JP4890878B2 - Fundus observation device - Google Patents

Fundus observation device Download PDF

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JP4890878B2
JP4890878B2 JP2006039085A JP2006039085A JP4890878B2 JP 4890878 B2 JP4890878 B2 JP 4890878B2 JP 2006039085 A JP2006039085 A JP 2006039085A JP 2006039085 A JP2006039085 A JP 2006039085A JP 4890878 B2 JP4890878 B2 JP 4890878B2
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fundus
image
image data
light
reference
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JP2007215733A (en
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央 塚田
勉 木川
康文 福間
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株式会社トプコン
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/102Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]

Description

  The present invention relates to a fundus oculi observation device used for observing the fundus oculi of a subject eye.

  Conventionally, fundus cameras have been widely used as fundus oculi observation devices. FIG. 15 illustrates an example of an external configuration of a conventional general fundus camera, and FIG. 16 illustrates an example of a configuration of an optical system built in the fundus camera (see, for example, Patent Document 1). Note that “observation” includes at least a case where a photographed image of the fundus is observed (others may include fundus observation with the naked eye).

  First, the external configuration of a conventional fundus camera 1000 will be described with reference to FIG. The fundus camera 1000 includes a gantry 3 mounted on a base 2 so as to be slidable in the front-rear and left-right directions (horizontal direction). The gantry 3 is provided with an operation panel 3a and a joystick 4 for the examiner to perform various operations.

  The examiner can move the gantry 3 three-dimensionally on the base 2 by operating the joystick 4. On the top of the joystick 4, an operation button 4a that is pressed when photographing the fundus is disposed.

  A support column 5 is erected on the base 2. The column 5 is provided with a chin rest 6 for mounting the subject's jaw and an external fixation lamp 7 for emitting light for fixing the eye E.

  On the gantry 3, a main body 8 that stores various optical systems and control systems of the fundus camera 1000 is mounted. The control system may be provided inside the base 2 or the gantry 3 or may be provided in an external device such as a computer connected to the fundus camera 1000.

  On the eye E side (the left side in FIG. 15) of the main body 8, an objective lens unit 8 a disposed to face the eye E is provided. In addition, an eyepiece unit 8b for observing the fundus of the eye E to be examined with the naked eye is provided on the examiner side of the main body 8 (the right direction in FIG. 15).

  Further, the main body 8 is provided with a still camera 9 for capturing a still image of the fundus of the eye E and an imaging device 10 such as a television camera for capturing a still image or a moving image of the fundus. Yes. The still camera 9 and the imaging device 10 are detachably attached to the main body 8.

  As the still camera 9, a digital camera equipped with an image sensor such as a charge coupled device (CCD) or a complementary metal oxide semiconductor (CMOS), or a film camera, depending on various conditions such as the purpose of inspection and the method of storing a captured image In addition, an instant camera or the like can be appropriately attached and used. The main body portion 8 is formed with a mounting portion 8c for selectively mounting such various still cameras 9.

  When the still camera 9 or the imaging device 10 is of a digital imaging system, the image data of the fundus image captured by the still camera 9 or the imaging device 10 is transmitted to a computer or the like connected to the fundus camera 1000, and the fundus image is displayed on the display. Can be observed. Further, the image data can be transmitted to an image recording apparatus connected to the fundus camera 1000 to form a database and used as electronic data for creating an electronic medical chart, for example.

  A touch panel monitor 11 is provided on the examiner side of the main body 8. On the touch panel monitor 11, a fundus image of the eye E to be examined that is created based on a video signal output from the (digital type) still camera 9 or the imaging device 10 is displayed. The touch panel monitor 11 displays an xy coordinate system with the center of the screen as the origin on the fundus image. When the examiner touches a desired position on the screen, a coordinate value corresponding to the touched position is displayed.

  Next, the configuration of the optical system of the fundus camera 1000 will be described with reference to FIG. The fundus camera 1000 is provided with an illumination optical system 100 that illuminates the fundus oculi Ef of the eye E, and an imaging optical system 120 that guides the fundus reflection light of the illumination light to the eyepiece unit 8b, the still camera 9, and the imaging device 10. It has been.

  The illumination optical system 100 includes an observation light source 101, a condenser lens 102, a photographing light source 103, a condenser lens 104, exciter filters 105 and 106, a ring translucent plate 107, a mirror 108, an LCD 109, an illumination diaphragm 110, a relay lens 111, and a perforated mirror. 112 and an objective lens 113 are included.

  The observation light source 101 is constituted by a halogen lamp, for example, and outputs steady light (continuous light) for fundus observation. The condenser lens 102 is an optical element that collects steady light (observation illumination light) emitted from the observation light source 101 and illuminates the observation illumination light almost evenly on the fundus.

  The imaging light source 103 is composed of, for example, a xenon lamp, and emits flash light when imaging the fundus oculi Ef. The condenser lens 104 is an optical element that collects flash light (imaging illumination light) emitted from the imaging light source 103 and uniformly irradiates the fundus oculi Ef with the imaging illumination light.

  The exciter filters 105 and 106 are filters used when performing fluorescence imaging of a fundus image of the fundus oculi Ef. Each of the exciter filters 105 and 106 can be inserted into and removed from the optical path by a drive mechanism (not shown) such as a solenoid. The exciter filter 105 is disposed on the optical path during FAG (fluorescein fluorescence imaging) imaging. On the other hand, the exciter filter 106 is disposed on the optical path during ICG (Indocyanine Green Fluorescence Imaging) imaging. Note that the exciter filters 105 and 106 are both retracted from the optical path during color photographing.

  The ring translucent plate 107 is disposed at a position conjugate with the pupil of the eye E to be examined, and includes a ring translucent portion 107 a centering on the optical axis of the illumination optical system 100. The mirror 108 reflects the illumination light emitted from the observation light source 101 and the photographing light source 103 in the optical axis direction of the photographing optical system 120. The LCD 109 displays a fixation target (not shown) for fixing the eye E to be examined.

  The illumination stop 110 is a stop member that blocks part of the illumination light for preventing flare and the like. The illumination stop 110 is configured to be movable in the optical axis direction of the illumination optical system 100, thereby adjusting the illumination area of the fundus oculi Ef.

  The aperture mirror 112 is an optical element that combines the optical axis of the illumination optical system 100 and the optical axis of the photographing optical system 120. A hole 112 a is opened in the center region of the perforated mirror 112. The optical axis of the illumination optical system 100 and the optical axis of the photographing optical system 120 intersect at a substantially central position of the hole 112a. The objective lens 113 is provided in the objective lens portion 8 a of the main body portion 8.

  The illumination optical system 100 having such a configuration illuminates the fundus oculi Ef in the following manner. First, at the time of fundus observation, the observation light source 101 is turned on and observation illumination light is output. This observation illumination light irradiates the ring translucent plate 107 through the condenser lenses 102 and 104 (the exciter filters 105 and 106 are retracted from the optical path). The light that has passed through the ring translucent portion 107 a of the ring translucent plate 107 is reflected by the mirror 108 and reflected by the perforated mirror 112 via the LCD 109, the illumination stop 110, and the relay lens 111. The observation illumination light reflected by the aperture mirror 112 travels in the optical axis direction of the imaging optical system 120, is focused by the objective lens 113, and enters the eye E to illuminate the fundus oculi Ef.

  At this time, since the ring translucent plate 107 is disposed at a position conjugate to the pupil of the eye E, a ring-shaped image of observation illumination light incident on the eye E is formed on the pupil. The fundus reflection light of the observation illumination light is emitted from the eye E through the central dark part of the ring-shaped image on the pupil. In this manner, the influence of the observation illumination light incident on the eye E on the fundus reflection light of the observation illumination light is prevented.

  On the other hand, when photographing the fundus oculi Ef, the photographing light source 103 emits flash light, and the photographing illumination light is irradiated onto the fundus oculi Ef through a similar route. In the case of fluorescent photographing, the exciter filter 105 or 106 is selectively arranged on the optical path depending on whether FAG photographing or ICG photographing.

  Next, the photographing optical system 120 will be described. The photographing optical system 120 includes an objective lens 113, a perforated mirror 112 (hole 112a), a photographing aperture 121, barrier filters 122 and 123, a variable power lens 124, a relay lens 125, a photographing lens 126, a quick return mirror 127, and a photographing. The medium 9a is included. Here, the imaging medium 9a is an arbitrary imaging medium (an imaging element such as a CCD, a camera film, an instant film, etc.) used for the still camera 9.

  The fundus reflection light of the illumination light emitted from the eye E through the central dark part of the ring-shaped image on the pupil enters the photographing aperture 121 through the hole 112a of the aperture mirror 112. The perforated mirror 112 reflects the corneal reflection light of the illumination light and acts so as not to mix the corneal reflection light into the fundus reflection light incident on the photographing aperture 121. Thereby, the occurrence of flare in the observed image or the photographed image is suppressed.

  The photographing aperture 121 is a plate-like member in which a plurality of circular translucent portions having different sizes are formed. The plurality of light-transmitting portions constitute diaphragms having different aperture values (F values), and the light-transmitting portions are alternatively arranged on the optical path by a driving mechanism (not shown).

  Each of the barrier filters 122 and 123 can be inserted into and removed from the optical path by a drive mechanism (not shown) such as a solenoid. When performing FAG imaging, the barrier filter 122 is disposed on the optical path, and when performing ICG imaging, the barrier filter 123 is disposed on the optical path. When performing color photography, both the barrier filters 122 and 123 are retracted from the optical path.

  The variable magnification lens 124 can be moved in the optical axis direction of the photographing optical system 120 by a driving mechanism (not shown). Thereby, it is possible to change the observation magnification and the imaging magnification, focus the fundus image, and the like. The photographing lens 126 is a lens that forms an image of fundus reflected light from the eye E on the photographing medium 9a.

  The quick return mirror 127 is rotatably provided around the rotation shaft 127a by a driving mechanism (not shown). When photographing the fundus oculi Ef with the still camera 9, the fundus reflected light is guided to the photographing medium 9a by jumping up the quick return mirror 127 obliquely provided on the optical path. On the other hand, when photographing the fundus with the imaging device 10 or observing the fundus with the examiner's naked eye, the fundus reflected light is reflected upward with the quick return mirror 127 obliquely arranged on the optical path. Yes.

  The photographing optical system 120 further includes a field lens (field lens) 128, a switching mirror 129, an eyepiece lens 130, a relay lens 131, a reflection mirror 132, for guiding the fundus reflection light reflected by the quick return mirror 127. A photographing lens 133 and an image sensor 10a are provided. The imaging element 10 a is an imaging element such as a CCD built in the imaging apparatus 10. On the touch panel monitor 11, a fundus oculi image Ef ′ photographed by the image sensor 10a is displayed.

  As with the quick return mirror 127, the switching mirror 129 is rotatable around the rotation shaft 129a. The switching mirror 129 reflects the fundus reflection light toward the eyepiece lens 130 while being obliquely provided on the optical path during observation with the naked eye.

  Further, when a fundus image is captured using the imaging device 10, the switching mirror 129 is retracted from the optical path to guide the fundus reflection light toward the imaging element 10a. In this case, the fundus reflection light is reflected by the mirror 132 via the relay lens 131 and imaged on the image sensor 10 a by the photographing lens 133.

  Such a fundus camera 1000 is a fundus oculi observation device used for observing the surface of the fundus oculi Ef, that is, the state of the retina. In other words, the fundus camera 1000 is a device for obtaining a two-dimensional fundus image when the fundus oculi Ef is viewed from the cornea direction of the eye E to be examined. On the other hand, there are tissues such as the choroid and sclera in the deep layer of the retina, and a technique for observing the state of these tissues has been desired. In recent years, a device for observing these deep tissues has been put into practical use. (For example, see Patent Documents 2 and 3).

  The fundus oculi observation device disclosed in Patent Documents 2 and 3 is a device (referred to as an optical image measurement device, an optical coherence topography device, or the like) that applies so-called OCT (Optical Coherence Tomography) technology. This fundus observation device bisects low-coherence light, guides one (signal light) to the fundus, guides the other (reference light) to a predetermined reference object, and passes the signal light and reference object through the fundus The apparatus forms a tomographic image of the fundus surface or deep tissue by detecting and analyzing interference light obtained by superimposing the reference light. Further, the optical image measurement device can form a three-dimensional image of the fundus oculi based on a plurality of tomographic images. Note that the optical image measurement device described in Patent Literature 2 is generally called a Fourier domain (Fourier Domain) OCT or the like.

  FIG. 17 shows an example of a tomographic image of the fundus obtained by a Fourier domain type optical image measurement device. Here, the image data of the tomographic image obtained by the optical image measurement device is data consisting of complex numbers. The image located above the one-dot chain line in FIG. 17 is a tomographic image G (Re) corresponding to a normal image (sometimes referred to as a “real image”) in an image obtained by analyzing the detection result of interference light. is there. In addition, the image located below the one-dot chain line is a tomographic image G (Im) corresponding to an inverse image (sometimes referred to as a “virtual image”) in the image.

  The normal image G (Re) and the reverse image G (Im) have symmetrical shapes with respect to the alternate long and short dash line in FIG. Further, the normal image G (Re) and the reverse image G (Im) have the same intensity. Here, the one-dot chain line in FIG. 17 is the position in the depth direction of the fundus corresponding to the position of the reference object.

JP 2004-350849 A JP 2003-543 A Japanese Patent Laying-Open No. 2005-241464

  As shown in FIG. 17, the tomographic image of the fundus obtained by such an optical image measurement device has the highest sensitivity (interference sensitivity) at the depth position corresponding to the position of the reference object. Sensitivity decreases. Therefore, a high-accuracy image is obtained for a portion such as the choroid GC near the depth position, but the accuracy of the image is reduced for a portion such as a fundus surface (retinal or the like) GS away from the depth position.

  In addition, when it is desired to obtain a highly accurate image for a part such as the fundus oculi surface GS, the position of the reference object may be adjusted so that the interference sensitivity at the part is increased. However, this adjustment work is complicated. The burden on the user may increase. Furthermore, this adjustment work increases the inspection time and may increase the burden on the subject.

  The present invention has been made to solve the above problems, and an object of the present invention is to provide a fundus oculi observation device that can easily acquire a high-accuracy tomographic image of a desired observation region of the fundus oculi. And

In order to achieve the above object, the invention described in claim 1 includes a light source that outputs low-coherence light, signal light that travels toward the fundus of the eye to be examined, and reference light that travels toward a reference object. An interference light generating means for generating interference light by superimposing the signal light passing through the fundus and the reference light passing through the reference object, and detecting means for detecting the generated interference light, A fundus oculi observation device comprising image forming means for forming image data of the tomographic image of the fundus oculi based on a detection result by the detection means, wherein the operation means, the type of the fundus observation site, and the position of the reference object And a control means for determining the position of the reference object based on the observation site of the fundus designated by operating the operation means, and the reference object in the traveling direction of the reference light. before so moved And a driving means for Ru is disposed in a position obtained is characterized by.

The invention according to claim 2 is the fundus oculi observation device according to claim 1, wherein the image forming means includes a tomographic image of the fundus including normal image data and reverse image data. Image data is formed, further comprising display means, wherein the control means generates interference based on the reference light that has passed through the reference object and the signal light that has passed through the fundus after being moved by the driving means. One of normal image data and reverse image data in image data of the fundus tomographic image formed based on light is selected based on the designated fundus observation site, and the selected normal image or the fundus tomographic image based on the image data of the inverse image Ru is displayed on the display means, is characterized in the this.

Further, the invention according to claim 3 is the fundus oculi observation device according to claim 1, wherein the driving means is configured to perform the division of the low-coherence light when the choroid is designated as the observation site. The reference object is moved to a position where the optical path length of the reference light is longer than the optical path length from the position to the surface of the fundus.

The invention according to claim 4 is the fundus oculi observation device according to claim 2, wherein when the choroid is designated as the observation site, the driving means is configured to perform the division of the low-coherence light. The reference object is moved to a position where the optical path length of the reference light is longer than the optical path length from the position to the surface of the fundus, and the control means selects normal image data in the image data of the tomographic image. The tomographic image of the fundus oculi based on the image data of the normal image is displayed on the display means.

The invention according to claim 5 is the fundus oculi observation device according to claim 2, wherein when the choroid is designated as the observation site, the driving means is configured to perform the division of the low-coherence light. The reference object is moved to a position where the optical path length of the reference light is longer than the optical path length from the position to the surface of the fundus, and the control means selects image data of an inverse image in the image data of the tomographic image. The direction of the fundus tomographic image based on the image data of the reverse image is reversed, and the tomographic image with the reversed direction is displayed on the display means.

The invention according to claim 6 is the fundus oculi observation device according to claim 1, wherein the driving means is configured to perform the division of the low-coherence light when the retina is designated as the observation site. The reference object is moved to a position where the optical path length of the reference light is shorter than the optical path length from the position to the surface of the fundus.

Further, the invention according to claim 7, the fundus observation device according to claim 2, when the retina is the designated as the observation site, said drive means, said division of said low coherence light The reference object is moved to a position where the optical path length of the reference light is shorter than the optical path length from the position to the surface of the fundus, and the control means selects image data of an inverse image in the image data of the tomographic image. The tomographic image of the fundus oculi based on the image data of the reverse image is displayed on the display means.

The invention according to claim 8 is the fundus oculi observation device according to claim 2, wherein when the retina is designated as the observation site, the driving means is configured to perform the division of the low-coherence light. The reference object is moved to a position where the optical path length of the reference light is shorter than the optical path length from the position to the surface of the fundus, and the control unit selects normal image data in the image data of the tomographic image. The direction of the tomographic image of the fundus based on the image data of the normal image is inverted, and the tomographic image with the inverted direction is displayed on the display means.

The invention according to claim 9 divides the output low-coherence light into signal light directed to the fundus of the eye to be examined and reference light directed to the reference object, and outputs the low-coherence light. Interference light generating means for generating interference light by superimposing signal light passing through the reference object and reference light passing through the reference object, detection means for detecting the generated interference light, and detection results by the detection means A fundus oculi observation device that forms image data of a tomographic image of the fundus oculi based on the fundus oculi observation device, wherein the image formation unit includes normal image data and reverse image data. Forming tomographic image data, and displaying means, driving means for moving the reference object in the direction of travel of the reference light, reference light passing through the reference object after movement and a signal passing through the fundus Life based on light One of the normal image data and the reverse image data in the tomographic image data of the fundus formed based on the interference light is selected based on the position of the reference object after the movement, and the selection Control means for causing the display means to display the tomographic image of the fundus oculi based on the image data of the normal image or the reverse image.

The invention described in claim 10 is the fundus oculi observation device according to claim 9 , wherein the driving means causes the low-coherence light from the division position to the surface of the fundus to be longer than the optical path length. When the reference object is moved to a position where the optical path length of the reference light becomes long, the control unit selects normal image data in the image data of the tomographic image, and the control unit selects the normal image data based on the normal image data A tomographic image of the fundus is displayed on the display means.

Further, the invention according to claim 11 is the fundus oculi observation device according to claim 9 , wherein the drive means is more than the optical path length from the division position of the low coherence light to the surface of the fundus. When the reference object is moved to a position where the optical path length of the reference light becomes long, the control unit selects image data of an inverse image in the image data of the tomographic image, and the image data based on the image data of the inverse image The direction of the tomographic image of the fundus is reversed, and the tomographic image with the reversed direction is displayed on the display means.

The invention according to claim 12 is the fundus oculi observation device according to claim 9 , wherein the driving means is more than the optical path length from the division position of the low-coherence light to the surface of the fundus. When the reference object is moved to a position where the optical path length of the reference light is shortened, the control unit selects image data of an inverse image in the image data of the tomographic image, and the image data based on the image data of the inverse image A tomographic image of the fundus is displayed on the display means.

The invention according to claim 13 is the fundus oculi observation device according to claim 9 , wherein the driving means is more than the optical path length from the division position of the low-coherence light to the surface of the fundus. When the reference object is moved to a position where the optical path length of the reference light is shortened, the control unit selects normal image data in the image data of the tomographic image, and the control unit selects the normal image data based on the normal image data. The direction of the tomographic image of the fundus is reversed, and the tomographic image with the reversed direction is displayed on the display means.

  According to the fundus oculi observation device according to the present invention, the fundus oculi observation device includes the drive unit that moves the reference object in the traveling direction of the reference light based on the fundus oculi observation region designated by operating the operation unit. Accordingly, it is possible to easily acquire an image of the depth position of the fundus corresponding to. In particular, by moving the reference object to a position corresponding to the depth position of the designated observation site or a depth position close to the observation site, the measurement of the observation site can be performed with high sensitivity. As described above, according to the present invention, it is possible to easily acquire a high-accuracy tomographic image for a desired observation site of the fundus.

  An example of a preferred embodiment of a fundus oculi observation device according to the present invention will be described in detail with reference to the drawings. Note that the same reference numerals as those in FIGS. 15 and 16 are used for the same components as in the prior art.

  First, the structure of the fundus oculi observation device according to the present embodiment will be described with reference to FIGS. FIG. 1 shows an example of the entire configuration of the fundus oculi observation device 1 according to the present embodiment. FIG. 2 shows an example of the configuration of the scanning unit 141 in the fundus camera unit 1A. FIG. 3 shows an example of the configuration of the OCT unit 150. FIG. 4 illustrates an example of a hardware configuration of the arithmetic control device 200. FIG. 5 shows an example of the configuration of the control system of the fundus oculi observation device 1. FIG. 6 shows an example of the configuration of the control system of the arithmetic and control unit 200.

[overall structure]
As shown in FIG. 1, a fundus oculi observation device 1 includes a fundus camera unit 1A that functions as a fundus camera, an OCT unit 150 that stores an optical system of an optical image measurement device (OCT device), and various arithmetic processes and control processes. Etc., and an arithmetic and control unit 200 that executes the above.

  One end of a connection line 152 is attached to the OCT unit 150. A connector portion 151 is attached to the other end of the connection line 152. This connector portion 151 is attached to the attachment portion 8c shown in FIG. In addition, an optical fiber is conducted inside the connection line 152. The OCT unit 150 and the fundus camera unit 1A are optically connected via a connection line 152. The detailed configuration of the OCT unit 150 will be described later with reference to FIG.

[Configuration of fundus camera unit]
The retinal camera unit 1A has an appearance configuration substantially similar to that of the conventional retinal camera 1000 shown in FIG. Also, the fundus camera unit 1A, like the conventional optical system shown in FIG. 16, illuminates an optical system 100 that illuminates the fundus oculi Ef of the eye E, and photographing that guides the fundus reflected light of the illumination light to the imaging device And an optical system 120.

  In addition, although mentioned later for details, the imaging device 10 in the imaging | photography optical system 120 of this embodiment detects the illumination light which has a wavelength of a near infrared region. The photographing optical system 120 is separately provided with an imaging device 12 for detecting illumination light having a wavelength in the visible region. Further, the photographing optical system 120 guides the signal light from the OCT unit 150 to the fundus oculi Ef and guides the signal light passing through the fundus oculi Ef to the OCT unit 150.

  The illumination optical system 100 includes an observation light source 101, a condenser lens 102, a photographing light source 103, a condenser lens 104, exciter filters 105 and 106, a ring translucent plate 107, a mirror 108, an LCD 109, an illumination stop 110, as in the conventional case. A relay lens 111, a perforated mirror 112, and an objective lens 113 are included.

  The observation light source 101 outputs illumination light having a wavelength in the visible region included in the range of about 400 nm to 700 nm. This observation light source 101 corresponds to an example of a “visible light source” of the present invention. The imaging light source 103 outputs illumination light having a wavelength in the near infrared region included in a range of about 700 nm to 800 nm. The near-infrared light output from the imaging light source 103 is set to be shorter than the wavelength of light used in the OCT unit 150 (described later).

  The photographing optical system 120 includes an objective lens 113, a perforated mirror 112 (hole 112a), a photographing aperture 121, barrier filters 122 and 123, a variable power lens 124, a relay lens 125, a photographing lens 126, a dichroic mirror 134, Field lens (field lens) 128, half mirror 135, relay lens 131, dichroic mirror 136, photographing lens 133, imaging device 10 (imaging device 10a), reflection mirror 137, photographing lens 138, photographing device 12 (imaging device 12a), A lens 139 and an LCD (Liquid Crystal Display) 140 are included.

  Unlike the conventional photographing optical system 120 shown in FIG. 16, the photographing optical system 120 according to the present embodiment has a dichroic mirror 134, a half mirror 135, a dichroic mirror 136, a reflection mirror 137, a photographing lens 138, a lens 139, and an LCD 140. Is provided.

  The dichroic mirror 134 reflects the fundus reflection light (having a wavelength included in the range of about 400 nm to 800 nm) of the illumination light from the illumination optical system 100 and the signal light LS (about 800 nm to 900 nm of the OCT unit 150). It has a wavelength included in the range;

  Further, the dichroic mirror 136 transmits illumination light having a wavelength in the visible region from the illumination optical system 100 (visible light having a wavelength of about 400 nm to 700 nm output from the observation light source 101) and changes the wavelength in the near infrared region. The illumination light (the near infrared light having a wavelength of about 700 nm to 800 nm output from the photographing light source 103) is reflected.

  On the LCD 140, an internal fixation target or the like is displayed. The light from the LCD 140 is collected by the lens 139, reflected by the half mirror 135, and then reflected by the dichroic mirror 136 via the field lens 128. Then, the light enters the eye E through the photographing lens 126, the relay lens 125, the variable power lens 124, the aperture mirror 112 (the aperture 112 a), the objective lens 113, and the like. Thereby, an internal fixation target or the like is projected onto the fundus oculi Ef of the eye E to be examined.

  The image pickup device 10a is an image pickup device such as a CCD or a CMOS built in the image pickup device 10 such as a television camera, and particularly detects light having a wavelength in the near infrared region (that is, the image pickup device 10 is It is an infrared TV camera that detects near-infrared light.) The imaging device 10 outputs a video signal as a result of detecting near infrared light. The touch panel monitor 11 displays a two-dimensional image (fundus image Ef ′) of the surface of the fundus oculi Ef based on this video signal. The video signal is sent to the arithmetic and control unit 200, and a fundus image is displayed on the display (described later). It should be noted that illumination light having a wavelength in the near-infrared region output from the imaging light source 103 of the illumination optical system 100 is used during fundus imaging by the imaging apparatus 10.

  On the other hand, the image pickup device 12a is an image pickup device such as a CCD or a CMOS built in the image pickup device 12 such as a TV camera, and particularly detects light having a wavelength in the visible region (that is, the image pickup device 12 is TV camera that detects visible light.) The imaging device 12 outputs a video signal as a result of detecting visible light. The touch panel monitor 11 displays a two-dimensional image (fundus image Ef ′) of the surface of the fundus oculi Ef based on this video signal. The video signal is sent to the arithmetic and control unit 200, and a fundus image is displayed on the display (described later). It should be noted that illumination light having a wavelength in the visible region output from the observation light source 101 of the illumination optical system 100 is used when photographing the fundus using the imaging device 12.

  The photographing optical system 120 of the present embodiment is provided with a scanning unit 141 and a lens 142. The scanning unit 141 has a configuration that scans light (signal light LS; described later) output from the OCT unit 150 on the fundus oculi Ef.

  The lens 142 makes the signal light LS guided from the OCT unit 150 through the connection line 152 enter the scanning unit 141 as a parallel light beam. The lens 142 acts to focus the fundus reflection light of the signal light LS that has passed through the scanning unit 141.

  FIG. 2 shows an example of a specific configuration of the scanning unit 141. The scanning unit 141 includes galvanometer mirrors 141A and 141B and reflection mirrors 141C and 141D.

  The galvanometer mirrors 141A and 141B are rotatable about the rotation shafts 141a and 141b, respectively. The rotating shafts 141a and 141b are disposed so as to be orthogonal to each other. In FIG. 2, the rotation shaft 141a of the galvano mirror 141A is arranged in a direction parallel to the paper surface of FIG. 2, and the rotation shaft 141b of the galvano mirror 141B is orthogonal to the paper surface of FIG. Arranged in the direction. That is, the galvano mirror 141B is configured to be rotatable in a direction indicated by a double-sided arrow in FIG. 2, and the galvano mirror 141A is configured to be rotatable in a direction orthogonal to the double-sided arrow. Accordingly, the pair of galvanometer mirrors 141A and 141B act so as to change the reflection direction of the signal light LS to directions orthogonal to each other. In addition, each rotation operation | movement of the galvanometer mirror 141A, 141B is driven by the below-mentioned mirror drive mechanism (refer FIG. 5).

  The signal light LS reflected by the galvanometer mirrors 141A and 141B is reflected by the reflection mirrors 141C and 141D and travels in the same direction as when incident on the galvanometer mirror 141A.

  As described above, the optical fiber 152 a is electrically connected to the inside of the connection line 152, and the end surface 152 b of the optical fiber 152 a is disposed so as to face the lens 142. The signal light LS emitted from the end surface 152b travels toward the lens 142 while expanding the beam diameter, but is converted into a parallel light beam by the lens 142. On the contrary, the signal light LS passing through the fundus oculi Ef is focused toward the end surface 152b by the lens 142.

[Configuration of OCT unit]
Next, the configuration of the OCT unit 150 will be described with reference to FIG. The OCT unit 150 shown in the figure has an optical system that is almost the same as that of a conventional optical image measurement device, divides light output from a light source into reference light and signal light, and performs reference via a reference object. An interferometer that generates interference light by superimposing light and signal light that has passed through the object to be measured (fundus Ef) is generated, and an image of the object to be measured (fundus Ef) is analyzed by analyzing the detection result of the interference light. Is formed.

  The low coherence light source 160 is configured by a broadband light source such as a super luminescent diode (SLD) or a light emitting diode (LED) that outputs low coherence light L0. The low coherence light L0 is, for example, light having a wavelength in the near infrared region and a temporal coherence length of about several tens of micrometers. The low coherence light L0 output from the low coherence light source 160 has a wavelength longer than the illumination light (wavelength of about 400 nm to 800 nm) of the fundus camera unit 1A, for example, a wavelength included in a range of about 800 nm to 900 nm. . This low coherence light source 160 corresponds to an example of the “light source” of the present invention.

  The low coherence light L0 output from the low coherence light source 160 is guided to an optical coupler 162 through an optical fiber 161 made of, for example, a single mode fiber or a PM fiber (Polarization maintaining fiber). The optical coupler 162 splits the low coherence light L0 into the reference light LR and the signal light LS.

  The optical coupler 162 has both functions of a means for splitting light (splitter) and a means for superposing light (coupler), but here it is conventionally referred to as “optical coupler”. .

  The reference light LR generated by the optical coupler 162 is guided by an optical fiber 163 made of a single mode fiber or the like and emitted from the end face of the fiber. The emitted reference light LR is collimated by the collimator lens 171 and then reflected by the reference mirror 174 (reference object) via the glass block 172 and the density filter 173.

  The reference light LR reflected by the reference mirror 174 passes through the density filter 173 and the glass block 172 again, and is condensed on the fiber end surface of the optical fiber 163 by the collimator lens 171. The collected reference light LR is guided to the optical coupler 162 through the optical fiber 163.

  The glass block 172 and the density filter 173 are used as delay means for matching the optical path lengths (optical distances) of the reference light LR and the signal light LS, and as means for matching the dispersion characteristics of the reference light LR and the signal light LS. It is working.

  Further, the reference mirror 174 is configured to be moved in the traveling direction of the reference light LR (the arrow direction shown in FIG. 3). Thereby, the optical path length of the reference light LR corresponding to the axial length of the eye E to be examined is secured. The reference mirror 174 is moved by a drive mechanism including a drive device such as a motor (reference mirror drive mechanism 243 described later; see FIG. 5).

  On the other hand, the signal light LS generated by the optical coupler 162 is guided to the end of the connection line 152 by an optical fiber 164 made of a single mode fiber or the like. An optical fiber 152 a is conducted inside the connection line 152. Here, the optical fiber 164 and the optical fiber 152a may be configured by a single optical fiber, or may be formed integrally by joining the end faces thereof. Good. In any case, it is sufficient that the optical fibers 164 and 152a are configured to transmit the signal light LS between the fundus camera unit 1A and the OCT unit 150.

  The signal light LS is guided through the connection line 152 and guided to the fundus camera unit 1A. Then, the eye E is passed through the lens 142, the scanning unit 141, the dichroic mirror 134, the photographing lens 126, the relay lens 125, the variable magnification lens 124, the photographing aperture 121, the hole 112a of the aperture mirror 112, and the objective lens 113. (At this time, the barrier filters 122 and 123 are respectively retracted from the optical path).

  The signal light LS incident on the eye E is imaged and reflected on the fundus (retina) Ef. At this time, the signal light LS is not only reflected by the surface of the fundus oculi Ef, but also reaches the deep region of the fundus oculi Ef and is scattered at the refractive index boundary. Therefore, the signal light LS passing through the fundus oculi Ef is light including information reflecting the surface morphology of the fundus oculi Ef and information reflecting the state of backscattering at the refractive index boundary of the deep fundus tissue. This light may be simply referred to as “fundus reflected light of the signal light LS”.

  The fundus reflection light of the signal light LS travels in the reverse direction in the above path, is condensed on the end surface 152b of the optical fiber 152a, enters the OCT unit 150 through the optical fiber 152, and returns to the optical coupler 162 through the optical fiber 164. Come. The optical coupler 162 superimposes the signal light LS and the reference light LR reflected by the reference mirror 174 to generate interference light LC. The generated interference light LC is guided to the spectrometer 180 through an optical fiber 165 made of a single mode fiber or the like.

  Here, the “interference light generating means” of the present invention is configured by an interferometer including at least an optical coupler 162, optical fibers 163 and 164, and a reference mirror 174. In the present embodiment, a Michelson interferometer is used. However, for example, any type of interferometer such as a Mach-Zehnder type can be appropriately used.

  The spectrometer (spectrometer) 180 includes a collimator lens 181, a diffraction grating 182, an imaging lens 183, and a CCD 184. The diffraction grating 182 of the present embodiment is a transmission diffraction grating, but of course, a reflection diffraction grating can also be used. Of course, other photodetecting elements can be used instead of the CCD 184. Such a light detection element corresponds to an example of the “detection means” of the present invention.

  The interference light LC incident on the spectrometer 180 is converted into a parallel light beam by the collimator lens 181 and then split (spectral decomposition) by the diffraction grating 182. The split interference light LC is imaged on the imaging surface of the CCD 184 by the imaging lens 183. The CCD 184 receives this interference light LC and converts it into an electrical detection signal, and outputs this detection signal to the arithmetic and control unit 200.

[Configuration of arithmetic control unit]
Next, the configuration of the arithmetic and control unit 200 will be described. The arithmetic and control unit 200 analyzes a detection signal input from the CCD 184 of the spectrometer 180 of the OCT unit 150 and performs a process of forming a tomographic image of the fundus oculi Ef of the eye E to be examined. The analysis method at this time is the same as the conventional Fourier domain OCT method.

  In addition, the arithmetic and control unit 200 performs a process of forming a two-dimensional image indicating the form of the surface (retina) of the fundus oculi Ef based on the video signals output from the imaging devices 10 and 12 of the fundus camera unit 1A.

  Furthermore, the arithmetic and control unit 200 executes control of each part of the fundus camera unit 1A and control of each part of the OCT unit 150.

  Control of the fundus camera unit 1A includes, for example, output control of illumination light by the observation light source 101 and the imaging light source 103, control of insertion / retraction operations of the exciter filters 105, 106 and barrier filters 122, 123 on the optical path, LCD 139, etc. Display control, movement control of the aperture stop 110 (control of the aperture value), control of the aperture value of the photographing aperture 121, control of movement of the variable power lens 124 (control of magnification), and the like. The arithmetic and control unit 200 controls the rotation operation of the galvanometer mirrors 141A and 141B in the scanning unit 141.

  On the other hand, as control of the OCT unit 150, output control of low coherence light by the low coherence light source 160, movement control of the reference mirror 174, control of the accumulation time of the CCD 184, and the like are performed.

  An example of the hardware configuration of the arithmetic and control unit 200 that operates as described above will be described with reference to FIG. The arithmetic and control unit 200 has a hardware configuration similar to that of a conventional computer. Specifically, it includes a microprocessor 201 (CPU, MPU, etc.), RAM 202, ROM 203, hard disk drive (HDD) 204, keyboard 205, mouse 206, display 207, image forming board 208, and communication interface (I / F) 208. It consists of These units are connected via a bus 200a.

  The microprocessor 201 executes an operation characteristic of the present embodiment by expanding the control program 204 a stored in the hard disk drive 204 on the RAM 202.

  Further, the microprocessor 201 executes control of each part of the device described above, various arithmetic processes, and the like. Also, control of each part of the device corresponding to operation signals from the keyboard 205 and mouse 206, control of display processing by the display 207, control of transmission / reception processing of various data and control signals by the communication interface 209, and the like are executed.

  The keyboard 205, the mouse 206, and the display 207 are used as a user interface of the fundus oculi observation device 1. The keyboard 205 is used as a device for inputting, for example, letters and numbers. The mouse 206 is used as a device for performing various input operations on the display screen of the display 207.

  The display 207 is an arbitrary display device such as an LCD or a CRT (Cathode Ray Tube), displays an image of the fundus oculi Ef formed by the fundus oculi observation device 1, and displays various operation screens and setting screens. To do.

  Note that the user interface of the fundus oculi observation device 1 is not limited to such a configuration. For example, a function for displaying and outputting various information such as a trackball, a joystick, a touch panel LCD, a control panel for ophthalmic examination, and the like. Any user interface means having a function of inputting various information can be used.

  The image forming board 208 is a dedicated electronic circuit that performs processing for forming an image (image data) of the fundus oculi Ef of the eye E. The image forming board 208 is provided with a fundus image forming board 208a and an OCT image forming board 208b. The fundus image forming board 208a is a dedicated electronic circuit that operates to form image data of a fundus image based on video signals from the imaging device 10 and the imaging device 12 of the fundus camera unit 1A. The OCT image forming board 208b is a dedicated electronic circuit that operates to form image data of a fundus image (tomographic image) based on a detection signal from the CCD 184 of the spectrometer 180 of the OCT unit 150. By providing such an image forming board 208, the processing speed of processing for forming image data of a fundus image can be improved.

  The communication interface 209 performs a process of transmitting a control signal from the microprocessor 201 to the fundus camera unit 1A or the OCT unit 150. The communication interface 209 receives video signals from the imaging devices 10 and 12 of the fundus camera unit 1 </ b> A and detection signals from the CCD 184 of the OCT unit 150 and inputs them to the image forming board 208. At this time, the communication interface 209 operates to input video signals from the imaging devices 10 and 12 to the fundus image forming board 208a and to input detection signals from the CCD 184 to the OCT image forming board 208b.

  When the arithmetic and control unit 200 is connected to a network such as a LAN (Local Area Network) or the Internet, the communication interface 209 is equipped with a network adapter such as a LAN card and a communication device such as a modem. It is possible to configure to perform data communication via a network. In that case, a server for storing the control program 204a can be installed, and the arithmetic and control unit 200 can be configured as a client terminal of the server.

[Control system configuration]
The configuration of the control system of the fundus oculi observation device 1 having the above configuration will be described with reference to FIGS. In the block diagram shown in FIG. 5, the part related to the operation and processing according to the present invention is particularly described in the configuration of the fundus oculi observation device 1. Further, the detailed configuration of the arithmetic and control unit 200 is described in the block diagram shown in FIG.

  The control system of the fundus oculi observation device 1 is configured around the control unit 210 of the arithmetic and control unit 200. The control unit 210 includes a microprocessor 201, a RAM 202, a ROM 203, a hard disk drive 204 (control program 204a), a communication interface 209, and the like.

  The control unit 210 executes the above-described control process by the microprocessor 201 that operates based on the control program 204a. In particular, the control of the mirror drive mechanisms 241 and 242 of the fundus camera unit 1A for independently operating the galvanometer mirrors 141A and 141B, and the reference mirror drive mechanism 243 for moving the reference mirror 174 in the traveling direction of the reference light LR. Execute control etc. The reference mirror drive mechanism 243 corresponds to an example of the “drive means” in the present invention.

  The control unit 210 also detects two types of images captured by the fundus oculi observation device 1, that is, a two-dimensional image (fundus image Ef ′) of the surface of the fundus oculi Ef by the fundus camera unit 1A and the detection obtained by the OCT unit 150. Control for displaying an image of the fundus oculi Ef formed based on the signal on the display 207 of the user interface 240 is performed. These fundus images can be individually displayed on the display 207, or they can be displayed side by side. Details of the configuration of the control unit 210 will be described later with reference to FIG.

  The image forming unit 220 forms the image data of the fundus image based on the video signals from the imaging devices 10 and 12 of the fundus camera unit 1A and the image of the fundus image based on the detection signal from the CCD 184 of the OCT unit 150. And processing to form data. The image forming unit 220 includes an image forming board 208. The image forming unit 220 corresponds to an example of the “image forming unit” in the present invention. The “image” and the “image data” corresponding to the “image” may be identified with each other.

  The image processing unit 230 performs various types of image processing on the fundus image formed by the image forming unit 220. For example, processing for forming a three-dimensional image of the fundus oculi Ef based on a tomographic image of the fundus oculi Ef based on a detection signal from the OCT unit 150, various correction processing such as brightness adjustment of the fundus oculi image, and the like are executed.

  As shown in FIG. 6, the user interface (UI) 240 includes a display unit 240A composed of a display device such as a display 207 and an operation unit 240B composed of an input device and an operation device such as a keyboard 205 and a mouse 206. . The display unit 240A corresponds to an example of the “display unit” of the present invention. The operation unit 240B corresponds to an example of the “operation unit” in the present invention.

  The display unit 240A and the operation unit 240B are used when designating an observation site of the fundus oculi Ef. Control unit 210 causes display unit 240A to display a predetermined observation mode designation screen. Here, the observation mode is set in advance for each region to be observed, such as the choroid observation mode selected when it is desired to observe the choroid of the fundus oculi Ef or the retina observation mode selected when the retina is desired to be observed. Has been.

  These observation modes are displayed on the observation mode designation screen in a selectable manner. As a display mode of the observation mode, for example, any method for displaying a desired one from a plurality of options such as a pull-down menu and a check box can be used. The user selects and designates a desired observation mode by operating the operation unit 240B.

(Detailed configuration of control unit)
Details of the configuration of the control unit 210 will be described with reference to FIGS. The control unit 210 corresponds to an example of the “control unit” of the present invention. The control unit 210 includes a main control unit 211, an image storage unit 212, an information storage unit 213, an image data selection unit 214, and an image inversion processing unit 215. A configuration in which the image inversion processing unit 215 is not provided can also be applied (described later).

  The main control unit 211 includes a microprocessor 201 and the like, and controls each part of the fundus oculi observation device 1 (described above).

  The image storage unit 212 stores image data G of a tomographic image of the fundus oculi Ef formed by the image forming unit 220. The storage process of the image data G in the image storage unit 212 and the read process of the image data G from the image storage unit 212 are executed by the main control unit 211. The image data G is the tomographic image data GA and GB shown in FIG. The image storage unit 212 includes a hard disk drive 204.

  In the information storage unit 213, observation mode information 213a is stored in advance. Information regarding the observation mode (observation mode) of the fundus oculi Ef by the fundus oculi observation device 1 is recorded in the observation mode information 213a.

  FIG. 7 shows an example of the observation mode information 213a. In the observation mode information 213a shown in FIG. 7A, a choroidal observation mode and a retina observation mode are set. In addition, for each observation mode, information indicating the position of the reference mirror 174, or image data of the normal image G (Re) or image data of the reverse image G (Im) in the image data G of the tomographic image is selected. Is recorded. Note that the normal image G (Re) and the reverse image G (Im) of the image data G have been described with reference to FIG.

  In the observation mode information 213a of FIG. 7A, “position A” is set as the position of the reference mirror 174 and “normal image (image data)” is set as image data to be selected with respect to the choroid observation mode. Has been. For the choroid observation mode, “position B” is set as the position of the reference mirror 174, and “reverse image (image data)” is set as image data to be selected.

  The main control unit 211 controls the reference mirror drive mechanism 243 based on the observation mode specified by the operation unit 240 and the observation mode information 213a so as to move the reference mirror 174 to the position indicated by the observation mode information 213a. To work.

  Here, the “position A” of the reference mirror 174 is a position indicated by a broken line in FIG. 8, and corresponds to a position A ′ on the back side (+ z direction side in FIG. 1) of the surface of the fundus oculi Ef. That is, the position A and the position A ′ have a positional relationship such that the optical path length (optical distance) from the optical coupler 162 is equal.

  Similarly, the “position B” of the reference mirror 174 is a position indicated by a dotted line in FIG. 8 and is a position corresponding to the position B ′ on the front side (the −z direction side in FIG. 1) of the surface of the fundus oculi Ef. B and the position B ′ have a positional relationship such that the optical path lengths from the optical coupler 162 are equal.

  The image measurement region G (A) in FIG. 8 is a region where an image (tomographic image) is obtained when the reference mirror 174 is disposed at the position A. The image measurement region G (B) is a region where an image (tomographic image) is obtained when the reference mirror 174 is disposed at the position B. The width in the z direction of these image forming regions G (A) and G (B) corresponds to the length of the coherent length of the low coherence light L0.

  FIG. 9A illustrates an example of a tomographic image GA acquired when the reference mirror 174 is disposed at the position A, that is, when the “choroidal observation mode” is designated. This tomographic image (image data) GA has a normal image (image data) GA (Re) and a reverse image (image data) GA (Im). The normal image GA (Re) and the reverse image GA (Im) are mutually targeted images.

  Note that the symbol GAS represents a portion corresponding to the surface of the fundus oculi Ef in the tomographic image of the normal image GA (Re) and the tomographic image of the reverse image GA (Im), and the symbol GAC represents a portion corresponding to the choroid. . In the normal image GA (Re) and the reverse image GA (Im), the choroidal part GAC is more sensitive than the partial GAS on the surface of the fundus oculi Ef.

  Similarly, FIG. 9B shows an example of a tomographic image GB acquired when the reference mirror 174 is disposed at the position B, that is, when the “retinal observation mode” is designated. This tomographic image (image data) GB has a normal image (image data) GB (Re) and a reverse image (image data) GB (Im). The normal image GB (Re) and the reverse image GB (Im) are mutually targeted images.

  The symbol GBS represents a portion corresponding to the surface of the fundus oculi Ef in the tomographic image of the normal image GB (Re) and the tomographic image of the reverse image GB (Im), and the symbol GBC represents a portion corresponding to the choroid. . In the normal image GB (Re) and the reverse image GB (Im), the surface portion of the fundus oculi Ef is more sensitive than the choroid portion GBC.

  The image data selection unit 214 selects image data (normal image / reverse image) corresponding to the designated observation mode based on the observation mode designated using the operation unit 240 and the observation mode information 213a.

  For this purpose, the main control unit 211 sends the observation mode designation content by the operation unit 240 to the image data selection unit 214, reads out the image data G and the observation mode information 213 a, and sends them to the image data selection unit 214. The image data G includes a normal image G (Re) and a reverse image G (Im). The image data selection unit 214 refers to the observation mode information 213a, acquires a component (normal image G (Re) or reverse image G (Im)) of the image data G corresponding to the designated content of the observation mode, and the component Are extracted from the image data G.

  For example, when “retinal observation mode” is designated by the operation unit 240, a signal indicating the designated content is input from the operation unit 240 to the main control unit 211. The main control unit 211 sends the designated content indicated by this signal to the image data selection unit 214. The image data selection unit 214 refers to the observation mode information 213a and recognizes that the image data to be selected corresponding to the designated content “retinal observation mode” is “reverse image”. Then, an inverse image GB (Im) is extracted from the image data G (in this case, the image data GB of the tomographic image in FIG. 9B).

  The image inversion processing unit 215 performs processing to invert the image data selected by the image data selection unit 214 in the z direction as necessary. The image inversion processing unit 215 does not operate when the observation mode information 213a is as shown in FIG. Therefore, when only the observation mode information 213a shown in FIG. 7A is used, the image inversion processing unit 215 need not be provided.

  The image inversion processing unit 215 is necessary when using the observation mode information 213a shown in FIG. 7B, for example. In the observation mode information 213a shown in FIG. 7B, “image data to be selected” corresponding to each observation mode is opposite to that in FIG. 7A.

  When the choroid observation mode is designated, the tomographic image (image data) GA in FIG. 9A is acquired. If the reverse image GA (Im) of the tomographic image GA is displayed on the display unit 240A as it is, the top and bottom are displayed upside down on the display screen (that is, the surface portion GAS of the fundus oculi Ef is on the lower side and the choroid portion is displayed). Displayed with GAC on top.) The image reversal processing unit 215 performs a process of reversing the inverse image GA (Im) in the depth direction so that the surface GAS of the fundus oculi Ef is displayed on the upper side and the choroidal portion GAC is displayed on the lower side.

  Hereinafter, the control mode of scanning of the signal light LS by the control unit 210 and the mode of processing of the detection signal from the OCT unit 150 by the image forming unit 220 and the image processing unit 230 will be described. Note that the processing of the image forming unit 220 and the like with respect to the video signal from the fundus camera unit 1A is the same as the conventional processing, and thus the description thereof is omitted.

[Scanning signal light]
As described above, the scanning of the signal light LS is performed by changing the direction of the reflecting surfaces of the galvanometer mirrors 141A and 141B of the scanning unit 141 of the fundus camera unit 1A. The control unit 210 controls the mirror driving mechanisms 241 and 242 to change the directions of the reflecting surfaces of the galvanometer mirrors 141A and 141B, respectively, and scans the signal light LS on the fundus oculi Ef.

  When the direction of the reflecting surface of the galvanometer mirror 141A is changed, the signal light LS is scanned in the horizontal direction (x direction in FIG. 1) on the fundus oculi Ef. On the other hand, when the direction of the reflecting surface of the galvanometer mirror 141A is changed, the signal light LS is scanned in the vertical direction (y direction in FIG. 1) on the fundus oculi Ef. Further, the signal light LS can be scanned in a direction in which the x direction and the y direction are combined by simultaneously changing the directions of the reflecting surfaces of both the galvanometer mirrors 141A and 141B. That is, by controlling these two galvanometer mirrors 141A and 141B, the signal light LS can be scanned in an arbitrary direction on the xy plane.

  FIG. 10 illustrates an example of a scanning mode of the signal light LS for forming an image of the fundus oculi Ef. FIG. 10A shows an example of a scanning mode of the signal light LS when the fundus oculi Ef is viewed from the direction in which the signal light LS enters the eye E (that is, when viewed from the −z direction to the + z direction in FIG. 1). Represents. FIG. 10B shows an example of an arrangement mode of scanning points (positions where image measurement is performed) on each scanning line on the fundus oculi Ef.

  As shown in FIG. 10A, the signal light LS is scanned in a rectangular scanning region R set in advance. In this scanning region R, a plurality (m) of scanning lines R1 to Rm are set in the x direction. When the signal light LS is scanned along each scanning line Ri (i = 1 to m), a detection signal of the interference light LC is generated.

  Here, the direction of each scanning line Ri is referred to as a “main scanning direction”, and a direction orthogonal to the direction is referred to as a “sub-scanning direction”. Therefore, scanning in the main scanning direction of the signal light LS is executed by changing the direction of the reflecting surface of the galvano mirror 141A, and scanning in the sub-scanning direction changes the direction of the reflecting surface of the galvano mirror 141B. Executed by.

  On each scanning line Ri, as shown in FIG. 10B, a plurality (n) of scanning points Ri1 to Rin are set in advance.

  In order to execute the scan illustrated in FIG. 10, the control unit 210 first controls the galvanometer mirrors 141A and 141B to set the incidence target of the signal light LS on the fundus oculi Ef to the scan start position RS ( Set to scan point R11). Subsequently, the control unit 210 controls the low coherence light source 2, causes the low coherence light L0 to flash, and causes the signal light LS to enter the scanning start position RS. The CCD 184 receives the interference light LC based on the fundus reflection light at the scanning start position RS of the signal light LS and outputs a detection signal to the control unit 210.

  Next, the control unit 210 controls the galvanometer mirror 141A, scans the signal light LS in the main scanning direction, sets the incident target at the scanning point R12, flashes the low coherence light L0, and scans the scanning point. The signal light LS is incident on R12. The CCD 184 receives the interference light LC based on the fundus reflection light at the scanning point R12 of the signal light LS, and outputs a detection signal to the control unit 210.

  Similarly, the controller 210 sequentially flashes the low coherence light L0 at each scanning point while sequentially moving the incident target of the signal light LS from the scanning points R13, R14,..., R1 (n−1), R1n. By emitting light, a detection signal output from the CCD 184 corresponding to the interference light LC for each scanning point is acquired.

  When the measurement at the last scanning point R1n of the first scanning line R1 is completed, the control unit 210 controls the galvanometer mirrors 141A and 141B at the same time so that the incident target of the signal light LS is changed along the line changing scan r. The second scanning line R2 is moved to the first scanning point R21. And the detection signal corresponding to each scanning point R2j is each acquired by performing the above-mentioned measurement about each scanning point R2j (j = 1-n) of this 2nd scanning line R2.

  Similarly, measurement is performed for each of the third scanning line R3,..., The m−1th scanning line R (m−1), and the mth scanning line Rm, and a detection signal corresponding to each scanning point. To get. Note that the symbol RE on the scanning line Rm is a scanning end position corresponding to the scanning point Rmn.

  Thereby, the control unit 210 acquires m × n detection signals corresponding to m × n scanning points Rij (i = 1 to m, j = 1 to n) in the scanning region R. Hereinafter, the detection signal corresponding to the scanning point Rij may be represented as Dij.

  The linked control of the scanning point movement and the output of the low-coherence light L0 as described above is performed, for example, by transmitting a control signal to the mirror driving mechanisms 241 and 242 and a control signal (output request signal) for the low-coherence light source 2. This can be realized by synchronizing the transmission timing with each other.

  When the galvanometer mirrors 141A and 141B are operated as described above, the control unit 210 stores the position of each scanning line Ri and the position of each scanning point Rij (coordinates in the xy coordinate system) as information indicating the operation content. It has come to keep. This stored content (scanning position information) is used in the image forming process as in the prior art.

[About image processing]
Next, an example of processing related to an OCT image by the image forming unit 220 and the image processing unit 230 will be described.

  The image forming unit 220 executes a process of forming a tomographic image of the fundus oculi Ef along each scanning line Ri (main scanning direction). Further, the image processing unit 230 executes a process for forming a three-dimensional image of the fundus oculi Ef based on the tomographic image formed by the image forming unit 220.

  The tomographic image forming process by the image forming unit 220 is configured to include a two-stage arithmetic process, as in the prior art. In the first stage of arithmetic processing, an image in the depth direction (z direction shown in FIG. 1) of the fundus oculi Ef at the scanning point Rij is formed based on the detection signal Dij corresponding to each scanning point Rij.

  FIG. 11 shows an aspect of a tomographic image formed by the image forming unit 220. In the second stage arithmetic processing, a tomographic image Gi of the fundus oculi Ef along this scanning line Ri is formed for each scanning line Ri based on the image in the depth direction at the n scanning points Ri1 to Rin above it. . At this time, the image forming unit 220 determines the arrangement and interval of the scanning points Ri1 to Rin with reference to the positional information (scanning position information described above) of the scanning points Ri1 to Rin, and forms the scanning line Ri. It is supposed to be. Through the above processing, m tomographic images G1 to Gm at different positions in the sub-scanning direction (y direction) are obtained. Each image data of these tomographic images G1 to Gm corresponds to the image data G in FIG.

  Next, a process for forming a three-dimensional image of the fundus oculi Ef by the image processing unit 230 will be described. A three-dimensional image of the fundus oculi Ef is formed based on the m number of tomographic images obtained by the above arithmetic processing. The image processing unit 230 forms a three-dimensional image of the fundus oculi Ef by performing a known interpolation process for interpolating an image between adjacent tomographic images Gi and G (i + 1).

  At this time, the image processing unit 230 determines the arrangement and interval of each scanning line Ri with reference to the position information of each scanning line Ri, and forms this three-dimensional image. In this three-dimensional image, a three-dimensional coordinate system (x, y, z) is set based on the position information (the above-described scanning position information) of each scanning point Rij and the z coordinate in the image in the depth direction. .

  Further, the image processing unit 230 can form a tomographic image of the fundus oculi Ef in a cross section in an arbitrary direction other than the main scanning direction (x direction) based on the three-dimensional image. When a cross section is designated, the image processing unit 230 identifies the position of each scanning point (and / or the interpolated depth direction image) on the designated cross section, and the depth direction image (and / or at each specific position). (Or an interpolated image in the depth direction) is extracted from the three-dimensional image, and a plurality of extracted images in the depth direction are arranged to form a tomographic image of the fundus oculi Ef in the designated cross section.

  Note that an image Gmj shown in FIG. 11 represents an image in the depth direction (z direction) at the scanning point Rmj on the scanning line Rm. Similarly, an image in the depth direction at each scanning point Rij on each scanning line Ri, which is formed in the above-described first stage arithmetic processing, is represented as “image Gij”.

[Operation]
An example of the operation of the fundus oculi observation device 1 having the above configuration will be described with reference to the flowchart shown in FIG.

  First, when the user operates the operation unit 240 to designate an observation mode (S1), the main control unit 211 specifies the position of the reference mirror 174 corresponding to the designated observation mode with reference to the observation mode information 213a. Then, the reference mirror drive mechanism 243 is controlled to move the reference mirror 174 to the specified position (S3).

  Next, in response to a user's measurement start request, the fundus oculi observation device 1 forms image data G of a tomographic image of the fundus oculi Ef (S4). The formed image data G is stored in the image storage unit 212 by the main control unit 211.

  Subsequently, the image data selection unit 214 selects a component (normal image / reverse image) of the image data G corresponding to the designated observation mode based on the observation mode designated by the user and the observation mode information 213a. (S5). (Here, the image inversion processing unit 215 inverts the image data of the selected component as necessary.)

  The main control unit 211 causes the display unit 240A to display a tomographic image of the component of the selected image data G (S6).

[Specific example of operation]
A specific example of the operation of the fundus oculi observation device 1 will be described with reference to FIGS.

(Step S1)
The user operates the operation unit 240B to designate a desired observation mode (choroidal observation mode / retinal observation mode) on the observation mode designation screen (described above) displayed on the display unit 240A.

(Steps S2, S3)
When the choroid observation mode is designated, the main control unit 211 controls the reference mirror drive mechanism 243 to place the reference mirror 174 at the position A.

  On the other hand, when the retinal observation mode is designated, the main control unit 211 controls the reference mirror driving mechanism 243 to place the reference mirror 174 at the position B.

(Step S4)
When the choroidal observation mode is designated, the fundus oculi observation device 1 forms tomographic image data GA shown in FIG. This image data GA has a normal image GA (Re) and a reverse image GA (Im). The formed image data GA is stored in the image storage unit 212.

  On the other hand, when the retina observation mode is designated, the fundus oculi observation device 1 forms the image data GB of the tomographic image shown in FIG. 9B. This image data GB has a normal image GB (Re) and a reverse image GB (Im). The formed image data GB is stored in the image storage unit 212.

(Steps S5 and S6)
When the choroid observation mode is designated, the image data selection unit 214 selectively extracts the normal image GA (Re) of the image data GA of the tomographic image. The main control unit 211 causes the display unit 240A to display the tomographic image GA (Re) based on the extracted image data of the normal image GA (Re).

  On the other hand, when the retinal observation mode is designated, the image data selection unit 214 selectively extracts the inverse image GB (Im) of the image data GB of the tomographic image. The main control unit 211 displays the tomographic image GA (Re) on the display unit 240A based on the image data of the extracted reverse image GB (Im).

[Action / Effect]
The operation and effect of the fundus oculi observation device 1 as described above will be described.

  The fundus oculi observation device 1 operates as follows: the reference mirror 174 is moved to a predetermined position (position A / position B based on the observation part (observation mode) of the fundus oculi Ef designated by operating the operation unit 240B. The reference light LR that has passed through the reference mirror 174 and the signal light LS that has passed through the fundus oculi Ef are superimposed to generate the interference light LC; the generated interference light LC is detected by the CCD 184. Based on the detection signal from the CCD 184, the image data G of the tomographic image of the fundus oculi Ef is formed; one of the normal image G (Re) and the reverse image G (Im) of the formed image data G is designated. The tomographic image of the fundus oculi Ef is displayed on the display unit 240A based on the image data of the selected normal image G (Re) or reverse image G (Im).

  According to the fundus oculi observation device 1 that operates in this manner, the position of the reference mirror 174 is changed corresponding to the designated fundus oculi observation part, thereby obtaining an image of the depth position of the fundus oculi Ef corresponding to the observation part. can do.

  In particular, by moving the reference mirror 174 to a position corresponding to the depth position of the designated observation site or a depth position close to the observation site, the measurement of the observation site can be performed with high sensitivity. For example, when it is desired to observe the choroid of the fundus oculi Ef, the reference mirror 174 is moved to the position A so that the sensitivity around the choroid is increased, and when it is desired to observe the retina, the reference mirror 174 is increased so that the sensitivity around the retina is increased. Is moved to position B.

  Further, the fundus oculi observation device 1 operates to select and display image data of the normal image G (Re) or the reverse image G (Im) in the image data G of the tomographic image according to the designated observation site. . Thereby, on the display screen of the display unit 240A, a tomographic image can be displayed in a suitable display mode in which, for example, the retina is disposed on the upper side and the choroid is disposed on the lower side.

  Thus, according to the fundus oculi observation device 1 of this embodiment, a high-accuracy tomographic image can be easily acquired for a desired observation site of the fundus oculi Ef, and the tomographic image can be displayed in a suitable display mode. it can.

[Modification]
The configuration detailed above is merely an example for favorably implementing the fundus oculi observation device according to the present invention. Therefore, arbitrary modifications within the scope of the present invention can be appropriately made. Hereinafter, some of such modifications will be described.

(Modification 1)
The observation mode information 213a shown in FIG. 7 is an example of what can be applied to the present invention. The information recorded in FIG. 7A and the information recorded in FIG. It is possible to provide an observation mode for any observation site other than the retina.

(Modification 2)
In the above embodiment, the position of the reference mirror 174 and the selected image data (normal image / reverse image) are set for each observation position of the fundus oculi Ef (that is, for each observation mode). The invention is not limited to this.

  As an example, the position of the reference mirror 174 is set for each observation position, and when the position of the reference mirror 174 is moved, the selected image data is determined based on the position after the movement. It can be configured as follows. Here, the selected image data is, for example, determined whether the position of the moved reference mirror 174 is the back side or the front side of the surface of the fundus oculi Ef, and is a normal image or a reverse image according to the determination result. Can be configured to select.

(Modification 3)
The block diagram shown in FIG. 13 represents an example of the configuration of the control system of the fundus oculi observation device according to the modification of the above embodiment. In this fundus oculi observation device, a reference mirror moving operation unit 244 and a reference mirror drive mechanism 245 are provided as a configuration for manually moving the reference mirror 174.

  The reference mirror movement operation unit 244 is configured by a knob provided on the housing of the fundus camera unit 1A, for example. When the user operates the reference mirror moving operation unit 244, the reference mirror driving mechanism 245 operates to move the reference mirror 174 in the traveling direction of the reference light LR.

  Here, the reference mirror drive mechanism 245 may consist only of a mechanical configuration such as a driving force transmission mechanism such as a gear, or may include an electrical configuration such as a motor. In the former case, the power applied by the user is mechanically transmitted to the reference mirror moving operation unit 244 to move the reference mirror 174. On the other hand, in the latter case, when the reference mirror moving operation unit 244 is operated, an operation signal corresponding to the operation content (for example, a pulse signal having the number of pulses corresponding to the rotation angle of the knob) is applied to the reference mirror driving mechanism 245 and is referred to. The mirror driving mechanism 245 generates a driving force based on this operation signal and moves the reference mirror 174.

  The reference mirror position detection unit 246 is a position sensor that detects the position of the reference mirror 174. The detection result is input to the main control unit 211.

  The reference mirror position determination unit 216 determines whether the position of the reference mirror 174 detected by the reference mirror position detection unit 246 is in front of or behind the predetermined position. This predetermined position is, for example, the position of the reference mirror 174 corresponding to the surface of the fundus oculi Ef of the eye E, the result of alignment of the fundus oculi observation device 1 with respect to the eye E (alignment in the z direction), and the position of the eye E It is set based on the measurement data of the axial length. Further, “front” means the direction of movement of the reference mirror 174 corresponding to the front side (the crystalline lens side) of the surface of the fundus oculi Ef as in the position B shown in FIG. As in the position A in the figure, it means the moving direction of the reference mirror 174 corresponding to the back side of the surface of the fundus oculi Ef.

  The image data selection unit 214 selects one of the normal image G (Re) and the reverse image G (Im) of the image data G based on the detection result by the reference mirror position determination unit 216.

  The flowchart shown in FIG. 14 represents an example of the operation of this modification.

  First, the user operates the reference mirror moving operation unit 244 to move the reference mirror 174 to a desired position (S11). At this time, the user displays a tomographic image on the display unit 240A while moving the position of the reference mirror 174, searches for a position where the sensitivity of a desired observation site (choroid, retina, etc.) becomes good, and the reference mirror 174 Determine the position.

  Next, the reference mirror position detection unit 246 detects the position after the reference mirror 174 is moved (S12). The reference mirror position determination unit 216. It is determined whether the detected position of the reference mirror 174 is in front of or behind the predetermined position (S13).

  Subsequently, the fundus oculi observation device forms image data G of a tomographic image of the fundus oculi Ef in response to a user's measurement start request (S14). The formed image data G is stored in the image storage unit 212.

  The image data selection unit 214 selects one of the normal image G (Re) and the reverse image G (Im) of the image data G based on the determination result by the reference mirror position determination unit 216 (S15). When the image data selection unit 214 determines that the position of the reference mirror 174 is ahead of the predetermined position (in this case, an image similar to the tomographic image GB in FIG. 9B is obtained). The inverse image G (Im) is selected. When the position of the reference mirror 174 is behind the predetermined position (an image similar to the tomographic image GA in FIG. 9A is obtained), the image data selection unit 214 displays the normal image G (Re). select.

  The main control unit 211 causes the display unit 240A to display a tomographic image based on the selected normal image G (Re) or reverse image G (Im) (S16).

  In this modification, the normal image G (Re) or the reverse image G (in the image data G of the tomographic image is selected in accordance with the position of the reference mirror 174 manually set by the user (the position where the sensitivity of the observation site becomes good). Im) image data is selected and displayed. Thereby, on the display screen of the display unit 240A, a tomographic image can be displayed in a suitable display mode in which, for example, the retina is disposed on the upper side and the choroid is disposed on the lower side. The displayed tomographic image is an image formed with high accuracy for a site to be observed.

(Other variations)
The fundus oculi observation device according to the present invention has a fundus camera (unit) as a device for forming a two-dimensional image of the fundus surface. For example, any ophthalmologic device such as a slit lamp (slit lamp microscope device) is used. It is also possible to form a two-dimensional image of the fundus surface.

  In the above embodiment, the fundus image is formed by the image forming unit 220 (the image forming board 208) and various control processes are performed by the control unit 210 (the microprocessor 201 or the like). Both of these processes can be performed by one or a plurality of computers.

It is a schematic block diagram showing an example of the whole structure of suitable embodiment of the fundus oculi observation device concerning the present invention. It is a schematic block diagram showing an example of a structure of the scanning unit incorporated in the fundus camera unit in a preferred embodiment of the fundus oculi observation device according to the present invention. It is a schematic block diagram showing an example of a structure of the OCT unit in suitable embodiment of the fundus oculi observation device concerning the present invention. It is a schematic block diagram showing an example of the hardware constitutions of the calculation control apparatus in suitable embodiment of the fundus oculi observation device concerning the present invention. It is a schematic block diagram showing an example of the structure of the control system of suitable embodiment of the fundus oculi observation device concerning the present invention. It is a schematic block diagram showing an example of the structure of the control system of the arithmetic and control unit in suitable embodiment of the fundus oculi observation device concerning the present invention. It is a figure showing the outline | summary of an example of the observation mode information previously memorize | stored in the arithmetic and control apparatus in suitable embodiment of the fundus observation apparatus which concerns on this invention. It is a schematic explanatory drawing for demonstrating the position of the reference mirror moved by suitable embodiment of the fundus oculi observation device concerning the present invention. It is the schematic showing an example of the tomographic image of the fundus acquired by the preferred embodiment of the fundus oculi observation device according to the present invention. FIG. 9A shows an example of a tomographic image acquired when the reference mirror is arranged at a position corresponding to the position A ′ in FIG. FIG. 9B shows an example of a tomographic image acquired when the reference mirror is arranged at a position corresponding to the position B ′ in FIG. It is the schematic showing an example of the scanning aspect of the signal light by suitable embodiment of the fundus oculi observation device concerning the present invention. FIG. 10A illustrates an example of a scanning mode of the signal light when the fundus is viewed from the incident side of the signal light with respect to the eye to be examined. FIG. 10B shows an example of an arrangement mode of scanning points on each scanning line. It is the schematic showing an example of the scanning aspect of the signal light by the suitable embodiment of the fundus oculi observation device concerning the present invention, and the aspect of the tomographic image formed along each scanning line. It is a flowchart showing an example of operation | movement of suitable embodiment of the fundus oculi observation device concerning the present invention. It is a schematic block diagram showing an example of the structure of the control system of the arithmetic and control unit in the modification of suitable embodiment of the fundus oculi observation device concerning the present invention. It is a flowchart showing an example of operation | movement of the modification of suitable embodiment of the fundus observation apparatus which concerns on this invention. It is a schematic side view showing an example of the appearance composition of the conventional fundus oculi observation device (fundus camera). It is the schematic showing an example of the internal structure (structure of an optical system) of the fundus observation apparatus (fundus camera) in the past. It is the schematic showing an example of the aspect of the tomographic image of the fundus acquired by the conventional fundus oculi observation device (optical image measurement device).

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Fundus observation apparatus 1A Fundus camera unit 8c Mounting part 10, 12 Imaging device 100 Illumination optical system 101 Observation light source 103 Imaging light source 120 Imaging optical system 134, 136 Dichroic mirror 141 Scan unit 141A, 141B Galvano mirror 142 Lens 150 OCT unit 151 Connector Unit 152 connection line 152a, 161, 163, 164, 165 optical fiber 160 low coherence light source 162 optical coupler 174 reference mirror 180 spectrometer 184 CCD
200 Arithmetic Control Device 201 Microprocessor 208 Image Forming Board 208a Fundus Image Forming Board 208b OCT Image Forming Board 210 Control Unit 211 Main Control Unit 212 Image Storage Unit 213 Information Storage Unit 213a Observation Mode Information 214 Image Data Selection Unit 215 Image Inversion Processing Unit 216 Reference mirror position determination unit 220 Image forming unit 230 Image processing unit 240 User interface 240A Display unit 240B Operation units 241, 242 Mirror drive mechanism 243, 245 Reference mirror drive mechanism 244 Reference mirror movement operation unit 246 Reference mirror position detection unit L0 Low Coherence light LR Reference light LS Signal light LC Interference light R Scanning region R1 to Rm Scanning line Rij (i = 1 to m, j = 1 to n) Scanning point G, G1 to Gm Tomographic image (image data)
G (Re), GA (Re), GB (Re) Normal image (image data)
G (Im), GA (Im), GB (Im) Inverse image (image data)
GAS, GBS Partial GAC corresponding to the surface of the fundus in the tomographic image, GBC Partial Gij corresponding to the choroid in the tomographic image (i = 1 to m, j = 1 to n) Image in the depth direction E Subject eye Ef Fundus Ef ′ Fundus Image (2D image)

Claims (13)

  1. A light source that outputs low coherence light;
    The output low-coherence light is divided into signal light directed to the fundus of the eye to be examined and reference light directed to the reference object, and interference is performed by superimposing the signal light passing through the fundus and the reference light passing through the reference object. Interference light generating means for generating light;
    Detecting means for detecting the generated interference light;
    An image forming means for forming image data of the tomographic image of the fundus based on the detection result by the detecting means;
    A fundus oculi observation device comprising:
    Operation means;
    Control means for preliminarily storing information associating the type of the observation site of the fundus and the position of the reference object, and determining the position of the reference object based on the observation site of the fundus designated by operating the operation means; ,
    Driving means Ru is disposed on the obtained position wherein by moving the reference object in the traveling direction of the reference light,
    Comprising
    A fundus oculi observation device characterized by that.
  2. The image forming unit forms image data of the tomographic image of the fundus including image data of a normal image and image data of a reverse image,
    Further comprising a display means,
    The control means includes a tomographic image of the fundus formed on the basis of interference light generated based on reference light that has passed through the reference object after being moved by the driving means and signal light that has passed through the fundus. One of normal image data and reverse image data in the image data is selected based on the designated fundus observation region, and the fundus tomography is based on the selected normal image or reverse image data. Ru display the image on the display means,
    The fundus oculi observation device according to claim 1, wherein the this.
  3. When the choroid is designated as the observation site, the driving means is configured such that the optical path length of the reference light is longer than the optical path length from the division position of the low-coherence light to the surface of the fundus. Move the reference object,
    The fundus oculi observation device according to claim 1.
  4. When the choroid is designated as the observation site,
    The driving means moves the reference object to a position where the optical path length of the reference light is longer than the optical path length from the division position of the low-coherence light to the surface of the fundus oculi,
    The control means selects normal image data in the image data of the tomographic image, and causes the display means to display the tomographic image of the fundus based on the normal image data;
    The fundus oculi observation device according to claim 2.
  5. When the choroid is designated as the observation site,
    The driving means moves the reference object to a position where the optical path length of the reference light is longer than the optical path length from the division position of the low-coherence light to the surface of the fundus oculi,
    The control means selects reverse image data in the image data of the tomographic image, inverts the direction of the tomographic image of the fundus based on the image data of the reverse image, and converts the tomographic image whose direction is inverted to the Display on the display means,
    The fundus oculi observation device according to claim 2.
  6. When the retina is designated as the observation site, the driving means is configured such that the optical path length of the reference light is shorter than the optical path length from the division position of the low-coherence light to the surface of the fundus. Move the reference object,
    The fundus oculi observation device according to claim 1.
  7. When the retina is designated as the observation site,
    The drive means moves the reference object to a position where the optical path length of the reference light is shorter than the optical path length from the division position of the low-coherence light to the surface of the fundus oculi,
    The control means selects image data of a reverse image in the image data of the tomographic image, and causes the display means to display the tomographic image of the fundus based on the image data of the reverse image;
    The fundus oculi observation device according to claim 2.
  8. When the retina is designated as the observation site,
    The drive means moves the reference object to a position where the optical path length of the reference light is shorter than the optical path length from the division position of the low-coherence light to the surface of the fundus oculi,
    The control means selects normal image data in the image data of the tomographic image, inverts the direction of the tomographic image of the fundus based on the image data of the normal image, and converts the tomographic image whose direction is inverted to the Display on the display means,
    The fundus oculi observation device according to claim 2.
  9. A light source that outputs low coherence light;
    The output low-coherence light is divided into signal light directed to the fundus of the eye to be examined and reference light directed to the reference object, and interference is performed by superimposing the signal light passing through the fundus and the reference light passing through the reference object. Interference light generating means for generating light;
    Detecting means for detecting the generated interference light;
    An image forming means for forming image data of the tomographic image of the fundus based on the detection result by the detecting means;
    A fundus oculi observation device comprising:
    The image forming unit forms image data of the tomographic image of the fundus including image data of a normal image and image data of a reverse image,
    Display means;
    Driving means for moving the reference object in the traveling direction of the reference light;
    The image data of the normal image and the reverse of the image data of the tomographic image of the fundus formed based on the interference light generated based on the reference light that has passed through the reference object and the signal light that has passed through the fundus. Control for selecting one of the image data of the image based on the position of the reference object after the movement, and displaying the tomographic image of the fundus based on the selected normal or reverse image data on the display means Means,
    Comprising
    A fundus oculi observation device characterized by that.
  10. When the reference means is moved to a position where the optical path length of the reference light is longer than the optical path length from the division position of the low-coherence light to the surface of the fundus by the driving means, the control means Selecting normal image data in the image data of the tomographic image and displaying the tomographic image of the fundus based on the normal image data on the display means;
    The fundus oculi observation device according to claim 9 .
  11. When the reference means is moved to a position where the optical path length of the reference light is longer than the optical path length from the division position of the low-coherence light to the surface of the fundus by the driving means, the control means , Selecting reverse image data in the image data of the tomographic image, reversing the direction of the tomographic image of the fundus based on the image data of the reverse image, and displaying the tomographic image with the reversed direction on the display means Let
    The fundus oculi observation device according to claim 9 .
  12. When the reference means is moved to a position where the optical path length of the reference light is shorter than the optical path length from the division position of the low-coherence light to the surface of the fundus by the driving means, the control means Selecting image data of a reverse image in the image data of the tomographic image, and displaying the tomographic image of the fundus based on the image data of the reverse image on the display means,
    The fundus oculi observation device according to claim 9 .
  13. When the reference means is moved to a position where the optical path length of the reference light is shorter than the optical path length from the division position of the low-coherence light to the surface of the fundus by the driving means, the control means Selecting normal image data in the image data of the tomographic image, reversing the direction of the tomographic image of the fundus based on the image data of the normal image, and displaying the tomographic image with the reversed direction on the display means Let
    The fundus oculi observation device according to claim 9 .
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