JP4873877B2 - Method for producing sodium alginate-containing tablet and tablet obtained by the production method - Google Patents

Description

  The present invention relates to a method for producing a tablet containing sodium alginate, a tablet obtained by the production method, and the tablet containing essential oil.

  In recent years, dietary fiber has attracted attention as a functional food having actions such as suppression of blood pressure increase, cholesterol level increase suppression, blood sugar level increase suppression, bowel regulation, and constipation suppression. For this reason, many foods containing dietary fiber are commercially available. Dietary fiber refers to indigestible polysaccharides such as lignin that are not hydrolyzed by human digestive enzymes, and is roughly classified into water-soluble dietary fiber and insoluble dietary fiber according to solubility in water. For this reason, it is calculated | required that a dietary fiber is shape | molded in the dosage form (especially tablet) liked with functional foods, such as a supplement.

  However, dietary fiber powder has poor adhesiveness, so it is difficult to prepare tablets even when trying to prepare tablets by a wet granulation method without blending binders and excipients. There were no known dietary fiber tablets. For this reason, in the production of dietary fiber-containing tablets, emphasis has been placed on blending binding components such as binders and excipients for binding dietary fiber. For example, using eggshell powder as a lubricant and tableting chitosan (see, for example, Patent Document 1), seaweed powder, moss powder and water and xylooligosaccharides are mixed and granulated. A technique of tableting and tableting after drying (for example, Patent Document 2) is known. However, the dietary fiber content per unit amount is reduced by blending the binding component, and in order to take a predetermined amount of dietary fiber, it is necessary to take a large amount of tablets. In addition, by blending water, a drying step is necessary thereafter, or the dietary fiber expands and dries and remains bulky. For this reason, in view of dietary fiber content per unit amount of tablet, the number of steps, cost, etc., it is desired to suppress the blending of binding components and moisture as much as possible.

On the other hand, effects such as awakening, sleep, appetite suppression, appetite promotion, smoke suppression, antiemesis, anti-fainting, aphrodisiac, asexuality, etc. can be obtained by applying, spraying, inhaling, chewing, etc. of aroma preparations (mainly natural essential oils) As aromatherapy has recently been attracting attention. However, when trying to produce essential oil-containing tablets, the essential oil component is oily, so it is difficult to fit into ordinary excipients and lubricants, causing problems such as oil floatation and essential oil stability, making tableting difficult. there were.
JP-A-10-225285 JP 2002-65213 A

  Accordingly, an object of the present invention is to provide a dietary fiber-containing tablet in which the combination of binding components is suppressed as much as possible, a tablet containing essential oil, and a method for producing these tablets.

  As a result of intensive studies in view of the above-mentioned problems of the prior art, the present inventors have found that it is a dietary fiber that has been recognized to be difficult to be tableted by tableting. Completion of the present invention by finding that tablets can be tableted and that essential oils that are incompatible with excipients and lubricants are stably held in tablets obtained by tableting sodium alginate I let you.

That is, the present invention provides the following production method and tablet.
Item 1. A method for producing a sodium alginate-containing tablet for tableting sodium alginate powder.
Item 2. Item 2. The production method according to Item 1, wherein the sodium alginate powder has an average particle size of 40 µm to 180 µm.
Item 3. Item 3. The method for producing a tablet according to Item 1 or 2, wherein essential oil is impregnated into a tablet obtained by tableting sodium alginate powder.
Item 4. Item 4. The method according to Item 3, wherein the essential oil is at least one selected from the group consisting of patchouli oil, jasmine oil, sandalwood oil, basil oil, melissa oil, juniper oil, lavender oil, and clove oil.
Item 5. The manufacturing method of claim | item 3 or 4 whose essential oil compounding quantity is 0.01-30 weight part with respect to 100 weight part of sodium alginate.
Item 6. Item 6. A sodium alginate-containing tablet obtained by the production method according to any one of Items 1 to 5.
Item 7. Item 7. The tablet according to Item 6, wherein the content of sodium alginate is 30 to 100% by weight.
The present invention can further include the following tablets.
Item 8. Item 7. A food composition comprising the tablet according to any one of Items 1 to 6.
Item 9. Item 7. A pharmaceutical composition comprising the tablet according to any one of Items 1 to 6.

  The production method of the present invention is characterized in that sodium alginate-containing tablets are produced by tableting sodium alginate powder. In the present specification, a tablet obtained by tableting sodium alginate powder may be referred to as a “plain tablet”. The uncoated tablets can be made into various forms of tablets, coated tablets, dragees, food compositions, and pharmaceutical compositions by impregnating essential oils, coating, sugar coating, and the like.

  Sodium alginate is a known substance, also known as a food additive, and can be produced, for example, by extraction from seaweed by a known method. Sodium alginate is commercially available, and those manufactured by Kimika Co., Ltd. and Kyosei Pharmaceutical Co., Ltd. are known. Although these can also be used for the sodium alginate used in this invention, it is not limited to these, The well-known sodium alginate can be used widely. In this production method, the molecular weight (weight average) of sodium alginate is not particularly limited as long as it is within the range that can be tableted, but is usually 20,000 to 120,000, preferably 40,000 to 70,000. The average particle size of the sodium alginate powder is not particularly limited, but is usually 10 μm to 850 μm, preferably 40 μm to 180 μm.

Next, in the production method of the present invention, the sodium alginate powder is compressed (direct powder compression, direct compression). Dietary fiber has been recognized as difficult to mold by tableting, but sodium alginate is possible. By tableting, the number of steps can be omitted as compared with a dry granule compression method or a wet granule compression method (indirect compression method) for compressing granules. For tableting, known tableting methods can be widely adopted. For example, a rotary (rotary) tableting machine, in which one or more knives / lights are attached to a turntable, and a single turn of the turntable can produce tablets as many as the number of knives / lights attached. A roller type tableting machine or the like can be employed. The tableting pressure can be appropriately set according to the shape and size of the tablet, the particle size of sodium alginate, the type of tableting machine, etc., but usually 0.5 ton / cm ^{2 to} 3 ton ( ton) / cm ² , preferably 1 ton / cm ² to 2 ton / cm ² .

  In the production method of the present invention, as long as tabletability is not impaired, sodium alginate powder, excipients (lactose, sucrose, D-mannitol, starch, calcium hydrogen phosphate, etc.), disintegrant (starch) , Carmellose calcium, croscarmellose sodium, sodium carboxymethyl starch), lubricant (magnesium stearate, purified talc, stearic acid, sucrose fatty acid ester, etc.), binder (crystalline cellulose, starch paste, hydroxypropyl) Cellulose, carmellose, polyvinyl alcohol, polyvinyl pyrrolidone, gum arabic, gelatin, tragacanth, water, ethanol, etc.) and other suitable additives can be mixed and tableted. The content of sodium alginate powder in the raw material powder for tableting is usually 90% by weight or more, preferably 95% by weight or more.

  The sodium alginate-containing tablet (plain tablet) thus obtained is useful as a dietary fiber tablet itself. For this reason, it is also useful as a health food, functional food, food for specified health use, food for the sick, and the like. The shape and size of the tablet are not particularly limited as long as it is a shape and size suitable for taking, for example, a circular shape, an elliptical shape, a square shape, and the weight is 100 to 800 mg, and the size is 6 to 12 mmφ. Preferably, it is circular and has a weight of 400 to 600 mg and a size of 7 to 10 mmφ.

  As described above, the uncoated tablets can be made into various forms of tablets, coated tablets, dragees, food compositions, and pharmaceutical compositions by impregnating essential oils, coating, sugar coating, and the like. The sodium alginate content in these forms is usually 30-100% by weight, preferably 50-100% by weight, more preferably 80-100% by weight, and even more preferably 90-100% by weight. When it is required to increase the amount of sodium alginate per unit amount, a narrow range can be selected from the above ranges.

  The sodium alginate-containing tablet (plain tablet) has good compatibility with the essential oil. By impregnating the essential oil into the plain tablet, the essential oil does not float and a tablet in which the essential oil is stably retained can be obtained. As a method of soaking essential oil, impregnating essential oil into uncoated tablets, spraying essential oil onto uncoated tablets, impregnating essential oil into uncoated tablets, impregnating uncompressed tablets and essential oil with a combination of reduced pressure and increased pressure A known method for holding a liquid in a tablet, such as a method or a method of impregnating at least the inner surface of a hollow expanded puffed tablet with essential oil, can be employed. Preferably, the essential oil is dropped into the uncoated tablet, the essential oil is sprayed onto the uncoated tablet, and the essential oil is impregnated into the uncoated tablet.

Essential oils include patchouli oil, anise oil, cypress oil, cedarwood oil, camphor oil, juniper oil, thyme oil, hyssop oil, bergamot oil, eucalyptus oil, benzoic oil, dairy oil, turpentine oil, pine oil, sage oil, Examples include oregano oil, chamomile oil, clary sage oil, cinnamon oil, geranium oil, rose oil, marjoram oil, lavender oil, and pilling oil. Among these, one kind can be used alone, or two or more kinds can be used in combination. Patchouli oil, jasmine oil, sandalwood oil, basil oil, melissa oil, juniper oil, lavender oil and clove oil are preferred. Patchouli oil in particular has excellent stability when held in sodium alginate. Patchouli oil is known to have an effect on defecation and therefore enhances the bowel movement of sodium alginate. Furthermore, the present inventor has confirmed that patchouli oil suppresses stomach belly caused by sodium alginate, and patchouli oil is also preferable in this respect. Moreover, the compounding quantity of essential oil is 0.01-30 weight part normally with respect to 100 weight part of sodium alginate in an uncoated tablet, Preferably it is 1-5 weight part.
In addition, other components of the essential oil can be added to the uncoated tablet, for example, a food composition such as a fragrance other than the essential oil, a coloring agent, an excipient, a lubricant, a binder, a disintegrant, and a pharmaceutical composition. And additives used in the above. A food composition and a pharmaceutical composition can be produced by a conventional method by adding these other components to the uncoated tablet. In addition, uncoated tablets (including uncoated tablets impregnated with essential oils) can be made into coated tablets (for example, compression-coated tablets, glue-coated tablets, sugar-coated tablets, film-coated tablets, etc.) as necessary. The coating method can be performed by a conventional method. Components for coating (for example, ethylcellulose, casein, methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose phthalate, methacrylic acid copolymer, cellulose acetate phthalate, shellac, gelatin Gum arabic powder, white sugar, white wax, carnauba wax, etc.) can be widely used.

  The intake of the tablet and composition of the present invention can be appropriately determined according to the age, weight, sex, purpose of intake, physical condition, etc. of the person who takes it, and is not particularly limited, but is usually intake of sodium alginate The amount can be taken once or several times a day so that the amount is about 0.01 to 4 g, preferably about 1 to 3 g per adult per day.

  In the present invention, since sodium alginate can be tableted by direct powder compression, tablets containing only sodium alginate can be prepared. As a result, a tablet excellent in the amount of dietary fiber per unit amount can be obtained. Further, it is advantageous in that the number of steps is small and a high temperature is not required as compared with other tablet molding methods. Furthermore, the tablet of the present invention has good compatibility with the essential oil, the oil floating is suppressed, and the essential oil is stably held in the tablet.

  EXAMPLES Hereinafter, although this invention is demonstrated in detail using an Example and a comparative example, this invention is not limited to these.

Example 1
1 kg of sodium alginate powder (average particle size 80 μm, Kimika Argin, manufactured by Kimika Co., Ltd.) was tableted with a single tableting machine (manufactured by Kikusui Seisakusho) at a tableting pressure of 2 ton / cm ² . 500 mg / piece tablets (circular) were obtained.
This tablet does not disintegrate even if it is pinched with a finger, and it is hard enough not to be chewed by teeth, and it is not confirmed cracking, cracking, chipping, etc. even if it is carried in a normal bag and carried through a normal life. Even when stored in a zipper bag, there was no cracking, cracking, chipping, etc., and thus it had sufficient hardness and shape retention in practical use.
Moreover, there was almost no adhesion of the sodium alginate powder to the tablet and thin of a tableting machine, and it was a level which can be mass produced.

Example 2
26 mg of patchouli mint oil (manufactured by Inabata Fragrance Co., Ltd.) was added dropwise to the tablet obtained in Example 1 and allowed to stand for 1 to 2 hours for permeation.
Even when the obtained tablet was pinched with a finger, the oil did not adhere to the finger. In addition, after storing this tablet in a plastic bag with a chuck at room temperature for one month, the amount of oil was measured (the weight of the tablet was measured with an electronic balance (manufactured by Sartorius Co., Ltd., and the change in weight was observed). There was no change, and the retention of essential oil was confirmed.
Also, it is hard enough not to be chewed by teeth, and it is not confirmed cracking, cracking, chipping, etc. even if it is carried in a chuck bag and carrying out normal life, and even if it is stored in a chuck bag for 1 month, it is cracked, cracked, Since there was no chipping, it had sufficient hardness and shape retention in practical use.

Comparative Example 1
Instead of sodium alginate powder, sorbitol (excipient, average particle size 120 μm) was used and tableted under the same conditions as in Example 1, and patchouli mint oil was added dropwise to the obtained tablets under the same conditions as in Example 2. .
Although it was able to be molded once by tableting, the surface has viscosity, sorbitol adheres to the kneading and thinning of the tableting machine, and sticking occurs. Mass production was not good. In addition, the oil-dropped tablet had oil on the surface after 3 hours and 24 hours, and was sticky when pinched with a finger. When this tablet was stored in a plastic bag with a chuck at room temperature and observed after 3 days, the tablet adhered to the bag.

Comparative Example 2
651 g sodium alginate, 35 g patchouli mint oil and 14 g sucrose fatty acid ester (lubricant, average particle size 120 μm, DK ester F-20W, manufactured by Daiichi Pharmaceutical Co., Ltd.) were mixed. When this mixture was tableted under the same conditions as in Example 1, the powder of the mixture was very smooth and could not be molded as a tablet.

Comparative Example 3
38 g sodium alginate and 2 g patchouli mint oil were mixed. Since the powder of the mixture was poor in fluidity, the angle of repose was measured (three-wheeled cylinder rotation method angle of repose measuring instrument (manufactured by Tsutsui Riken Kikai Co., Ltd.)) and found to be 65 degrees. When the angle of repose exceeds 45 degrees, the fluidity of the powder is deteriorated and the supply to the tableting machine is not performed smoothly. For this reason, mass production with a tableting machine has been difficult.

  The present invention is useful in the fields of dietary fiber tablets and dietary fiber-containing compositions.

Claims (4)

A method for producing a sodium alginate-containing tablet, comprising impregnating essential oil into a tablet obtained by tableting sodium alginate powder. The production method according to claim 1, wherein the essential oil is at least one selected from the group consisting of patchouli oil, jasmine oil, sandalwood oil, basil oil, melissa oil, juniper oil, lavender oil and clove oil. The manufacturing method of Claim 1 or 2 whose essential oil compounding quantity is 0.01-30 weight part with respect to 100 weight part of sodium alginate. The sodium alginate containing tablet obtained by the manufacturing method in any one of Claims 1-3.