JP5063235B2 - Tablet inspection device and PTP packaging machine - Google Patents

Description

  The present invention belongs to a technical field including a tablet inspection apparatus used in manufacturing a PTP sheet and a PTP packaging machine equipped with the tablet inspection apparatus.

  In general, a PTP sheet is attached to a packaging film made of resin in which a pocket portion filled with tablets or the like is formed, and the packaging film so that the opening side of the pocket portion is sealed to the packaging film. It is comprised from the cover film made from aluminum.

  In manufacturing the PTP sheet, a foreign tablet mixing inspection for detecting the mixing of the different tablets is performed before the cover film is attached after the pockets are filled with tablets or the like.

As such an inspection method, it is common to perform an appearance inspection for inspecting a difference in appearance such as the color, size, and shape of a tablet. For example, in the color identification inspection, the tablet is first irradiated with light from the illumination means, and the reflected light is color-imaged by a camera. Then, RGB data, which is color image data, is subjected to HIS conversion to obtain hue H, saturation S, luminance I, and luminance statistics (average, standard deviation, etc. of the spectrum distribution of H, S, I) and these and a predetermined standard The color abnormality of the tablet is detected from the similarity with the value (see, for example, Patent Document 1).
Japanese Patent Laid-Open No. 10-104076

  However, among the tablets, many of the uncoated tablets, which are just pressed and solidified with drug powder, are white and disk-shaped, and are approximately the same size. It was difficult to discriminate by.

  The present invention has been made in view of the above circumstances, and relates to mixing inspection of different types of tablets in the manufacturing process of PTP sheets, and a tablet inspection apparatus and a PTP packaging machine capable of dramatically improving inspection accuracy. It is one of the main purposes to provide.

  In the following, each means suitable for solving the above-described problems will be described in terms of items. In addition, the effect etc. peculiar to a corresponding means are added as needed.

Means 1. In the manufacturing process of the PTP sheet, after the uncoated tablet is accommodated in the pocket portion formed on the belt-shaped packaging film to be conveyed, before the cover film is attached in a sealed state so as to close the pocket portion A tablet inspection device used in the stage,
Illumination means comprising a light source capable of irradiating predetermined light to the uncoated tablet and the packaging film;
The illumination means is provided on the opposite side through the packaging film, and at least imaging means capable of imaging transmitted light that is irradiated from the light source and passes through the uncoated tablet,
An image processing device for processing an image signal output from the imaging means,
The image processing device is configured to be able to detect mixing of different types of tablets using different transmitted light amounts between different types of uncoated tablets based on image data obtained from the image signal , and
The image processing apparatus obtains an average luminance value of a plurality of pixels in a portion corresponding to the uncoated tablet in the image data, and determines whether the average luminance value is within an allowable range, thereby mixing different types of tablets. The tablet inspection device is configured to be capable of detecting a tablet.

  According to the above means 1, in the process of manufacturing the PTP sheet, the cover film is sealed so as to close the pocket portion after the uncoated tablet is accommodated in the pocket portion formed in the belt-shaped packaging film to be conveyed. In the previous stage of attachment, inspection for mixing of different types of tablets is performed by a tablet inspection apparatus. That is, predetermined light is emitted from the light source of the illumination means to the uncoated tablet and the packaging film. Moreover, the transmitted light which is irradiated from at least the light source and passes through the uncoated tablet is imaged by the imaging means provided on the opposite side of the illumination means via the packaging film. In the image processing apparatus, the image signal output from the image pickup unit is processed, and mixing of the different types of tablets is detected based on the image data obtained from the image signal.

  The uncoated tablet refers to a tablet in which the surface of the tablet is not coated with a film, such as a sugar-coated tablet or a film-coated tablet, and the raw material powder is simply pressed and hardened. Therefore, such uncoated tablets have different amounts of transmitted light among different varieties due to differences in the size and thickness of the raw material particles and the pressure at the time of tableting. That is, the above means uses this difference to determine the type of uncoated tablet. As a result, different types of uncoated tablets with similar appearances such as color, size, and shape can be identified, and the inspection accuracy related to mixing inspection of different types of tablets can be dramatically improved.

Further , according to the above means 1 , the mixing of different types of tablets is determined by relatively simple processing such as obtaining the luminance average value of a plurality of pixels corresponding to the uncoated tablet and determining whether or not this is within the allowable range. it can. In this means 1 , for example, an allowable range is set for each type of uncoated tablet (the same applies to means 2 ).

Moreover, when the dividing line, the marking, etc. are formed in the uncoated tablet surface, these formation parts are thin compared with other general parts, and it is easy to permeate | transmit light more. For this reason, the luminance is higher in these formation parts than in other general parts. Therefore, when the average luminance value of the entire portion corresponding to the uncoated tablet is obtained, the variety of the uncoated tablet cannot be properly grasped, and there is a concern that the inspection accuracy is lowered. In view of this, by using the following means 2 to 5 , it is possible to suppress the influence of the dividing line and the marking on the inspection.

Means 2 . The image processing device extracts a predetermined number of pixels from the plurality of pixels of the image data corresponding to the uncoated tablet in ascending order of luminance, obtains an average luminance value of the predetermined number of pixels, The tablet inspection apparatus according to means 1, wherein the tablet inspection apparatus is configured to be able to detect mixing of different types of tablets by determining whether or not the average luminance value is within an allowable range.

By acquiring the luminance average value as in the above-described means 2 , it is possible to make a more appropriate determination and further improve the inspection accuracy.

Means 3 . The image processing device sets a portion of the image data corresponding to the uncoated tablet, excluding a portion corresponding to a dividing line or a marking, as an inspection target area for obtaining the luminance average value. The tablet inspection apparatus according to means 1 or 2 .

According to the above means 3 , even if it has a dividing line and a marking, it is possible to carry out an accurate inspection similar to the case without these. For example, by performing a mask process on a part corresponding to a dividing line or marking, an area excluding the part can be set as an inspection target area.

Means 4 . 4. The tablet inspection according to claim 3 , wherein the image processing apparatus specifies binarized image data obtained by binarizing the image data with a predetermined threshold as a reference, and then specifies the inspection target area. apparatus.

According to the above-mentioned means 4 , among the parts corresponding to the uncoated tablet, the part corresponding to the dividing line or the engraving and the other general part are classified by the level of brightness based on a predetermined threshold. The inspection target area can be set with high accuracy. As a result, more appropriate determination can be performed, and further improvement in inspection accuracy can be achieved.

Means 5 . The image processing apparatus sets a plurality of inspection target areas for obtaining the luminance average value in a portion corresponding to the uncoated tablet in the image data, obtains the luminance average value for each of the inspection target areas, Any one of means 1 to 4 is configured to be able to detect mixing of different types of tablets by determining whether or not a luminance average value is within an allowable range corresponding to each of the inspection target areas. Tablet inspection device.

According to the above means 5 , since it is possible to discriminate for each part even in the case of an uncoated tablet having a different thickness at the central portion and a peripheral portion, such as a lens lock, and a different amount of transmitted light, it is more accurate. The determination can be performed, and the inspection accuracy can be further improved.

Means 6 . A PTP packaging machine comprising the tablet inspection apparatus according to any one of means 1 to 5 .

By providing the tablet inspection apparatus in the PTP packaging machine as in the above means 6 , there is a merit that defective products can be efficiently excluded in the manufacturing process of the PTP sheet.

  Hereinafter, an embodiment will be described with reference to the drawings. In this embodiment, the PTP sheet is inspected for defects in the PTP packaging machine by installing the tablet inspection device in the PTP packaging machine.

  As shown in FIGS. 2A and 2B, the PTP sheet 1 is attached to the container film 3 as a packaging film having a plurality of pocket portions 2 and the container film 3 so as to close the pocket portions 2. And a sealing film 4 as a covered cover film.

  The container film 3 is made of, for example, a relatively hard thermoplastic resin material having a predetermined rigidity, such as PP (polypropylene) or PVC (polyvinyl chloride), and has light transparency (here, transparent). Presents). The sealing film 4 is made of aluminum.

  Each pocket portion 2 accommodates one flat lock 5 which is a disk-shaped uncoated tablet. Although the flat tablet 5 of the present embodiment has a color close to white, the color is not limited to this.

  As shown in FIG. 1, the PTP packaging machine 7 automatically wraps the flat tablet 5 on the container film 3. Specifically, a belt-shaped resin film such as PP or PVC is fed to the heating device 12 and the molding device 13 by the film feed roll 9 and the tension rolls 10 and 11, and the pocket portion 2 for filling the flat lock 5 is used as the resin film. To form. Then, when the container film 3 in which the pocket portions 2 are formed on the resin film is sent to the bottom of the filling device 14, the filling device 14 automatically fills the pocket portions 2 with the flat locks 5.

  On the other hand, the sealing film 4 formed in a belt shape is guided toward the film receiving roll 18 via the tension rolls 16 and 17. A heating roll 19 can be pressed against the film receiving roll 18, and a lattice-like line (not shown) formed in a slightly convex shape is provided on the outer peripheral surface of the heating roll 19. The container film 3 and the sealing film 4 are fed between the rolls 18 and 19. The sealing film 4 is attached to the container film 3 by passing both the films 3 and 4 between the rolls 18 and 19 in a heated and pressed state. Thus, a long PTP film 20 in which the flat lock 5 is filled in each pocket portion 2 is manufactured.

  Now, on the downstream side of the filling device 14 and the upstream side of the film receiving roll 18 and the heating roll 19, a tablet inspection device for inspecting defects of the container film 3 along the transfer path of the container film 3. 21 is disposed. The tablet inspection device 21 performs an inspection mainly intended to detect mixing of tablets (heterogeneous tablets) of different varieties from the flat tablet 5.

  After the inspection, after the sealing film 4 is attached to the container film 3, the PTP film 20 is cut into one PTP sheet by a punching device (not shown). When a defective product is determined by the tablet inspection device 21, the PTP sheet that has been determined to be defective is separately discharged by a defective sheet discharge mechanism (not shown).

  Now, the outline of the PTP packaging machine 7 is as described above. In the following, the tablet inspection apparatus 21 will be described more specifically based on FIGS.

  The tablet inspection device 21 includes an illumination device 22 as illumination means, a camera 23 as imaging means, an image processing device 24, a monitor 25, a keyboard 26, and the like.

  First, the lighting device 22 will be described in detail. The illuminating device 22 in this embodiment is provided in the pocket part 2 side of the container film 3 (refer FIG. 1), and surface emission is possible. As shown in FIG. 3, the illuminating device 22 has a diffusion plate 27 extending in parallel with the container film 3 on the side close to the container film 3 (upper side in the figure), and an LED mounting substrate 28 is provided in the inside thereof. Is provided. A large number of infrared LEDs 28 a as light sources are arranged on the LED mounting substrate 28. The wavelength of infrared light is desirably about 760 nm to 1100 nm, and more preferably 850 nm to 950 nm.

  Further, an angle transmittance control filter 29 as a direct incident light limiting unit is attached to the surface of the diffusion plate 27 on the container film 3 side. As shown in FIG. 4, the angle transmittance control filter 29 is configured to be able to totally reflect light on a straight line L <b> 1 that connects at least the light source (here, the infrared light LED 28 a) and the center of the lens portion of the camera 23. At the same time, the light within the angle of view θ of the lens portion can be totally reflected with respect to the straight line L1. In other words, the angular transmittance control filter 29 is configured to transmit only light larger than the angle of view θ of the lens unit. As a result, direct incidence of infrared light from the light source (infrared light LED 28a) on the camera 23 is restricted.

  Further, the camera 23 constituting the imaging means is provided on the opposite side (upper side in FIG. 1) to the illumination device 22 via the container film 3, and among the light irradiated from the illumination device 22, The light transmitted through the container film 3 and the flat tablet 5 can be imaged. In this embodiment, a CCD camera that is sensitive to at least infrared light is employed as the camera 23.

  Thus, in this embodiment, the infrared light diffused and obliquely irradiated from the illumination device 22 illuminates the container film 3 and the flat lock 5, and the light transmitted therethrough is two-dimensionally imaged by the camera 23. It is comprised so that. The image data captured by the camera 23 is converted into a digital signal inside the camera 23 and then input to the image processing device 24 in the form of a digital signal.

  As shown in FIG. 5, the image processing device 24 includes an image memory 41 corresponding to the camera 23, a masking unit 42, a binarizing unit 43, a determination memory 44, an inspection result and statistical data memory 45, and a camera timing control unit 46. In addition, the image forming apparatus includes a CPU and an input / output interface 47, and can perform image data processing, defect determination (inspection), and the like as described below.

  The two-dimensional image data captured by the camera 23 is converted into a digital signal and then stored in the corresponding image memory 41. Further, at the time of inspection, the image data is subjected to masking processing by the masking means 42 and then stored again in the image memory 41. Similarly, after being binarized by the binarizing means 43, the image data 41 again. Is remembered.

  The CPU and the input / output interface 47 execute various processing programs while using the stored contents of the determination memory 44 and the like, and send control signals to the PTP packaging machine 7 or various signals such as operation signals from the PTP packaging machine 7. Is for sending and receiving. Thereby, for example, the defective sheet discharge mechanism of the PTP packaging machine 7 can be controlled. The CPU and input / output interface 47 also has a function of sending display data to the monitor 25. With this function, binary or grayscale image data, a defect inspection result, and the like can be displayed on the monitor 25. Further, the CPU and input / output interface 47 has a function of inputting data from the keyboard 26.

  The inspection result and statistical data memory 45 stores data such as coordinates relating to image data, inspection result data, statistical data obtained by probabilistically processing the inspection result data, and the like. These inspection result data and statistical data can be appropriately displayed on the monitor 25 based on the control of the CPU and the input / output interface 47. Further, the CPU and the input / output interface 47 can send a control signal to the PTP packaging machine 7 based on these inspection result data and statistical data.

  The camera timing control means 46 controls the timing at which image data captured by the camera 23 is taken into the image memory 41. Such timing is controlled based on a signal from an encoder (not shown) provided in the PTP packaging machine 7, and images (photographs) in sheet units (for example, PTP sheet units to be punched) by the camera 23 every time the container film 3 is fed by a predetermined amount. Is done.

  Next, the procedure of the defect inspection (inspection for mixing different types of tablets) will be described with reference to the flowchart of FIG.

  As shown in the figure, in the “inspection routine”, first, in step S101, a grayscale image to be inspected is acquired.

  In step S102, an inspection target area is set for each pocket portion 2 (flat lock 5). A known method is used to specify the inspection area. For example, there is a method of setting a window according to the position of each pocket portion 2 (flat lock 5) of the grayscale image data acquired in step S101. The window is for demarcating the area in the flat lock 5 and the area of the sheet portion outside the flat lock 5 as the inspection target area. When the window is set for the inspection, Masking is performed on the area outside the inspection target area. The method for specifying the inspection target area is not limited to this, and other methods may be used.

  In step S103, based on the grayscale image data acquired in step S101, the luminance average value k of all pixels in each inspection target area (flat lock 5) for all pocket portions 2 per inspection (per sheet). Is calculated.

  In subsequent step S104, the difference between each luminance average value k calculated in step S103 and the luminance reference value fo set in advance for each pocket portion 2 for each pocket portion 2 is determined in advance for each pocket portion 2. It is determined whether or not the set allowable value α or less. That is, it is determined whether each luminance average value k is within an allowable range. Note that the luminance reference value fo is calculated based on the luminance value of the flat lock 5 obtained for each pocket portion 2 by sampling several non-defective products (PTP sheets that are clearly not defective) prior to the inspection, for example. The

  If it is determined that the average luminance value k of the flat lock 5 is within the permissible range for all pocket portions 2 per inspection, the non-defective product is determined in step S105, and the process is terminated. On the other hand, if a negative determination is made, defective product determination is performed in step S106, and this process is temporarily terminated. These inspection results are output to the monitor 25 and the PTP packaging machine 7 (including the defective sheet discharge mechanism).

  As described above in detail, according to the present embodiment, the infrared LED 28a of the illumination device 22 is irradiated with infrared light to the flat lock 5 and the container film 3 by the camera 23 provided on the opposite side. The transmitted light that passes through the flat lock 5 and the like is imaged. The image processing device 24 detects the mixing of tablets (heterogeneous tablets) of a different type from the flat tablet 5 based on the image data obtained from the image signal.

  The flat tablet 5, which is an uncoated tablet simply formed by pressing and hardening the raw material powder, has different amounts of transmitted light among different varieties due to differences in the size and thickness of the raw material particles and the pressure during tableting. For example, light is easily transmitted when the size of the raw material particles is relatively large, and light is not easily transmitted when the size is small. That is, if the size of the raw material particles is large, the image tends to be bright.

  Using this, in the present embodiment, the average brightness value k of the flat lock 5 is obtained, and it is determined whether or not the difference between the average brightness value k and a preset brightness reference value fo is equal to or less than an allowable value α. Thus, a tablet of a different kind from the flat tablet 5 is discriminated.

  As a result, the appearance such as color, size, shape, etc. can be discriminated even if it is a different kind of uncoated tablet similar to the flat lock 5, and the inspection accuracy related to the heterogeneous tablet mixing inspection is greatly improved. be able to.

  In the present embodiment, since the luminance reference value fo and the like are set for each pocket 2 (flat lock 5) and compared with the average luminance value k, the luminance reference value common to all pockets 2 is used. The inspection accuracy can be further increased compared to the case where the above is set.

  In the embodiment described above, for example, a part of the configuration can be appropriately changed as follows. Of course, other modifications not exemplified below are also possible.

  (A) In the said embodiment, although the flat lock 5 is illustrated as an example of the mode of the uncoated tablet used as a test object, the kind of uncoated tablet is not restricted to this, For example, it is thickness by a center part and a peripheral part. These may be uncoated tablets, so-called lens locks, and the like. However, when inspecting the lens lock, it is necessary to consider that the amount of transmitted light varies depending on the part. Therefore, for example, the inspection area is divided and set at the central portion and the peripheral portion, a predetermined number of pixels are extracted from each area, and a luminance average value is obtained for each area. Then, the luminance average value for each area is compared with the luminance reference value preset for each area. By doing in this way, since it can discriminate | determine for every site | part, even if it is an uncoated tablet from which thickness differs by site | parts and the transmitted light amount differs, the mixing | blending test | inspection of a different type | mold tablet can be performed.

  (B) The flat tablet 5 of the above embodiment is exemplified by a flat surface, but is not limited thereto. For example, the surface may be formed with a dividing line, a marking, or the like on the surface.

  In addition, when the dividing line, an inscription, etc. are formed in the surface of the flat lock 5, these formation parts are thin compared with another general part, and it is easy to permeate | transmit light more. For this reason, the luminance is higher in these formation parts than in other general parts. Therefore, when the luminance average value k of the entire flat lock 5 including this part is calculated, the type cannot be properly grasped, and there is a concern that the inspection accuracy is lowered.

  For example, in FIG. 7, (a) is a plan view schematically showing a flat lock 5 having a dividing line PL at the center and having a "C" -shaped stamp KM, and (b) (A) is the JJ sectional view taken on the line, (c) is a graph which shows the image signal (luminance) curve along the JJ line. As can be seen from this, the flat lock 5 is more likely to transmit light as it is thinner due to the dividing line PL or the like. For this reason, the thinner the portion, the brighter the image.

  Therefore, when the flat lock 5 has the dividing line PL or the like, for example, a mask process is applied to the part where the dividing line PL or the like is formed, and the inspection is performed after removing the influence of the dividing line PL or the like. It is preferable to implement.

  At this time, the position of the dividing line PL or the like can be specified based on, for example, binary image data obtained by binarizing the inspection grayscale image. In the binarization process, as shown in FIG. 7C, first, a binarized image A (see FIG. 8) having a reference threshold value δ0 or more and a first threshold value δ1 or less (within range d1) is acquired. To do. In the image A, the general part of the flat lock 5 excluding the secant line PL and the marking KM is bright. And the position of secant PL etc. is specified based on this.

  (C) In the above embodiment, the average luminance value k of all the pixels in the flat lock 5 (inspection area) is calculated. However, the present invention is not limited to this. For example, from among a plurality of pixels in the flat lock 5 A configuration may be adopted in which a predetermined number of pixels are selected in descending order of luminance, an average luminance value of the predetermined number of pixels is calculated, and it is determined whether or not the average luminance value is within an allowable range. In this way, more appropriate determination can be made, and further improvement in inspection accuracy can be achieved.

  (D) In the above embodiment, the heterogeneous tablet mixing inspection is performed based on the average luminance value k of the flat tablet 5, but the inspection method is not limited to this, and the transmitted light transmitted through the flat tablet 5 is transmitted. Other methods may be used as long as the inspection is performed based on image data obtained by imaging.

  For example, after acquiring the binarized image A as shown in FIG. 8, the area of the general part (the bright part in FIG. 8) of the flat lock 5 excluding the secant line PL and the marking KM is obtained, and the area is within the allowable range. By determining whether or not it is a heterogeneous lock, it may be determined. In this case, a threshold for binarization and an allowable range of area are set for each type of uncoated tablet.

  (E) In the above embodiment, the illumination device 22 is provided on the pocket portion 2 side and the camera 23 is provided on the opposite side, but the arrangement relationship between the two may be reversed. In this case, there are advantages such as being able to realize an inspection that is kind to the eyes of the operator. Of course, it is also possible to perform inspection on both sides by providing a combination of a lighting device and a camera in which the arrangement relationship between them is reversed.

  (F) In the above embodiment, the infrared light LED 28a capable of irradiating infrared light is employed as the light source, but a light source capable of irradiating visible light (for example, red light, blue light, white light, etc.) is employed. It is good as well. However, since infrared light has a higher transmittance of the flat lock 5 or the like than visible light, a more accurate inspection can be performed. In addition, a colored film may be employed as the container film 3, but even in such a case, there is a merit that it is easy to ignore a dimming element due to coloring.

  (G) In the above embodiment, since the luminance reference value fo is set for each pocket portion 2, processing such as shading correction is not particularly performed, but of course, the luminance reference value unified by performing shading correction or the like. May be set.

It is a schematic diagram which shows schematic structure, such as a PTP packaging machine in one Embodiment. (A) is a perspective view which shows a PTP sheet, (b) is a partial expanded sectional view which shows a PTP sheet. It is a fragmentary sectional view which shows an illuminating device typically. It is explanatory drawing which illustrates typically the function of an angle transmittance control filter among illuminating devices. It is a block diagram which shows the electric constitution of a tablet inspection apparatus. It is a flowchart which shows an "inspection routine." (A) is the top view which shows the tablet which has a secant in the center, and was stamped, (b) is the JJ sectional view taken on the line of (a), (c) These are graphs showing image signal (brightness) curves along the line JJ. It is a schematic diagram which shows the image after binarization.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1 ... PTP sheet, 2 ... Pocket part, 3 ... Container film, 4 ... Sealing film, 5 ... Flat lock, 7 ... PTP packaging machine, 21 ... Tablet inspection device, 22 ... Illumination device, 23 ... Camera, 24 ... Image Processing unit, k: luminance average value, fo: luminance reference value, α: allowable value.

Claims (6)

In the manufacturing process of the PTP sheet, after the uncoated tablet is accommodated in the pocket portion formed on the belt-shaped packaging film to be conveyed, before the cover film is attached in a sealed state so as to close the pocket portion A tablet inspection device used in the stage,
Illumination means comprising a light source capable of irradiating predetermined light to the uncoated tablet and the packaging film;
The illumination means is provided on the opposite side through the packaging film, and at least imaging means capable of imaging transmitted light that is irradiated from the light source and passes through the uncoated tablet,
An image processing device for processing an image signal output from the imaging means,
The image processing device is configured to be able to detect mixing of different types of tablets using different transmitted light amounts between different types of uncoated tablets based on image data obtained from the image signal , and
The image processing apparatus obtains an average luminance value of a plurality of pixels in a portion corresponding to the uncoated tablet in the image data, and determines whether the average luminance value is within an allowable range, thereby mixing different types of tablets. The tablet inspection device is configured to be capable of detecting a tablet.   The image processing device extracts a predetermined number of pixels from the plurality of pixels of the image data corresponding to the uncoated tablet in ascending order of luminance, obtains an average luminance value of the predetermined number of pixels, The tablet inspection apparatus according to claim 1, wherein the tablet inspection apparatus is configured to be able to detect mixing of different types of tablets by determining whether or not the average luminance value is within an allowable range. The image processing device sets a portion of the image data corresponding to the uncoated tablet, excluding a portion corresponding to a dividing line or a marking, as an inspection target area for obtaining the luminance average value. The tablet inspection apparatus according to claim 1 or 2 . The tablet according to claim 3 , wherein the image processing device specifies the inspection target area after obtaining binarized image data obtained by binarizing the image data with a predetermined threshold as a reference. Inspection device. The image processing apparatus sets a plurality of inspection target areas for obtaining the luminance average value in a portion corresponding to the uncoated tablet in the image data, obtains the luminance average value for each of the inspection target areas, by determining whether the allowable range luminance average value corresponding to said each inspection target area, that is detectably configuration contamination heterogeneous tablet to any one of claims 1 to 4, characterized in The tablet inspection apparatus described. A PTP packaging machine comprising the tablet inspection device according to any one of claims 1 to 5 .

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