JP4874962B2 - 粘膜炎の治療のためのスルグリコチドの使用 - Google Patents
粘膜炎の治療のためのスルグリコチドの使用 Download PDFInfo
- Publication number
- JP4874962B2 JP4874962B2 JP2007517663A JP2007517663A JP4874962B2 JP 4874962 B2 JP4874962 B2 JP 4874962B2 JP 2007517663 A JP2007517663 A JP 2007517663A JP 2007517663 A JP2007517663 A JP 2007517663A JP 4874962 B2 JP4874962 B2 JP 4874962B2
- Authority
- JP
- Japan
- Prior art keywords
- sulglycotide
- mucositis
- treatment
- cells
- mucosa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
放射線誘発された損傷からの腸粘膜のクローン原性細胞の保護におけるスルグリコチドの効力を評価する目的で、動物試験を行った。クローン原性細胞の保護は、正常な上皮の修復を促進する腸の陰窩(crypt)の生存を保証する。本試験で処置された動物は、H.ピロリ(pylori)を有していないか、またはそれらの胃腸の粘膜がこの細菌により引き起こされる炎症の特徴的な兆候を示さない。
集められたデータは、照射損傷へのスルグリコチドの効力および、効力と投与された異なる投与量との間の関連を強調する。最小投与量(12.5 mg/kgおよび50 mg/kg)では、スルグリコチドは、クローン原性細胞および腸の陰窩への損傷に対していかなる予防効果をも示さず;陰窩の生存の増加の証拠および、従って照射損傷からの保護の証拠は、200mg/kgの投与量で見出される(35%)。200 mg/kgより多い投与量はまた、保護的な効力を示さない。しかしながら、予防期間中に有効でありながら、200mg/kgの投与量は、照射後処置の群において活性を示さない。
Claims (3)
- 抗腫瘍治療による口腔粘膜炎の治療のための医薬組成物であって、スルグリコチドを含み、該スルグリコチドが1日当たり800mg/kgの量で投与され、該組成物が局所投与形態である、前記組成物。
- 抗腫瘍治療による口腔粘膜炎の予防のための医薬組成物であって、スルグリコチドを含み、該スルグリコチドが1日当たり200mg/kgの量で投与され、該組成物が局所投与形態である、前記組成物。
- 抗腫瘍治療が化学療法および/または放射線療法である請求項1又は2に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2004A000989 | 2004-05-18 | ||
IT000989A ITMI20040989A1 (it) | 2004-05-18 | 2004-05-18 | Uso del sulglicotide per iul trattamento delle mucositi |
PCT/IT2005/000272 WO2005110458A1 (en) | 2004-05-18 | 2005-05-12 | Use of sulglicotide for the treatement of mucositis |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007538066A JP2007538066A (ja) | 2007-12-27 |
JP2007538066A5 JP2007538066A5 (ja) | 2008-06-26 |
JP4874962B2 true JP4874962B2 (ja) | 2012-02-15 |
Family
ID=34971240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007517663A Expired - Fee Related JP4874962B2 (ja) | 2004-05-18 | 2005-05-12 | 粘膜炎の治療のためのスルグリコチドの使用 |
Country Status (9)
Country | Link |
---|---|
US (1) | US7662777B2 (ja) |
EP (1) | EP1747010B1 (ja) |
JP (1) | JP4874962B2 (ja) |
CN (1) | CN1972705B (ja) |
BR (1) | BRPI0511165A (ja) |
CA (1) | CA2565084C (ja) |
IL (1) | IL178907A0 (ja) |
IT (1) | ITMI20040989A1 (ja) |
WO (1) | WO2005110458A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101851285B (zh) * | 2009-04-03 | 2012-09-12 | 四川德博尔制药有限公司 | 硫酸糖肽的制备方法 |
KR101819709B1 (ko) * | 2017-01-13 | 2018-01-17 | (주)아이엠디팜 | 설글리코타이드 또는 이의 약학적으로 허용가능한 염을 포함하는 안구건조증의 예방 또는 치료용 약학 조성물 |
CN115845127B (zh) * | 2022-12-29 | 2023-11-24 | 海南众森生物科技有限公司 | 一种多糖止血修复生物胶液及其制备方法和用途 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63253029A (ja) * | 1987-01-12 | 1988-10-20 | クリノス・インドウストリア・フアルマコビオロジカ・ソチエタ・ペル・アチオニ | 製薬学的組成物 |
US20030064913A1 (en) * | 2001-08-16 | 2003-04-03 | Sonis Stephen T. | Treatment and prevention of mucositis in cancer patients |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE169226T1 (de) * | 1991-04-12 | 1998-08-15 | Creative Biomolecules Inc | Verwendung von aus blutplättchen gewonnenem wachstumsfaktor zur herstellung eines medikaments zur behandlung von gastrointestinaler geschwüre |
US5496828A (en) * | 1994-08-22 | 1996-03-05 | Eli Lilly And Company | Methods of inhibiting ulcerative mucositis |
US20030236217A1 (en) | 2002-05-21 | 2003-12-25 | Shalwitz Robert A. | Treatment of mucositis |
-
2004
- 2004-05-18 IT IT000989A patent/ITMI20040989A1/it unknown
-
2005
- 2005-05-12 CN CN2005800159271A patent/CN1972705B/zh not_active Expired - Fee Related
- 2005-05-12 WO PCT/IT2005/000272 patent/WO2005110458A1/en active Application Filing
- 2005-05-12 EP EP05742993.8A patent/EP1747010B1/en not_active Not-in-force
- 2005-05-12 BR BRPI0511165-0A patent/BRPI0511165A/pt not_active IP Right Cessation
- 2005-05-12 CA CA2565084A patent/CA2565084C/en not_active Expired - Fee Related
- 2005-05-12 JP JP2007517663A patent/JP4874962B2/ja not_active Expired - Fee Related
- 2005-05-12 US US11/569,095 patent/US7662777B2/en not_active Expired - Fee Related
-
2006
- 2006-10-26 IL IL178907A patent/IL178907A0/en not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63253029A (ja) * | 1987-01-12 | 1988-10-20 | クリノス・インドウストリア・フアルマコビオロジカ・ソチエタ・ペル・アチオニ | 製薬学的組成物 |
US20030064913A1 (en) * | 2001-08-16 | 2003-04-03 | Sonis Stephen T. | Treatment and prevention of mucositis in cancer patients |
Also Published As
Publication number | Publication date |
---|---|
WO2005110458A1 (en) | 2005-11-24 |
US7662777B2 (en) | 2010-02-16 |
EP1747010A1 (en) | 2007-01-31 |
IL178907A0 (en) | 2007-03-08 |
JP2007538066A (ja) | 2007-12-27 |
BRPI0511165A (pt) | 2007-12-04 |
ITMI20040989A1 (it) | 2004-08-18 |
CA2565084C (en) | 2013-09-03 |
CA2565084A1 (en) | 2005-11-24 |
CN1972705A (zh) | 2007-05-30 |
US20080234180A1 (en) | 2008-09-25 |
EP1747010B1 (en) | 2015-01-21 |
CN1972705B (zh) | 2011-11-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Chaveli-López et al. | Treatment of oral mucositis due to chemotherapy | |
RU2162327C2 (ru) | Лечение рака и профилактика метастазирования | |
Sheibani et al. | Efficacy of benzydamine oral rinse in prevention and management of radiation‐induced oral mucositis: a double‐blind placebo‐controlled randomized clinical trial | |
Lehocky et al. | Early enteral feeding in severe acute pancreatitis: can it prevent secondary pancreatic (super) infection? | |
KR20130137696A (ko) | 테트라사이클린류를 함유하는 항염증성 조성물 및 이의 치료 용도 | |
WO2019015279A1 (zh) | Sirt1抑制剂在预防和治疗放射引起的肠道疾病中的应用 | |
EP1704860B1 (en) | Benzamidine derivatives for treatment and prevention of mucositis | |
KR100883999B1 (ko) | 점막염 치료를 위한 설글리코타이드의 용도 | |
JP4874962B2 (ja) | 粘膜炎の治療のためのスルグリコチドの使用 | |
Mason et al. | Drug-induced esophagitis | |
Malaker | Clinical experience with radioprotectors | |
Sartori et al. | Acute gastroduodenal mucosal injury after cisplatin plus etoposide chemotherapy: clinical and endoscopic study | |
TW201902469A (zh) | 二甲雙胍與丁酸鈉於治療慢性發炎造成之病狀的用途 | |
WO2006043336A1 (ja) | 胃粘膜疾患の治療又は予防のための組成物 | |
CN104116732B (zh) | 一种穿心莲内酯的应用 | |
Guo et al. | Topical sucralfate for pain after oral CO2 laser surgery: a prospective, randomized, controlled trial | |
Hall | Rational selection of gastrointestinal drugs for cats and dogs | |
Koc et al. | Therapeutic effect of oral recombinant human granulocyte macrophage-colony stimulating factor in radiotherapy-induced esophagitis | |
Casey | Gastritis and proton pump inhibitors | |
Wiseman et al. | Methods to prevent colonic injury in pelvic radiation | |
Thawani et al. | Mucosal and Esophageal Toxicites of Radiation Therapy | |
RU2219940C1 (ru) | Способ лечения хронического атрофического гастрита | |
Adikwu et al. | The effect of snail mucin on the ulcer healing rate of clarithromycin | |
Horwhat et al. | Radiation enteritis | |
US8323702B2 (en) | Composition and method for treating ulcers |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080502 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080502 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110217 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110516 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110523 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110614 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20111007 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111011 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20111107 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20111124 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20141202 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |