JP5015704B2 - Formulation package - Google Patents

Description

  The present invention relates to a pharmaceutical package, and more particularly to a pharmaceutical package in which a formulation to be taken orally is packaged.

  As a packaged product packaged with orally ingested preparations, conventionally, packaged medicines that have been separately stored in glassine paper or aluminum sheets for each amount of preparations such as powders and tablets, etc., have been implemented . In addition, it has also been traditionally taken after wrapping the preparation in a thin sheet of wafer.

  However, in the case of a packaged medicine, when the package is opened and the preparation is put into the mouth, the preparation is easily spilled or scattered, and the whole amount may not be taken. In addition, when the preparation is a powder or fine granule, it may cause coughing or coughing when taken. In addition, in the case of drugs with a strong bitterness, there is a problem that it is difficult to swallow as it is.

  On the other hand, when taking a preparation wrapped in a sheet-shaped wafer, there is an advantage that it is difficult to get a bitter taste even with powders etc., but the whole structure wrapped with the wafer is folded and bulky. There was a problem that the sense of discomfort was large and it was difficult to swallow. In addition, there is also a problem that the work of wrapping the preparation with a sheet-like wafer every time it is taken is complicated. In addition, during the operation of wrapping the preparation in a sheet-like wafer, the preparation may be spilled or scattered, making it difficult to know whether the required amount has been taken.

  Therefore, the present inventors seal the edible film superimposed to form a bag-shaped container, and store various dosage forms in this bag-shaped container, and prepare the preparation together with the bag-shaped container. We have proposed a drug product package that can be taken. According to the present invention, it is possible to reduce the risk of peeling and to feel a bitter taste, and to take the preparation with reduced discomfort in the oral cavity. It becomes easy to manage whether or not the medicine has been taken.

  Since the invention concerning the pharmaceutical package using the bag-shaped container made of the edible film is not published, the invention does not fall under the literature known invention.

  However, although edible films have high gas barrier properties with respect to oxygen gas, many other gases and water vapor have low barrier properties, and there are formulations that are contained in a bag-like container by permeation of gas or water vapor. There is a risk of deterioration and deterioration. Moreover, when a formulation contains a volatile component, there exists a possibility that the component may permeate | transmit an edible film and may volatilize outside the bag-shaped container. Furthermore, when the edible film which comprises a bag-shaped container is water-soluble, there exists a possibility that it may absorb moisture by the water | moisture content in an external environment, a shape may change, and films may adhere. Therefore, the above-described invention requires further contrivance in terms of storage stability.

  In addition, in order to take the preparation together with the bag-shaped container, it is necessary to prevent contamination of the bag-shaped container due to adhesion of dust and microorganisms in the environment. Here, in order to improve the preservability of the preparation package and prevent the bag-like container from being contaminated, it can be assumed that the preparation package is further packaged. Therefore, it is required that this advantage is not lost by further packaging.

  Accordingly, in view of the above circumstances, the present invention is a preparation package in which the preparation is stored in a bag-shaped container formed of an edible film, which has improved storage stability and prevents contamination due to adhesion of dust and the like. In addition, an object of the present invention is to provide a preparation package that is easy to take.

  In order to solve the above-mentioned problems, the preparation package according to the present invention includes a “bag-shaped container having a circumferential seal portion formed by sealing an edible edible film, and a drug for ingestion” A pharmaceutical package comprising a formulation containing a component and contained in the bag-shaped container, the separation line provided in the bag-shaped container so as to surround the inner periphery of the seal portion from the outside, and the bag And a pair of gas barrier coating films adhered to the bag-shaped container outside the separation line.

  The “edible film” can be formed using an edible film forming agent. Examples of the edible film forming agent include chitin, chitosan, casein, sodium caseinate, gelatin, collagen, soy protein, egg white. , Starch, pectin, arabinoxylan, soybean polysaccharide, sodium alginate, carrageenan, agar, glucomannan, galactomannan, xanthan gum, pullulan, zein, shellac and other natural polymers, dextrin, etherified starch, esterified starch, hypromellose (HPMC) ; Former Japanese Pharmacopoeia “Hydroxypropylmethylcellulose”), hydroxypropylcellulose (HPC), water-soluble hydroxyethylcellulose (HEC), methylcellulose (MC), carboxymethylcellulose (CMC) Semi-synthetic polymers such as polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP), polyethylene glycol polyvinyl alcohol copolymer, sodium polyacrylate, polyacrylamide (PAA), polyethylene oxide (PEO), polyethylene glycol (PEG), etc. These synthetic polymers can be used. Further, a plurality of types of film forming agents can be appropriately blended and used.

  The “edible film” can be formed by containing other components in addition to the edible film forming agent. For example, as a plasticizer, triethyl citrate, glycerin, sorbitol, triacetin, propylene glycol, polyoxyethylene (105) polyoxypropylene (5) glycol, polysorbate, macrogol, glyceryl monostearate, mannitol, etc. Thus, the flexibility of the edible film can be increased and the occurrence of cracks and tears can be prevented. In addition, flavors such as sucralose, aspartame, stevia, xylitol, and licorice and flavors such as spearmint flavor, lemon flavor, and menthol can be added to season and smell the bag-like container, and the taste of the stored product And can mask odors. Furthermore, an edible film can be formed by containing an emulsifier, a colorant and the like.

  The “sealing” can be performed by thermocompression bonding by external heating or thermocompression bonding by internal heating using radio waves or ultrasonic waves. Alternatively, it can be performed by pressure bonding without heating, such as pressure bonding using gelatinized high-viscosity starch or the like, or applying water or the like to the peripheral portion of the edible film and partially melting and pressure bonding. . In addition, emboss press-bonding can also be performed by sealing using a concave type and a convex type. Further, the “circumferential shape” of the seal portion may be a circumferential shape having a certain width or a circumferential shape having a small width and close to a line.

  Examples of the “superposition” of the edible film include an aspect in which two edible films are overlapped and an aspect in which one edible film is folded and overlapped. The shape of the bag-like container is not particularly limited, and may be a polygonal shape such as a quadrilateral, a triangle, a pentagon, or a hexagon, a circle, an ellipse, or the like in plan view.

  The dosage form of the “formulation” is not particularly limited, and powders (powder), granules, pills, tablets, liquids, pastes and the like can be used. Moreover, the below-mentioned film-form preparation and its grinding agent can also be used. Furthermore, the “drug component” contained in the preparation is not particularly limited as long as it is for oral consumption, and can be a herbal medicine or a herbal medicine component combined with a herbal medicine in addition to a so-called western medicine component. In the present invention, the “formulation” is not limited to a pharmaceutical product. Among foods intended to supplement nutrients that tend to be deficient, such as vitamins and minerals, It is used with the intention of including no dietary supplements.

  In addition, when storing a liquid agent as a formulation, an edible film may be formed using a film forming agent that is insoluble in the liquid agent, or a layer insoluble in the liquid agent may be coated on the inside of the edible film. desirable. For example, when the liquid agent is water-based, an edible film that is hardly soluble in water by making the water-soluble polymer into a crosslinked structure can be used. Alternatively, a hydrophobic material may be coated on the inside of the water-soluble edible film. As the hydrophobic material, natural resins such as shellac, beeswax, sugar cane wax, carnauba wax, and rosin can be used.

  Examples of the “separation line” include a relatively long cut line having a portion left uncut and a perforated cut line. In addition, as a form in which the separation line is provided “so as to surround the inner periphery of the seal portion from the outside”, when the separation line is provided in the region of the seal portion having a certain width, the seal portion is placed on the inner side and sealed. A case where a cut-off line is provided in a region that is not present can be exemplified. Note that the separation line can be provided regardless of the shape of the inner periphery of the seal portion.For example, when the seal portion is formed in a circumferential shape or a square circumferential shape, the separation line is a circle so as to surround it. It can be provided in a shape, semicircular shape, elliptical shape, or square shape. Further, in these shapes, a separation line can be provided so that the outer periphery has a corrugated shape or a jagged tooth shape.

  As the “gas barrier coating film”, a well-known packaging film having gas barrier properties can be used. For example, an aluminum foil, a film in which a thin film of metal or inorganic oxide is formed by vapor deposition or sputtering, A film coated with a material having a high gas barrier property such as polyvinylidene chloride can be used.

  “Gas barrier properties” are generally often evaluated with carbon dioxide, nitrogen, and oxygen, and the Japanese Industrial Standard distinguishes between gas permeability (JIS K7126) and water vapor permeability (JIS K7107) for water vapor transmission. However, the term “gas barrier property” is used in this specification and claims, including the barrier property against water vapor.

  “Adhesion” between the coated film and the bag-shaped container (edible film constituting the bag-shaped container) is formed by forming an edible film with a thermoplastic film forming agent such as pullulan, hypromellose, polyvinyl alcohol, etc. Can be performed by thermocompression bonding. Alternatively, these thermoplastic film forming agents, or proteins such as soybean protein and egg white can be applied as adhesives to at least one of a coated film and an edible film, followed by thermocompression bonding.

  With the above configuration, according to the present invention, since the bag-shaped container in which the preparation is stored is covered with the coating film from the front and back surfaces, contamination due to adhesion of dust or microorganisms to the bag-shaped container is prevented. Is done. In addition, since the coated film has gas barrier properties, it is possible to suppress deterioration and deterioration of the preparation due to gas permeation and loss of volatile components in the preparation to the outside, and moisture absorption of the edible film constituting the bag-shaped container. Is suppressed.

  And in a bag-shaped container, a formulation can be accommodated in a hollow space formed by an unsealed portion surrounded by a circumferential seal portion, and a separation line is provided so as to surround the inner periphery of the seal portion from the outside. By this, the part inside the separation line can be separated from other parts including the preparation and taken. At this time, the coated film is adhered to the bag-like container outside the separation line, and the coated film is not adhered to the part to be separated and taken (hereinafter referred to as “oral administration part” for convenience). It is easy to remove the coating film covering the administration part, and only the oral administration part can be taken easily. In consideration of ease of taking, it is desirable to provide a separation line so that the length of the longest part of the oral administration portion is 10 mm to 20 mm.

  The preparation package according to the present invention is “at least one of the pair of covering films is constituted by a first covering film and a second covering film, and the first covering film is bonded to the bag-shaped container. And an opening that exposes at least a portion of the bag-like container inside the separation line, the second covering film covers the opening, and at least along the periphery of the opening The first covering film is releasably adhered ”.

  The covering film constituted by the first covering film and the second covering film may be either one or both of the pair of covering films. The first coated film and the second coated film may be the same type of film or different types of films.

  The “opening portion” may be at least a portion inside the severing line of the bag-shaped container, that is, any part that exposes the oral administration part in the opening, and includes a part slightly outside the severing line in the bag-shaped container. It may be exposed in the opening. Moreover, although an opening part is provided corresponding to the position (position where a separation line is provided) of an oral administration part, the shape of an opening part can be set irrespective of the shape of an oral administration part. For example, regardless of whether the oral administration portion is circular or square, the opening can be provided in various shapes such as a circle, an ellipse, and a rectangle so as to expose the opening.

  As long as the second covering film is adhered to the first covering film "at least along the periphery of the opening", the second covering film may be adhered to the first covering film only at the periphery of the opening. It may be adhered to the entire surface of one covering film. The “adhesion” between the first coating film and the second coating film can be performed by laminating an adhesive layer (sealant) such as polyethylene or polypropylene and thermocompression bonding. The “peeling” of “peelable adhesion” may be any of cohesive peeling, delamination, and interface peeling.

  With the above configuration, according to the present invention, the bag-shaped container formed of the edible film is covered with the first coating film except for the portion exposed from the opening, and the portion exposed from the opening is Since the second coating film is coated with the second coating film, and the second coating film is bonded to the first coating film at least along the periphery of the opening, the front and back surfaces of the bag-shaped container are entirely covered with the coating film. It will be covered with. This prevents contamination of the oral administration part due to adhesion of dust, microorganisms and the like, and suppresses moisture absorption of the edible film and alteration / deterioration of the preparation due to gas permeation.

  In addition, since the first coating film is provided with an opening, and the oral administration part is located in the opening, the oral administration part is removed by removing the second coating film covering the opening. Easily exposed to the external environment. At this time, the adhesion of the second coated film to the first coated film is peelable, and since the second coated film is not adhered to the oral administration part, the second coated film is easily removed from the opening. be able to. Thereby, the oral administration part exposed to the opening can be separated and can be taken easily and quickly.

  The preparation package according to the present invention can be "the first covering film is an aluminum foil and the second covering film is a transparent or translucent film".

  As a “transparent or translucent” gas barrier coating film, a thin film made of silicon oxide, aluminum oxide, titanium oxide or the like is formed on a transparent or translucent plastic film such as polyethylene terephthalate by vacuum deposition or plasma deposition. A film can be used.

  With the above configuration, the first covering film that is directly bonded to the bag-shaped container is made of an aluminum foil that is extremely excellent in gas barrier properties and light-shielding properties. Is expensive. Moreover, since the 2nd coating film which coat | covers an opening part is transparent or translucent, the part in which the formulation is accommodated can be visually recognized. Accordingly, the consumer can use the product with a sense of security, and even when there are a plurality of similar-form preparation packages, the contents can be easily identified, and misuse of the preparation can be prevented.

  The preparation package according to the present invention can be "the second covering film is adhered to the first covering film leaving a region to be a picking tongue piece at an end".

  With the above configuration, according to the present invention, the end of the second coating film is provided with a portion that is not bonded to the first coating film, and this can be used as a tongue piece for picking. And it is easy to perform the operation of turning up the second coated film by pinching the tab for picking with a fingertip, and the second coated film can be easily peeled off.

  In addition, since the second coating film is bonded to the first coating film at a portion other than the end portion that becomes the tab for picking, the second coating film is peeled off compared to a case where the area of the portion not bonded is large. The possibility that the second coating film may be inadvertently peeled off when not necessary can be reduced.

  In addition, the 2nd coating film of the part used as the tongue piece for pinching can make it easier to pinch with a finger tip by making it protrude outside from the edge part of a 1st coating film. In this case, the shape of the protruding portion can be various shapes such as a triangular shape and a semicircular arc shape.

  The preparation package according to the present invention is as follows: “A plurality of the bag-shaped containers are continuously provided in at least one direction, and the second coating film is provided at a position substantially corresponding to a boundary between the adjacent bag-shaped containers. It has a ruptured portion.

  “Continuous arrangement” of a plurality of bag-shaped containers is provided in two or more rows even if they are arranged in one row as long as they are arranged in at least one direction. It may be.

  Examples of the “breaking portion” include a perforated cutting line, a relatively long cutting line having an uncut portion, a uniaxially stretched film formed with an open end such as a V notch, and a cut tape. .

  According to the present invention, according to the present invention, since a plurality of continuous forms form one unit of the pharmaceutical package, handling in the distribution process and storage / carrying by the consumer are convenient. Furthermore, at the time of use, the 2nd coating film can be peeled for every bag-shaped container by breaking the fracture | rupture part formed in the 2nd coating film. Thereby, the second covering film can be peeled one by one without affecting the adjacent bag-shaped containers.

  The preparation package according to the present invention is described as follows: “The broken portion is constituted by a discontinuous cutting line, and extends from one side of the second coating film toward the other side, and the end is the first side. It can be “inside the side of the two-coated film”.

  Among the broken portions exemplified above, perforated cutting lines and cutting lines having uncut portions correspond to “discontinuous cutting lines”.

  With the above configuration, according to the present invention, since the end of the discontinuous cutting line that is a rupture portion does not reach the side of the second coating film, when peeling off the second coating film, the portion ahead of the end is It remains attached to the product packaging without being separated. Thereby, it is possible to prevent the second coating film from being separated one by one and becoming garbage every time the oral administration part is separated and taken one by one.

  As described above, as an effect of the present invention, it is a preparation package in which a preparation is stored in a bag-shaped container formed of an edible film, and the storage stability is improved and contamination due to adhesion of dust and the like is prevented. In addition, it is possible to provide a preparation package that is easy to take.

  Hereinafter, the pharmaceutical package which is the best embodiment of the present invention will be described with reference to FIGS. Here, FIG. 1 is (a) perspective view and (b) exploded perspective view of the preparation package of the present embodiment, FIG. 2 is an end view taken along line XX in FIG. 1 (a), and FIG. FIG. 4 is a plan view for explaining a region to be sealed, FIG. 4 is a perspective view showing a drug product packaging body according to another embodiment, and FIG. 5 is an exploded perspective view showing a drug product packaging body according to still another embodiment. 6 is a perspective view of the preparation package of FIG. 5, and FIG. 7 is an explanatory view for explaining a method of using the preparation package. 1, 2, and 4 to 7, the dimensions in the thickness direction of the film are exaggerated in order to clearly show the configuration. In FIG. 3, the sealed area or the bonded area is shaded. Furthermore, the formulation accommodated in the bag-like container is omitted in any drawing.

  As shown in FIGS. 1 and 2, the pharmaceutical package 11 of the present embodiment has a circumferential seal portion 2 formed by sealing the edible film 1 superimposed thereon (FIGS. 3A and 3B). A packaging container 11 comprising a bag-shaped container 3 having a reference) and a formulation containing a drug component for ingestion and housed in the bag-shaped container 3, the outer periphery 2 c of the seal portion 2 being outside A separation line 30 provided on the bag-like container 3 so as to surround the cover, and the bag-like container 3 are respectively covered from the front and back surfaces, and the gas barrier property bonded to the bag-like container 3 outside the separation line 30 A pair of covering films 20a and 20b is provided.

  Here, the edible film 1 is cast, for example, a step of dissolving an edible film forming agent in a liquid medium to prepare a high viscosity solution, a step of casting the high viscosity solution on a base surface, and the step of casting. It can be manufactured through a step of drying the prepared solution to form a film and a step of peeling the formed film from the base surface.

  In this embodiment, the superimposed edible film 1 is heat-pressed (heat sealed) so that the inner periphery 2c of the seal portion 2 is circular. This seal is not sealed as shown in FIG. 3 (b) even if the seal portion 2 is formed in a wide circumferential shape (doughnut shape) as shown in FIG. 3 (a). The sealing portion 2 may be formed by leaving the portion to be a part in a circular shape and sealing the other part entirely.

  The preparation is accommodated in the hollow space 4 formed by the unsealed portion inside the seal portion 2. Such a preparation can be sealed as follows, for example. First, when the edible film 1 is placed on the base surface on which a circular recess corresponding to the unsealed portion is formed, and air is sucked from the back surface of the base surface through a minute through hole formed in the base surface, The edible film 1 is deformed along the concave portion of the base surface. The weighed preparation is put there, and another edible film 1 is placed thereon and heat sealed. Thereby, formation of the bag-shaped container 3 by the edible film 1 and encapsulation of the preparation in the bag-shaped container 3 are simultaneously performed. In addition, the heat sealing of the edible film 1 can also be performed simultaneously with the heat sealing of the coating films 20b, 21, and 22 described later.

  In order to perform heat sealing satisfactorily, gelatin, casein sodium, zein, polyvinyl alcohol, polyvinyl pyrrolidone, starch, modified starch, pullulan, arabinoxylan, soy protein, etc. are provided on at least the portion of the edible film 1 that becomes the seal portion 2. An edible film forming agent having excellent heat sealability may be laminated.

  As described above, by storing the preparation in the bag-shaped container 3 composed of the edible film 1, and taking the preparation together with the bag-shaped container 3, the solubility of the edible film 1 is adjusted and the drug component is adjusted. It is possible to adjust where it is absorbed mainly in the body not by the preparation but by the bag-shaped container. For example, in the case of a preparation requiring immediate action, the bag-shaped container is dissolved or dissolved by moisture in the oral cavity by forming the bag-shaped container with a water-soluble edible film such as gelatin, pullulan, sodium alginate, etc. The drug component can be rapidly absorbed from the mucous membrane in the oral cavity. When the film-forming agent is highly water-soluble, the bag-like container is easily dissolved or disintegrated naturally by moisture in the oral cavity, and can be taken without water, even for people with low swallowing function. In addition to being easy to take the formulation, the formulation is excellent in portability and can be taken regardless of location. Conversely, the water solubility of the edible film can be reduced to make it difficult to dissolve in the oral cavity, and the drug component can be allowed to act gently. Also, gastric soluble edible film forming agents such as polyvinyl acetal diethylaminoacetate and aminoalkyl methacrylate copolymer E, methacrylic acid copolymer L, methacrylic acid copolymer LD, hydroxypropylmethylcellulose phthalate, hydroxypropylmethylcellulose acetate succinate, etc. By forming an edible film using an enteric edible film forming agent, the preparation can be made gastric or enteric regardless of the solubility of the preparation.

  In the bag-like container 3, the separation line 30 that allows the oral administration part 8 to be separated is formed by the connection part 35 left uncut and the relatively long cuts 31 and 32 (see FIG. 3D) of the seal part 2. It is formed in a substantially circular shape that is substantially concentric with the inner circumference 2c. The portion inside the separation line 30 corresponds to the oral administration unit 8 that is separated from the bag-shaped container 3 and is taken.

  Of the pair of covering films 20a and 20b, the covering film 20b covering the back surface of the bag-shaped container 3 is made of an aluminum foil. On the other hand, the covering film 20 a that covers the front (front) surface of the bag-shaped container 3 is constituted by the first covering film 21 and the second covering film 22. Here, the 1st coating film 21 of this embodiment is aluminum foil, and has comprised the opening part 25. FIG. The opening 25 is circular, and its diameter is set to be slightly larger than the outer diameter of the oral administration unit 8 (about 1 to 5 mm in diameter). And as shown in FIG.3 (c), the 1st coating film 21 except the opening part 25 is edible on the surface of the bag-shaped container 3 in the position where the opening part 25 becomes concentric with the oral administration part 8. As shown in FIG. The oral administration part 8 and the edible film 1 on the periphery thereof are exposed from the opening 25 by being adhered to the film 1.

  The second covering film 22 is composed of a film obtained by depositing an inorganic oxide on transparent polyethylene terephthalate. Here, the shape of the second covering film 22 is a substantially pentagon in which a substantially triangular shape having one side as a base extends from one side of a substantially square portion. As shown in FIG. This part is attached to the first covering film 21 so as to be peelable except for the part covering the opening 25, so that the non-adhered substantially triangular part serves as a picking tongue piece 27. Furthermore, in the present embodiment, a substantially arc-shaped cutout 29 is provided at a position corresponding to the apex of the picking tongue piece 27 in the first covering film 21 and the covering film 20a.

  Here, the adhesion between the edible film 1 and the first coating film 21 (aluminum foil) constituting the bag-shaped container 3 and the adhesion between the edible film 1 and the coating film 20b (aluminum foil) are proteins or It can be performed by heat-sealing a thermoplastic resin such as pullulan, HPMC, PVA or the like as an adhesive layer. The first coating film 21 (aluminum foil) and the second coating film 22 (transparent gas barrier film) are bonded by laminating an adhesive layer on at least one of the first coating film 21 and the second coating film 22. However, it can be performed by heat sealing. For example, an adhesive layer in which different types of thermoplastic resins such as a linear short-chain branched polyethylene (LLDPE) and a polypropylene resin are mixed is laminated on both the first coating film 21 and the second coating film 22. Then, by heat-sealing, it is possible to bond both together so as to be capable of cohesive peeling.

  In addition, the heat seal which adheres the edible film 1 and the 1st coating film 21, the heat seal which adheres the edible film 1 and the coating film 20b, and adhere | attaches the 1st coating film 21 and the 2nd coating film 22 The heat sealing to be performed can be performed simultaneously or separately. In addition, as described above, these heat seals can be performed simultaneously with or separately from the heat seal that seals the edible films 1 superimposed on each other.

  In addition to the above-described form in which one preparation package 11 includes one bag-like container 3, as shown in FIG. 4, a plurality of bag-like containers 3 are provided as a preparation package 12 arranged in a row. You can also. A perforated cutting line 40 is formed in the second covering film 22 of the preparation package 12 at a position corresponding to the boundary between the adjacent bag-like containers 3. The cutting line 40 extends from one side of the second covering film 22 to the other side with the starting end 41, and the end 42 does not reach the side of the second covering film 22, It is located more inside. The cutting line 40 corresponds to the “breaking part” and the “discontinuous cutting line” of the present invention.

  In addition, a plurality of bag-like containers 3 can be arranged in a plurality of rows. For example, as shown in FIGS. 5 and 6, a formulation packaging body 13 in which the bag-like containers 3 are arranged in two rows, and You can also Also in this preparation package 13, as in the case of the preparation package 12, the cutting line 40 has the side edge of the second coating film 22 as the start edge 41 and the end edge 42 is located inside the side edge. The cutting line 40 belonging to the first column and the cutting line 40 belonging to the second column are separated without being continuous.

  In any of the pharmaceutical packaging bodies 11, 12, and 13, the separation line 30 is provided so that three arc-shaped cuts form a substantially circular shape through three connecting portions 35, as shown in FIG. As shown in d), one of the three cuts 31 has a semicircular arc shape, and the two cuts 32 are formed in a quarter circular arc shape. And in the substantially circular cut-off line 30, the cut 31 is arrange | positioned in the semicircle part by the side of the side by which the tab piece 27 for picking is provided in the 2nd coating film 22. As shown in FIG. In other words, the substantially circular cut-off line 30 is set such that the connecting portion 35 does not exist in the semicircular portion on the side.

  Next, a method of using the preparation package 11, 12, 13 of the above embodiment will be described using the preparation package 13 as an example with reference to FIG. In addition, the part which attached | subjected the oblique line in FIG. 7 is a transparent 2nd coating film.

  In use, first the picking tongue 27 is picked with a fingertip and lifted. At this time, the first covering film 21 and the covering film 20b have a notch 29 formed at a position corresponding to the apex of the picking tongue piece 27, so that the picking tongue piece 27 is easier to pick. ing.

  In the case of the preparation package 11, the oral administration portion 8 is exposed in the opening 25 by further turning up the tongue piece 27 for picking and peeling off the second coating film 22. In the case of the pharmaceutical packaging bodies 12 and 13, by turning up the second coating film 22 while cutting along the cutting line 40 provided at a position corresponding to the boundary with the adjacent bag-shaped container 3, One oral administration part 8 is exposed in the opening 25. At this time, since the end 42 of the cutting line 40 does not reach the side of the second coating film 22, the second coating film 22 remains attached to the preparation package 13 without being completely peeled off.

  And only the oral administration part 8 can be isolate | separated from the formulation packaging body 13, and it can take by separating the oral administration part 8 exposed to the opening part 25 with the separation line 30. FIG. When the oral administration part 8 is cut off, the connecting part 35 does not exist in the semicircular part on the side of the substantially circular cut-off line 30 on the side where the picking tongue piece 27 is provided. The oral administration portion 8 is lifted along the semicircular cut 31 by bending the portion of the portion downward. Thereby, operation which cuts off an oral administration part can be performed very easily. Moreover, since the diameter of the opening 25 is set to be slightly larger than the diameter of the oral administration part 8, and the separation line 30 does not overlap with the inner periphery of the opening 25, the operation for separating the oral administration part 8 also by this It is easy to do.

  As described above, according to the drug product packaging bodies 11, 12, and 13 of the present embodiment, the bag-shaped container 3 made of the edible film 1 is covered with the first coating except for the portion exposed from the opening 25. While the film 21 is adhered, the portion exposed from the opening 25 is covered with the second covering film 22, and in addition, the second covering film 22 covers the opening 25 and the tab tongue 27. Since it is adhere | attached on the 1st coating film 21 except for, the front and back of the bag-shaped container 3 are entirely coat | covered with the coating films 21, 22, and 20b. Thereby, contamination of the oral administration part 8 due to adhesion of dust or microorganisms is prevented, and moisture absorption of the edible film 1 and alteration / deterioration of the preparation due to gas permeation are suppressed.

  Moreover, if the 2nd coating film 22 is peeled, since the oral administration part 8 will be easily exposed to the opening part 25 of the 1st coating film 21, the oral administration part 8 will be cut off by the detachment line 30, and it will be taken simply and quickly. be able to. In addition, a pinching tongue piece 27 that is not bonded to the first covering film 21 is provided at the end of the second covering film 22, and the first covering film 21 and the covering film 20 b have a picking tongue piece 27. Since the notch 29 is formed at the corresponding position, the operation of peeling the second covering film 22 by picking the picking tongue piece 27 with the fingertip is easy.

  Furthermore, since the covering film 20b and the first covering film 21 that are directly bonded to the bag-shaped container 3 are made of an aluminum foil that is extremely excellent in gas barrier properties and light shielding properties, the bag-shaped container 3 can be formed. The storability of the food film 1 is high. Moreover, since the 2nd coating film 22 which coat | covers the opening part 25 is transparent, and the oral administration part 8 can be visually recognized through the 2nd coating film 22, a consumer confirms a mode that the formulation was accommodated. Therefore, the preparation package 11, 12, 13 can be used with a sense of security. Moreover, misuse of a formulation can also be prevented.

  In addition, since the form in which the plurality of bag-like containers 3 are continuously provided is one unit in the preparation packaging bodies 12 and 13, handling in the distribution process and storage / carrying by the consumer are convenient. Furthermore, since the cutting line 40 is provided in the 2nd coating film 22 of the formulation packaging bodies 12 and 13, one piece without affecting the 2nd coating film 22 of the part which coat | covers the adjacent oral administration part 8. FIG. Only the second coating film 22 that covers the oral administration part 8 can be peeled off. In addition, since the second coating film 22 is not completely peeled and remains attached to the preparation package, the peeled second coating film 22 is removed each time the oral administration part 8 is separated and taken one by one. It is prevented that each piece is separated into garbage.

  The present invention has been described with reference to the preferred embodiments. However, the present invention is not limited to the above-described embodiments, and various improvements can be made without departing from the scope of the present invention as described below. And design changes are possible.

  For example, in the above embodiment, the case where the first coating film is made of aluminum foil and the second coating film is made of a transparent film is exemplified. When it is not necessary to visually check, both the first covering film and the second covering film can be made of aluminum foil. Thereby, it becomes a coating film excellent in gas barrier property and light-shielding property.

  Moreover, although the case where the tongue piece for picking was formed in the substantially triangular shape was illustrated, it is not limited to this, It can also form in the circular arc shape and square shape which bulge outside. Furthermore, although the case where the opening is circular is illustrated, it is not limited to this, and various shapes such as an ellipse and a polygon can be used.

  In addition, although the case where the separation line is formed by the connecting portion and the cut is illustrated, the present invention is not limited to this, and for example, the separation line can be formed in a perforated shape. Further, the shape of the separation line is not limited to a substantially circular shape. For example, if an oval shape or a quadrangular shape with a corner portion being substantially arc-shaped, the outer shape of the oral administration portion is rounded, and there is less discomfort in the oral cavity as in the case of a circular shape.

  Moreover, although the case where one side of a pair of coating film was comprised with the 1st coating film and the 2nd coating film was illustrated, it is not limited to this, Both coating films are both the 1st coating film and the 2nd coating film It may be configured. Thereby, the 2nd coating film can be peeled and the oral administration part can be cut off from either the front or back side of the preparation package.

  Or as shown in FIG. 8, it can be set as the formulation packaging body 14 by which a pair of coating film is each comprised with the single coating films 20a and 20b. In this case, in at least one of the covering films, a peeling means 49 that can peel the covering film is provided in a portion that covers the edible film 1 inside the separation line 30 without being adhered to the edible film 1. And good. FIG. 8 illustrates a case where the peeling means 49 is configured by a perforated cut line formed in a circular shape having a slightly smaller diameter than the circular separation line 30. Even in such a configuration, although the degree is lower than that of the pharmaceutical packaging bodies 11, 12, and 13 of the above-described embodiment, contamination of the oral administration part due to adhesion of dust and the like is suppressed, and moisture absorption of the edible film 1 and In addition, it is possible to suppress deterioration and deterioration of the preparation due to gas permeation.

  Furthermore, character information, symbols, etc. regarding the preparation to be packaged can be added by printing or foil pressing such as gold or silver on the coated film. Moreover, distinguishability can be imparted to the preparation package by coloring the coating film.

  In addition, although the case where the formulation packaging bodies 12 and 13 comprise five oral administration parts and comprise one row was illustrated, the number of arranged continuously is not limited to this. For example, if one oral administration part is provided and one row is formed, it will be suitable for taking the preparation in units of one week.

It is the (a) perspective view and (b) exploded perspective view of the formulation package of this embodiment. FIG. 2 is an end view taken along line XX in FIG. It is a top view explaining the area | region to seal. It is a perspective view which shows the formulation package of other embodiment. It is a disassembled perspective view which shows the formulation package of other embodiment. It is a perspective view of the formulation packaging body of FIG. It is explanatory drawing explaining the usage method of a formulation package. It is (a) perspective view and (b) exploded perspective view which show the other example of application of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Edible film 2 Seal part 2c Inner circumference 3 of a seal part Bag-shaped container 8 Oral administration part 11, 12, 13, 14 Formulation packaging body 20a, 20b Cover film 21 1st cover film (cover film 20a)
22 Second coating film (coating film 20a)
25 Opening 27 Picking tongue 30 Separation line 40 Cutting line (breaking part, discontinuous cutting line)

Claims (6)

A bag-like container having a circumferential seal portion formed by sealing an overlapped edible film, and a pharmaceutical package comprising a drug ingredient containing a drug component for oral consumption and contained in the bag-like container Body,
A separation line provided in the bag-like container so as to surround the inner periphery of the seal portion from the outside,
A pharmaceutical packaging body comprising a pair of gas barrier coating films that cover the bag-shaped container from the front and back surfaces and are bonded to the bag-shaped container on the outer side of the separation line. At least one of the pair of covering films is constituted by a first covering film and a second covering film,
The first covering film includes an opening that is adhered to the bag-shaped container and exposes at least a part of the bag-shaped container from the separation line;
2. The preparation package according to claim 1, wherein the second covering film covers the opening and is detachably bonded to the first covering film along at least the periphery of the opening. .   The said 1st coating film is aluminum foil, The said 2nd coating film is a transparent or translucent film, The formulation package body of Claim 2 characterized by the above-mentioned. The said 2nd coating film is adhere | attached on said 1st coating film, leaving the area | region used as the tongue piece for a pick in an edge part, The pharmaceutical package body of Claim 2 or Claim 3 characterized by the above-mentioned. A plurality of the bag-like containers are arranged in at least one direction,
The said 2nd coating film comprises the fracture | rupture part provided in the position substantially corresponding to the boundary of the said adjacent bag-shaped container, The Claim 2 thru | or 4 characterized by the above-mentioned. Formulation package.   The rupture portion is constituted by a discontinuous cutting line, extends from one side of the second coating film to the other side, and ends at the inner side of the side of the second coating film. The preparation package according to claim 5, wherein

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