JP4872724B2 - Component container support device - Google Patents

Description

  The present invention relates to a component container support device that is applied to a blood component separation device that collects only a serum portion in a component container in a serum and a blood cell part separated in a blood reservoir.

  Currently, in the field of regenerative medicine, research is being carried out to promote regeneration of a subject's tissue by transplanting the stem cell collected from the subject to the subject after being expanded or differentiated outside the body. Stem cells have attracted attention as cells that have the pluripotency to differentiate into various tissues and organs and are the key to regenerative medicine.

  In vitro growth of stem cells is known to be effective if serum is added to the medium, but for the purpose of human treatment, use serum derived from animals other than humans. This should be avoided for safety reasons, and it is required to use serum prepared from blood derived from humans, particularly from subjects. Compared with blood tests, relatively more serum is required for stem cell culture in the field of regenerative medicine.

As a blood component separation device that separates and collects a predetermined component from blood components, for example, a separator that holds a centrifuged blood bag to push out the contents in the blood bag and communicates with the blood bag via a tube An apparatus for moving plasma into a bag is disclosed (see Patent Document 1). In addition, the leukocyte bag after the blood component inside is centrifuged is hung on the hanger of the fixing plate, the handle of the device is operated to remove it from the hook, and the leukocyte bag is pressed against the fixing plate by the press plate, A component having a low specific gravity (plasma component) is transferred to the plasma bag via the connecting tube. And the apparatus which obstruct | occludes a connection tube when the space | interval between a fixed board and a pressing board becomes a predetermined space | interval is disclosed (refer patent document 2).
Japanese Patent Publication No.55-17585 JP 2002-143295 A

  However, in the above-described apparatus, a predetermined blood component is moved from one bag storing centrifuge blood to one sorting bag. For this reason, only one bag in which a predetermined blood component is stored can be obtained by one operation, and the operation efficiency is not good.

  Here, in order to improve the working efficiency, a blood bag as a blood reservoir that stores blood separated for each component is pressed, for example, a serum component is pushed out of the blood bag, and a plurality of component storage units are formed. It is conceivable to move to a separate bag. However, there are differences in the amount of serum components collected in each sort bag due to various factors, for example, the position of each sort bag and the difference in the length of each connecting tube connected to each sort bag. May occur. For this reason, it is necessary to divide serum components evenly into a plurality of sorting bags.

  As one method for equalizing the amount of serum in a plurality of sorting bags, it is conceivable to subdivide while measuring the weight of each sorting bag. However, there are individual differences in the amount of serum, and it is difficult to measure the weight of serum in the blood collection bag before it is divided into fractionation bags. For this reason, it is difficult to equalize the amount of serum in a plurality of sorting bags.

  Furthermore, when the serum is collected in the sorting bag, the air that was in the blood collection bag and the connecting tube flows into the sorting bag, and in the sorting bag together with the air that has been in the sorting bag before the collection of the serum. Air accumulates in the air. It is preferable that this air is not present in order to stabilize the amount of serum in the blood collection bag. Therefore, it is necessary to extract air from the blood collection bag. Conventionally, in order to evacuate the air in the connecting tube and the sorting bag, an operation of holding the sorting bag with each hand has been performed. For this reason, it was difficult to remove air efficiently.

  Further, Patent Document 1 discloses returning air in a sorting bag to a blood collection bag. However, in this case, it is effective when one collection bag is connected to one blood collection bag, but in the case where a plurality of collection bags are connected to one blood collection bag, The air may flow into other sorting bags and is not effective.

  The present invention has been made in view of the problems as described above, and realizes subdividing predetermined components in the blood reservoir in equal amounts into a plurality of component storage portions and preventing air from remaining inside. An object of the present invention is to provide a component storage unit supporting device.

  Here, “serum” refers to a pale yellow liquid whose fluidity decreases when the collected blood is allowed to stand and then separated from the red clot (blood clot).

  In order to achieve the above object, the present invention provides the following.

  (1) Pressing force applied to the blood reservoir and the blood, which has support means that is disposed below the blood reservoir in which blood in a state of being separated for each component is stored and supports a plurality of component reservoirs A connecting pipe connected to the blood storage part for a predetermined component collected from blood in a state separated for each component in the blood storage part by a pressure generated by a drop between the storage part and the support means The component storage unit supporting device used when the predetermined component is subdivided into the plurality of component storage units by being moved to the plurality of component storage units via the support pipe, and A fixed plate for installing the plurality of component storage portions with a connection portion with the component storage portion facing upward, a movable plate disposed opposite to the fixed plate and opening and closing a plate surface of the fixed plate, and the movable plate Attached to the fixed plate side And a biasing means for said movable plate, said when closing the plate surface of the fixed plate, the component storage part supporting device for pressurizing the plurality of the component storage part at the same time.

  According to the invention of (1), when the predetermined components collected from the blood flow into the plurality of component storage portions and the respective component storage portions swell, the plurality of component storage portions are formed by the fixed plate and the movable plate. Since both side portions in the thickness direction are restricted, the storable capacity in each component accommodating portion is kept constant. Further, for example, when the storage amount of the predetermined component increases in the predetermined component storage portion, the movable plate rotates against the urging force of the urging means. At this time, since the pressure in the predetermined component storage portion increases, the inflow amount of the predetermined component decreases, and accordingly, the predetermined component flows into the component storage portion with a low pressure. As a result, the predetermined component is subdivided into equal amounts in the plurality of component accommodating portions.

  Moreover, since the connection part of a connection pipe and a component accommodating part is orient | assigned upwards, air comes to accumulate on the upper part of a component accommodating part. At this time, the movable plate is in a rotating state due to the pressure from the plurality of component storage parts swelled by the pressure from the blood storage part, but by releasing the pressure from the blood storage part, the plurality of component storage parts Is pressed by the urging force of the urging means. As a result, air can be easily returned to the connecting pipe side. Thus, the residual amount of air in the plurality of component storage portions can be reduced.

  (2) In the invention of (1), the movable plate is provided at a lower portion of the fixed plate so as to be rotatable via a hinge portion, and further includes a lever portion for rotating the movable plate, and the urging means Consists of a spring member that constantly urges the movable plate in the direction of rotating the movable plate toward the fixed plate, engages with the lever portion on the main body of the device, and controls the rotation of the movable plate. The component accommodating part support apparatus which provided the lever holding | maintenance part which maintains the state by which the board surface of the board was opened.

  According to the invention of (2), when setting the component accommodating portion on the fixed plate, first, the movable plate is rotated downward by the operation of the lever portion, and the lever portion is engaged with the lever holding portion, Set the ingredient container on the fixed plate. Next, by releasing the engagement state between the lever holding portion and the lever portion and closing the movable plate, the plurality of component accommodating portions can be simultaneously pressurized by the movable plate. As a result, when a predetermined component flows into the component housing portion and pressure is applied to the movable plate from the inside to rotate the movable plate, the spring member biases the movable plate in a direction to return the plurality of components. It is automatically adjusted so that the pressure applied to the housing is uniform. As described above, it is possible to facilitate the work of setting the component accommodating portion, and it is possible to subdivide the predetermined component into equal amounts in the plurality of component accommodating portions.

  (3) In the invention of (1) or (2), the fixing plate is a component storage unit support device provided with hanger means for suspending the component storage unit at a plurality of positions at the same height.

  According to the invention of (3), for example, the component accommodating portion is set on the fixed plate by forming the hole for hanging on the hanger means in the component accommodating portion near the connecting portion between the connecting pipe and the component accommodating portion. When doing, it can set easily so that the connection part of a connection pipe and a component accommodating part may face upwards.

  (4) In the invention of (3), the component housing part has a plurality of connection parts connectable to the connection pipe, and any one of the plurality of connection parts is connected to the connection pipe. The hanger means is a connecting portion, and the height of the connecting portion connected to the connecting pipe is substantially the same as or relatively higher than the height of the other connecting portions. The component accommodating part support apparatus supported in the state which inclined the accommodating part.

  According to invention of (4), even if the height of the connection part connected with the connection pipe in a component accommodating part and the other connection part differs, it is connected by supporting in the state which inclined the component accommodating part. The height of the connecting portion connected to the tube can be substantially the same as or relatively high as the height of the other connecting portions. For this reason, the blood component from the connection part connected with a connection pipe | tube becomes easy to flow in in a component accommodating part, and the air which remains in a component accommodating part can be reduced as much as possible.

  (5) In the inventions of (1) to (4), the predetermined component is a component container supporting device that is a serum component.

  According to the invention of (5), serum components can be collected from the blood components separated in the blood reservoir.

  As described above, according to the component storage unit supporting device of the present invention, since the equally spaced plate surfaces are arranged on both sides of the plurality of component storage units, the storable capacity in each component storage unit is Since it is kept constant, it becomes possible to divide the predetermined component collected from the blood into a plurality of component storage portions into equal amounts. Further, since the connecting portion between the connecting pipe and the component accommodating portion is directed upward, the air in the plurality of component accommodating portions accumulates in the upper portion in the component accommodating portion, for example, from the connecting tube to the component accommodating portion. It is possible to easily discharge the air to the outside, and as a result, it is possible to reduce the residual amount of air in the component storage unit.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.
FIG. 1 is an explanatory diagram showing the configuration of a serum collection system using the component container support device of the present invention. The serum collection system 1 presses the blood reservoir and a blood component separator 2 that collects only serum from a blood reservoir that stores blood separated for each component and moves it to a predetermined component reservoir. It is roughly divided into a pressurizing device 3 that moves the internal serum component to contain components and a component containing portion support device 4 that supports the component containing portion.

  The blood component separation device 2 includes a blood collection bag 100 as a blood storage part in which blood is stored, a plurality of sorting bags 200 as component storage parts for storing serum collected from the blood collection bag 100, and a part of the serum. The adjustment bag 300 temporarily stores, the connection tubes 400 to 406 connecting the blood collection bag 100, the sorting bag 200, and the adjustment bag 300, and the branch tubes 450 to 452 that branch the flow path from the blood collection bag 100. Has been.

  FIG. 2 is an explanatory view showing the configuration of the pressurizing device, FIG. 2 (a) shows the overall configuration of the pressurizing device, and FIG. 2 (b) is an enlarged view of the main part of FIG. 2 (a). is there. As shown in FIG. 2A, a fixed plate 31 is erected in a vertical direction on a base 30 having a horizontal plane. A movable plate 32 is rotatably provided at a lower portion of the fixed plate 31 via a hinge portion (not shown). The movable plate 32 is formed as a single flat plate by connecting the lower metal plate 32 a and the upper transparent plate 32 b, and the surface of the movable plate 32 is substantially the same as the plate surface of the fixed plate 31. It is a plate surface of the same size. One end of a lever 33 is attached to the opposite side of the metal plate 32a facing the fixed plate 31. The shaft portion of the lever 33 is provided so as to form an acute angle with respect to the opposite surface of the movable plate 32 to the surface facing the fixed plate 31. Is provided. Further, a substantially L-shaped lever hook 36 is provided on the front portion of the base 30. A hook 35 is erected on the upper portion of the fixed plate 31, and a substantially L-shaped lever hook 36 is rotatably provided on the front portion of the base 30.

  2A, the lever 33 is lowered, the movable plate 32 is rotated downward, and engaged with the lever hook 36, whereby the plate surface of the fixed plate 31 is opened. Maintained. Further, by releasing the engagement by the lever hook 36, the movable plate 32 is rotated upward by the urging force of the torsion spring 34 (see FIG. 2B), and the plate surface of the fixed plate 31 and the movable plate 32. The plate surface comes into contact. Here, when the engagement with the lever hook 36 is released, the lever 33 is engaged after the hand is put on the lever 33 so that the plate surface of the movable plate 32 does not collide with the plate surface of the fixed plate 31. It is preferable that the movable plate 32 is rotated upward by operating the lever 33.

  Further, as shown in FIG. 2B, the movable plate 32 is engaged with the fixed plate 31 and a part of the movable plate 32 on both sides at the center lower portion, and the movable plate 32 is always attached to the fixed plate 31. A torsion spring 34 is provided to urge the movable plate 32 in the closing direction, that is, so that the movable plate 32 rotates toward the fixed plate 31. The spring constant of the torsion spring 34 is such that when the lever 33 is lowered and the movable plate 32 is rotated downward, the blood collection bag 100 ( 1), an appropriate pressing force can be applied.

  Although details will be described later, the blood collection bag 100 storing the blood after centrifugation is suspended on the hook 35 of the fixed plate 31 and brought into contact with the plate surface, and the movable plate together with the lever 33 while maintaining the state. By rotating 32 and closing the movable plate 32, the blood collection bag 100 is sandwiched between the fixed plate 31 and the movable plate 32 with a predetermined pressure applied. Further, by rotating the lever 33 downward, the movable plate 32 is rotated downward in conjunction with the lever 33, the plate surface of the fixed plate 31 is opened, and the blood collection bag 100 can be installed and replaced. Become.

  FIG. 3 is an explanatory view showing the configuration of the component storage unit support device, FIG. 3 (a) shows the overall configuration of the component storage unit support device, and FIG. 3 (b) shows the main part of FIG. 3 (a). It is an enlarged one. As shown in FIG. 3A, a fixed plate 41 is erected in a vertical direction on a base 40 having a horizontal plane. Under the fixed plate 41, a movable plate 42 is rotatably provided via a hinge portion (not shown). The movable plate 42 is formed by connecting a lower metal plate 42a and an upper transparent plate 42b to form a substantially T-shaped flat plate. One end of a lever 43 is attached to the opposite side of the metal plate 42a facing the fixed plate 41. The shaft portion of the lever 43 is provided so as to form an acute angle with respect to the opposite surface of the movable plate 42 to the surface facing the fixed plate 41. On the other hand, the other end of the lever 43 is provided with a spherical body so that it can be easily operated. Further, a substantially L-shaped lever hook 46 is rotatably provided on the front portion of the base 40.

  In addition, three sets of hooks 45 are erected on the upper surface of the fixed plate 41, and these hooks 45 are provided in parallel in the horizontal direction. The hook 45 hangs the sorting bag 200. In the present embodiment, the three sorting bags 200 can be set on the fixing plate 41 at the same time. In addition, the size of the plate surface of the transparent plate 42 b is set to a size that can be simultaneously opposed to at least a portion of the bag body in all the sorting bags 200 set on the fixed plate 41.

  3A, the lever 43 is lowered, the movable plate 42 is rotated downward, and the lever 43 is engaged with the lever hook 46, whereby the plate surface of the fixed plate 41 is released. Maintained. Further, by releasing the engagement by the lever hook 46, the movable plate 42 is rotated upward by the urging force of the torsion spring 44 (see FIG. 3B), and the plate surface of the fixed plate 41 and the movable plate 42 are moved. The plate surface comes into contact. Here, when the engagement by the lever hook 46 is released, the lever 43 is engaged after the hand is put on the lever 43 so that the plate surface of the movable plate 42 does not collide with the plate surface of the fixed plate 41. It is desirable that the movable plate 42 is rotated upward by operating the lever 43.

  Further, as shown in FIG. 3B, the movable plate 42 is engaged with the fixed plate 41 and a part of the movable plate 42 on both sides at the lower center of the movable plate 42. A torsion spring 44 is provided to urge the movable plate 42 so that the movable plate 42 rotates toward the fixed plate 41. The spring constant of the torsion spring 44 is the sorting bag 200 that is clamped between the movable plate 42 and the fixed plate 41 by the bias of the torsion spring 44 when the lever 43 is lowered and the movable plate 42 is rotated downward. It is set so that an appropriate pressing force can be applied to. In the present embodiment, in FIG. 1, the pressing force applied to the sorting bag 200 is greater than the sum of the pressing force applied to the blood collection bag 100 by the pressurizing device 3 and the drop pressure from the blood collection bag 100 to the sorting bag 200. Is set to be small.

  FIG. 4 is an explanatory view showing a state in which the sorting bag 200 is set in the storage unit support device. The empty sorting bag 200 is set on the fixed plate 41, and the movable plate 42 is rotated together with the lever 43 to close the movable plate 42, whereby the sorting bag 200 is placed between the fixed plate 41 and the movable plate 42. Be placed. Further, by rotating the lever 43 downward, the movable plate 42 is rotated downward in conjunction with the lever 43 and the plate surface of the fixed plate 41 is opened, so that the sorting bag 200 can be installed and replaced. Become.

  The adjustment bag 300 is detachably supported by the stand 5 (see FIG. 1). That is, when the adjustment bag 300 is attached to the stand 5, the adjustment bag 300 is positioned vertically above the sorting bag 200. Furthermore, the connection tube 405 connected to the adjustment bag 300 is set to a length that allows the adjustment bag 300 to be positioned vertically below the sorting bag 200 when the adjustment bag 300 is removed from the stand 5.

  FIG. 5 is an explanatory diagram showing the configuration of the blood component separation device.

  A connection port 102 is formed at the upper edge of the main body 101 of the blood collection bag 100, and one end of a connection tube 400 is airtightly connected to the connection port 102. In addition, a communication tube 103 (not shown) for connecting the blood collection bag 100 and the connection tube 400 is provided in the lumen portion of the connection port 102. A branch pipe 450 is connected to the other end of the connection tube 400, and a branch pipe 451 is connected to one branch path of the branch pipe 450 via a connection tube 401, and each branch path of the branch pipe 451 is connected. The sorting bag 200 is hermetically connected via the connecting tubes 402 and 403. A branch pipe 452 is connected to the other branch path of the branch pipe 450 via a connection tube 404, and the adjustment bag 300 is hermetically connected to one branch path of the branch pipe 452 via a connection tube 405. ing. In addition, the sorting bag 200 is hermetically connected to the other branch path of the branch pipe 452 via a connecting tube 406.

The main body 101 of the blood collection bag 100 is constituted by a bag, and each is made of soft polyvinyl chloride or the like. Moreover, the inside of the blood collection bag 100 is sterilized in advance. In addition, holes 110 are formed on both sides of the connection port 102 provided in the upper part of the blood collection bag 100 so as to be loosely fitted to the hook 35 (see FIG. 3). Further, a plurality of glass processed bodies 105 serving as blood coagulation promoting individuals are accommodated in the main body 101. The glass processed body 105 has, for example, a substantially spherical shape made of soda glass. Moreover, in this embodiment, although it is set as the structure provided with the glass processing body 105 in the blood collection bag 100, when obtaining the blood coagulation promotion function, the surface area of the glass processing body 105 with respect to the blood volume which can be stored is 0.1. It is preferable to set with a relationship of (mm ² / ml) or more.

  Note that the glass processed body 105 is not joined to the inner wall of the main body portion 101 or the like, and when the main body portion 101 is given a shaking action or a vibration action, the glass processed body 105 is in a state in which it can float inside the main body portion 101. Is set.

In order to prevent the red blood cells in the blood from being destroyed and causing hemolysis when the body 101 is shaken or vibrated after the blood is stored, or even when the blood is centrifuged, It is preferable to set the glass processed body 105 with a surface area having a relationship of 25.0 (mm ² / ml) or less with respect to the amount of blood that can be stored in the main body 101 of the blood collection bag 100.

  Moreover, the main body parts 201 and 301 of the sorting bag 200 and the adjustment bag 300 are formed of a bag body, and each is made of soft polyvinyl chloride or the like. These are also sterilized in advance. In addition, holes 210 that are loosely fitted to the hooks 45 are formed on both sides of the connection port 205 provided in the upper part of the sorting bag 200. A hole 320 is formed in the upper part of the adjustment bag 300. The hole 320 is used to suspend the hole 320 on a predetermined instrument with the connection port 305 facing up. In addition, a hole 310 for loosely fitting and hanging the adjustment bag 300 on the suspension hanger 5a of the stand 5 is formed at a portion opposite to the connection port 305 of the connection tube 405 in the adjustment bag 300 in the vertical direction. ing.

  Further, the connecting tubes 401 to 406 serve as a lead-out path for leading out the separated blood components. These connection tubes 401 to 406 are made of a flexible resin material, for example, a material such as soft polyvinyl chloride.

  Further, the size of the connecting tube 400 is set such that the inner diameter dimension thereof is smaller than the outer dimension dimension of the glass processed body 105. This is to prevent the glass processed body 105 from entering the connecting tube 400 when preparing and deriving serum.

  Furthermore, as shown in FIG. 1, in the blood component separation device 2, blood and extraction are performed by sandwiching the required portions of the connection tubes 401 to 406, that is, the connection tubes 400, 402, 403, 405, and 406 with clamps 500 to 504. When the obtained serum is derived, the flow path can be switched. In this embodiment, the connection tube 400 is provided with a clamp 500, the connection tube 405 is provided with a clamp 501, and the connection tubes 402, 403, and 406 are provided with clamps 502, 503, and 504.

  Next, the collection | recovery operation | work of the serum component using the apparatus shown in FIG. 1 is demonstrated. First, the blood collection bag 100 storing the collected blood is applied to a centrifuge (not shown) to separate the blood into components. At this time, the serum component forms the uppermost layer in the component layer in the blood collection bag 100. In the blood component separation device 2, the clamp 500 and the clamp 501 are closed in advance, and the clamps 502, 503, and 504 are opened. Furthermore, the support position of the adjustment bag 300 set on the stand 5 is the highest, and then the blood collection bag 100 set on the pressurizing device 2 is high, and the sorting bag set on the component storage unit support device 4. The positions of the pressure device 2, the component storage unit support device 4, and the stand 5 are set so that the position of 200 is the lowest.

  Next, the blood collection bag 100 is set in the pressurizing device 3. First, the lever 33 is lowered and the movable plate 32 is rotated downward to open the plate surface of the fixed plate 31. Next, the blood collection bag 100 is brought into contact with the plate surface of the fixed plate 31 with the connection port 102 facing upward, the hole 110 of the blood collection bag 100 is loosely fitted to the hook 35, and the blood collection bag 100 is suspended. While maintaining the above, the movable plate 32 is rotated together with the lever 33 to close the movable plate 32. At this time, the urging force of the torsion spring 34 is applied to the blood collection bag 100 via the movable plate 32, whereby the blood collection bag 100 is sandwiched between the fixed plate 31 and the movable plate 32 with a predetermined pressure applied. The

  Next, the sorting bag 200 is set on the component storage unit support device 4. First, the lever 43 is lowered and the movable plate 42 is rotated downward to open the plate surface of the fixed plate 41. Next, the hole 210 of the sorting bag 200 is loosely fitted to the hook 45 and the sorting bag 200 is suspended. By hanging the sorting bag 200 on all three hooks 45, the three sorting bags 200 are set on the fixing plate 41 with the connection port 205 facing upward. At this time, the three sorting bags 200 are positioned vertically below the blood collection bag 100. Then, the movable plate 42 is rotated together with the lever 43 to close the movable plate 42.

  Next, the communication tube 103 is broken, and the blood collection bag 100 and the connection tube 400 are communicated. Further, the clamp 500 is manually opened, and the flow path of the connection tube 400 is opened. At this time, the serum component in the blood collection bag 100 is pushed out by the pressurization by the pressurization device 3, and the serum is put into the three sorting bags 200 via the connecting tubes 400 to 404, 406 as shown by arrows in FIG. The component moves. As a result, serum components are stored in the three sorting bags 200. After the passage of time, as the storage amount increases, the sorting bag 200 expands, and the sorting bag 200 presses the movable plate 42 and slightly rotates. Here, when the clamp 500 is opened, as shown by the arrows in FIG. 6, the air remaining in the connection tubes 400 to 404 and 406 is pushed out together with the serum components into the three sorting bags 200 and separated. Accumulated on top of bag 200. When a predetermined amount of serum component is stored in the three sorting bags 200, the clamp 500 is closed and the flow path of the connecting tube 400 is closed.

  Next, after positioning the adjustment bag 300 below the sorting bag 200, the clamp 501 is manually opened, and the flow path of the connection tube 405 is opened. At this time, since the three sorting bags 200 are pressurized by the movable plate 42, as shown by the arrows in FIG. A part moves to the adjustment bag 300 through the connection tubes 401-406. Then, when all of the air moves from the three sorting bags 200 to the adjustment bag 300 and the connection tubes 401 to 406 are filled with serum components, the clamp 501 is closed and the flow path of the connection tube 405 is closed. To do.

  Next, the adjustment bag 300 is suspended from the suspension hanger 5 a of the stand 5. At this time, since the connection port 305 of the adjustment bag 300 faces downward, in the adjustment bag 300, the vicinity of the connection port 305 is filled with the serum component, and air is stored in the upper portion thereof. In such a state, the clamp 501 is opened and the flow path of the connecting tube 405 is opened, thereby adjusting the pressure by the pressure difference between the adjustment bag 300 and the sorting bag 200 as shown by the arrow in FIG. Serum components in the bag 300 move to the three sorting bags 200. Then, after the serum component is exhausted in the adjustment bag 300, the clamp 502 to 504 is closed to collect the serum component from the blood collection bag 100 and divide it into three sorting bags 200. If it is difficult for the serum component to move from the adjustment bag 300 to the three sorting bags 200, pressure is applied to the adjustment bag 300 by hand to push out the serum components, or the lever 43 is slightly lowered to reduce the three sorting bags. The pressure applied to 200 may be reduced.

  After the separation and collection work is completed, the connection tubes 402, 403, and 406 are melted and the flow path is closed, and then the individual sorting bags 200 are separated from the blood component separation device 2.

  According to the present embodiment configured as described above, the following operational effects can be obtained.

  According to the present embodiment, when the serum flows into the three sorting bags 200 and the respective component storage portions swell, the thickness direction of the plurality of sorting bags 200 by the fixed plate 41 and the movable plate 42. Since both side portions of the sorting bag 200 are regulated, the storable capacity of each sorting bag 200 is kept constant. Further, for example, when the amount of stored serum in a predetermined sorting bag 200 is larger than that of other sorting bags 200, the movable plate 42 rotates against the bias of the torsion spring 44. At this time, since the pressure in the predetermined sorting bag 200 increases, the inflow amount of the serum component decreases, and the serum component flows into the sorting bag 200 having a low pressure accordingly. As a result, the serum components are subdivided equally into the three sorting bags 200.

  In addition, since the connection port 205 faces upward, air accumulates in the upper part of the sorting bag 200. At this time, the sorting bag 200 is inflated by the pressure from the blood collection bag 100, and at the same time, the sorting bag 200 is pressed by the movable plate 42. Here, by closing the clamp 501 and releasing the pressure from the blood collection bag 100, the plurality of component storage portions are pressed by the urging means, and as a result, air is supplied to the connecting tubes 401 to 406 side. It can be easily returned. Thus, the residual amount of air in the three sorting bags 200 can be reduced.

  Further, when the sorting bag 200 is set on the fixed plate 41, the movable plate 42 is rotated downward to open the plate surface of the fixed plate 41, and after the sorting bag 200 is set on the fixed plate 41, the movable plate 42 is movable. The plate 42 is closed. As a result, a gap having an equal interval is formed between the plate surface of the fixed plate 41 and the plate surface of the movable plate 42, and the three sorting bags 200 are sandwiched in the gap.

  In addition, when the sorting bag 200 is inflated and pressure is applied to the movable plate 42 from the inside and the movable plate 42 is rotated, the torsion spring 44 biases the movable plate 42 in a direction to return the plurality of sorting plates. The pressure applied to the bag 200 is automatically adjusted to be uniform. As described above, it is possible to facilitate the operation of setting the three sorting bags 200, and it is possible to subdivide the serum into three sorting bags 200 in equal amounts.

  Further, by forming a hole 210 for hooking on the hook 45 in the sorting bag 200 in the vicinity of the connection port 205, when the sorting bag 200 is set on the fixing plate 41, the connection port 205 is directed upward. Can be set easily.

  By the way, as shown in FIG. 9, the sorting bag 200 is provided with a connection port 205 in the center of the upper portion, and a connection port 206 on the side of the connection port 205. The connection port 205 and the connection port 206 are formed in a cylindrical shape. One end of the connection port 205 and the connection port 206 is formed so that a connection tube or the like can be connected, and the other end is introduced into the sorting bag 200. Outlets 205a and 206a are formed. Further, the upper side inside the sorting bag 200 is formed obliquely so as to become narrower toward the connection port 205. For this reason, the position of the introduction outlet 206a of the connection port 206 is slightly lower than the position of the introduction outlet 205a of the connection port 205. In the sorting bag 200 shown in FIG. 8, both the connection port 205 and the connection port 206 can be used as an introduction port for taking in serum. In addition, the connection port 205 and the connection port 206 have a structure corresponding to each application.

  Here, FIG. 4 shows a case where the connection port 205 is used as an introduction port for taking in serum, and as described above, serum can be collected without waste. However, when the connection port 206 is used as a take-out port, the serum near the connection port 205 is likely to gather on the connection port 205 side, so that it is difficult to take out the serum near the introduction outlet 205a. On the other hand, when the connection port 206 is used as a serum introduction port, when the serum is transferred from the blood collection bag 100, there is a risk that the serum will not easily enter the vicinity of the connection port 205. Since it can be used as a mouth, the serum inside the sorting bag 200 can be used without waste. The second embodiment described below is made in view of the latter.

  10 and 11 are explanatory views showing the configuration of the second embodiment of the component container support device of the present invention. In addition, about the member same as the member in the component accommodating part support apparatus shown in FIG. 3, or the member of the same function, the same code | symbol is attached | subjected and detailed description is abbreviate | omitted. In the component storage unit support device 4 of the second embodiment, the pair of hooks 45 in the component storage unit support device 4 shown in FIG. 3 are arranged obliquely with respect to the horizontal direction. Specifically, the height of the introduction outlet 205a of the connection port 205 and the height of the introduction outlet 206a of the connection port 206 are substantially the same and are positioned so as to be the highest in the sorting bag 200, or of the introduction outlet 206a. The angle of the pair of hooks 45 is set so that the position is higher than the position of the introduction outlet 205a. In the second embodiment, if the angle of the hook 45 is in the range of 10 ° to 45 °, it is possible to prevent the remaining of air, and more preferably, it is set in the range of 15 ° to 30 °. It is desirable.

  Then, by suspending the sorting bag 200 on the hook 45, as shown in FIG. 11, the height of the introduction outlet 205a of the connection port 205 is substantially the same as the height of the introduction outlet 206a of the connection port 206, and the sorting is performed. It is positioned so as to be the highest in the bag 200. While maintaining this state, the serum components are transferred from the blood collection bag 100 to the plurality of sorting bags 200 by collecting the serum according to the procedure described with reference to FIGS.

  As described above, according to the second embodiment, even when the sorting bag 200 includes the plurality of connection ports 205 and 206 and the connection port 206 at a low position is used as the serum component inlet, It is possible to smoothly transfer serum components from the blood collection bag 100 to the plurality of sorting bags 200 without leaving air inside.

  In addition, according to 2nd Embodiment shown in FIG. 10, FIG. 11, although the angle of a pair of hook 45 is being fixed, you may comprise so that the angle of the hook 45 may vary. For example, one hook may be fixed and the other hook may be configured to be movable in the circumferential direction around the one hook and fixed at a desired position. Specifically, in the circumferential direction A plurality of through holes may be provided along the other side, and the other hook may be configured to be attachable and detachable with screws. Further, instead of the plurality of through holes, one arc-shaped long hole may be provided. With this configuration, even if the upper side of the inside of the sorting bag 200 is inclined, even if either the connection port 205 or the connection port 206 is not located in the central portion, the sorting bag It is possible to smoothly transfer the serum from the blood collection bag 100 to the plurality of sorting bags 200 without leaving air inside the 200.

  According to the second embodiment, the sorting bag 200 is suspended such that the height of the connection port 206 is the same as or higher than that of the connection port 205. However, in actuality, an error due to the size and formation position of the hole 320 of the sorting bag 200 is included, and therefore the height of the connection port 206 may be slightly lower than the connection port 205. However, since pressure is applied to the serum when the serum is transferred, the serum is not left inside the sorting bag 200 even if the connection port 206 is slightly lower than the connection port 205. Smooth transfer is possible.

  As mentioned above, although embodiment of this invention was described, this invention is not restricted to what was mentioned above. For example, in the above-described embodiment, serum components are collected, but other components in blood components may be extracted. In the above-described embodiment, the three sorting bags 200 are set on the fixing plate 41. However, it is needless to say that the number may be larger than that. The effect is achievable. In the above-described embodiment, the clamp 500 is opened after the movable plate 42 is closed in the component storage unit support device 4. However, the present invention is not limited thereto, and the clamp 500 is opened with the movable plate 42 opened. After closing, the movable plate 42 may be closed, the clamp 501 may be opened, and the air extraction operation may be performed.

It is explanatory drawing which shows the structure of the serum collection system using the component accommodating part support apparatus of this invention. It is explanatory drawing which shows the structure of the pressurization apparatus of FIG. It is explanatory drawing which shows the structure of the component accommodating part support apparatus of FIG. It is explanatory drawing which shows the structure of the blood component separation apparatus of FIG. It is explanatory drawing which shows the state which set the fractionation bag to the component accommodating part support apparatus. It is explanatory drawing which shows the state which has distributed the blood component from the blood collection bag to the fractionation bag. It is explanatory drawing which shows the state which is moving the air in a fractionation bag to an adjustment bag. It is explanatory drawing which shows the state which has distributed the blood component from the adjustment bag to the fractionation bag. It is explanatory drawing which shows the structure of a sorting bag. It is explanatory drawing which shows the structure of the component accommodating part support apparatus of 2nd Embodiment of this invention. It is explanatory drawing which shows the state which set the sorting bag to the component accommodating part support apparatus of FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Serum collection system 2 Blood component separation apparatus 3 Pressurization apparatus 4 Component accommodating part support apparatus 5 Stand 5a Suspension hanger 30,40 Base 31,41 Fixed plate 32,42 Movable plate 32a, 42a Metal plate 32b, 42b Transparent plate 33 43 Lever 34, 44 Torsion spring 35, 45 Hook 36, 46 Lever hook 100 Blood collection bag 101, 201, 301 Main body 102, 205, 305 Connection port 105 Glass processed body 200 Preparative bag 205, 206 Connection port 110, 210, 310 Hole 300 Adjustment bag 400, 401, 402, 403, 404, 405, 406 Connecting tube 450, 451, 452 Branch pipe 500, 501, 502, 503, 504 Clamp

Claims (5)

The blood is disposed under the blood reservoir in which the blood separated for each component is stored, and has support means for supporting the plurality of component reservoirs, and by applying pressure to the blood reservoir, the blood The predetermined component collected from the blood in a state of being separated for each component in the storage unit is moved to the plurality of component storage units via a connection pipe connected to the blood storage unit, thereby the predetermined component Is a component storage unit support device used when subdividing into a plurality of component storage units,
The support means includes a fixed plate for installing the plurality of component accommodating portions with the connecting portion between the connecting pipe and each component accommodating portion facing upward, a plate disposed opposite to the fixed plate, and a plate surface of the fixed plate. A movable plate that opens and closes, and a biasing means that biases the movable plate toward the fixed plate,
The movable plate is a component container support device that simultaneously pressurizes the plurality of component containers when the plate surface of the fixed plate is closed. The movable plate is provided at a lower portion of the fixed plate so as to be rotatable via a hinge portion, and further includes a lever portion for rotating the movable plate,
The biasing means comprises a spring member that constantly biases the movable plate in the direction of rotating the movable plate toward the fixed plate.
The component housing according to claim 1, wherein the apparatus main body is provided with a lever holding portion that engages with the lever portion to restrict the rotation of the movable plate and maintains the plate surface of the fixed plate open. Part support device.   The component holding part support device according to claim 1, wherein the fixing plate has hanger means for suspending the component containing part at a plurality of positions at the same height. The component accommodating portion has a plurality of connecting portions connectable to the connecting pipe, and any one of the plurality of connecting portions is a connecting portion connected to the connecting pipe,
The hanger means is a state in which the component accommodating portion is tilted so that the height of the connecting portion connected to the connecting pipe is substantially the same as or relatively higher than the height of the other connecting portions. The component accommodating part support apparatus of Claim 3 supported by.   The said predetermined component is a serum component, The component accommodating part support apparatus of any one of Claims 1-4.

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