JP5101261B2 - Epidural cooling system - Google Patents

Description

  The present invention relates to an epidural space cooling system used for cooling the epidural space adjacent to the spinal cord in clinical practice such as cardiovascular surgery, orthopedic surgery, and cell transplantation.

In order to cool the perfusate during perfusion of organs and the whole body in clinical practice, a heat exchanger is installed in the circuit, in which case the heat exchanger is installed downstream of the pump, that is, on the outflow side. (For example, see Patent Document 1, Patent Document 2, Non-Patent Document 1, and Non-Patent Document 2).
Japanese Patent No. 3220244 Japanese Patent No. 3360995 Ikuo Abe, Yuichi Ueda, “Latest Artificial Cardiopulmonary—Theory and Practice—Second Edition”, Nagoya University Press, February 2003 Takao Inoue, Hideo Adachi, “Latest extracorporeal circulation-from basic to clinical-”, published by Kanehara Publishing Co., Ltd., June 1997

  Sufficient heat exchange efficiency when performing continuous cooling of the spinal cord in a cooling system that cools the epidural space by placing a catheter with a perfusate circulation channel in the epidural space surrounding the spinal cord In order to obtain (cooling efficiency), it is necessary to increase the flow rate of the perfusate flowing inside the cooling catheter. As a method for this, it is conceivable to increase the perfusion pressure or decrease the flow resistance. In this respect, the cooling catheter is thin and the low temperature perfusate has a high viscosity, so that the pressure loss increases. Therefore, a pump capable of producing a high pressure is required. However, roller pumps used in clinical practice have a structure that does not easily generate high pressure, and the circuit configuration in which a conventional heat exchanger is installed on the pump outflow side increases the viscosity as the temperature of the perfusate decreases. There was a limit in obtaining a sufficient flow rate due to an increase in channel resistance. On the other hand, pumps that generate high pressure generally require high processing accuracy and are expensive, and thus cannot be used as disposable parts in epidural space cooling systems.

  When cooling the spinal cord by inserting a cooling catheter into the human epidural space, the present invention provides a high pressure that allows the required perfusate flow rate to flow even when the catheter channel resistance is high. It is an object to provide an epidural space cooling system that can be used.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors have provided a heat exchanger for cooling the perfusate flowing into the cooling catheter on the inflow side of the pump, so that the perfusate at the time of pump inflow The perfusion solution was found to be able to maintain a high perfusion pressure by bringing the temperature to the lowest temperature in the circuit, and a longer distance from the heat exchanger outlet to the catheter due to a pump entering between the heat exchanger and the catheter. It has been found that the temperature rise of the perfusion solution can be suppressed by applying insulation treatment to the pump part where the perfusate is in direct or indirect contact and the piping from the outlet of the heat exchanger to the inlet of the cooling catheter. The present invention has been reached.

  That is, the present invention relates to the epidural space cooling system including a cooling catheter for cooling the spinal cord inserted into the epidural space, a pump, a heat exchanger, and a cooler, and controls the temperature of the perfusate flowing into the cooling catheter. The gist of the epidural space cooling system is characterized in that a heat exchanger to be lowered is installed on the pump inflow side.

  Another aspect of the present invention is an epidural space cooling system including a cooling catheter for cooling the spinal cord, a pump, a heat exchanger, and a cooler, which is inserted into the epidural space, from the heat exchanger outlet to the cooling catheter. The gist of the epidural space cooling system is characterized in that the piping system from the cooling catheter outlet to the heat exchanger inlet is covered with a heat insulating material.

  Another aspect of the present invention is an epidural space cooling system including a cooling catheter for cooling the spinal cord, a pump, a heat exchanger, and a cooler, which is inserted into the epidural space, from the heat exchanger outlet to the cooling catheter. The piping system from the inlet to the inlet and the piping from the cooling catheter outlet to the heat exchanger inlet are filled with dry gas in the space between the outer tube and the inner tube, or the pressure is reduced to a double tube. The epidural space cooling system is characterized by the above.

  Another aspect of the present invention is an epidural space cooling system including a cooling catheter for cooling the spinal cord, a pump, a heat exchanger, and a cooler, which is inserted into the epidural space, from the heat exchanger outlet to the cooling catheter. The piping system from the inlet to the inlet and the piping from the cooling catheter outlet to the heat exchanger inlet is made into a double pipe, and the coolant flows through the gap between the outer pipe and the inner pipe. The gist of the extra-membrane space cooling system.

  Another aspect of the present invention is an epidural space cooling system including a cooling catheter for cooling the spinal cord inserted into the epidural space, a pump, a heat exchanger, and a cooler. The gist of the epidural space cooling system is characterized in that a heat insulating material is used in the indirectly contacting portion.

  In each of the present invention described above, preferably, the pump is any one of a constant displacement rotary pump, a reciprocating pump, a turbo pump, and a regenerative pump, and more preferably, the constant displacement rotary pump is It is a roller pump, most preferably the epidural space cooling system using an insulating material in the pump head part of the pump and the part of the roller in contact with the pump tube.

  Further, in each of the above-described present inventions, preferably, the cooling catheter is a catheter having a plurality of lumens, and has at least one perfusate inflow lumen and perfusate outflow lumen, and the perfusate inflow lumen and the perfusate The gist of the present invention is an epidural space cooling system that is a cooling catheter in which a perfusate circulation channel is formed in the catheter by communicating the outflow lumen at the distal end of the catheter.

  According to the present invention, the pump outlet pressure can be increased, the flow rate of the perfusate in the catheter can be increased, and a roller pump, a constant displacement pump with low processing accuracy, or the like can be used. Furthermore, the temperature of the perfusate in the circuit can be kept low.

  The epidural space cooling system of the present invention has a basic configuration of a cooling catheter, a pump, a heat exchanger, and a cooler. When a roller pump is used as an example of the pump and a heat insulating pipe is used as an example of piping between the components, FIG. 1 shows the connection relationship of each component. That is, a perfusate circulation circuit is formed through the cooling catheter 1, the roller pump 2, and the heat exchanger 3, and a cooler 4 is connected to the heat exchanger 3, and each component is connected by a heat insulating pipe 7. .

  The greatest feature of the epidural space cooling system of the present invention is that the heat exchanger 3 is installed on the inlet side of the roller pump 2. Therefore, the perfusate 5 flowing out from the cooling catheter 1 passes through the heat insulating tube 7 and flows into the heat exchanger 3, and heat exchange is performed between the refrigerant 6 and the perfusate 5 sent from the cooler 4 to the heat exchanger 3. As a result, the perfusate 5 reaches the lowest temperature in the perfusion circuit and is sucked into the roller pump 2 through the heat insulating tube 7. As a result, a highly viscous perfusate 5 is present in the roller pump 2, resulting in an increase in the closing pressure of the roller pump 2. As a result, the perfusion pressure of the perfusate 5 can be increased. Although the flow resistance of the cooling catheter 1 increases when the temperature of the perfusate 5 is low, the flow rate equivalent to that before cooling can be maintained by increasing the perfusion pressure as described above.

  Hereinafter, each structure in the epidural space cooling system of this invention is demonstrated.

The cooling catheter in the present invention may have any shape as long as the insertion site can be cooled. Preferably, in the catheter having a plurality of lumens, at least the perfusate inflow lumen and the perfusate outflow lumen are provided. The perfusate inflow lumen and the perfusate outflow lumen may communicate with each other at the distal end of the catheter so that a perfusate circulation channel is formed in the catheter (for details, refer to WO03 / 105736 pamphlet, (See Kaih 2007-167127). As an example, FIG. 9 shows a shape in which the lumens communicate with each other at the distal end of a biaxial double lumen catheter.
FIG. 9A shows an overall view of a local cooling catheter of the type described above. Lumens are in communication with each other at the tip (FIG. 9B). The lumen shape is not particularly limited as long as it is a biaxial double lumen. However, since the contact area with the outer wall of the catheter is preferably large, FIG.

  The pump in the present invention may be any pump as long as it can transport a fluid, but preferably a roller pump, a gear pump, a reciprocating pump, a turbo pump, and a regenerative pump.

  The deadline pressure of the roller pump is a pressure at which fluid starts to leak from the gap between the tubes applanated by the roller. The higher the viscosity of the fluid, the more difficult it is to leak and the deadline pressure becomes higher. Since the fluid tends to increase in viscosity as the temperature decreases, the pump cutoff pressure can be increased by lowering the temperature of the fluid.

  Various constant-volume rotary pumps, including gear pumps, are pumps that transport fluid using the space created by the combination of parts, but they require high processing accuracy and are expensive and not suitable for disposal. . However, it is possible to suppress leakage of working fluid from the gap by increasing the viscosity of the fluid even when using a pump with low processing accuracy, which is highly likely to leak from the gap in the combination of parts. Sufficient performance (pressure) can be maintained. If a reduction in processing accuracy is allowed, the unit price of the product can be reduced, so that disposal can be achieved. Further, since the constant displacement rotary pump has no pulsation, the pressure applied to the circuit is constant, which is advantageous for circuit resistance.

  Similarly, by increasing the viscosity of the fluid in other pumps, it becomes possible to maintain a high pressure even with low machining accuracy, and it becomes possible to make it disposable.

  Originally, the heat exchanger for lowering the temperature of the fluid is an indispensable part of the epidural space cooling system, so there is no risk of raising the price of the entire system. In addition, when the temperature is lowered, the flow resistance of the cooling catheter also increases, but the temperature of the fluid passing through the cooling catheter needs to be kept as low as possible regardless of the system configuration method. There is nothing.

[Principle of increase in deadline pressure]
FIG. 2 shows changes in temperature and viscosity when water is used as the perfusate (cited from mechanical engineering manual). It can be seen that when the temperature is lowered from 25 ° C. to 0 ° C., the viscosity is nearly doubled. Therefore, the shut-off pressure of the roller pump also increases accordingly. In actual measurement, the roller pump cutoff pressure at room temperature was 480 KPa, but increased to 750 KPa by cooling the fluid to 3 ° C. A similar tendency to change in viscosity is observed when a perfusate other than water is used.

  Due to the pump mechanism, the pump tube cannot be wrapped with a heat insulating material or made into a double tube, and its own heat insulating performance is low. Also, rollers and pump heads are usually made of a metal material having a high thermal conductivity such as aluminum, and the inflow of heat into the perfusate flowing inside the pump tube cannot be ignored. On the other hand, it is preferable to use a heat insulating material such as a synthetic resin or ceramics in a portion of the roller and the pump head that comes into contact with the pump tube, because heat transfer to the perfusate flowing inside the pump tube can be suppressed.

  A gear pump usually consists of two gears, a pump housing, and a rotating shaft. Gears and pump housings are usually made of a metal material having high thermal conductivity, and the inflow of heat into the perfusate flowing inside the pump housing cannot be ignored. On the other hand, heat transfer to the perfusate flowing inside the pump housing can be suppressed by using a heat insulating material such as synthetic resin or ceramics in the gear, the pump housing, and the portion that contacts the rotating shaft.

  The heat exchanger in the present invention may be any generally known heat exchanger, but preferably a spiral heat exchanger, a plate heat exchanger, a double pipe heat exchanger, a multi-tube cylindrical type. A heat exchanger, a multi-tube heat exchanger, a spiral tube heat exchanger, a spiral heat exchanger, a spiral plate heat exchanger, a tank coil heat exchanger, and a tank jacket heat exchanger are preferable.

  The cooler according to the present invention may be any commonly used one, but a cooler using a Peltier element is preferable because the apparatus can be downsized and no noise is generated.

  Further, a method may be used in which heat is exchanged by directly contacting a Peltier element or the like with a metal heat exchanger without using a refrigerant in the cooling device.

  In the present invention, the perfusate flowing in the perfusate circulation circuit, the refrigerant that reciprocates between the cooler and the heat exchanger, and the coolant in the case of using a double pipe as a pipe to be described later are not particularly limited. High water, physiological saline, ethylene glycol, ethylene glycol aqueous solution are preferred.

  The piping system in the present invention is not particularly limited as long as the perfusate can circulate through the circuit through each configuration. Preferably, it is desirable that the pipe is subjected to a treatment for enhancing the heat insulating effect. Specific examples thereof include covering the pipe system with a heat insulating material, or connecting the pipe system to an outer pipe and an inner pipe. A dry gas can be sealed in the space between them, or a double pipe can be decompressed, or a double pipe can be used as the piping system to allow the coolant to flow through the gap between the outer pipe and the inner pipe.

  When the epidural space is cooled using the epidural space cooling system of the present invention, the temperature of the perfusate is 30 ° C to -10 ° C, preferably 10 ° C to -5 ° C, more preferably 5 ° C. The flow rate of the perfusate may be set to 200 to 10 mL / min, preferably 150 to 50 mL / min. The flow rate of the coolant when the pipe is a double pipe is 5 to 0.1 L / min, preferably 0.5 to 0.1 L / min.

Details of the present invention will be described below based on embodiments shown in the drawings.
The pumps used in each example are roller pumps (manufactured by Izumi Kogaku Kagaku Kogyo Co., Ltd., artificial heart-lung machine HAS type, model HAS-P150) except for Example 6. In Example 6, as shown in FIG. A gear pump was made and used.

  As the cooling catheter, a polyurethane cooling catheter having an outer diameter of 1.5 mm and a length of 30 cm was used as shown in FIG. 9 in all examples. For the piping, soft vinyl chloride (length, about 3 m in total, flow path inner diameter, 3 mm) was basically used. Physiological saline was used as the perfusate, and an ethylene glycol aqueous solution was used as the refrigerant of the cooler. The heat exchanger outflow temperature of the perfusate was set to 1 ° C to 3 ° C, and the flow rate was 80 to 100 mL / min.

Example 1 (see FIG. 3)
FIG. 3 shows a first embodiment of the present invention. The epidural space cooling system is comprised by the heat exchanger 3 connected to the cooling catheter 1, the roller pump 2, and the cooler 4 in the figure. The outlet of the heat exchanger 3 is connected to the inlet of the roller pump 2 via a pipe 12. Further, the outlet of the roller pump 2 is connected to the inlet of the cooling catheter 1 via a tube 13. The outlet of the cooling catheter 1 is connected to the inlet of the heat exchanger 3 via a tube 14.

  The perfusate 5 flowing out of the cooling catheter 1 passes through the tube 14 and flows into the heat exchanger 3. Heat exchange is performed between the refrigerant 6 sent from the cooler 4 to the heat exchanger 3 and the perfusate 5, and the perfusate 5 reaches 2 ° C. which is the lowest temperature in the perfusion circuit and passes through the pipe 12. Is sucked into the roller pump 2. The viscosity of the perfusate 5 sucked into the roller pump 2 was about 1.7 mPa · s, which was the highest in the perfusion circuit. As the viscosity of the perfusate 5 increases, the cutoff pressure of the roller pump 2 increases, so that the perfusion pressure of the perfusate 5 can be increased, and as a result, the perfusate flow rate of 80 to 100 mL / min is maintained. It was.

Comparative Example 1
In the system of Example 1, the system was configured in the same manner except that the positions of the roller pump and the heat exchanger were switched and connected, and the perfusate was circulated under the same conditions as in Example 1. As a result, when the catheter inflow temperature of the perfusate was 5 ° C. or less, the amount of the perfusate was reduced to 50 mL / min or less.

Example 2 (see FIG. 4)
FIG. 4 shows a second embodiment of the present invention. In the figure, an epidural space cooling system is constituted by the cooling catheter 1, the roller pump 2, and the heat exchanger 3 connected to the cooler 4. The outlet of the heat exchanger 3 is connected to the inlet of the roller pump 2 via an elastic tube 15 made of a soft vinyl chloride tube in which foamed urethane rubber is wound as a heat insulating material 18 to a thickness of 1 to 2 cm. Further, the outlet of the roller pump 2 is connected to the inlet of the cooling catheter 1 through an elastic tube 16 around which a heat insulating material 19 is similarly wound. The outlet of the cooling catheter 1 is connected to the inlet of the heat exchanger 3 through an elastic tube 17 around which a heat insulating material 20 is wound.

  The perfusate 5 flowing out from the cooling catheter 1 passes through the elastic tube 17 and flows into the heat exchanger 3. Heat exchange is performed between the refrigerant 6 sent to the heat exchanger 3 from the cooler 4 and the perfusate 5, and the perfusate 5 reaches the lowest temperature of about 2 ° C. in the perfusion circuit. Passed through and sucked into the roller pump 2. The viscosity of the perfusate 5 sucked into the roller pump 2 was about 1.7 mPa · s, which was the highest in the perfusion circuit. As the viscosity of the perfusate 5 increased, the closing pressure of the roller pump 2 increased, the perfusion pressure of the perfusate 5 could be increased to 700 KPa, and the perfusate flow rate could be maintained at 80-100 mL / min. It was also shown that the catheter inflow temperature of the perfusate can be kept at 5 ° C. or less despite being 1.5 m or more away from the heat exchanger due to the heat insulating material.

Example 3 (see FIG. 5)
FIG. 5 shows a third embodiment of the present invention. In the figure, an epidural space cooling system is constituted by the cooling catheter 1, the roller pump 2, and the heat exchanger 3 connected to the cooler 4. The outlet of the heat exchanger 3 is connected to the inlet of the roller pump 2 via a double pipe 21. Further, the outlet of the roller pump 2 is connected to the inlet of the cooling catheter 1 via a double tube 22. The outlet of the cooling catheter 1 is connected to the inlet of the heat exchanger 3 via a double tube 23. Taking the double tube 22 as an example, the double tube 22 encloses a dry gas in a space between the outer tube 24 and the inner tube 25 to provide a heat insulating effect.

  The perfusate 5 flowing out from the cooling catheter 1 passes through the inner tube of the double tube 23 and flows into the heat exchanger 3. Heat exchange is performed between the refrigerant 6 sent from the cooler 4 to the heat exchanger 3 and the perfusate 5, and the perfusate 5 reaches about 2 ° C. and the lowest temperature in the perfusion circuit. Is sucked into the roller pump 2 through the inner pipe. The viscosity of the perfusate 5 sucked into the roller pump 2 was about 1.7 mPa · s, which was the highest in the perfusion circuit. As the viscosity of the perfusate 5 increased, the closing pressure of the roller pump 2 increased, the perfusion pressure of the perfusate 5 could be increased to 700 KPa, and the perfusate flow rate could be maintained at 80-100 mL / min. It was also shown that the catheter inflow temperature of the perfusate can be kept at 5 ° C. or less despite being 1.5 m or more away from the heat exchanger due to the heat insulating material.

Example 4 (see FIG. 6)
FIG. 6 shows a fourth embodiment of the present invention. In the figure, an epidural space cooling system is constituted by the cooling catheter 1, the roller pump 2, and the heat exchanger 3 connected to the cooler 4. The outlet of the heat exchanger 3 is connected to the inlet of the roller pump 2 via a double pipe 26. Further, the outlet of the roller pump 2 is connected to the inlet of the cooling catheter 1 via a double tube 27. The outlet of the cooling catheter 1 is connected to the inlet of the heat exchanger 3 via a double tube 28. In the double pipes 26, 27, and 28, an ethylene glycol aqueous solution flows as a cooling liquid in the gap between the inner pipe and the outer pipe, thereby suppressing the heat from entering the inner pipe from the outside. The cooling pipe perfusion gap of the double pipe is connected to the heat exchanger 3 via cooling pipes 30 and 29, and the cooling liquid 31 is perfused by the cooling liquid perfusion pump 32.

  The perfusate 5 flowing out from the cooling catheter 1 passes through the inner tube of the double tube 28 and flows into the heat exchanger 3. Heat exchange is performed between the refrigerant 6 sent from the cooler 4 to the heat exchanger 3 and the perfusate 5, and the perfusate 5 reaches the lowest temperature of about 2 ° C. in the perfusion circuit. It is sucked into the roller pump 2 through the inner tube. The viscosity of the perfusate 5 sucked into the roller pump 2 was the highest in the perfusion circuit and was about 1.7 mPa · s. As the viscosity of the perfusate 5 increased, the closing pressure of the roller pump 2 increased, the perfusion pressure of the perfusate 5 could be increased to 700 KPa, and the perfusate flow rate could be maintained at 80-100 mL / min. It was also shown that the catheter inflow temperature of the perfusate can be kept at 5 ° C. or less despite being 1.5 m or more away from the heat exchanger due to the heat insulating material.

Example 5 (see FIG. 7)
FIG. 7 shows a fifth embodiment of the present invention. The epidural space cooling system is comprised by the heat exchanger 3 connected to the cooling catheter 1, the roller pump 2, and the cooler 4 in the figure. The roller pump 2 usually comprises two rollers 9, a pump head 8 and a pump tube 10. By using polyethylene as the heat insulating material 33 at the portions of the roller 9 and the pump head 8 that are in contact with the pump tube 10, heat transfer to the perfusate 5 flowing inside the pump tube 10 is suppressed. Insulated tubes from the outlet of the heat exchanger 3 to the inlet of the roller pump 2, from the outlet of the roller pump 2 to the inlet of the cooling catheter 1, and from the outlet of the cooling catheter 1 to the inlet of the heat exchanger 3 7 is connected using a double pipe filled with dry air, and the inflow of heat into the perfusate 5 flowing in the system is suppressed.

  The perfusate 5 flowing out of the cooling catheter 1 passes through the heat insulating tube 7 and flows into the heat exchanger 3. Heat is exchanged between the refrigerant 6 sent from the cooler 4 to the heat exchanger 3 and the perfusate 5, and the perfusate 5 reaches the lowest temperature of about 2 ° C. in the perfusion circuit. Passed through and sucked into the roller pump 2. The viscosity of the perfusate 5 sucked into the roller pump 2 is about 1.7 mPa · s, which is the highest in the perfusion circuit. As the viscosity of the perfusate 5 increased, the closing pressure of the roller pump 2 increased, the perfusion pressure of the perfusate 5 could be increased to 700 KPa, and the perfusate flow rate could be maintained at 80-100 mL / min. It was also shown that the catheter inflow temperature of the perfusate can be kept at 5 ° C. or less despite being 1.5 m or more away from the heat exchanger due to the heat insulating material.

Example 6 (see FIG. 8)
FIG. 8 shows a sixth embodiment of the present invention. In the drawing, the epidural space cooling system is constituted by the cooling catheter 1, the gear pump 34, and the heat exchanger 3 connected to the cooler 4. The gear pump 34 uses the synthetic resin acrylic as a heat insulating material such as synthetic resin or ceramics at the portion where the two gears 35 are in contact with the pump housing 36 and the perfusate 5 of the rotary shaft 37. The heat transfer to the perfusate 5 flowing through can be suppressed.

  The perfusate flow rate could be maintained at 80-100 mL / min. It was also shown that the catheter inflow temperature of the perfusate can be kept at 5 ° C. or less despite being 1.5 m or more away from the heat exchanger due to the heat insulating material.

It is explanatory drawing which shows the basic structure of this invention. It is a figure which shows the influence of the temperature change of the viscosity of water. It is the schematic which shows 1st Example of this invention. It is the schematic which shows 2nd Example of this invention. It is the schematic which shows 3rd Example of this invention. It is the schematic which shows 4th Example of this invention. It is the schematic which shows 5th Example of this invention. It is the schematic which shows 6th Example of this invention. It is the schematic which shows an example of the type with which a lumen | rumen mutually communicates in the front-end | tip part of a biaxial double lumen catheter. (A) Schematic showing an example of the overall shape (B) Longitudinal sectional view of the distal end of the cartel (C) Partial sectional view of the catheter A-A '

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Cooling catheter 2 Roller pump 3 Heat exchanger 4 Cooler 5 Perfusate 6 Refrigerant 7 Heat insulation pipe 8 Pump head 9 Roller 10 Pump tube 11 Epidural space 12 Pipe 13 Pipe 14 Pipe 15 Elastic pipe 16 Elastic pipe 17 Elastic pipe 18 Heat insulating material 19 Heat insulating material 20 Heat insulating material 21 Double pipe 22 Double pipe 23 Double pipe 24 Outer pipe 25 Inner pipe 26 Double pipe 27 Double pipe 28 Double pipe 29 Cooling liquid pipe 30 Cooling liquid pipe 31 Cooling Liquid 32 Coolant perfusion pump 33 Heat insulating material 34 Gear pump 35 Gear 36 Pump housing 37 Rotating shaft 38 Double lumen cooling catheter 39 Branching section 40 Catheter tip section 41 Branch pipe (extension pipe)
42 Hub 43 Perfusate inflow or perfusate outflow lumen 44 Perfusate outflow or perfusate inflow lumen 45 Septum 46 Perfusate inflow lumen and perfusate outflow lumen communication part

Claims (6)

A spinal cord cooling catheter inserted into the epidural space;
A roller pump, a reciprocating pump, a turbo pump or a regenerative pump;
A heat exchanger,
A cooling machine,
An epidural space cooling system comprising:
The heat exchanger that lowers the temperature of the perfusate flowing into the spinal cord cooling catheter is installed on the pump inflow side, and the pump head portion and the roller of the pump are in contact with the pump tube, and are insulated. An epidural space cooling system characterized by using a material. The epidural space cooling system according to claim 1, wherein the piping system from the heat exchanger outlet to the spinal cord cooling catheter inlet and the piping system from the spinal cord cooling catheter outlet to the heat exchanger inlet are insulated. The epidural space cooling system according to claim 1, wherein the epidural space cooling system is coated with a material . In the epidural space cooling system according to claim 1, a piping system from the heat exchanger outlet to the spinal cord cooling catheter inlet, and a piping system from the spinal cord cooling catheter outlet to the heat exchanger inlet, 2. The epidural space cooling system according to claim 1 , wherein a dry gas is enclosed in a space between the outer tube and the inner tube, or a reduced pressure double tube is used . In the epidural space cooling system according to claim 1, a piping system from the heat exchanger outlet to the spinal cord cooling catheter inlet, and a piping system from the spinal cord cooling catheter outlet to the heat exchanger inlet, The epidural space cooling system according to claim 1 , wherein a cooling liquid is made to flow through a gap between the outer pipe and the inner pipe as a double pipe . The epidural space cooling system according to claim 1 , wherein a heat insulating material is used in a part where the perfusate directly or indirectly contacts the pump. Cooling system. The spinal cord cooling catheter is a catheter having a plurality of lumens, and has at least one perfusate inflow lumen and perfusate outflow lumen, and the perfusate inflow lumen and the perfusate outflow lumen communicate with each other at the distal end of the catheter. The epidural space cooling system according to any one of claims 1 to 5, which is a spinal cord cooling catheter in which a perfusate circulation channel is formed in the catheter.