JP4879000B2 - Disinfectant - Google Patents

Description

  The present invention relates to a sterilization deodorant, and more particularly, to a sterilization deodorant that prevents fragrance from changing in fragrance by containing menthol and fragrance in a porous body.

  A wide variety of fragrances are used for fragrance in fragrances, deodorants and the like used in general living spaces. However, in combination with various additives used for formulation, there is a problem with the stability of the fragrance, such as the fragrance (fragrance quality) being impaired or the deterioration or change of the fragrance over time. Is seen.

In order to solve such a problem, means aimed at stabilizing the fragrance have been studied so far. For example, using a carrier having a double structure composed of two kinds of inorganic materials (Patent Document 1), a perfume, a specific oil-absorbing carrier, a binder, etc. are consolidated by extrusion granulation to form particles and stability during transportation. (Patent Document 2), and a method of stabilizing a fragrance by blending it into a spherical silicone resin powder and a fragrance composition (Patent Document 3) is known.
JP 58-159751 A JP-A-2005-330362 JP-A-9-263525

  However, in the formulation, it is often used in combination with various additives as described above rather than using only the fragrance, and menthol and the fragrance are used together as the inventor proceeds to study in such a situation. As a result, a change in fragrance (occurrence of off-flavor) was observed. However, since there is no effective means for solving such a problem even in view of the prior art, the present invention provides a means for solving this problem.

As a result of intensive studies to solve the above-mentioned problems, the present inventor has obtained a porous body, in particular, to prevent a change in the fragrance that occurs when menthol and a fragrance are used in combination, and to stably maintain for a long time. The inventors have found that a porous body that is calcium silicate or aluminum silicate is effective, and has completed the present invention. That is, the present invention is achieved by the following means (1) to ( 4 ).

(1) A sterilizing and deodorizing agent that stably maintains the fragrance of a fragrance by containing menthol and a fragrance in a porous body that is calcium silicate or aluminum silicate.
(2) It is characterized by holding 1 to 100% by mass of menthol and 2 to 200% by mass of a fragrance with respect to 100% by mass of a porous body which is calcium silicate or aluminum silicate (1) The disinfectant and deodorant described in 1.
(3) The disinfectant and deodorant according to (3), wherein the particle size of the porous body made of calcium silicate or aluminum silicate is 0.5 to 10 mm.
(4) A disinfectant deodorant fragrance characterized by mixing menthol and a fragrance to form a liquid, and impregnating and holding the liquid in a porous body made of calcium silicate or aluminum silicate . A method of stabilizing fragrance .

  By this invention, the fragrance | flavor in the disinfection deodorant containing a menthol and a fragrance | flavor can be maintained stably for a long period of time. By using the sterilizing and deodorizing agent of the present invention, it is possible to effectively perform sterilization and deodorization in a car such as an automobile or a railway, a room such as a house or a building, an air conditioner circuit, or the like. When used in these, it is excellent in sterilizing effect and can maintain a fragrance for a long period (about 2 weeks). Moreover, there is no burning odor even if it is used after being evaporated by heating.

  Hereinafter, the present invention will be described in more detail based on embodiments of the present invention.

  The present invention relates to a sterilizing and deodorizing agent containing menthol and a fragrance in a porous body, and a sterilizing and deodorizing effect is mainly obtained by the action of menthol as an active ingredient. The effect of sterilization assists the sterilization and deodorization effect, and the product value is enhanced by improving the feeling of use by adding fragrance.

  As a fragrance, for example, soap, lemon, forest, lavender, apple, peach, lime, orange, rose, herb mint, marine, musk, coconut, vanilla, grapefruit, etc. Rather, one type or a combination of two or more types appropriately selected from the group consisting of natural fragrances, synthetic fragrances, natural extracts and the like is used depending on the application.

  Examples of the fragrance used for preparing the fragrance having the fragrance include lemon oil, lime oil, grapefruit oil, mandarin oil, thyme red oil, pine oil, citronella oil, eucalyptus oil, lemongrass oil, orange oil, Bergamot oil, camomil oil, pinene, limonene, linalool, linalool oxide, anethole, rubofix, hexenyl salicylate, florarozone, helional, ethylmethylphenylglycidate, raspberry ketone, undecalactone, deltadecalactone, gammadecalactone, deltown decalactone , Delta dodecalactone, gamma dodecalactone, deltanonalactone, raspberry ketone, poilenate, allylphenoxyacetate, α Is β-damascone (2,6,6-trimethyl-trans-1-crotonylcyclohexene-1 or 2), dimethylbenzylcarbinyl acetate, furtate, decenol, diphenylmethane, cisjasmon, dihydrojasmon, edion, dimethylanthranilate Methyl anthranilate, cyclamenaldehyde (p-isopropyl-α-methylhydrocinnamic aldehyde), methyl-β-naphthyl ketone, benzophenone, tonalide (7-acetyl-1,1,3,4,4,6-hexa) Methyltetrahydronaphthalene), phenylacetaldehyde, allyl ionone, dihydro-β-ionone, ionone α, ionone β, cedryl methyl ether, moth synth, cashmere, celestride, ethylene brush rate, mu Sconone, pentalide, cybetone, phenylethylphenylacetate, ethylvanillin, vanillin, heliotropin, heliotropylacetate, methylnonylacetaldehyde, allylcyclohexanepropionate, eugenol, citronenol, magnole, citronellylate, diphenyloxide, rosinol, Hexylcinnamic aldehyde, lyial (p-tert-butyl-α-methylhydrocinnamic aldehyde), lyral [4- (4-hydroxy-4-methylpentyl) -3-cyclohexene-1-carboxaldehyde], helional, citronellal , Hydroxycitronellal, methyl ionone, cedarwood oil, cedrol, cedryl acetate, acetyl cedrene, cedryl methyl 1 type or 2 or more types of natural perfume, synthetic perfume, natural extract such as ether, iso-e super, sandal synth, patchouli oil, pearlride, indole, cinnamic alcohol, coumarin, amyl salicylate, benzyl salicylate Can be mentioned. Moreover, it is good also as a desired fragrance | flavor combining not only the said fragrance | flavor but these.

  As menthol, for example, isomers such as L-menthol and dl-menthol and mixtures thereof can be used, and those extracted from natural products by a known method (for example, JP-A-8-187039) can be used. Alternatively, those synthesized by a known method (for example, JP-A-2002-30009) may be used.

  Examples of the porous body include a silicon-containing compound. Examples of the silicon-containing compound include silicates and aluminosilicates, and specific examples thereof include amorphous silicate (“Tokusil NR” manufactured by Tokuyama), bentonite (“Laundrosil DGA powder” manufactured by Sud Kemi), and silica. Examples thereof include calcium acid (“FLORITE” manufactured by Tokuyama) and aluminum siliconate (“TIXOLEX 25” manufactured by Han-France Chemical). Among these, calcium silicate and aluminum silicate are particularly preferable.

  The particle size of the silicon-containing compound is 0.5 to 10 mm, preferably 1 to 5 mm. When the disinfecting deodorant of the present invention is applied as the preparation B for heat evaporation used in the self-heating device 1, the silicon-containing compound remains in the container after heating. Even if the apparatus 1 rolls over and cleans up after cleaning, the particle size within this range can be easily removed with a vacuum cleaner or the like without rising up to the surroundings. This can improve the convenience for the user. In the manufacturing process, it is easy to handle and does not soar.

  The disinfectant and deodorant of the present invention preferably holds 1 to 100% by mass of menthol and 2 to 200% by mass of fragrance with respect to 100% by mass of the porous body. As the disinfectant and deodorant of the present invention, a silicon-containing compound retaining menthol and a fragrance may be used as it is, or it may be granulated as follows. When used as the above-mentioned preparation B for heat transpiration, it is preferably used as it is because there is almost no burning odor.

  In order to obtain the disinfectant and deodorant of the present invention, menthol (crystalline) is first mixed with a fragrance (liquid) to form a liquid, and then the liquid is immersed in a porous material and dropped to a saturated impregnation amount. What is necessary is just to hold | maintain in the range. It can be used as the porous body itself obtained as described above, or granulated using a binder or other base material.

  The disinfectant and deodorant of the present invention may be used by mixing medicinal ingredients, binders, solvents and the like. These medicinal ingredients, binders, solvents and the like can be used in necessary amounts within a range that does not adversely affect the effects of the present invention.

  The form of the disinfecting and deodorizing agent of the present invention can be appropriately determined according to the disinfecting and deodorizing object and application (purpose of use). Specific examples include a liquid form, a solid form obtained by granulating and drying a disinfecting deodorant (eg, powder form, granule form, tablet form, etc.), cream form (including paste form and gel form). , Spraying agent form (spray form) and the like.

  When granulating and drying the disinfectant and deodorant of the present invention to obtain a solid form, the medicinal component can be retained by spraying and dipping after granulation, in addition to kneading at the time of granulation. Examples of the binder used for granulation include celluloses such as carboxymethylcellulose, hydroxymethylcellulose, and hydroxypropylmethylcellulose, starches such as starch and starch, natural polymer compounds such as gum arabic, polyvinyl alcohol, and polyvinylpyrrolidone. 1 type, or 2 or more types, such as synthetic polymer compounds, etc. are mentioned. Moreover, as a solvent used in the case of granulation, 1 type (s) or 2 or more types, such as water, alcohols, paraffins, ethers, esters, are mentioned.

  The disinfecting deodorant of the present invention can be prepared and used in a form supported on a suitable support. Examples of the support include paper, nonwoven fabric, woven fabric, wood, various fiber materials, and various resins (film, sheet, etc.).

  The disinfectant and deodorant of the present invention can be applied to, for example, the preparation B for heat evaporation used in the self-heating device 1 shown in FIG. The preparation B for heat evaporation is used by being contained in a container, and the medicinal component in the preparation is evaporated by heating by a heating means arranged outside the container.

  Examples of the container include a plastic container, a paper container, a metal container, a ceramic container, and a glass container. Moreover, as a heating means, for example, a heat generation method using a reaction between a water heat generation substance such as calcium oxide, magnesium chloride, aluminum chloride, calcium chloride, iron chloride and water (see FIG. 1); iron powder and ammonium chlorate Air oxidation exothermic method using metals that generate heat by oxidation reaction such as iron and potassium sulfate mixture; electric heating method using nichrome wire, positive temperature coefficient thermistor, semiconductor heater, etc .; platinum catalyst method It is done.

  The illustrated self-heating device 1 includes a bottomed cylindrical outer container 2, and a hydrothermal substance A is accommodated from the bottom to the side. Further, the inside of the outer container 2 is partitioned into two spaces by a partition member 4. The outer container 2 has a plurality of water holes at the bottom, and the water holes are closed by a member having water permeability, for example, a nonwoven fabric sheet 3. In use, by placing the self-heating device 1 in a container 20 containing water W, the water W flows into the outer container 2 through the water passage hole, and further penetrates the nonwoven fabric sheet 3 to come into contact with the hydrothermal substance A. The heat evaporating agent B is heated by the reaction heat generated at that time, and the active ingredient is vaporized, and is released to the outside (inside the room) through the vent hole of the hot melt film 7 and the opening of the lid member 6.

  Agents such as a disinfectant, a deodorant, a fragrance, an insecticide, and a pest repellent can be optionally added to the disinfectant and deodorant of the present invention. These agents may be dipped and held in a silicon-containing compound as described above, or kneaded into a granulated granule or the like and held in an effective amount by spraying, dipping, or the like.

  Examples of the disinfectant include isopropylmethylphenol, p-hydroxybenzoate (ethyl, propyl, butyl), IPBC, chlorhexidine gluconate, chlorhexidine hydrochloride, N- (dichlorofluoromethylthio) -phthalamide, N ′-(dichlorofluoromethylthio). ) N, N′-dimethyl-N′-phenyl-sulfamide, polyoctylpolyaminoethylglycine, thiabentazole, triclosan, p-chlorometaxylenol (PCMX), sorbic acid and the like.

  Examples of the deodorant include lauryl methacrylate, geranyl chlorinate, catechin, 4-hydroxy-6-methyl-3- (4-methylpentanoyl) -2-pyrone, cyclodextrin, polyphenol, oxyflavan, flavonol and the like. Is mentioned.

  Examples of insecticides include natural pyrethrin, pyrethrin, allethrin, phthalthrin, resmethrin, framethrin, permethrin, phenothrin, ciphenothrin, praretrin, transfluthrin, methfluthrin, profluthrin, imiprothrin, empentrin, ethofenprox, and sylfluofen. Compounds: Carbamate compounds such as propoxur and carbaryl; Organophosphorus compounds such as fenitrothion and DDVP; Oxadiazole compounds such as metoxadiazone; Phenylpyrazole compounds such as fipronil; Neonicotinoid compounds such as imidacloprid and dinotefuran; Amidoflumet Nitroguadinine-based compounds such as metoprene and hydroprene insect juvenile hormone-like compounds; Anti-juvenile hormone-like compounds such as ecdyson; molting hormone-like compounds such as ecdysone; essential oils such as phytoncide, light-loading oil, orange oil, cinnamon oil, and clove oil; It is done.

  Examples of the pest repellent include DEET, di-n-butyl succinate, hydroxyanisole and the like.

  Furthermore, you may contain a disintegrating agent, a rust preventive agent, a stabilizer, etc. as needed. Examples of the disintegrant include organic acid esters such as paraoxybenzoic acid ester, stearic acid ester, ethyl lactate, and chlorophenyl salicylate; organic acids such as malic acid, fumaric acid, tartaric acid, adipic acid, and succinic acid. When these disintegrating agents are used, the disintegration of the preparation by heating is promoted, and the transpiration of the medicinal components becomes smoother.

  Examples of the rust inhibitor include 1,2,3-benzotriazole, dicyclohexylammonium nitrite and the like. Examples of the stabilizer include dibutylhydroxytoluene and butylhydroxyanisole. Furthermore, if necessary, various surfactants, efficacy enhancers, dyes and the like can be used.

  Examples of the object (bad odor component) to be deodorized by the disinfectant and deodorant of the present invention include sulfur compounds such as mercaptan, nitrogen-containing compounds such as indole, skatole, ammonia, urea, and amine. .

  As an object to be deodorized by the disinfectant and deodorant of the present invention, for example, car odor, toilet odor, kitchen odor, refrigerator odor, food odor such as fish and vegetables, cigarette odor, clothes odor, The smell of shoes, the bad smell derived from the river and the sea, the bad smell from various factories, the foot odor, the smell of pets, etc. can be mentioned. Moreover, microorganisms such as Escherichia coli, mold, yeast, and general bacteria can be listed as targets to be sterilized by the sterilizing and deodorizing agent of the present invention. The disinfecting and deodorizing agent of the present invention can be used in various forms depending on the object to be disinfected and deodorized. That is, the disinfecting and deodorizing agent of the present invention includes, for example, in-car disinfecting deodorant, kitchen disinfecting deodorant, toilet disinfecting deodorant, indoor disinfecting deodorant, and garbage disinfecting. It can be used as a deodorant, an industrial disinfectant, a pet disinfectant, and the like.

<Sample preparation>
In the formulation described in Table 3, L-menthol and the fragrance described in Table 1 were first mixed to form a liquid, and the obtained liquid was immersed in calcium silicate or talc to a saturated amount and held.

<Evaluation of stability>
An aluminum gusset bag was filled with a sterilization deodorant having the formulation shown in Table 3, and sealed to prepare a specimen. Sample 9 is an example of the present invention. After the specimen was stored at 50 ° C. for 1 month, the gusset bag was cut with scissors, the scent inside the gusset bag was directly sniffed, and sensory evaluation was performed by 10 panelists at the evaluation points shown in Table 2. The results are shown in Table 3.

<Evaluation by car>
In the apparatus shown in FIG. 1, the disinfecting deodorant prepared as described above was used as the heat transpiration agent B. Next, the self-heating device 1 was sealed with an aluminum gusset bag to prepare a sample. Sample 9 is an example of the present invention. The fragrance of the specimen was sensory-evaluated by the following procedure, and evaluated according to the evaluation points shown in Table 2.
(1) The engine of an actual vehicle [ordinary vehicle (sedan)] was started, the air conditioner switch was set to “OFF”, the blowing was set to “VENT”, the inside air switching was set to “RECIRC”, and the fan was set to “Hi”.
(2) Water (23 ml) was placed in the container 20.
(3) The container 20 was placed horizontally in the center of the feet of the passenger seat, and a sample was placed.
(4) After the sample was immersed in water, the chemical began to evaporate after 1 to 2 minutes. At that time, the door was closed with the fan set to “Hi” and left for about 10 minutes.
(5) After leaving, the windows and doors were opened and ventilated for about 10 minutes. Thereafter, sensory evaluation was performed by 10 panelists at the evaluation points shown in Table 2 in the car. The results are shown in Table 3.

  As shown in Table 3, as a result of evaluating the stability of specimens 1 to 9, a combination of L-menthol and a fragrance resulted in a change in fragrance over time (sample 3), impregnating talc. When the sample was held, the change was remarkably odorous (Sample 6). On the other hand, by impregnating and holding calcium silicate, such a problem was solved, the change of the fragrance seen over time itself was also eliminated, and the original fragrance of the fragrance could be maintained. In addition, the fragrance | flavor No. described in Table 1. All of 1 to 15 were tested, and the same result was obtained in all cases. Therefore, it was judged that the present invention can prevent the change of the fragrance regardless of the kind of the fragrance.

  Further, as shown in Table 3, the same results were obtained when the transpiration preparation was actually transpirationed in the vehicle. From these results, it was found that the present invention effectively prevents a change in fragrance and provides an excellent commercial value. In this test as well, the perfume No. described in Table 1 was used. All of 1 to 15 were tested, and similar results were obtained in all cases. That is, a change in fragrance (occurrence of off-flavor) is seen by the combination of menthol and fragrance, the off-flavor becomes stronger when talc is used, and the change of fragrance is improved by using calcium silicate I understood.

  Furthermore, in the vehicle in which the specimen 9 was heated and evaporated, the fragrance due to the fragrance was maintained for about two weeks. Moreover, compared with the disinfecting deodorant by the same system, there is almost no burning odor at the time of use, and it is excellent in the feeling of use. As a result of testing in the same manner as in <Car Evaluation>, 90% or more of 15 monitors evaluated that there was almost no burning odor. By the way, the same evaluation was only 7% for commercial products with the same system.

<Evaluation of sterilization effect>
Self-heating device using the apparatus shown in FIG. 1 in the same manner as in the above <Evaluation by car> using 1 g, 0.1 g, and 0.01 g of L-menthol instead of 0.2 g of L-menthol of the specimen 9 Was used to evaluate the sterilization effect.

  The filtrate obtained by adding 10 ml of physiological saline to the slant culture medium in which Aspergillus niger and Penicillium were cultured was diluted 1000-fold, and 100 μl was added dropwise to a petri dish containing an agar medium. This petri dish containing an agar medium was affixed upside down inside the top surface of a cubic box (30 cm × 30 cm × 30 cm), and the self-heating device was evaporated in the cubic box. One week later, the petri dish was taken out and allowed to stand at 25 ° C. for 2 days, and then the sterilization rate (%) was evaluated. As a reference, the sterilization rate (%) when isopropylmethylphenol (hereinafter also referred to as “IPP”), which is a fungicide, was similarly used was evaluated and compared with the case of L-menthol. The results are shown in Table 4.

  As shown in Table 4, L-menthol exhibits a higher sterilizing effect than IPP, which is a fungicide, against Aspergillus niger and blue mold, and has an excellent sterilizing effect in actual use (use in vehicles). It was proved.

It is sectional drawing which shows one use form of the preparation for heat transpiration.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Self-heating device 2 Outer container 3 Nonwoven fabric sheet 4 Partition member 6 Lid member 7 Heat-melt film 20 Container A Hydrothermal substance B Heating transpiration preparation W Water

Claims (4)

A disinfectant and deodorant characterized in that fragrance of fragrance is stably maintained by containing menthol and fragrance in a porous body made of calcium silicate or aluminum silicate.       The menthol is held at 1 to 100% by mass and the fragrance is held at 2 to 200% by mass with respect to 100% by mass of the porous body which is calcium silicate or aluminum silicate. Disinfectant and deodorant.       The disinfectant and deodorant according to claim 1 or 2, wherein the particle size of the porous body made of calcium silicate or aluminum silicate is 0.5 to 10 mm. Menthol and fragrance are mixed to form a liquid, and the liquid is impregnated and held in a porous body made of calcium silicate or aluminum silicate . Stabilization method.

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