JP4950277B2 - 細胞ブロック作製システム及びその使用方法 - Google Patents
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
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- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
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- Biotechnology (AREA)
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- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Materials For Medical Uses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
Claims (17)
- 面内を延びる平らな床部(2123,2223,2016,2725)と、
中心軸及び前記床部(2123,2223,2016)に対して略垂直に延びる側壁を有してチャンバ(2012,2138)を形成するチューブ(2122A,2222,2722)と、
長手軸に沿って延在し、前記チャンバ(2012,2138,2738)と連通する出口を有する注射針(2004,2104,2704)であって、前記出口が、前記チューブの前記中心軸と同軸であり、前記平らな床部の近くに設けられ、前記注射針の前記長手軸にある注射針と、
前記平らな床部に検体を向けるために、前記チューブの中心軸にわたって前記出口の一部を覆うよう延在するカバーと、
前記チャンバ(2012,2138,2738)と連通する真空源(2032,2038,2040,2142,2143,2701,2705)と、
を具えることを特徴とする器具。 - 前記真空源が、前記チューブ(2122A,2122,2738,2722)に隣接するバレル(2038,2701,2722,2142)と、
前記バレル(2038,2701,2142)の中を移動可能なプランジャ(2040,2705,2143,2705)と、を具えることを特徴とする請求項1に記載の器具。 - 前記チューブ(2002,2123,2016,2422)が前記バレルに(2142,2038)に取り外し可能に結合されていることを特徴とする請求項2に記載の器具。
- 前記バレル(2038,2142)が前記チューブ(2123,2016,2422)にねじ込まれることを特徴とする請求項3に記載の器具。
- 前記チューブ(2122A,2122,2123)が前記バレル(2038,2701,2722,2142)に隣接して直接接続されることを特徴とする請求項2に記載の器具。
- 前記バレル(2038,2701,2722,2142)が、手で接合部(2703)に力を加えると前記チューブ(2738)から前記バレル(2038,2701,2722,2142)を分離し易くするよう構成された接合部(2703)によって前記チューブ(2738)に接続されることを特徴とする請求項2に記載の器具。
- 前記バレル(2722,2701)が、1つの本体として前記チューブ(2738)に一体形成されていることを特徴とする請求項2に記載の器具。
- 前記注射針(2004)が、前記床部(2123,2223,2016)から距離を空けて設けられた開口を有していることを特徴とする請求項1に記載の器具。
- 前記開口が前記チューブ(2122A,2122)の中心軸に対して非平行な方向に向いていることを特徴とする請求項8に記載の器具。
- さらに、第1のチューブ(2122A,2122)及び前記注射針を取り外し可能に受容する閉鎖端を有する第2のチューブ(2119)を具えることを特徴とする請求項1に記載の器具。
- 前記床部(2123,2223,2016)及び前記注射針が、前記チューブ(2122A,2122)に接続且つ取り外し可能に連結されていることを特徴とする請求項1に記載の器具。
- 前記床部(2123,2223,2016)及び前記チューブ(2122A,2122)が1つの本体として一体形成されていることを特徴とする請求項1に記載の器具。
- さらに、カセット(30)を具えており、
前記カセットが少なくとも1の空洞(54A)を有する容器(30A)を具えており、
前記空洞が、細胞ブロックの形状及び向きを実質的に維持しながら、前記チャンバ(2012,2138)の中に形成されて前記チャンバ(2012,2138)から取り出される細胞ブロックを受容するように、それぞれの空洞が前記チャンバ(2012,2138)の形状及び大きさに対応する形状及び大きさを有していることを特徴とする請求項1に記載の器具。 - さらに、携帯型の培養運搬器具(2316)を具えており、
前記携帯型の培養運搬器具(2316)が、前記チャンバ(2012,2138)に加えられるマトリクスを収容するマトリクス容器(2326)を受容するよう構成された内部空間(2324)と、
前記マトリクス容器の内容物を加熱するよう構成された前記内部空間の近くのヒータ(2319)と、を具えていることを特徴とする請求項1に記載の器具。 - さらに、外側に弾性的に付勢された複数のアーム(85)を有する鉗子(80)を具えており、
前記アームが、前記チューブ(2122A,2122)の内面にほぼ一致するような形状の下部(81,82)を有することを特徴とする請求項1に記載の器具。 - 前記注射針(2104)が前記床部(2123)の近くで前記チューブ(2138)に直接接続された端部を有していることを特徴とする請求項1に記載の器具。
- 前記真空源が、前記チャンバ(2012,2138)を真空に引くよう構成された真空チューブを具えることを特徴とする請求項1に記載の器具。
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
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US78388106P | 2006-03-20 | 2006-03-20 | |
US60/783,881 | 2006-03-20 | ||
US80175906P | 2006-05-20 | 2006-05-20 | |
US60/801,759 | 2006-05-20 | ||
US84603606P | 2006-09-20 | 2006-09-20 | |
US60/846,036 | 2006-09-20 | ||
US85279806P | 2006-10-19 | 2006-10-19 | |
US60/852,798 | 2006-10-19 | ||
PCT/US2007/064343 WO2007109639A2 (en) | 2006-03-20 | 2007-03-20 | Cytoblock preparation system and methods of use |
Publications (2)
Publication Number | Publication Date |
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JP2009529919A JP2009529919A (ja) | 2009-08-27 |
JP4950277B2 true JP4950277B2 (ja) | 2012-06-13 |
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Application Number | Title | Priority Date | Filing Date |
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JP2009501690A Expired - Fee Related JP4950277B2 (ja) | 2006-03-20 | 2007-03-20 | 細胞ブロック作製システム及びその使用方法 |
Country Status (7)
Country | Link |
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US (3) | US8152738B2 (ja) |
EP (1) | EP2021455A4 (ja) |
JP (1) | JP4950277B2 (ja) |
CN (1) | CN101460604B (ja) |
BR (1) | BRPI0709331A2 (ja) |
CA (1) | CA2646888A1 (ja) |
WO (1) | WO2007109639A2 (ja) |
Families Citing this family (52)
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EP1487346B1 (de) | 2002-03-19 | 2005-08-31 | Bard Dublin ITC Limited | Vakuum-biopsievorrichtung |
DE10314240A1 (de) | 2003-03-29 | 2004-10-07 | Bard Dublin Itc Ltd., Crawley | Druckerzeugungseinheit |
WO2006005343A1 (en) | 2004-07-09 | 2006-01-19 | Sonion Roskilde A/S | Length detection system for biopsy device |
JP4955681B2 (ja) | 2005-08-10 | 2012-06-20 | シー・アール・バード・インコーポレーテッド | 直線駆動装置を有する単一挿入複数サンプリング生検デバイス |
ES2539578T3 (es) | 2005-08-10 | 2015-07-02 | C.R. Bard, Inc. | Dispositivo de biopsia de múltiples muestras e inserción única con diversos sistemas de transporte |
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WO2008024684A2 (en) | 2006-08-21 | 2008-02-28 | C.R. Bard, Inc. | Self-contained handheld biopsy needle |
WO2008040812A1 (en) | 2006-10-06 | 2008-04-10 | Sonion Roskilde A/S | Tissue handling system with reduced operator exposure |
EP2086417B1 (en) | 2006-10-24 | 2015-07-01 | C.R.Bard, Inc. | Large sample low aspect ratio biopsy needle |
US8241225B2 (en) | 2007-12-20 | 2012-08-14 | C. R. Bard, Inc. | Biopsy device |
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US9931105B2 (en) * | 2008-12-16 | 2018-04-03 | Nico Corporation | System and method of taking and collecting tissue cores for treatment |
BRPI0924422A2 (pt) | 2009-03-16 | 2016-01-26 | Bard Inc C R | dispositivo de biópsia e método para controlar um dispositivo de biópsia |
ES2690737T3 (es) | 2009-04-15 | 2018-11-22 | C.R. Bard Inc. | Gestión de fluido |
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2007
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CN101460604B (zh) | 2012-12-19 |
CN101460604A (zh) | 2009-06-17 |
US20140162311A1 (en) | 2014-06-12 |
JP2009529919A (ja) | 2009-08-27 |
EP2021455A2 (en) | 2009-02-11 |
WO2007109639A2 (en) | 2007-09-27 |
US8152738B2 (en) | 2012-04-10 |
US20070218542A1 (en) | 2007-09-20 |
US8541217B2 (en) | 2013-09-24 |
CA2646888A1 (en) | 2007-09-27 |
BRPI0709331A2 (pt) | 2011-07-12 |
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