JP5006872B2 - Refrigerator for storing glass bottles and cartridge for use in the refrigerator - Google Patents

Description

  The invention comprises a cabinet having an internal space for accommodating glass bottles arranged in a row, a cooling element for cooling the internal space and at least one door or dispenser for removing the glass bottle from the internal space. (Biological) relates to a refrigerator for storing glass bottles containing pharmaceutical substances, in particular vaccines for animals. The present invention also relates to a cartridge suitable for use in such a refrigerator.

  Refrigerators for storing glass bottles are known. German utility model DE200007889U1 has a heat insulation layer (2), a holder for ampoules, a heat deflection plate (4) connected to a Peltier module (5), and a fan (indicated by the numeral 1 in the figure) ) It relates to a heat insulating case for drugs. The electronic control block (6) has a voltage controller, an operating voltage control system, an overheat protection system and a thermostat. This control block (6) controls the Peltier module (5) and the fan. In addition, the front wall of the case serves as a door.

  WO 87/07704 relates to a cooling chamber designed to receive an insulin ampoule. Its size is such that it can accommodate ampoules from all European manufacturers. This cooling chamber is suitable for refrigeration units designed for main power and battery use.

  Danish Patent No. 468380 is placed in contact with the side wall of the refrigerator storage compartment to allow the use of a refrigerator that maintains the storage temperature even under conditions of long-term power interruption to the compressor. The present invention relates to an apparatus for a refrigerator driven by a compressor having a cooling heat storage device. This cooling heat storage device consists of a number of vertical tubes 17 that stand in close contact with each other and contain a fluid having a freezing point of about 0 ° C. The tube 17 is placed on a flat surface portion 19 on the upper edge of the refrigerator, and is brought into a predetermined position using an upper frame 18 having a tube chute.

  It is an object of the present invention to provide an improved refrigerator for storing glass bottles containing (biological) drug substances.

  For this purpose, the refrigerator according to the invention comprises a guide part arranged inside the space and adapted to slidably accommodate a row of glass bottles.

  Each of the guides or each set of guides preferably comprises a distribution compartment in which the glass bottle can be easily removed from the guide, preferably at one end of each guide or set of guides.

  This guide facilitates a more systematic, safe and / or sanitary use of the refrigerator and, as will be described below, one or more relatively small entrances, for example one or more drawers or air Allows the use of one or more relatively small doors or dispensers such as locks.

  These rows are associated with a means such as a spring in a direction having a vertical component, i.e. extending rather than horizontal, and / or at least some of the guides for biasing the glass bottle towards the dispensing compartment It is preferred that In such an embodiment, when the glass bottle is pushed, for example, towards the distribution compartment at one end of the guide, so that the glass bottle is held in place at said distribution compartment and the glass bottle in that compartment is removed Gravity and / or springs can be used to push the remaining glass bottles into the dispensing compartment.

  If each dispenser door is located in one or more rows of dispensing compartments and only a limited number of glass bottles or just one glass bottle is accessible, the temperature fluctuation inside the interior space is Reduce effectively.

  More preferably, the cabinet comprises at least two detachable housings, the first housing contains the glass bottle and the second housing comprises a cooling element. As a result, the first housing is portable and can be carried, for example, by a doctor or veterinarian. Especially if the first housing will be transported over a relatively long distance or otherwise separated from the second housing for a long time, the person's means of transport, usually a car or van, or For example, the second operating room or annex is preferably equipped with an auxiliary second housing with a cooling element.

  The present invention also relates to a cartridge for use in the refrigerator described above, comprising a guide portion adapted to slidably accommodate a plurality of glass bottles. Such a cartridge can be used as a means to bundle multiple glass bottles and facilitate glass bottle distribution and cabinet refilling.

  Within the framework of the present invention, the word “cartridge” includes cassettes, clips, and indeed anything that is suitable for slidingly holding a row of glass bottles.

  The invention will now be described in more detail with reference to the drawings, which schematically show presently preferred embodiments.

  It should be noted that the drawings are not necessarily to scale and details not necessary for an understanding of the present invention may be omitted. The terms “upper side”, “lower side”, “vertical”, “horizontal”, “front side”, “rear side”, “side”, etc. relate to the embodiment directed in the figure. Further, elements that are at least substantially identical or perform at least substantially the same function are indicated by the same number.

  FIG. 1 shows a refrigerator 1 according to the invention for storing glass bottles containing pharmaceutical or biopharmaceutical substances, in particular vaccines for animals. The refrigerator 1 is detachably mounted on the front side of the rear housing 3 using, for example, hooks and slots, magnets or Velcro (registered trademark), and the rear housing 3 to be mounted on the wall or inside the vehicle. A cabinet 2 having a front housing 4 is provided.

  The rear housing 3 is a cooling element (not shown), preferably a Peltier sandwiched between two thermally conductive plates, for example two aluminum plates, whose front side of the plate extends over a substantial section of the front wall of the rear housing 3. Store the element. A ventilation grid 5 is included on the bottom and top surfaces. Further, the rear housing 3 includes a ventilation device for cooling the high temperature side of the cooling element, a cooling element and a ventilation device, a control unit connected to a connector provided in the front wall of the rear housing 3, and a battery pack or main unit. A transformer to be connected to the power supply or vehicle battery is provided.

  The front housing 4 corresponds to the rear housing 3 in width and height and, as will be described below, in an internal space 9 that houses a number of glass bottles 10 arranged in a substantially vertical row along the guide. Three sets of doors 6, 7, 8 are provided to allow all access. The lowermost door 8 extends substantially vertically, and the upper rim of each of these doors (6) is pivotally connected to the front housing 4. By pivoting one of these doors 8 forwards and upwards, for example, the bottom glass bottle 10 in a group of three adjacent rows is exposed and thus from each row of this glass bottle 10. Removal is possible.

  The top door 6 extends substantially horizontally and is pivotally mounted in the upper wall of the front housing 4. By pivoting one of these doors 6 upwards and backwards, for example a group of three adjacent rows of glass bottles 10 is also exposed.

  When the front housing 4 is attached to the rear housing 3, the rear wall of the front housing 4 abuts against the Peltier element.

  Permanent guides such as vertical ducts or partitions extending along the inner row of the interior space 9 will provide an effective means for slidably receiving the glass bottle 10, but an elongate cartridge It is preferable that 11 is detachably mounted side by side in the space 9.

  An example of a preferred cartridge 11 for use in the refrigerator 1 of the present invention is shown in FIGS. 2A and 2B. This preferred cartridge 11 comprises two parallel side walls 12 connected by a rear wall 13 and a bottom wall 14. The side walls 12 are separated by a distance slightly larger than the width of the glass bottle 10. In this preferred embodiment, the bottom wall 14 conforms to the shape of the glass bottle 10, i.e. has a semicircular cross section. Two retaining strips 15, which are inclined towards the plane of symmetry of the cartridge 11, extend a distance along almost the entire length of the side wall 12, ie above the bottom wall 14 corresponding to the width of the glass bottle 10. Together with the side walls 12, these holding strips 15 form an effective guide for slidingly holding the rows of glass bottles 10 and define a dispensing position at the bottom end of the cartridge 11, ie the bottom glass bottle 10. Can be pulled out of the cartridge 11 in a direction substantially perpendicular to the remaining rows of glass bottles.

  This dispensing position can in principle also be used to fill the cartridge 11 with a glass bottle, but preferably has a filling compartment at the other end of the cartridge 11 as shown in FIGS. 2A and 2B. It is preferable to further provide. That is, the cartridge 11 can be filled by sliding the neck of the glass bottle 10 between the holding strips 15 and placing the glass bottle in the top opening of the cartridge 11.

  In the embodiment shown in the drawings, the front wall of the front housing 4 further comprises one or more, for example two, relatively large doors 7 that allow access to the interior space 9 for maintenance or cleaning. Alternatively, the front wall is fixedly attached to the front housing 4 or forms an integral whole with the front housing.

  The front wall further includes a switch that turns the Peltier element on and off, and a warning light that indicates that a selected threshold for the minimum temperature stored in the control unit has been reached. Alternatively or additionally, the cabinet can be provided with a regulator, setting and / or actual temperature (eg measured using a thermocouple placed in the interior space), for example to set the required temperature. A small indicator may be provided and / or a speaker to sound an alarm when a selected threshold is reached. The rear wall of the front housing is detachably connected to a connector on the front wall of the rear housing, thus the switch, warning light, regulator, indicator and other elements for operating the refrigerator to the control unit. A corresponding connector for connection is provided.

  The rear and front compartment walls are preferably made from an injection molded thermoplastic polymer such as ABS, PC or fiber-filled PP. At least the front housing wall uses, for example, a layer of foamed polyurethane or polyester foam, and optionally a reflective film of aluminum, sandwiched between the inner and outer walls of the injection molded thermoplastic polymer. Insulated. The insulated compartment on the door is preferably surrounded by a seal (16) such as a rubber ring.

  In addition, a portion of the front wall, for example the lower compartment of the relatively large door 7, is transparent and double so that the person using the cabinet can see which glass bottles and therefore which drug substance is in which row. It is preferably made from a transparent material, such as PS or PC of the membrane.

  This cartridge is also preferably made from an injection molded thermoplastic polymer, in particular a transparent PC.

  In use, this refrigerator is mounted on the wall of, for example, a veterinary operating room, the Peltier element is switched on, and when a sufficiently low temperature is reached, the top door is opened and each contains a cartridge containing a plurality of glass bottles. It is loaded into the internal space. Glass bottles in each cartridge or group of cartridges store different vaccines, for example PPi freeze-dried pellets (as shown in the Intervet® product catalog 2005) (lyophilizer or “cake”), Parvo Includes cartridges that store C, Corona, KC, DHPPI, and Puppy DP. When a particular vaccine is to be administered, the corresponding lower door is opened and the glass bottle is removed from the appropriate row and a diluent, usually water, a water-in-oil emulsion or an oil-in-water emulsion, obtains an injectable material Injected into a glass bottle.

  From the above description, the refrigerator according to the present invention facilitates or even imposes a more systematic, safe and / or hygienic use, and only a limited amount of cooled air inside the refrigerator during removal of the glass bottle. It will be apparent that it only escapes and substantially avoids a substantial decrease in the inner temperature.

  Cartridges can be filled with individual glass bottles by a person using the refrigerator of the present invention, for example a veterinarian or assistant, but pre-filled (front) to store pre-filled cartridges or rows of glass bottles through existing channels Even the housing is preferably distributed.

  The invention is not limited to the embodiments described above which can be varied in a number of ways within the scope of the claims. For example, the cabinet preferably includes an additional compartment for storing pre-filled syringes or diluents. In order to prevent overcooling of the injectable substance, it is preferred that this cooling (Peltier) element does not extend over the compartment for storing the diluent or that this compartment is isolated from the cooling element.

FIG. 2 is a perspective view of a refrigerator according to the present invention with the top door and the bottom door open. FIG. 2 is a perspective view of an empty cartridge suitable for use in a refrigerator. FIG. 3 is a perspective view of a filled cartridge suitable for use in a refrigerator.

Claims (4)

(Bio) a method of storing life-and-death transporting glass bottles for storing drug product quality,
Comprising the steps of: providing a refrigerator, the refrigerator, a cabinet having between inner space for accommodating the vials arranged in columns, a cooling element for cooling the inter internal space, the internal spatial or et glass at least one Tobirama other dispenser for taking out the bottle is disposed inside between internal space, and a plurality of guide portions which made a row of glass bottles to slidingly accommodated, said cabinet The first housing has an internal space and a guide, the second housing comprises a cooling element, the method further comprising:
Storing a glass bottle in the internal space of the first housing;
Removing the first housing from the second housing;
Transporting the first housing to a remote location for use by a physician or veterinarian. 2. A transport means, usually a car or van, is used to transport the first housing, the transport means comprising an auxiliary second housing with a cooling element. The method described in 1. 3. A method according to claim 1 or 2, characterized in that another auxiliary second housing with a cooling element is present at a remote location. A refrigerator device that enables storage and transportation of glass bottles containing (biological) drug substances, the cabinet having an internal space for accommodating the glass bottles arranged in a row, and a cooling element for cooling the internal space And at least one door or dispenser for removing the glass bottle from the internal space, and a plurality of guides arranged inside the internal space and adapted to slidably accommodate the row of glass bottles,
The refrigerator apparatus, wherein the cabinet includes two housings that are detachable from each other, the first housing includes an internal space and a guide portion, and the second housing includes a cooling element.

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