JP5099345B2 - Method and apparatus for sensing drinking alcohol using skin gas - Google Patents

Description

In the present invention, human hands and fingers have a large number of blood vessels, and their density is high. Therefore, the sampling of skin gas from this hand or finger is excellent for measuring alcohol in the blood. The present invention relates to a method and an apparatus for sensing drunk alcohol using skin gas utilizing this, and relates to an apparatus that integrates collection of skin gas and measurement by an alcohol sensor.
This provides a small apparatus that can be used easily and can be easily carried.

Currently, alcohol checkers and alcohol breath sensors for breath are commercially available. As another method, a method of detecting an alcohol component from sweat is disclosed, but this method is a method in which a gas chromatograph and a sweat meter are connected as shown in Japanese Patent Publication No. 10-239309. Yes, it cannot be easily implemented. (Patent Document 1)
Further, as disclosed in Japanese Patent Publication No. 2002-195919, a method of collecting acetone from the skin using skin gas is disclosed. (Patent Document 2)
According to this, a coloring method has been proposed as a simple measuring method, but there is no method using an alcohol coloring agent, and the method has not been developed yet. A gas chromatograph is cited for measurement by other means, but this does not provide a simple measurement method.
Furthermore, as disclosed in Japanese Patent Publication No. 2006-343258 as a method for measuring skin release components, this is a method for measuring skin release components released from the skin. There is a method for measuring a skin release component that can be analyzed by using a large stationary device. According to this, as a method of measuring the skin gas released from the skin surface, the skin release component released from the skin is collected in a collection container, the inside of the repair container and the skin surface are washed with a hydrophilic solvent, In this method, the washing liquid obtained by the above method is subjected to solid phase extraction, and the solid phase obtained thereby is subjected to gas chromatography mass spectrometry. As a result, even a very small amount of skin-released components can be measured using a stationary large-scale device with short-time sampling and pretreatment, but there is a problem in terms of carrying with a handy type . (Patent Document 3)

JP-A-10-239309 JP 2002-195919 A JP 2006-343258 A

  The object of the present invention is that the hands and fingers have a large number of blood vessels, and their density is high. Therefore, sampling of skin gas from hands and fingers is excellent for measuring alcohol in blood. In view of this, it is an object of the present invention to provide a method and an apparatus that enable measurement in which collection of skin gas and measurement by an alcohol sensor are integrated. Furthermore, it is to provide a small device that can be used easily and can be easily carried.

  The alcohol in the skin gas is measured using an alcohol sensor, collected from the hand or finger, and the alcohol and water vapor in the skin gas are measured using the alcohol sensor and humidity sensor. is there. At this time, the humidity sensor that detects water vapor reflects the activity of the skin tissue.

  The water vapor component is sweat gland activity and direct transpiration of skin tissue. Moisture from the sweat glands and moisture from the skin tissue (out of the skin and becomes water vapor) occur at a ratio of about 1: 1.

  It can be understood that the output of the alcohol sensor, in which the skin activity is corrected with the amount of water vapor, reflects the alcohol activity more accurately. Thereby, correction | amendment of skin alcohol can be implemented and the difference by age can be correct | amended.

The present invention solves this conventional problem, and is as follows.
(1) Skin gas sampling is performed on the entire hand, finger, part of the arm or other human skin surface to collect the skin gas. About collection, although it is disclosed by patent publication 2002-195919, the hand and finger | toe were covered with the tetrafluoro polyethylene bag, and it implemented. The sensor kit has a gas suction part for sucking the skin gas collected in this way.
(2) The alcohol sensor and the humidity sensor are arranged in series or in parallel. The skin gas sucked by the pump obtains an alcohol sensor and a humidity sensor and is released to the outside. Alternatively, the sample gas is returned to the sampling bag, and the skin gas is again introduced to the alcohol sensor and the humidity sensor and circulated to obtain a measurement value of the equilibrium.
(3) Use indoor air as the gas circulating inside the kit, obtain a desiccant / air cleaner beforehand, and use the indoor air in a clean dry state. By doing so, the normal operation of the sensor is ensured.
(4) The sensor kit is made in a portable size that can be carried, can be lowered by hand and carried, and can be operated at a place where skin gas is collected.

  According to the present invention, hands and fingers have a large number of blood vessels, and their density is high. Therefore, sampling of skin gas from hands and fingers is excellent for measuring alcohol in blood. In view of this, it is an object of the present invention to provide a method and an apparatus that enable measurement in which collection of skin gas and measurement by an alcohol sensor are integrated. Furthermore, it is to provide a small device that can be used easily and can be easily carried.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
FIG. 1 is a configuration diagram of a sensor kit 1 that covers skin gas sampling for the entire hand or finger or other human skin surface 2 and collects the skin gas. About collection, the hand and finger which are already well-known methods are covered with the bag 3 made from tetrafluoropolyethylene. The sensor kit 1 has a gas suction part 4 for sucking the skin gas collected in this way.
The alcohol sensor 5 and the humidity sensor 6 are configured in series (in the drawing, they are in series but may be arranged in parallel). The skin gas sucked by the pump 7 returns to the sampling bag again through the alcohol sensor 5 and the humidity sensor 6 , and the skin gas is again guided to the alcohol sensor 5 and the humidity sensor 6 and circulated to obtain an equilibrium measurement value.
As the gas circulating inside the sensor kit 1, indoor air is used, and a pipe 8 containing a desiccant / air cleaner is obtained in advance, and the indoor air is used in a clean dry state. The flow of skin gas is controlled by the three-way valve 9 and the three-way valve 10. By doing so, the normal operation of the sensor is ensured.
Since the sensor kit 1 has such a configuration, the sensor kit 1 is made into a portable size that can be carried, and can be easily lowered by hand and operated in a place where skin gas is collected.

Next, the operation procedure of the present invention will be described with reference to the drawings.
(1) The sample bag is filled with clean air by turning on the pump and operating the three-way valve 9 and the three-way valve 10 so that the gas flows in the directions of numbers 8, 9, 5, 6, 7, 10, 3 in the figure. .
(2) By operating the pump ON and the three-way valve 9 and the three-way valve 10, the clean air in the sample bag is sucked with the gas flow in the directions of numbers 3, 9, 5, 6, and 7 in the figure.
(3) The above operations (1) and (2) are repeated 2-3 times.
(4) After supplying clean air into the sample bag again by the operation of (1), the three-way valve 10 is closed and the skin gas from the hand is collected for 3 minutes.
(5) While the three-way valve 10 is closed, that is, the gas flow along the straight line of the three-way valve 10 is stopped, the collected skin gas in the sample bag is again treated by the operation of (2) with the alcohol sensor and humidity. Lead to sensor and perform measurement. The measured value is displayed on the display means, and the value can be obtained immediately.
(6) During the operation (5), the three-way valve 10 is opened, gas is circulated along the straight line in FIG. 1 , and the skin gas is circulated in all the paths so that the sensor sensitivity is balanced.

  An embodiment that further embodies the present invention will be described. As an alcohol intake condition, 350 ml of beer is consumed within 5 minutes. Next, skin gas sampling is performed, and the hand is covered with a bag made of a polyfluoroethylene sheet for 3 minutes. The bag is then flushed with normal air and then 100 ml of normal air is pumped into the bag and held for 3 minutes. After 3 minutes, the gas sample containing the skin gas is measured with the alcohol sensor kit 1.

    Tables 1 and 2 are tables showing the test results of subjects A and B, and Tables 1 and 2 show two consecutive ones. It shows the output from the alcohol sensor from 15 minutes after ingestion of 350 ml of beer of subject A (male, weight 80 kg) and subject B <male, weight 63 kg> after alcohol intake. Check the response.

As can be seen from Table 3, the output of the alcohol sensor in the skin gas after alcohol intake, that is, the change over time in the alcohol concentration is shown. The sensor output on the vertical axis shows 1 ppm for 5.26 V and 5 ppm for 9.67 V.
It shows that alcohol ingested by collecting skin gas is detected.

  It is expressed as the amount of water vapor that evaporates from the skin as a factor of skin activity. This amount of water vapor is an effective measure of skin activity. Divide the alcohol concentration in the skin gas by the amount of water vapor to determine the relative alcohol concentration in the skin gas. Examination of this change in subjects revealed that it could be an indicator.

The vertical axis in Table 4 shows the value obtained by dividing the output of the alcohol sensor 5 in the skin gas after ingestion of alcohol by the amount of water vapor from the skin, that is, the output of the humidity sensor 6 in order to correct the activity of the skin. . This value is the relative skin gas alcohol concentration. With this display, a change with time in the concentration of the skin gas alcohol corrected by the activity of the skin is recognized. That is, in subject A, the relative skin gas alcohol concentration increased in 80 minutes, indicating that the alcohol relative concentration is high at this time.
Similarly, in subject A, the relative skin gas alcohol concentration becomes higher in 40 minutes after alcohol intake from the comparison with Table 3.

Next, the change with time of alcohol concentration in skin gas after alcohol intake will be described.
As shown in Table 5, the skin gas was sampled and once kept in a sample storage bag, the alcohol concentration in the sample storage bag was confirmed.
As a result, as shown in Table 5, which is a graph for subject B <male>, before taking T-B1 beer, taking 50 ml of beer after measuring T-A1, taking 295 ml of beer after measuring T-A2, -A3 21 minutes after ingesting 295 ml beer, T-A4 84 minutes after ingesting 295 ml beer, it was confirmed that the alcohol component was released from the skin gas using skin gas.

The sensor confirmed the alcohol intake and the alcohol concentration in the skin gas. The results are shown in Table 6.
Table 6 shows the relationship between the alcohol concentration in the skin gas and the amount of alcohol consumed. It was observed that the alcohol concentration in the skin gas increased with increasing alcohol intake. Although there are individual differences among humans, the amount of alcohol in skin gas is significantly increased.

    In addition, a finger experiment was performed, and similar results were obtained.

    In addition, when skin gas was collected with a bag of 5 cm square of arms and collected with a sensor kit, alcohol in the skin gas could be measured in the same manner even with the arms. The alcohol concentration in skin g vinegar was lower than when the bag was placed on the hand.

    As can be seen from these results, the present invention is excellent in the measurement of alcohol in blood by gas sampling. Therefore, it is possible to provide a small-sized apparatus that can be easily used and easily carried, and to provide a highly reliable non-invasive alcohol measurement method.

  It is a lineblock diagram of sensor kit 1 of the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Sensor kit 2 Human skin surface 3 Tetrafluoro polyethylene bag 4 Suction part 5 Alcohol sensor 6 Humidity sensor 7 Pump 8 Tube containing desiccant and air cleaner 9 Three-way valve 10 Three-way valve

Claims (1)

Covers the entire hand or fingers, other human skin surfaces, has a bag that collects the skin gas, and a gas suction part that inhales the collected skin gas, and has an alcohol sensor and humidity sensor The skin gas sucked by the pump passes through the alcohol sensor and humidity sensor, and then returns to the sampling bag again. The skin gas is again guided to the alcohol sensor and humidity sensor and circulated to obtain the equilibrium measurement value. Sensing method of drinking alcohol using characteristic skin gas.

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