JP5046413B2 - ヒトｆａｄプレセニリン突然変異をもつ標的遺伝子組換え非ヒト哺乳動物および生殖による子孫 - Google Patents

ヒトｆａｄプレセニリン突然変異をもつ標的遺伝子組換え非ヒト哺乳動物および生殖による子孫 Download PDF

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JP5046413B2
JP5046413B2 JP2002513891A JP2002513891A JP5046413B2 JP 5046413 B2 JP5046413 B2 JP 5046413B2 JP 2002513891 A JP2002513891 A JP 2002513891A JP 2002513891 A JP2002513891 A JP 2002513891A JP 5046413 B2 JP5046413 B2 JP 5046413B2
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gene
mutation
mammal
mice
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JP2004533802A (ja
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スコツト，リチヤード・ダブリユー
ローム，アンドリユー・ジー
ドーフマン，カレン
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セフアロン・インコーポレーテツド
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JP2002513891A 2000-07-20 2001-07-19 ヒトｆａｄプレセニリン突然変異をもつ標的遺伝子組換え非ヒト哺乳動物および生殖による子孫 Expired - Fee Related JP5046413B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/621,897 2000-07-20
US09/621,897 US6734336B1 (en) 1997-08-29 2000-07-20 Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring
PCT/US2001/022693 WO2002008407A2 (en) 2000-07-20 2001-07-19 Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring

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JP2004533802A JP2004533802A (ja) 2004-11-11
JP5046413B2 true JP5046413B2 (ja) 2012-10-10

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JP2002513891A Expired - Fee Related JP5046413B2 (ja) 2000-07-20 2001-07-19 ヒトｆａｄプレセニリン突然変異をもつ標的遺伝子組換え非ヒト哺乳動物および生殖による子孫

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EP (1) EP1304922A2 (de)
JP (1) JP5046413B2 (de)
AU (2) AU2001276995C1 (de)
CA (1) CA2416381A1 (de)
WO (1) WO2002008407A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2856409B1 (fr) * 2003-06-20 2007-08-31 Aventis Pharma Sa Methodes de detection de la maladie d'alzheimer
FR2860391B1 (fr) * 2003-10-02 2006-01-27 Aventis Pharma Sa Animaux transgeniques presentant les troubles majeurs lies a la maladie d'alzheimer
US20070266449A1 (en) * 2006-05-12 2007-11-15 Zivin Robert A Generation of animal models

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US589094A (en) * 1897-08-31 Jacob ormerod
US5586226A (en) * 1990-05-16 1996-12-17 Canon Kabushiki Kaisha Control method and device for a unicolor printer
US5898094A (en) * 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
RU2266002C2 (ru) * 1998-01-08 2005-12-20 Дайити Фармасьютикал Ко., Лтд. Способ получения отличного от человека животного с мутированным нокин-геном, способ тестирования вещества на применимость для лечения болезни альцгеймера (варианты), плазмида (варианты), способ получения первичной культуры клеток или субкультивируемой клетки

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AU7699501A (en) 2002-02-05
CA2416381A1 (en) 2002-01-31
JP2004533802A (ja) 2004-11-11
WO2002008407A3 (en) 2003-01-09
AU2001276995C1 (en) 2006-10-26
AU2001276995B2 (en) 2006-02-02
WO2002008407A2 (en) 2002-01-31
EP1304922A2 (de) 2003-05-02
WO2002008407A9 (en) 2003-02-27

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