powder 5
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Yellow iron oxide Appropriate amount Cobalt titanate Appropriate amount Dimethyl distearyl ammonium hectorite 1.5
Polyvinyl alcohol 0.1
Hydroxyethyl cellulose 0.1
Sodium acrylate / 2-acrylamido-2-methylpropanesulfonic acid copolymer 0.1
(Product name: SIMULGEL EG, SEPPIC)
(Acroyldimethyltaurate ammonium / VP) copolymer 0.1
(Product name: Aristoflex AVC, Clariant)
Perfume Appropriate amount of purified water

Formulation Example 3
Wrinkle correspondence O / W cream formula (wt%)
Liquid paraffin 8
Vaseline 3
Dimethylpolysiloxane 2
Dow Corning 9041 Silicone Elastomer Blend 0.1
(Dimethicone cross-polymer dimethylpolysiloxane blend, Dow Corning)
Stearyl alcohol 3
Behenyl alcohol 2
Glycerin 5
Dipropylene glycol 4
Trehalose 1
Tetra-2-ethylhexanoic acid pentaerythrit 4
Polyisoethylene glyceryl monoisostearate 2
Polyoxyethylene glycerol monostearate 1
Lipophilic glyceryl monostearate 2
Citric acid 0.05
Sodium citrate 0.05
Potassium hydroxide 0.015
Oil-soluble licorice extract 0.1
Merirot extract 0.1
Retinol palmitate (1 million units) 0.25
Tocopherol acetate 0.1
Biodyne EMPP 5
P-hydroxybenzoate appropriate amount phenoxyethanol appropriate amount dibutylhydroxytoluene appropriate amount trisodium edetate 0.05
4-t-butyl-4′-methoxydibenzoylmethane 0.01
2-Ethylhexyl paramethoxycinnamate 0.1
β-carotene 0.01
Polyvinyl alcohol 0.5
Hydroxyethyl cellulose 0.5
Carboxyvinyl polymer 0.05
(Acroyldimethyltaurine ammonium / VP) copolymer 5
(Product name: Aristoflex AVC, Clariant)
Purified water Residual fragrance

Formulation Example 4
O / W cream formula for moisturizing (wt%)
Liquid paraffin 10
Dimethylpolysiloxane 2
Dow Corning 9045 Silicone Elastomer Blend 3
(Dimethicone cross polymer decamethylcyclopentasiloxane blend, company name Dow Corning)
Glycerin 10
1,3-butylene glycol 2
Erythritol 1
Polyethylene glycol 1500 5
Squalane 15
Tetra-2-ethylhexanoic acid pentaerythrit 5
Potassium hydroxide 0.1
Sodium hexametaphosphate 0.05
Tocopherol acetate 0.05
Biodyne EMPP 0.1
Nettle extract 1
P-Hydroxybenzoate appropriate amount hydroxypropyl methylcellulose 0.3
Polyvinyl alcohol 0.1
Carboxyvinyl polymer 0.2
Sodium acrylate / 2-acrylamido-2-methylpropanesulfonic acid copolymer 0.5
(Product name: SIMULGEL EG, SEPPIC)
Acrylic acid / alkyl methacrylate copolymer (Pemulene TR-2) 0.1
Scale-like inorganic composite powder 5
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Purified water residue

Formulation Example 5 W / O sunscreen formulation (% by weight)
Dimethylpolysiloxane 5
Decamethylcyclopentasiloxane 10
Trimethylsiloxysilicate 3
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 5
Polyoxyethylene / methylpolysiloxane copolymer 3
(Dimethicone / Vinyl Dimethicone) Cross Polymer 30
(Product name: KSG-16, Shin-Etsu Chemical Co., Ltd.)
Dipropylene glycol 3
Cetyl 2-ethylhexanoate 1
Silicone coated fine particle zinc oxide (60nm) 10
Talc 1
Silicone coated fine particle titanium oxide (40nm) 7
Biodyne EMPP 1
Hibotaurine 0.1
Clara extract 0.01
Adenosine triphosphate disodium 0.5
Iris root extract 0.1
P-hydroxybenzoate appropriate amount phenoxyethanol appropriate amount edetate trisodium 0.2
Dimethyl distearyl ammonium hectorite 1
Polymethylmethacrylic acid copolymer spherical powder 3
Scale-like inorganic composite powder 1
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Mica titanium 0.1
Purified water Residual fragrance

Formulation Example 6 O / W cream formula (wt%)
Glycerin 3% by mass
Decamethylcyclopentasiloxane 7
Dimethylpolysiloxane 5
Polyoxyethylene sorbitan monooleate (20EO) 1
Polyethylene glycol 20000 0.5
Polyvinyl alcohol 1
Ethanol 5
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 3
Trimethylsiloxysilicate 0.1
Dimorpholinopyridazinone 0.1
Potassium hydroxide 0.12
Mica titanium 0.1
Dow Corning 9045 Silicone Elastomer Blend 20
(Dimethicone cross polymer decamethylcyclopentasiloxane blend, company name Dow Corning)
(Acroyldimethyltaurine ammonium / VP) copolymer 2
(Product name: Aristoflex AVC, Clariant)
Sodium acrylate / 2-acrylamido-2-methylpropanesulfonic acid copolymer 0.1
(Product name: SIMULGEL EG, SEPPIC)
Carbomer 0.01
Acrylic acid / alkyl methacrylate copolymer (Pemulene TR-2) 0.05
Scale-like inorganic composite powder 5
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Aluminum oxide 0.01
Xanthan gum 0.1
Sodium carboxymethylcellulose 0.05
Biodyne EMPP 5
Tranexamic acid 1
Carrot extract 0.1
Retinol palmitate (1 million units) 0.01
Paraoxybenzoic acid ester Appropriate amount Phenoxyethanol Appropriate perfume Appropriate amount Ion-exchanged water Residual

Formulation Example 7
W / O cream formula (wt%)
Dipropylene glycol 1
Decamethylcyclopentasiloxane 5
Dimethylpolysiloxane 1
Polyoxyethylene / methylpolysiloxane copolymer 2
Glyceryl tri-2-ethylhexanoate 0.1
Polyoxyethylene sorbitan monostearate (20 EO) 0.05
Polyethylene glycol 9000 2
Polyvinyl alcohol 0.5
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 5
Dimorpholinopyridazinone 0.1
Potassium hydroxide 0.03
Aluminum oxide 0.1
Titanium oxide 1
Dow Corning 9041Silicone Elastomer Blend 40
(Dimethicone cross-polymer dimethylpolysiloxane blend, Dow Corning)
(Acroyldimethyltaurate ammonium / VP) copolymer 0.1
(Product name: Aristoflex AVC, Clariant)
Sodium acrylate / 2-acrylamido-2-methylpropanesulfonic acid copolymer 0.1
(Product name: SIMULGEL EG, SEPPIC)
Carbomer 0.01
Acrylic acid / alkyl methacrylate copolymer (Pemulene TR-2) 0.05
Talc 1
Scale-like inorganic composite powder 1
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Scale-like inorganic composite powder 1
(Sericite coated with titanium oxide, aluminum oxide, silicic anhydride, trade name: Coverleaf AR-20121M, Catalyst Chemical Industry Co., Ltd.)
Spherical nylon powder 1
Silicic anhydride 1
Hydroxyethyl cellulose 0.1
Biodyne EMPP 1
Hawthorn extract 0.1
Paraoxybenzoic acid ester Appropriate amount Phenoxyethanol Appropriate perfume Appropriate amount Ion-exchanged water Residual

Formulation Example 8 O / W cream formula for preventing wrinkles and sagging (wt%)
Glycerin 5
Decamethylcyclopentasiloxane 1
Dodecamethylcyclohexasiloxane 3
Dimethylpolysiloxane 5
Methylphenyl polysiloxane 1
Octyl methoxycinnamate 0.1
Tetra-2-ethylhexanoic acid pentaerythrite 1
Polyoxyethylene sorbitan monolaurate (20E.O.) 0.1
Polyoxyethylene / methylpolysiloxane copolymer 1
(Product name: Polyether-modified silicone oil KF-6018, Shin-Etsu Chemical Co., Ltd.)
Soybean ferment extract 3
Polyethylene glycol 6000 2
Citric acid 0.1
Sodium citrate 0.1
Sodium metaphosphate 0.05
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 0.1
(Dimethicone / vinyl dimethicone) Cross polymer 10
(Product name: KSG-16, Shin-Etsu Chemical Co., Ltd.)
Dow Corning 9041Silicone Elastomer Blend 5
(Dimethicone cross-polymer dimethylpolysiloxane blend, Dow Corning)
(Acroyldimethyltaurate ammonium / VP) copolymer 0.1
(Product name: Aristoflex AVC, Clariant)
Acroyldimethyltauronium ammonium / Beheneth-25 methacrylate crosspolymer 0.05
(Product name: Aristoflex HMB, Clariant)
Acrylic acid / alkyl methacrylate copolymer (Pemulene TR-2) 0.05
Acrylic acid amide / 2-acrylamido-2-methylpropanesulfonic acid copolymer 0.5
(Product name: SIMULGEL 600, SEPPIC)
Ammonium polyacrylate 0.5
(Product name: SIMULGEL A, SEPPIC)
Scale-like inorganic composite powder 1
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Scale-like inorganic composite powder 1
(Sericite coated with titanium oxide, aluminum oxide, silicic anhydride, trade name: Coverleaf AR-20121M, Catalyst Chemical Industry Co., Ltd.)
(Dimethicone / Vinyl Dimethicone) Cross Polymer 1
(Product name BY29-119, Tow Dow Corning Silicone Co., Ltd.)
Biodyne EMPP 1
Kyonin extract 0.1
Paraoxybenzoic acid ester Appropriate amount Phenoxyethanol Appropriate perfume Appropriate amount Ion-exchanged water Residual

Formulation Example 9
O / W emulsion formulation (wt%)
Dimethylpolysiloxane 3
Decamethylcyclopentasiloxane 4
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 0.5
Dow Corning 9040 Silicone Elastomer Blend 0.5
(Dimethicone cross polymer decamethylcyclopentasiloxane blend, company name Dow Corning)
Ethanol 5
Glycerin 6
1,3-butylene glycol 5
Polyoxyethylene methyl glucoside 3
Sunflower oil 1
Squalane 2
Potassium hydroxide 0.1
Sodium hexametaphosphate 0.05
Hydroxypropyl-β-cyclodextrin 0.1
Dipotassium glycyrrhizinate 0.05
Loquat leaf extract 0.1
Sodium L-glutamate 0.05
Nettle extract 0.1
Lavender oil 0.1
Vitamin E 0.1
Giant extract 0.1
Hibotaurine 0.01
Thiotaurine 0.1
Mortierella oil 0.5
Arbutin 3
Sodium acetyl hyaluronate 0.1
Marjoram extract 0.1
Biodyne EMPP 0.1
Dimorpholinopyridazinone 0.1
Xanthan gum 0.1
Carboxyvinyl polymer 0.1
Acrylic acid / alkyl methacrylate copolymer (Pemulene TR-1) 0.1
(Acroyldimethyltaurine ammonium / VP) copolymer 1
(Product name: Aristoflex AVC, Clariant)
Bengala appropriate amount yellow iron oxide appropriate amount scaly inorganic composite powder 1
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Mica titanium 0.1
P-Hydroxybenzoate appropriate amount purified water remaining

Formulation Example 10
O / W emulsion formulation (wt%)
Dimethylpolysiloxane 2
(Dimethicone / Vinyl Dimethicone) Cross Polymer 15
(Product name: KSG-16, Shin-Etsu Chemical Co., Ltd.)
Behenyl alcohol 1
Batyl alcohol 0.5
Glycerin 5
1,3-butylene glycol 7
Erythritol 2
Biodyne EMPP 5
Silica-coated zinc oxide 0.1
Valerian extract 0.1
Palm oil 3
Squalane 6
Tetra-2-ethylhexanoic acid pentaerythlit 2
Polyoxyethylene glyceryl isostearate 1
Polyoxyethylene glycerol monostearate 1
Potassium hydroxide Appropriate amount Sodium hexametaphosphate 0.05
Phenoxyethanol appropriate amount carboxyvinyl polymer 0.1
Sodium acrylate / 2-acrylamido-2-methylpropanesulfonic acid copolymer 0.1
(Product name: SIMULGEL EG, SEPPIC)
Purified water residue

Formulation Example 11
O / W emulsion formulation (wt%)
Liquid paraffin 7
Vaseline 3
Decamethylcyclopentasiloxane 2
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 0.1
Dow Corning 9041 Silicone Elastomer Blend 3
(Dimethicone cross-polymer dimethylpolysiloxane blend, Dow Corning)
Behenyl alcohol 1
Glycerin 5
Dipropylene glycol 7
Polyethylene glycol 1500 2
Jojoba oil 1
Isostearic acid 0.5
Stearic acid 0.5
Behenic acid 0.5
Tetra-2-ethylhexanoic acid pentaerythrit 3
Cetyl 2-ethylhexanoate 3
Glycerol monostearate 1
Polyoxyethylene glycerol monostearate 1
Potassium hydroxide 0.1
Sodium hexametaphosphate 0.05
Stearyl glycyrrhetinate 0.05
L-Arginine 0.1
Trimethylglycine 0.1
Ascovir-2-glucoside 0.1
Xylitol 1
Iris root extract 0.1
Tocophenol acetate 0.1
Acetylated sodium hyaluronate 0.1
Biodyne EMPP 1
Edetate trisodium 0.05
4-t-butyl-4'-methoxydibenzoylmethane 0.1
2-Ethylhexyl paramethoxycinnamate 0.1
Carboxyvinyl polymer 0.15
(Acroyldimethyltaurine ammonium / VP) copolymer 0.5
(Product name: Aristoflex AVC, Clariant)
Scale-like inorganic composite powder 0.5
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Mica titanium 0.1
Paraoxybenzoic acid ester Appropriate amount Purified water Residual perfume Appropriate amount

Formulation Example 12
W / O daytime emulsion formula (wt%)
Formulation Dimethylpolysiloxane 2
Decamethylcyclopentasiloxane 25
Dodecamethylcyclohexasiloxane 10
Polyoxyethylene / methylpolysiloxane copolymer 1.5
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 10
Dow Corning 9045 Silicone Elastomer Blend 5
(Dimethicone cross polymer decamethylcyclopentasiloxane blend, company name Dow Corning)
Trimethylsiloxysilicate 1
1,3-butylene glycol 5
Squalane 0.5
Talc 5
Dipotassium glycyrrhizinate 0.1
Tocophenol acetate 0.1
Biodyne EMPP 0.1
L-serine 1
Carrot extract 0.1
Edetate trisodium 0.05
4-t-butyl-4'-methoxydibenzoylmethane 1
2-methoxyhexyl paramethoxycinnamate 5
Diparamethoxycinnamic acid mono-2-ethylhexanoic acid glyceryl 1
Silicone coated fine particle titanium oxide (40nm) 4
Dimethyl distearyl ammonium hectorite 0.5
Spherical polyethylene powder 3
Sodium acrylate / 2-acrylamido-2-methylpropanesulfonic acid copolymer 0.1
(Product name: SIMULGEL EG, SEPPIC)
Scale-like inorganic composite powder 1
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Mica titanium 0.1
Phenoxyethanol Appropriate amount Purified water Residual perfume Appropriate amount

Formulation Example 13
Lotion formula (wt%)
Ethyl alcohol 5
Glycerin 1
1,3-butylene glycol 5
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.2
Sodium hexametaphosphate 0.03
Trimethylglycine 1
Sodium polyaspartate 0.1
α-tocopherol 2-L-ascorbic acid phosphate diester potassium 0.1
Thiotaurine 0.1
Hawthorn extract 0.1
Western mint extract 0.1
α-Glucosyl hesperidin 0.01
Ascorbic acid phosphate magnesium 0.01
Potassium 4-methoxysalicylate 1
Iris root extract 0.1
Biodyne EMPP 0.01
HEDTA 3 sodium 0.1
Carboxyvinyl polymer 0.05
Sodium acrylate / 2-acrylamido-2-methylpropanesulfonic acid copolymer 0.05
(Product name: SIMULGEL EG, SEPPIC)
Potassium hydroxide 0.02
Appropriate amount of phenoxyethanol Purified water

Formulation Example 14
Lotion formula (wt%)
Ethanol 10
Glycerin 2
Dipropylene glycol 1
Isostearic acid 0.1
Poly (oxyethylene / oxypropylene) / methylpolysiloxane copolymer 1
Lauryldimethylaminoacetic acid betaine 0.1
Citric acid 0.02
Sodium citrate 0.08
Sodium hexametaphosphate 0.01
Hipotaurine 0.1
Nettle extract 0.1
Ogon Extract 0.1
Biodyne EMPP 1
Lavender oil 0.001
(Acroyldimethyltaurate ammonium / VP) copolymer 0.01
(Product name: Aristoflex AVC, Clariant)
Phenoxyethanol appropriate amount active hydrogen water 1
Purified water residue

Formulation Example 15
Pack prescription (wt%)
Ethanol 10
1,3-butylene glycol 6
Polyethylene glycol 4000 2
Olive oil 1
Macadamia nut oil 1
Phytosteryl hydroxystearate 0.05
Lactic acid 0.05
Sodium lactate 0.1
L-ascorbic acid sulfate disodium salt 0.1
α-tocopherol 2-L-ascorbic acid potassium phosphate diester 0.1
Tocophenol acetate 0.1
Merirot extract 0.1
Molasses extract 1
Sodium chondroitin sulfate 0.1
Biodyne EMPP 3
Sodium carboxymethylcellulose 0.2
Polyvinyl alcohol 12
(Acroyldimethyltaurine ammonium / VP) copolymer 2
(Product name: Aristoflex AVC, Clariant)
Sodium acrylate / 2-acrylamido-2-methylpropanesulfonic acid copolymer 0.1
(Product name: SIMULGEL EG, SEPPIC)
Dow Corning 9041 Silicone Elastomer Blend 3
(Dimethicone cross-polymer dimethylpolysiloxane blend, Dow Corning)
Paraoxybenzoic acid ester Appropriate amount of purified water Residual fragrance

Formulation Example 16
Powder solid foundation formulation (wt%)
Dimethylpolysiloxane 5
Dow Corning 9045 Silicone Elastomer Blend 5
(Dimethicone cross polymer decamethylcyclopentasiloxane blend, company name Dow Corning)
Isostearic acid 0.5
Diisostearyl malate 3
Glyceryl tri-2-ethylhexanoate 1
Sorbitan sesquiisostearate 1
Spherical PMMA-coated mica 6
Prism Tone Powder YR 1
Fine zinc oxide 0.5
Fine particle titanium oxide 2
Synthetic phlogopite 2
Metal soap treated talc 8
Spherical silica 5
Tocophenol acetate 0.1
δ Tocopherol 0.1
Kyonin extract 0.1
Biodyne EMPP 0.1
P-Hydroxybenzoate Methylbis (trimethylsiloxy) silylisopentyl trimethoxycinnamate 1
2-Ethylhexyl paramethoxycinnamate 3
Spherical polyalkyl acrylate powder 6
Methyl hydrogen polysiloxane-coated talc Residual methyl hydrogen polysiloxane-coated sericite 5
Methyl hydrogen polysiloxane coated titanium oxide 15
Scale-like inorganic composite powder 10
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Mica titanium 1
Methyl hydrogen polysiloxane coated pigment (colorant) 5

Formulation Example 17
Powder solid foundation formulation (wt%)
Ceresin 0.5
Dimethylpolysiloxane 2
Methylphenyl polysiloxane 1
(Dimethicone / vinyl dimethicone) Cross polymer 10
(Product name: KSG-16, Shin-Etsu Chemical Co., Ltd.)
Squalane 7
Squalane (vegetable) 1
Sorbitan sesquiisostearate 1
Glycerol-modified silicone resin coated calcined sericite 16
Glycerol-modified silicone resin-coated sericite 7
Yellow iron oxide coated mica titanium 0.1
Fine particle titanium oxide 5
Talc 10
Titanium oxide coated sericite 0.1
Boron nitride 2.5
Bengala-coated mica titanium 0.1
Phytosterol 0.1
Ascorbyl dipalmitate 0.1
DL-α-tocopherol acetate 0.1
D-δ-tocopherol 0.1
Biodyne EMPP 0.1
Hawthorn extract 0.1
P-Hydroxybenzoate appropriate amount 2-methoxyhexyl paramethoxycinnamate 1
Spherical polyalkyl acrylate powder 8
Methyl hydrogen polysiloxane-coated mica Residual methyl hydrogen polysiloxane-coated iron oxide Titanium oxide sintered product 5
Methylhydrogenpolysiloxane-coated sericite 5
Methyl hydrogen polysiloxane coated titanium oxide 4
Methyl hydrogen polysiloxane coated flaky titanium oxide 5
Methyl hydrogen polysiloxane coated pigment (colorant) 5
Perfume

Formulation Example 18
Powder solid foundation formulation (wt%)
α-Olefin oligomer 3
Vaseline 3
Dow Corning 9040 Silicone Elastomer Blend 3
(Dimethicone cross polymer decamethylcyclopentasiloxane blend, company name Dow Corning)
Macadamia nut oil 0.1
Sorbitan sesquiisostearate 1
Alkyl-modified silicone resin coated yellow iron oxide 2
Alkyl modified silicone resin coated bengara 1
Alkyl-modified silicone resin coated black iron oxide 0.5
Yellow iron oxide coated mica titanium 5
Synthetic phlogopite 5
Titanium oxide 1
Zinc oxide 1
Low-temperature calcined zinc oxide 4
Firing sericite 10
Phlogopite 1
Aluminum oxide 1
Scale-like inorganic composite powder 15
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Talc Residual synthetic phlogopite 5
Cross-linked silicone powder (Trefil E-506) 10
DL-α-tocopherol acetate 0.1
D-δ-tocopherol 0.1
Biodyne EMPP 5
Paraoxybenzoate Equivalent amount Kyonin extract 0.1
2-Ethoxyhexyl paramethoxycinnamate 1
Calcium alginate powder 1
Perfume

Formulation Example 19
Solid foundation formulation (wt%)
α-Olefin oligomer 10
Microcrystalline wax 0.5
Dow Corning 9041 Silicone Elastomer Blend 3
(Dimethicone cross-polymer dimethylpolysiloxane blend, Dow Corning)
Ceresin 5
Dimethylpolysiloxane 15
Methylphenylpolysiloxane 10
Macadamia nut oil 0.1
Carnauba 0.1
Glyceryl tri-2-ethylhexanoate 7
Cetyl 2-ethylhexanoate 10
Sorbitan sesquiisostearate 1.5
Mica 0.5
Aluminum stearate 1
Cross-linked silicone powder (Trefil E-506) 8
N-lauroyl-L-lysine 0.1
D-δ-tocopherol appropriate amount Biodyne EMPP 0.1
Merirot extract 0.1
Bengala appropriate amount yellow iron oxide appropriate amount calcium alginate powder 1
Nylon powder Residual spherical silica 1
Titanium oxide 1

Formulation Example 20
Emulsion foundation formulation (wt%)
Microcrystalline wax 1
Dimethylpolysiloxane 15
Decamethylcyclopentasiloxane 2
Dow Corning 9045 Silicone Elastomer Blend 3
(Dimethicone cross polymer decamethylcyclopentasiloxane blend, company name Dow Corning)
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 0.5
1,3-butylene glycol 6
Candelilla Row 3
Isostearic acid 1
Ethylene glycol fatty acid ester 0.1
Lanolin fatty acid octyldodecyl 0.5
2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine 4
Titanium oxide 7.5
Barium sulfate 5
Titanium oxide 7
Talc 3
Silicic anhydride 4
Cross-linked silicone powder (Trefil E-506) 0.1
Sodium metaphosphate 0.1
Hydroxypropyl-β-cyclodextrin 0.1
DL-α-tocopherol acetate 0.1
Hamelis extract 0.1
Peonies extract 0.1
Sodium chondroitin sulfate 0.1
Sodium hyaluronate 0.1
Biodyne EMPP 0.1
Nettle extract 0.1
P-hydroxybenzoate appropriate amount bengara appropriate amount yellow iron oxide appropriate amount black iron oxide appropriate amount scaly inorganic composite powder 1
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Xanthan gum 0.1
Sodium carboxymethylcellulose 0.1
Sodium acrylate / 2-acrylamido-2-methylpropanesulfonic acid copolymer 0.5
(Product name: SIMULGEL EG, SEPPIC)
Merrilot extract 2
Purified water residue

Formulation Example 21
W / O foundation prescription (wt%)
Dimethylpolysiloxane 3
Decamethylcyclopentasiloxane 10
Polyoxyethylene / methylpolysiloxane copolymer 3
Dodecamethylcyclohexasiloxane 5
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 0.1
(Dimethicone / Vinyl Dimethicone) Cross Polymer 5
(Product name: KSG-16, Shin-Etsu Chemical Co., Ltd.)
Glycerin 4
1 3-Butylene glycol 5
Palmitic acid 0.5
Distearyldimethylammonium chloride 0.2
Metal soap treated talc 2
Cross-linked silicone powder (Trefil E-506) 0.1
Bengala-coated mica titanium 0.5
N-lauroyl-L-lysine 2
Sodium L-glutamate 2
Tocopherol acetate 0.1
δ-tocopherol 0.1
P-Hydroxybenzoate Appropriate amount Phenoxyethanol 0.2
Spherical nylon powder 1
Spherical polyalkyl acrylate powder 3
Merrilot extract 2
Hawthorn extract 1
Biodyne EMPP 5
Purified water Residual dextrin fatty acid-treated talc 3
Dextrin fatty acid-treated titanium dioxide 15
Dextrin fatty acid-treated yellow iron oxide 3
Dextrin fatty acid-treated black iron oxide 0.5

Formulation Example 22
O / W foundation formula (wt%)
Dimethylpolysiloxane 8
Dow Corning 9040 Silicone Elastomer Blend 20
(Dimethicone cross polymer decamethylcyclopentasiloxane blend, company name Dow Corning)
Behenyl alcohol 0.5
Batyl alcohol 0.5
1,3-butylene glycol 5
Macadamia nut oil 0.1
Isostearic acid 1.5
Stearic acid 1
Behenic acid 0.5
Cetyl 2-ethylhexanoate 5
Polyoxyethylene glycerol monostearate 1
Self-emulsifying glyceryl monostearate 1
Yellow iron oxide coated mica titanium 2
Titanium oxide 4
Talc 0.5
Kaolin 3
Synthetic phlogopite 0.1
Cross-linked silicone powder 0.1
Silicic anhydride 5
Potassium hydroxide 0.2
Triethanolamine 0.8
DL-α-tocopherol acetate 0.1
Sodium hyaluronate 0.1
Biodyne EMPP 0.1
Iris root extract 0.1
P-Hydroxybenzoic acid ester 2-ethylhexyl paramethoxycinnamate 1
Bengala appropriate amount yellow iron oxide appropriate amount black iron oxide appropriate amount xanthan gum 0.1
Sodium acrylate / 2-acrylamido-2-methylpropanesulfonic acid copolymer 1
(Product name: SIMULGEL EG, SEPPIC)
Bentonite 1
Scale-like inorganic composite powder 5
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Sodium carboxymethylcellulose 0.1
Purified water Residual fragrance

Formulation Example 23
Foundation formula (wt%)
Dodecamethylcyclohexasiloxane 15
Decamethylcyclopentasiloxane Residue
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 5
Dow Corning 9041 Silicone Elastomer Blend 30
(Dimethicone cross-polymer dimethylpolysiloxane blend, Dow Corning)
Ethanol 10
Isostearic acid 0.5
Myristic acid-treated zinc oxide 0.5
Palmitic acid dextrin-coated titanium oxide 10
Dalmic palmitate coated talc 7
(Silicone surface-treated titanium oxide 30nm) 5
Cross-linked silicone powder 1
Spherical silica 2
L-ascorbyl magnesium phosphate 0.2
DL-α-tocopherol acetate 0.1
D-δ-tocopherol 0.1
Glutathione 0.1
Valerian extract 0.1
Psycho extract 1
Biodyne EMPP 2
2-methoxyhexyl paramethoxycinnamate 5
Bengala coated with dextrin palmitate Appropriate amount Dextrin palmitate coated yellow iron oxide Appropriate amount Dextrin palmitate coated black iron oxide

Formulation Example 24
Makeup base formulation (wt%)
Dimethylpolysiloxane 5
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 0.1
Dow Corning 9045 Silicone Elastomer Blend 30
(Dimethicone cross polymer decamethylcyclopentasiloxane blend, company name Dow Corning)
Decamethylcyclopentasiloxane Residual ethyl alcohol 8
Bitumen coated mica titanium 0.5
Scale-like inorganic composite powder 5
(Talc coated with titanium oxide, aluminum oxide, silicic acid anhydride, trade name: Coverleaf AR-80, Catalyst Chemical Industry Co., Ltd.)
Methylsiloxane network polymer 5
Cross-linked silicone powder (Trefil E-506) 5
Citric acid 0.02
Sodium citrate 0.08
Tocopherol acetate 0.1
δ-tocopherol 0.1
Merrilot extract 3
Turmeric extract 0.01
Valerian extract 0.1
Biodyne EMPP 0.1
Purified water 1
Poly (oxyethylene / oxypropylene) / methylpolysiloxy acid copolymer 5

Formulation Example 25
Makeup base formulation (wt%)
Dimethylpolysiloxane 5
3-Tris (trimethylsiloxy) silylpropylcarbamic acid pullulan 1
(Dimethicone / Vinyl Dimethicone) Cross Polymer 15
(Product name: KSG-16, Shin-Etsu Chemical Co., Ltd.)
Decamethylcyclopentasiloxane 25
Polyoxyethylene / methylpolysiloxane copolymer 3
Glycerin 1
1,3-butylene glycol 5
Xylit 0.5
Isostearic acid 0.5
Silica anhydride coated with alkyl-modified silicone resin 2
Talc 0.5
Aluminum stearate 1
Bengala-coated mica titanium 0.1
Sodium hexametaphosphate 0.05
Dipotassium glycyrrhizinate 0.1
L-serine 0.1
Hypericum extract 0.1
DL-α-tocopherol acetate 0.2
Thiotaurine 0.1
Togenashi extract 0.1
Peonies extract 0.1
Kyonin extract 0.1
Lysolecithin 0.01
Acetylated sodium hyaluronate 0.1
Yukinoshita Extract 0.1
Biodyne EMPP 0.1
Paraoxybenzoic acid ester Appropriate amount Phenoxyethanol Appropriate amount Dextrate palmitate-coated iron oxide yellow 0.1
Dimethyl distearyl ammonium hectorite 1
Purified water Residual trimethylsiloxysilicate 1.5
Spherical silica 1
Spherical polyethylene powder 5
Perfume

Formulation Example 26
Tablet formulation (wt%)
Microcrystalline cellulose 35.0
Purified white sugar 29.0
Carboxymethylcellulose 10.0
Corn starch 10.0
Talc 10.0
Polyvinylpyrrolidone 5.0
Iris Root Extract 1.0

Formulation Example 27
Injection formulation (wt%)
Phosphate buffer solution (0.1M pH6.0) 10.0
Propylene glycol 4.0
Polyoxyethylene 3.7
Sodium chloride 0.9
Sesame oil 0.2
Nettle extract 0.1
Purified water residue

The result of the screening of a VEGFC expression promoter is shown.

Claims (1)

Apricot extract, Kanoko Saw extract, hawthorn extract, and characterized in that it consists of one or more plant extract is selected from Odorikosoueki scan or al group consisting, VEGF-C production promoter.

Images