JP4826991B2 - Circuit for automatic peritoneal dialysis machine with sanitizing filter - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a peritoneal dialysis device used for the treatment of patients with renal failure, and more particularly to a circuit for peritoneal dialysis that is optimal for use in an automatic peritoneal reflux device.
[0002]
[Prior art]
Peritoneal dialysis is a convenient and less restrictive treatment method that allows patients with chronic renal failure to perform treatment with their own hands by exchanging dialysate at home or at work. Recently, in order to improve the patient's quality of life and medical efficiency, APD therapy is performed intensively at night or during the day (automatic peritoneal dialysis therapy in which peritoneal dialysis fluid is replaced with an automatic infusion / drainage device). Is popular. Since this method is mechanically operated, it is ideal for use by busy patients, patients who have difficulty in regular exchange operations, or patients with physical disabilities.
[0003]
Specifically, a dialysis fluid container containing a large amount of dialysis fluid is connected to a dialysis set (connected to a catheter placed in the patient's abdominal cavity), etc., depending on the preset time, amount of fluid to be injected, and number of times. The dialysis solution is automatically injected into the patient's abdominal cavity and drained. In this method, since the peritoneal dialysis treatment is performed while the patient is sleeping or the like, the time that is restrained by the dialysate exchange operation can be reduced. Moreover, since the dialysate can be exchanged in a limited time, the dialysis efficiency can be increased. In recent years, treatment using these devices has gradually spread, but it is also pointed out that this treatment method is likely to cause peritonitis (because it is caused by contamination of the connector part due to repeated liquid exchange).
[0004]
Even in the case of APD therapy using an automatic peritoneal dialysis device, connection / desorption (desorption) between the APD circuit (connected to the peritoneal catheter placed in the patient's abdominal cavity) and the dialysate container is necessary. Failure to make these connections clean and reliable can cause serious problems for the patient. Therefore, the facility uses a dedicated machine at the time of connection, or educates in advance so that the patient or the like can operate the technique accurately and safely.
[0005]
However, when handling an automatic peritoneal perfusion device, dialysis patients often have to pay attention to operations other than fluid exchange, and contamination and infection of the desorption site are not sufficiently prevented at present. is there. Furthermore, it is difficult for the patient to perform an accurate detachment operation due to the inconvenient operation due to his / her aging, various complications, the inadequate situation of the caregiver, and the like. In particular, in APD therapy, since a large amount of dialysate is often injected, desorption is frequently performed between the dialysis set or the cartridge for feeding and the dialysate container. When a heating circuit for heating the dialysate is used, the number of desorptions is further increased. The more frequent the desorption, the greater the chance of contamination and infection.
[0006]
However, providing means for preventing contamination / infection increases the number of steps that the patient has to operate, increasing the burden on the patient. In addition, if the mechanism of the prevention means becomes complicated, there is a risk of increasing erroneous operations. In addition, if an attempt is made to make a product having a high anti-contamination effect, the device becomes expensive, and there is a problem that no patient can use it. Therefore, when the APD therapy is performed, it is necessary to provide the apparatus with a contamination / infection prevention mechanism that is simple and surely effective.
[0007]
On the other hand, some ideas of using a sterilization filter when performing peritoneal dialysis have been disclosed. For example, even if contamination or infection occurs at the connection site between the dialysate container and the patient catheter, etc., by using a filter at any location (downstream of the contamination occurrence site) of the dialysate injection means, This is to prevent the invasion of bacteria into the abdominal cavity and is disclosed in Japanese Patent Application Laid-Open Nos. 57-112873 and 60-249971.
[0008]
The one disclosed in the above-mentioned prior application is intended to trap bacteria and bacteria with a sterilization filter mounted on the downstream side even if the flow path is contaminated at the connection part, and the infusion filter used for infusion is diverted. It is what. Although the above was useful as an idea itself, it was not practically usable for peritoneal dialysis therapy. This is because there were various problems as follows.
[0009]
(1) Since infiltration of dialysate into the filter by self-priming takes a long time, it is desirable to use a device for that purpose for discharging and injecting the solution. In the current automatic peritoneal dialysis apparatus, not only inhalation / discharge of dialysate but also inhalation / discharge of the stored fluid in the patient's abdominal cavity is used as a diaphragm type inhalation / discharge means. When the stored liquid flows into the diaphragm and the stored liquid containing biological components passes through or comes into contact with the filter, the flow rate is remarkably reduced due to clogging of the filter, and finally the liquid is blocked.
[0010]
▲ 2 ▼ When using multiple chemical bags, the air present in the next bag flows into the filter infiltrated with the liquid from one bag, causing air lock (clogging by air and clogging). End up. (3) In order to prevent inflow of stored liquid into the filter and contact with biological components, if a channel switching means or another channel is provided, the circuit structure itself must be changed. Also, the modified circuit cannot be used for the current automatic exchange device. Furthermore, there is a possibility that the operation for switching the flow path is troublesome or the possibility of erroneous operation increases.
[0011]
[Problems to be solved by the invention]
Accordingly, an object of the present invention is to provide a peritoneal dialysis apparatus (set) that can prevent contamination and infection during dialysate exchange in APD therapy with a simpler structure. In addition, even when an operation that is likely to cause contamination or infection is performed at the time of attachment / detachment (connection / detachment), a peritoneal dialysis device (set) that can finally prevent entry of bacteria and bacteria into the patient's abdominal cavity and therefore It is to provide the means.
[0012]
[Means for Solving the Problems]
In the first aspect of the present invention, at one end, a dialysate container is provided which is connected to one or a plurality of dialysate containers containing fresh dialysate, or provided with a connector connectable to the dialysate container. A suction / discharge means side connection part (hereinafter also referred to as a suction side connection part) having a container connection part (hereinafter also referred to as a dialysate side connection part) and connected to a liquid suction / discharge means at another end. A peritoneal dialysis circuit having a sterilization filter attached to the middle part of the both ends, the circuit having a dialysis fluid line connecting the sterilization filter and the dialysate container A drainage line (for draining the liquid stored in the patient's abdominal cavity) that branches between the sterilization filter and the suction side connection part, and the branch part of the drainage line and the removal A flow path that can be opened and closed by opening and closing means between the bacteria filter. A circuit for automated peritoneal dialysis apparatus, characterized in that a closing part.
[0013]
In addition to the above configuration, the present invention can take various embodiments as described below. That is, as one embodiment, the peritoneal dialysis circuit further branches from the abdominal cavity line communicating with the patient's abdominal cavity between the suction / discharge means side connecting portion and the drainage line branching portion.
[0014]
Moreover, as another embodiment, the peritoneal dialysis circuit is provided with a heating line for heating the dialysate between the dialysate side connecting portion and the sterilization filter.
[0015]
In another embodiment, the peritoneal dialysis circuit is provided with a concentration change line for changing the concentration of dialysate to be administered to a patient between the dialysate side connecting portion and the sterilization filter. is there.
[0016]
In another embodiment, the peritoneal dialysis circuit includes at least the dialysate line and the heating line connected by a manifold. [When there are a plurality of dialysate storage containers, there may be a plurality of dialysate lines, and each dialysate line may be connected by a manifold (manifold). ]
[0017]
As another embodiment, at least the dialysate side connection part, the heating line, the sterilization filter, the flow path opening / closing part, the drainage line, and the suction side connection part are incorporated in a closed manner (integrally). Or a circuit for the peritoneal dialysis.
[0018]
Moreover, as another embodiment, the sterilization filter is the circuit for peritoneal dialysis having a gas accommodating portion for storing a gas present in the liquid at an upper portion.
[0019]
In another embodiment, the sterilization filter is the peritoneal dialysis circuit in which a cylindrical housing is divided into two chambers by a flat membrane filter.
[0020]
In another embodiment, the sterilization filter is the peritoneal dialysis circuit having a water permeability of at least 2.30 ml / min · cm 2. Preferably, the peritoneal dialysis circuit has a water permeation performance of a sterilization filter in a range of 3.5 to 7.5 ml / min · cm 2.
[0021]
As another embodiment, the peritoneal dialysis circuit is the peritoneal dialysis circuit having an effective pore size of the sterilization filter in the range of 0.22 to 0.45 μm.
[0022]
The second aspect of the present invention has a suction / discharge means side connecting portion connected to the liquid suction / discharge means at one end, and one or a plurality of fresh dialysis fluids are accommodated at the other end. A dialysate line connected to a dialysate storage container connecting portion (hereinafter also referred to as a dialysate side connection portion) having a connector that can be connected to any of the above dialysate storage containers, or a connector connectable to any of the above dialysate storage containers; And at least three flow paths of a drainage line (for draining fluid stored in the patient's abdominal cavity) are formed in parallel, and the line and suction / discharge means are connected to the dialysate line. A flow path opening / closing section for connecting / closing the flow path on the side is provided, and a sterilization filter is further provided between the flow path opening / closing section and the dialysate side connection section in the dialysate line. , Each to the drainage line A circuit for automated peritoneal dialysis apparatus, characterized in that a flow channel opening and closing means for opening and closing the flow path.
[0023]
Furthermore, the present invention can take various embodiments as described below in addition to the above-described configuration. That is, as one embodiment, at least the three lines (dialysis fluid line, abdominal cavity line, drainage line) and a line including the suction side connecting portion are incorporated in a closed manner (integral or non-detachable). This is a circuit for the peritoneal dialysis described above.
[0024]
As another embodiment, a heating line for heating the dialysate is formed in parallel with the other three lines from the other end, and the heating line is connected to the other three lines. The peritoneal dialysis circuit is incorporated in a closed manner (integral or non-detachable).
[0025]
Moreover, as another embodiment, the sterilization filter is the circuit for peritoneal dialysis having a gas accommodating portion for storing a gas present in the liquid at an upper portion.
[0026]
In another embodiment, the sterilization filter is the peritoneal dialysis circuit in which a cylindrical housing is divided into two chambers by a flat membrane filter.
[0027]
In another embodiment, the sterilization filter is the peritoneal dialysis circuit having a water permeability of at least 2.30 ml / min · cm 2. Preferably, the peritoneal dialysis circuit has a water permeation performance of a sterilization filter in a range of 3.5 to 7.5 ml / min · cm 2.
[0028]
As another embodiment, the peritoneal dialysis circuit has an effective pore size of the sterilization filter in a range of 0.22 to 0.45 μm.
[0029]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, a plurality of embodiments of the present invention will be briefly described with reference to the drawings. FIG. 1 is a schematic diagram showing an example of a circuit 1 for a peritoneal dialysis device of the present invention. One end of the circuit 1 is a suction / discharge means side connecting portion (suction side connecting portion) 1a connected to the flexible chamber 2 as suction / discharge means. The flexible chamber 2 is preferably incorporated in advance in the circuit 1 from the viewpoint of preventing contamination. The other end of the circuit 1 is a dialysate side connecting portion 1b that is connected to a plurality of dialysate bags 3a, 3b, 3c. In this example, the dialysate side connecting portion 1b is provided with the bag side connector 1c that can be detachably connected to the container connector 3d connected to the dialysate container, but it may be connected directly to each bag.
[0030]
A sterilization filter 4 for removing bacteria and bacteria from the peritoneal dialysis fluid to be injected into the patient's abdominal cavity is provided at the intermediate portion (not meaning the center) between the suction / discharge means side connection portion and the dialysate side connection portion. It is installed. Further, a drainage line 6 that communicates with the drainage bag 5 is branched between the sterilization filter 4 and the suction side connecting portion 1a. In addition, it has a flow path opening / closing part fitted with an opening / closing valve 7 between the branching point of the drainage line 6 and the sterilization filter 4, and the dialysate line 1 d and the heating line 9 are connected to the drainage line 6. It can be cut off from.
[0031]
And between the branch part of the drainage line 6, and the suction side connection part 1a, the abdominal cavity line 12 connected to a patient abdominal cavity has branched. At the distal end of the abdominal line 12, a patient side connector 14 for connecting to the peritoneal catheter 13 or an extension tube (not shown) connected to the peritoneal catheter is attached.
[0032]
On the other hand, between the sterilization filter 4 and the bag-side connector 1c, a heating line 9 that communicates with the warming bag 8, a concentration change line 11 that communicates with a dialysate container 10 of a different composition, etc., as necessary. The liquid supply line is branched.
[0033]
A mechanism for the outflow / inflow of dialysate by the dialysate circuit 1 of this example will be briefly described. The suction / discharge means illustrated in this example is a flexible chamber 2, and by applying a negative pressure or a positive pressure to the chamber 2, the liquid is sucked into the chamber or discharged outside the chamber. To feed the solution.
[0034]
And from each bag (drainage bag, warming bag, dialysate bag) through each line (drainage line, heating line, dialysate line, etc.) connected to the peritoneal dialysis circuit, inside the flexible chamber 2 The liquid is sucked into the patient and injected into the patient's abdominal cavity or another bag (heating bag, drainage bag) different from the sucked bag. With this method, the amount that can be delivered at one time cannot exceed the capacity of the chamber 2, and therefore, when the amount of delivered fluid is large, the fluid is delivered by repeatedly expanding and contracting the chamber.
[0035]
Even if a disinfection filter is used, if contamination occurs at the place where the filter is connected to the patient's abdominal cavity, it will be meaningless, so the line should be removed as much as possible on the downstream side (patient side) of the peritoneal dialysis circuit of the present invention. In other words, it is desirable that each line is incorporated from the beginning, in other words, an integrally formed line. In this example, at least the heating line 9, the sterilization filter 4, the open / close valve (flow channel opening / closing part) 7, the drainage line 6, the flexible line in the downstream circuit (patient side) circuit of the dialysate side connection part 1b. The constituent elements of the sex chamber 2 and the like are incorporated in advance so that these desorption operations are not required when the liquid is exchanged. According to another expression, it is formed in a closed system so as to prevent contamination.
[0036]
Next, a preferable sterilization filter for use in the present invention will be described. FIG. 3 shows an example of a suitable sterilization filter 4. As in this example, by providing a gas accommodating portion 41 that accommodates gas in the upper part, the liquid passage surface of the filter is configured not to cause an air lock with gas (mixed during liquid circulation). Is desirable.
[0037]
The sterilization filter 4 is divided into two chambers by a flat membrane filter 43 disposed obliquely in the cylindrical housing 42 as shown in FIG. The dialysate first flows into the pre-permeation chamber 45 through the inflow pipe 44, passes through the flat membrane filter 43, then flows into the post-permeation chamber 46, and flows out through the outflow pipe 47. Since the inflowing gas is lighter than the liquid, it is accommodated in the upper gas accommodating portion 41. In APD therapy, by using a plurality of dialysate bags, even if gas is mixed into the dialysate, the gas is stored in the gas storage unit 41 before the gas passes through the filter. Air lock can be prevented.
[0038]
The permeation performance of the flat membrane filter 43 is not particularly limited, but those having too low permeability are not preferable because it takes a long time to circulate a large amount of dialysate. Accordingly, those having a water permeability of 2.30 ml / min · cm 2 or more are desirable. As a factor affecting the water permeability, there is a membrane area of the filter 43. Therefore, in order to improve water permeability, the membrane area of the filter is preferably in the range of 20 to 45 cm2.
[0039]
However, even if the water permeation performance is large, it is meaningless if the sterilization performance of the liver kidney is lowered, so that the effective pore diameter of the filter 43 is preferably 0.22 to 0.45 μm.
[0040]
FIG. 2 is a schematic diagram showing another example of the circuit 1 for the peritoneal dialysis device of the present invention. The peritoneal dialysis circuit 1 shown in FIG. 2 has a suction side connection portion 1a connected to a flexible chamber 2 as suction / discharge means at one end, and a manifold (various manifold) at the other end. The flow path of the dialysate line 1d, the abdominal cavity line 12, the drainage line 6, and the heating line 9 is connected in parallel via a pipe 15. Furthermore, the dialysate line 1d, the abdominal cavity line 12, the drainage line 6, and the heating line 9 are connected to the dialysate bags 3a, 3b, and 3c, the patient-side connector 14, the drainage bag 5, and the warming bag 8, respectively. Yes.
[0041]
The end of the dialysate line 1d is a dialysate side connecting portion 1b, and the dialysate bag 3 may be provided with a connector (not shown) that can be connected to an attached connector. In addition, opening / closing valves 7a, 7b, 7c, and 7d are attached to the respective lines so that the respective flow paths can be opened and closed. And in this example, the site | part with which the on-off valve 7b on the dialysate line was mounted | worn is a flow-path opening / closing part.
[0042]
In this example, in the dialysate line 1d, the sterilization filter 4 is mounted between the manifold 15 and the dialysate side connecting portion 1b, and the open / close valve 7b is provided between the manifold 15 and the sterilization filter 4. . Thus, by providing an opening / closing means between the manifold 15 and the sterilization filter 4 where the liquid from each line may flow in, the stored liquid from the abdominal cavity permeates the sterilization filter. Or it prevents contact with the filter. Further, in this example, the above three lines (dialysis fluid line 1d, abdominal cavity line 12, drainage line 6), the suction side connecting portion 1a side, and the heating line 9 are not contaminated as described above. From the point of view, the one integrated in advance is used.
[0043]
【Example】
Hereinafter, a procedure for performing an automatic peritoneal dialysis treatment using the above-described APD circuit will be briefly described. In the circuit shown in FIG. 1, operations are performed in the following order. First, the bag-side connector 1 c of the dialysis circuit 1 is connected to the plurality of dialysate bags 3. At this time, since the open / close means of the conduit attached to each dialysate bag 3 is closed, the dialysate does not flow into the circuit 1.
[0044]
Next, the patient-side connector 14 is connected to the patient's peritoneal catheter 13 or an extension tube (not shown) connected thereto. Also at this time, since the opening / closing means (not shown) attached to the catheter or the extension tube is closed, the liquid does not flow into the circuit 1. Alternatively, an open / close valve (open / close means) 7d may be provided in the abdominal cavity line 12 as necessary.
[0045]
After confirming the connection between the circuit 1 and the two locations, the opening / closing valve 7b is opened and the opening / closing valve 7d is closed. The attached flow path closing clamp (not shown) is opened in the dialysate bag 3a, and negative pressure is applied to the flexible chamber 2. Then, the dialysate flows into the chamber 2 from the dialysate bag 3 a through the dialysate line 1 d and the sterilization filter 4. At this time, the heating line 9, the concentration changing line 11, and the drainage line 6 are closed by electromagnetic valves (not shown) installed in the respective lines.
[0046]
Next, the solenoid valve loaded in the dialysate line 1d is closed, and the solenoid valve loaded in the heating line 9 is opened. When a positive pressure is applied to the chamber 2 in this state, the dialysate flows into the warming bag 8 from the chamber 2 through the sterilization filter 4 and the warming line 9. By repeating the above operation, the dialysate is transferred from the dialysate bag 3a to the warming bag 8, and when the dialysate bag 3a becomes empty, the dialysate is similarly discharged from the next dialysate bag 3b. The heating bag is heated by a heater so that the dialysate is heated to about body temperature.
[0047]
While the dialysate is warmed by the warming bag 8, the liquid previously stored in the patient's abdominal cavity is drained. The patient side line opening / closing means (not shown) and the valve 7d are opened, and the valve 7b is closed. Then, a negative pressure is applied to the chamber 2 to allow the stored fluid to flow into the chamber 2 from the patient abdominal cavity 30. Next, the valve 7 d is closed and positive pressure is applied to the chamber 2. Then, the stored liquid stored in the chamber 2 is discharged to the drain bag 5. This operation is repeated to transfer all the stored fluid from the patient's abdominal cavity to the drainage bag 5. Since the valve 7b is closed during the above drain operation, the stored liquid does not come into contact with the sterilization filter 4.
[0048]
When the stored liquid is completely discharged, the valve 7b is opened and the valve 7d is closed. With the solenoid valve loaded in each of the dialysate line 1d, the drainage line 6, and the concentration changing line 11 closed and the solenoid valve of the heating line 9 opened, negative pressure is applied to the chamber 2 and the chamber 2 The dialysate in the heating bag is allowed to flow into the inside. Next, a positive pressure is applied to the chamber 2 with the valve 7b closed and the electromagnetic valve of the drainage line 6 opened. Then, the dialysate in the chamber 2 is transferred to the drainage bag 5. In this way, the inside of the chamber 2 (used for draining the patient reservoir) is cleaned. This cleaning operation may be performed by determining the amount of the dialysate cleaning solution and the number of repetitions of suction and discharge depending on the degree of necessity of cleaning the chamber 2.
[0049]
When the washing operation is completed, the operation shifts to an operation for injecting the dialysate into the patient's abdominal cavity. The solenoid valve loaded in each of the dialysate line 1d, the concentration changing line 11, and the drain line 6 is closed, and negative pressure and positive pressure are alternately applied to the chamber 2, and the valves 7b and 7d are alternately set. By opening and closing, the dialysate in the warming bag 8 is injected into the abdominal cavity of the patient by the mechanism as described above. When all the operations associated with dialysis are completed, the patient-side connector 14 is detached from the patient line 13 and the dialysis circuit 1 is discarded.
[0050]
When fluids (reservoir and dialysate) are exchanged as described above, the clogged filter and flow rate decrease due to the retained fluid even if the chamber for sucking and discharging dialysate and patient reservoir is shared. Can be prevented. In the present embodiment, the on-off valve 7 (b, d) and the electromagnetic valve have been described separately, but the same operation is possible even if the on-off valve 7 is replaced with an electromagnetic valve.
[0051]
Also in the circuit shown in FIG. 2, the operation is performed by basically the same procedure as described above. First, the several dialysate bag 3 is connected with the dialysate side connection part 1b of the dialysis circuit 1. FIG. Further, the patient line 13 is connected to the patient side connector 14 of the dialysis circuit 1. Next, for injection into the heating line, with the valves 7c and 7d closed, the valves 7a and 7b are alternately opened and closed, and negative pressure and positive pressure are alternately applied to the chamber 2 to thereby dialysate. The liquid is transferred from the bag 3 to the heating bag 8. While the temperature of the heating bag is raised, the patient reservoir is drained.
[0052]
The stored liquid is discharged from the patient abdominal cavity 30 to the drainage bag 5 by alternately opening and closing the valves 7c and 7d with the valves 7a and 7b closed, and alternately applying negative and positive pressures to the chamber 2. Done. As described above, the suction / discharge of the chamber 2 is repeated until the stored liquid is discharged from the abdominal cavity of the patient.
[0053]
For cleaning and priming of the circuit 1, the dialysate contained in the warming bag flows into the chamber 2 and is discharged into the drainage bag 5. This cleaning (priming) operation is performed by alternately opening and closing the valves 7a and 7d with the valves 7b and 7c closed, and alternately applying a negative pressure and a positive pressure to the chamber 2.
[0054]
When the washing (priming) operation is completed, the operation shifts to a dialysate injection operation into the patient's abdominal cavity. This liquid injection operation is performed by alternately opening and closing the valves 7a and 7c with the valves 7b and 7d closed, and alternately applying a negative pressure and a positive pressure to the chamber 2. Also in the circuit and operation procedure of this example, the patient reservoir does not pass through or contact the sterilization filter 4, so there is no concern about blockage or a decrease in flow rate. When the liquid injection operation is completed, the patient connector 14 is detached from the patient line 13 and the dialysis circuit 1 is discarded.
【The invention's effect】
The peritoneal dialysis circuit of the present invention provides the following advantages. First, contamination and infection during dialysate exchange in APD therapy can be prevented with a simple structure and mechanism. Second, even when an operation that may cause contamination / infection is performed at the time of desorption (connection / detachment), it is possible to prevent bacteria and bacteria from finally entering the patient's abdominal cavity.
[Brief description of the drawings]
FIG. 1 is a schematic view showing one embodiment of a circuit for peritoneal dialysis according to the present invention.
FIG. 2 is a schematic view showing another embodiment of the circuit for peritoneal dialysis of the present invention.
FIG. 3 is a schematic view of a sterilization filter that can be suitably used in the circuit for peritoneal dialysis of the present invention.
[Explanation of symbols]
1. Circuit for peritoneal dialysis machine 1a. Suction side connecting portion 1b. Dialysate side connector 1c. Bag side connector 1d. Dialysate line 2. 2. Flexible chamber Dialysate bag 3a. First dialysate bag 3b. Second dialysate bag 3c. Third dialysate bag 3d. 3. Container connector 4. Disinfection filter 5. drainage bag 6. drainage line Open / close valve 7a. Open / close valve (heating line)
7b. Open / close valve (dialysis fluid line)
7c. Open / close valve (abdominal cavity line)
7d. Open / close valve (drainage line)
8). 8. Heating bag Heating line 10. 10. Dialysate bag (of different fluid composition) Concentration change line 12. Abdominal line 13. Peritoneal catheter (or patient line)
14 Patient side connector 15. Manifold 30. Patient (abdominal cavity)
41. Gas storage part 42. Cylindrical housing 43. Flat membrane filter 44. Inflow pipe 45. Pre-transmission chamber 46. Post-transmission chamber 47. Outflow pipe

Claims (16)

At one end, a dialysate storage container connecting portion (hereinafter referred to as “connector”) connected to a dialysate storage container (one or a plurality) containing fresh dialysate, or provided with a connector connectable to the dialysate storage container A dialysate side connecting portion), and a patient side connector that can be connected to the patient's peritoneal catheter or an extension tube connected to the catheter at the other end. Has a suction / discharge means side connecting portion (hereinafter also referred to as a suction side connecting portion) connected to suction / discharge means for sucking / discharging dialysate and drainage fluid from the patient , A peritoneal dialysis circuit having a sterilization filter attached to an intermediate part between the suction side connection part, the circuit comprising a patient's peritoneal catheter or an extension tube connected to the catheter, suction / drainage means, and a sterilization filter When And peritoneal line communication, a dialysate line for communicating the dialysate container and the sterilizing filter, a solution stored for branch (into the patient peritoneal cavity between said sterilization filter and the suction-side connecting portion discharge A drainage line (for draining), and a channel opening / closing part that can be opened and closed by an opening / closing means between the branch part of the drainage line and the abdominal cavity line and the sterilization filter. A circuit for an automatic peritoneal dialysis machine. The circuit for an automatic peritoneal dialysis device according to claim 1 , wherein a heating line for heating the dialysate is provided between the dialysate side connection portion and the sterilization filter. The automatic peritoneal dialysis apparatus according to any one of claims 1 and 2 , wherein a concentration change line for changing a concentration of a dialysate to be administered to a patient is provided between the dialysate side connecting portion and the sterilization filter. Circuit. 4. The automatic peritoneal dialysis device circuit according to claim 2, wherein at least the dialysate line and the heating line are connected by a manifold. At least the dialysate side connection part, the heating line, the sterilization filter, the flow channel opening / closing part, the drainage line, and the suction side connection part are incorporated in a closed manner (so as to be integral or non-detachable). 5. The circuit for an automatic peritoneal dialysis device according to any one of claims 2 to 4 . The circuit for an automatic peritoneal dialysis device according to any one of claims 1 to 5 , wherein the sterilization filter has a gas accommodating portion for storing a gas present in the liquid at an upper portion. The circuit for an automatic peritoneal dialysis device according to claim 6 , wherein the sterilizing filter is obtained by dividing a cylindrical housing into two chambers by a flat membrane filter. The circuit for an automatic peritoneal dialysis device according to any one of claims 6 and 7 , wherein the sterilization filter has a water permeability of 2.20 ml / min · cm 2. The circuit for an automatic peritoneal dialysis device according to any one of claims 6 to 8 , wherein an effective pore size of the sterilizing filter is in a range of 0.22 to 0.45 µm. One end has a suction / discharge means side connecting part that connects to the suction / discharge means for sucking / discharging dialysate and patient drainage , and the other end contains fresh dialysate. A dialysis fluid connected to a dialysis fluid storage container connecting portion (hereinafter also referred to as a dialysis fluid side connection portion) having a connector that can be connected to one or a plurality of dialysis fluid storage containers or to be connected to any of the dialysis fluid storage containers Line, an abdominal line connected to the patient's abdominal cavity, and a drainage line (for draining the liquid stored in the patient's abdominal cavity) are formed in parallel through the manifold , the sterilization and filter is provided between the said manifold and該除bacteria filter and flow path switching unit is provided, yet the abdominal line, to open and close the drainage respective flow path to the line Automated peritoneal dialysis system circuit, characterized in that the provided flow channel opening and closing means for. At least the above three lines (dialysate line, abdominal cavity line, drainage line) and a line including the suction side connecting portion are incorporated in a closed manner (integral or non-detachable). The circuit for an automatic peritoneal dialysis device according to claim 10 . From the other end, a heating line for heating the dialysate is formed in parallel with the other three lines, and the heating line is closedly incorporated with the other three lines ( The circuit for an automatic peritoneal dialysis device according to any one of claims 10 and 11 , which is formed integrally or non-detachable. The circuit for an automatic peritoneal dialysis device according to any one of claims 10 to 12 , wherein the sterilization filter has a gas accommodating portion for storing a gas present in the liquid at an upper portion. The circuit for an automatic peritoneal dialysis apparatus according to claim 13 , wherein the sterilizing filter is obtained by dividing a cylindrical housing into two chambers by a flat membrane filter. The circuit for an automatic peritoneal dialysis device according to any one of claims 13 and 14 , wherein the sterilization filter has a water permeability of 2.30 ml / min · cm 2. The circuit for an automatic peritoneal dialysis device according to any one of claims 13 to 15 , wherein an effective pore size of the sterilizing filter is in a range of 0.22 to 0.45 µm.

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