JP3241013U - Package for filling composite water-soluble gel containing active ingredients - Google Patents

Abstract

Kind Code: A1 The present invention provides a package for filling a composite water-soluble gel containing an active ingredient, which is applicable to the development of medicines and health foods that can be rapidly absorbed and acted upon.
A package (100) for filling a composite water-soluble gel (110) containing an active ingredient comprises a composite water-soluble gel used for absorption in the sublingual mucosa and in which a natural extract is dissolved, and a composite water-soluble gel in the central portion. A seal side 122 formed by sealingly joining the edge portions of two overlapping packaging sheets 121 so as to form an airtight container chamber A for accommodating a user to tear the packaging sheet. and a wrapping material 120 provided with a cutout of the . A composite water-soluble gel containing an active ingredient can be ingested through the gastrointestinal tract by tearing the packaging material and putting the active ingredient contained in the composite water-soluble gel into the oral cavity and being ingested transmucosally.
[Selection drawing] Fig. 1

Description

FIELD OF THE INVENTION The present invention relates to a package, and more particularly to a package for filling a complex water-soluble gel containing an active ingredient that is compatible with storage and portability.

Commercial dietary supplements, whether in the form of drinks, powders, capsules or lozenges, are usually ingested through the intestine. The active ingredients contained in such intestinal products are inactivated by the action of various enzymes in the intestine and by the action of acids and alkalis, and the absorption from the intestine takes time. . Related studies are progressing, and the oral mucosal absorption system is becoming an effective means of nutrient intake. The oral mucosal absorption system reduces the destructive action of enzymes, acids and alkalis on the active substances and reduces the time to take action, so that these nutrients are not swallowed and can achieve their desired effects.

The oral/sublingual mucosa absorption system has been confirmed for a long time, but it is used only in the pharmaceutical industry, and its application to the sublingual mucosa absorption of health foods is still small.

Based on the above, the problem to be solved by the present invention is to provide a package for filling a composite water-soluble gel containing an active ingredient of an oral/sublingual mucosal absorption system that is easy to use even for non-specialists in the pharmaceutical industry. to provide.

The present invention provides a package having a composite water-soluble gel containing active ingredients. The packaging body is composed of two layers superimposed so as to form a composite water-soluble gel used for absorption of the sublingual mucosa and in which a natural extract is dissolved, and an airtight chamber containing the composite water-soluble gel in the central portion. It includes a sealing edge formed by sealingly joining an edge portion of a packaging sheet, and a packaging material provided with a notch for a user to tear the packaging sheet at the edge portion.

In one embodiment, the composite water-soluble gel containing the active ingredients is water, natural extracts, gel structure materials, or combinations thereof.

In one embodiment, the composite water-soluble gel containing the active ingredient further comprises an absorption enhancer to facilitate absorption of the active agent by the oral mucosa.

In one embodiment, the package according to claim 1, wherein the packaging sheet is formed into a bottle shape including a bottle cap-shaped upper portion, a bottle neck portion and a bottle body.

In one embodiment, the packaging material is a bottle container.

The package according to the present invention is "a composite water-soluble gel used for absorption of the sublingual mucosa and in which a natural extract is dissolved, and an airtight container chamber for accommodating the composite water-soluble gel in the central portion. A packaging material provided with a sealing edge formed by sealingly joining the edge portions of two packaging sheets that are put together, and a notch for the user to tear the packaging sheet at the edge portion. Due to its technical features, it is easy to use even for non-specialists in the pharmaceutical industry, and it is used as a package for filling medicines and health foods that can be quickly absorbed and acted.

In order to make the above objects, features, advantages and embodiments of the present invention comprehensible, the description of the drawings is provided.

1 is a schematic diagram showing the appearance of a package for filling a composite water-soluble gel containing an active ingredient according to one embodiment of the present invention; FIG. 1 is a schematic diagram showing the appearance of a package for filling a composite water-soluble gel containing an active ingredient according to one embodiment of the present invention; FIG. FIG. 4 is a diagram showing numerical values for quantifying the yellowness of urine in Experimental Examples 1 to 4 of the Experimental Examples of the present invention;

In order to make the description of the present invention more detailed, embodiments and specific examples according to the present invention are described below, but the present invention is not limited to these. Each of the following embodiments may be combined or permuted, if advantageous, and features of other embodiments may be added to one embodiment, so that this will not be described repeatedly below.

The composite water-soluble gel transports the active ingredient through the oral mucosa rather than through the gastrointestinal system, thus avoiding inactivation of the active ingredient before it is utilized by the human body. . Moreover, the active ingredient in the composite water-soluble gel is rapidly released and carried to the user's blood to act quickly. It is important for the user that the active ingredient be rapidly released and absorbed.

Based on the total weight of the composite water-soluble gel, water is about 5 wt% to 15 wt% and gel structural material is about 40 wt% to 60 wt%. Components of the gel structure material include water-soluble edible gums, cyclodextrins, maltodextrins, cellulose derivatives, maltose syrups, chitin or chitosan, fructose, oligosaccharides, amylopectin and combinations thereof. Bio-enhancer ingredients include capsaicin, piperine, wasabi extract, citric acid, malic acid, tartaric acid, phosphoric acid, lactic acid, vitamin C, or combinations thereof.

FIG. 1 is an external view of a package 100 having a composite water-soluble gel 110 containing active ingredients depicted in accordance with one embodiment of the present invention. A natural extract, which is a composite water-soluble gel 110 containing active ingredients, is dissolved in the composite water-soluble gel. The packaging material 120 defines an airtight container chamber A so as to be of a sealing type, and the airtight container chamber A is filled with the composite water-soluble gel 110 containing the active ingredient.

Moreover, as shown in FIG. 1 , the packaging material 120 in the package 100 includes two packaging sheets 121 . After the packaging sheet 121 is folded, the overlapping edges of the packaging sheet 121 are hot pressed together to form the sealing edge 122 and the airtight container chamber A is formed.

As shown in FIG. 2 , the packaging sheet 121 includes a bottle cap-shaped upper portion 123 , a bottle neck portion 124 and a bottle body 125 . A cut 126 leading to the airtight container chamber is provided where the bottle cap-shaped upper portion 123 and the bottle neck portion 124 are connected. The width of the incision 126 gradually decreases into the airtight container chamber, so that the direction in which the user's force is applied coincides with the direction in which the force is received at the deepest point of the incision 126, thus saving more effort in tearing the incision 126. And smooth the torn mouth.

Also, as shown in FIG. 2, in this embodiment, the two opposing sides of the bottle body 125 of each packaging sheet 121 each have a concave arc. Due to the above mentioned shape design, said airtight container chamber A is easily gripped.

The composite water-soluble gel structure according to the present invention is easy to adhere to the sublingual mucosa, thus prolonging the retention time of the contents of the product in the mouth, and increasing the retention time of the active ingredient in the mouth, so that the sublingual absorption is improved. Efficiency can be improved. In addition, even if the composite water-soluble gel is applied to the cheek side of the oral cavity or other places in the oral cavity, it is possible to prolong the retention time of the active ingredient and improve mucosal absorption in other places in the oral cavity.

In addition, the composite water-soluble gel according to the present invention has immediate effect. Immediate effect means that the effect is exhibited within 5 minutes to 1 hour after administration. Preferably, the drug exerts its effect within 30 minutes after administration, and since it can be taken, it does not affect gastrointestinal absorption other than oral absorption.

In one embodiment of the present invention, piperine, a component of the absorption enhancer, modulates the arrangement of lipid molecules in cell membranes by altering the microstructure of epithelial cells, thereby increasing the availability of nutrients from epithelial cells to the circulatory system. As heat is generated during metabolism, along with increased penetration of the blood vessels, dilatation of blood vessels, increased blood flow to the mucous membranes, and more efficient transport of the active substance in the blood to the major large blood vessels.

For a better understanding of the present invention, the following examples demonstrate the efficiency of absorption by the human body when the active ingredient is present in the water-soluble gel structure, drink, jelly or capsule according to the present invention.

Example 1: Comparison of body absorption efficiency of vitamin _B2 products contained in different dosage forms

20 mg of vitamin B ₂ was prepared into a composite water-soluble gel for sublingual mucosa absorption according to Experimental Example 1. A drink of Experimental Example 2 was prepared by dissolving the product of Experimental Example 1 in 200 cc of water. 20 mg of vitamin B ₂ was prepared into jelly according to Experimental Example 3. Capsules according to Experimental Example 4 were produced by filling capsule No. 0 with 20 mg of vitamin B ₂ and 300 mg of lactose.

The same person drank 200 mL of drinking water at 9 am for four consecutive days, and then the sublingual mucosa according to Experimental Example 1, the drink according to Experimental Example 2, the jelly dosage form of Experimental Example 3, and the jelly dosage form of Experimental Example 4. Each took a capsule dosage form. Moreover, since the drink according to Experimental Example 2 was dissolved in water, it was not necessary to drink drinking water. Urine color was measured at different times (09:00, 09:30, 10:00, 11:00, 12:00, 13:00 and 15:00). Vitamin _B2 has a golden color, so after collecting the urine, a camera is used to photograph the specimen, optical analysis is performed using Adobe's color detection system, and the "B" in the HSB section of the color picker is selected. After 100% and analysis in CMYK color mode, the Y values were quantified and the measurement results for each group are shown in FIG.

As shown in FIG. 3, the drink of Experimental Example 2 and the jelly of Experimental Example 3 are absorbed through the intestinal tract, metabolized by the kidneys, and excreted as urine, so urine turns yellow after 60 minutes. and became most yellow at 120 minutes. The capsules of Experimental Example 4 were first digested with gastric acid, then absorbed through the intestinal tract, metabolized by the kidneys, and excreted as urine. Most yellow in minutes. Compared to them, the composite water-soluble gel used for absorption of the sublingual mucosa according to Experimental Example 1 is absorbed via the sublingual mucosa and enters the circulation quickly, so urine turns yellow after 30 minutes. , most yellow at 60 minutes. This experiment showed that vitamin _B2 was the most rapidly metabolized and excreted by the kidneys because it is absorbed via the sublingual mucosa and enters the circulation rapidly.

The present invention provides a composite water-soluble gel containing an active ingredient and may be an easy-to-carry, ready-to-eat snack package.

What has been disclosed above is merely a preferred and practicable embodiment of the present invention, and the scope of the claims of the present invention is not limited thereto. Therefore, all equivalent technical modifications made using the contents of the specification and drawings of the present invention are included in the scope of the claims of the present invention.

DESCRIPTION OF SYMBOLS 100... Package 110... Composite water-soluble gel 120... Packaging material 121... Packaging sheet 122... Seal edge 123... Bottle cap-shaped upper part 124... Bottle neck part 125... Bottle main body 126... Cut line A... Airtight container chamber

Claims (5)

A package for filling a composite water-soluble gel used for sublingual mucosa absorption,
a composite water-soluble gel used for sublingual mucosa absorption and in which a natural extract is dissolved;
A seal side formed by sealing and joining the edge portions of two overlapping packaging sheets so as to form an airtight container chamber for containing the composite water-soluble gel in the central portion, a packaging material provided with cuts for tearing the packaging sheet;
packaging, including 2. The package of Claim 1, wherein the composite water-soluble gel containing the active ingredient is water, natural extracts, gel structure substances, or combinations thereof. The package according to Claim 1, wherein the composite water-soluble gel containing the active ingredient further comprises an absorption enhancer for promoting absorption of the active ingredient by the oral mucosa. The package according to claim 1, wherein the packaging sheet is formed into a bottle shape including a bottle cap-shaped upper portion, a bottle neck portion and a bottle body. The package according to claim 1, wherein the packaging material is a bottle container.

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