JP4903937B2 - キャリヤー媒介体及びターゲティング媒介体としての細菌ゴースト - Google Patents
キャリヤー媒介体及びターゲティング媒介体としての細菌ゴースト Download PDFInfo
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- JP4903937B2 JP4903937B2 JP2000603652A JP2000603652A JP4903937B2 JP 4903937 B2 JP4903937 B2 JP 4903937B2 JP 2000603652 A JP2000603652 A JP 2000603652A JP 2000603652 A JP2000603652 A JP 2000603652A JP 4903937 B2 JP4903937 B2 JP 4903937B2
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19909770A DE19909770A1 (de) | 1999-03-05 | 1999-03-05 | Bakterienghosts als Träger- und Targetingvehikel |
| DE19909770.4 | 1999-03-05 | ||
| PCT/EP2000/001906 WO2000053163A1 (de) | 1999-03-05 | 2000-03-03 | Bakterienghosts als träger- und targetingvehikel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002538198A JP2002538198A (ja) | 2002-11-12 |
| JP4903937B2 true JP4903937B2 (ja) | 2012-03-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000603652A Expired - Fee Related JP4903937B2 (ja) | 1999-03-05 | 2000-03-03 | キャリヤー媒介体及びターゲティング媒介体としての細菌ゴースト |
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| Country | Link |
|---|---|
| US (2) | US20120040829A1 (xx) |
| EP (1) | EP1158966B1 (xx) |
| JP (1) | JP4903937B2 (xx) |
| AT (1) | ATE242630T1 (xx) |
| AU (1) | AU778166B2 (xx) |
| CA (1) | CA2370714C (xx) |
| DE (2) | DE19909770A1 (xx) |
| NZ (1) | NZ514408A (xx) |
| WO (1) | WO2000053163A1 (xx) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19909770A1 (de) | 1999-03-05 | 2000-09-07 | Werner Lubitz | Bakterienghosts als Träger- und Targetingvehikel |
| GB9908195D0 (en) | 1999-04-09 | 1999-06-02 | Microbiological Res Authority | Treatment of intracellular infection |
| ATE429484T1 (de) | 2001-06-11 | 2009-05-15 | Applied Nanosystems Bv | Verfahren zur bindung von acma-typ protein anker fusionen an mikroorganismen zellwandmaterialien |
| DE10335796A1 (de) * | 2003-08-05 | 2005-03-03 | Lubitz, Werner, Prof. Dr. | Verschliessen von Bakterienghosts durch bioaffine Wechselwirkungen |
| US20070134214A1 (en) * | 2003-08-13 | 2007-06-14 | Feng Xu | Inactivated host cell delivery of polynucleotides encoding immunogens |
| US20080254058A1 (en) * | 2004-12-14 | 2008-10-16 | Alk-Abello A/S | Pharmaceutical Composition Comprising a Bacterial Cell Displaying a Heterologous Proteinaceous Compound |
| US9878043B2 (en) * | 2006-06-23 | 2018-01-30 | Engeneic Molecular Delivery Pty Ltd | Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells |
| WO2009015852A1 (de) | 2007-07-27 | 2009-02-05 | Werner Lubitz | Virus-modifizierte bakterienghosts |
| ES2525205T3 (es) * | 2011-11-09 | 2014-12-18 | Werner Lubitz | Vacuna para su uso en inmunoterapia tumoral |
| US10526574B2 (en) | 2014-02-21 | 2020-01-07 | Bird-C Gmbh & Co. Kg | Fed-batch process for the production of bacterial ghosts |
| EP3195878A1 (en) * | 2016-01-22 | 2017-07-26 | Werner Lubitz | Bacterial ghosts for the treatment of cancer |
| JP7376208B2 (ja) | 2017-10-25 | 2023-11-08 | アレーロ セラピューティクス ビーヴイ | 抗原特異的製剤の投与による免疫疾患の治療 |
| WO2021094091A1 (en) * | 2019-11-15 | 2021-05-20 | Henkel Ag & Co. Kgaa | Perfume carrier composition comprising bacterial spores |
| CN114681601A (zh) * | 2020-12-31 | 2022-07-01 | 基础治疗有限公司 | 脑膜炎奈瑟氏球菌疫苗及其应用 |
| CN114853743B (zh) * | 2022-06-08 | 2023-08-22 | 常州大学 | 一种基于胞嘧啶的花菁探针及其制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2541685A1 (de) * | 1975-09-18 | 1977-03-24 | Toepfer Gmbh | Verfahren zur ermoeglichung der resorption von wirkstoffen aus dem magendarmkanal, die ueblicherweise per os oder per anum verabreicht keine wirksamkeit zeigen |
| US5702916A (en) | 1982-09-16 | 1997-12-30 | Gx Biosystems A/S | Biological Containment |
| GB8328918D0 (en) * | 1983-10-28 | 1983-11-30 | Unilever Plc | Alkaline phosphatase |
| GB8608964D0 (en) * | 1986-04-12 | 1986-05-14 | Pannell N A | Producing microbially encapsulated materials |
| DE3715840A1 (de) * | 1987-05-12 | 1988-12-01 | Boehringer Mannheim Gmbh | Fuer ein lytisch wirksames, chimaeres protein kodierende rekombinante dna und ihre verwendung |
| DE3919644A1 (de) * | 1989-06-16 | 1990-12-20 | Diagen Inst Molekularbio | Mittel zur prophylaktischen und therapeutischen behandlung von viralen infektionen |
| DE4005874A1 (de) * | 1990-02-24 | 1991-11-07 | Boehringer Mannheim Gmbh | Traegergebundene rekombinante proteine, verfahren zur herstellung und verwendung als immunogene und vakzine |
| AU659796B2 (en) | 1990-03-07 | 1995-06-01 | Engelhard Corporation | Animal feed additive and method for inactivating mycotoxins present in animal feeds |
| US5328985A (en) * | 1991-07-12 | 1994-07-12 | The Regents Of The University Of California | Recombinant streptavidin-protein chimeras useful for conjugation of molecules in the immune system |
| US5830463A (en) * | 1993-07-07 | 1998-11-03 | University Technology Corporation | Yeast-based delivery vehicles |
| DE19633698A1 (de) | 1996-08-21 | 1998-02-26 | Lubitz Werner Prof Dr | Neue Systeme zur Regulation der Genexpression |
| US5871714A (en) | 1997-10-16 | 1999-02-16 | Pharmacal Biotechnologies, Inc. | Compositions for controlling bacterial colonization |
| DE19909770A1 (de) | 1999-03-05 | 2000-09-07 | Werner Lubitz | Bakterienghosts als Träger- und Targetingvehikel |
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1999
- 1999-03-05 DE DE19909770A patent/DE19909770A1/de not_active Withdrawn
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2000
- 2000-03-03 NZ NZ514408A patent/NZ514408A/xx not_active IP Right Cessation
- 2000-03-03 AT AT00912549T patent/ATE242630T1/de not_active IP Right Cessation
- 2000-03-03 AU AU34272/00A patent/AU778166B2/en not_active Ceased
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- 2000-03-03 EP EP00912549A patent/EP1158966B1/de not_active Expired - Lifetime
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- 2000-03-03 DE DE50002531T patent/DE50002531D1/de not_active Expired - Lifetime
- 2000-03-03 JP JP2000603652A patent/JP4903937B2/ja not_active Expired - Fee Related
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2011
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2016
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Also Published As
| Publication number | Publication date |
|---|---|
| DE50002531D1 (de) | 2003-07-17 |
| US20160220499A1 (en) | 2016-08-04 |
| AU778166B2 (en) | 2004-11-18 |
| CA2370714A1 (en) | 2000-09-14 |
| AU3427200A (en) | 2000-09-28 |
| CA2370714C (en) | 2010-02-09 |
| NZ514408A (en) | 2004-01-30 |
| US20120040829A1 (en) | 2012-02-16 |
| JP2002538198A (ja) | 2002-11-12 |
| EP1158966B1 (de) | 2003-06-11 |
| EP1158966A1 (de) | 2001-12-05 |
| ATE242630T1 (de) | 2003-06-15 |
| DE19909770A1 (de) | 2000-09-07 |
| US9763890B2 (en) | 2017-09-19 |
| WO2000053163A1 (de) | 2000-09-14 |
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