JP2003024435A - Circuit with sterilization filter for automatic peritoneal dialyzer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a peritoneal dialyzer (set) capable of preventing the contamination and infection in exchange of a dialyzing liquid in APD(automatic peritoneal dialysis) therapy with a further simple structure. SOLUTION: This peritoneal dialyzing circuit suitable for an automatic peritoneal dialyzer with a liquid sucking/discharging mechanism comprises a sterilization filter provided in a prescribed position of the circuit.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a peritoneal dialysis apparatus used for treating a patient with renal failure, and more particularly to a circuit for peritoneal dialysis which is optimal for use in an automatic peritoneal perfusion device.

[0002]

2. Description of the Related Art Peritoneal dialysis is a simple and convenient treatment method which allows patients with chronic renal failure to be treated by changing the dialysate at home or at work by themselves. Recently, APD therapy (intensive peritoneal dialysis therapy that exchanges peritoneal dialysis fluid with an automatic infusion / drainage device) that performs intensive treatment at night or during the day to improve the quality of life and medical efficiency of patients. Is widespread. Since the method is operated by a machine, it is suitable for use by a busy patient, a patient who has difficulty in performing a regular replacement operation, or a physically handicapped patient.

As a concrete treatment, a dialysate container containing a large amount of dialysate is connected to a dialysis set or the like (connected to a catheter left in the abdominal cavity of a patient) and the like, and a preset time, an injection amount, The dialysate is automatically injected into the abdominal cavity of the patient and discharged according to the number of times. In this method, since the peritoneal dialysis treatment is performed while the patient is sleeping, it is possible to reduce the time for which the operation of exchanging the dialysate is restricted. In addition, since the dialysate can be exchanged in a limited amount of time, the dialysis efficiency can be improved. In recent years, treatments using these devices have been gradually spread, but on the other hand, it has been pointed out that this treatment method is likely to cause peritonitis (because of the contamination of the connector portion due to the fluid exchange at the time of occurrence).

Even in the case of APD therapy using an automatic peritoneal dialysis device, it is necessary to connect / disconnect (disconnect) the APD circuit (which is connected to the peritoneal catheter left in the abdominal cavity of the patient) and the dialysate container. is there. Failure to make these connections cleanly and reliably can cause serious problems for the patient. Therefore, in the facility, a dedicated machine is used at the time of connection, or education is given in advance so that the patient or the like can operate the procedure accurately and safely.

However, when handling an automatic peritoneal perfusion device, a dialysis patient often has to pay attention to operations other than the operation associated with fluid exchange, and contamination or infection at the desorption site cannot be sufficiently prevented. Is the current situation. Furthermore, it is difficult for a patient to perform an accurate attachment / detachment operation because of inconvenient operation due to his / her own aging, various complications, insufficient conditions of a caregiver, and the like. Particularly in APD therapy, a large amount of dialysate is often injected, so that the cartridge for the dialysis set or liquid delivery and the dialysate storage container are frequently attached and detached. When a heating circuit for heating the dialysate is used, the number of times of desorption is further increased. As the frequency of desorption increases, so does the opportunity for contamination and infection.

However, if a means for preventing contamination / infection is provided, the number of strokes that the patient has to operate increases, and the burden on the patient increases. Further, if the mechanism of the prevention means becomes complicated, there is a risk of erroneous operation. Further, there is a problem in that, if an attempt is made to produce a highly effective anti-contamination effect, the device becomes expensive and cannot be used by any patient. Therefore, when the above APD therapy is performed, it is necessary to provide a simple and surely effective contamination / infection prevention mechanism in the device.

[0007] On the other hand, several ideas for utilizing a sterilizing filter when performing peritoneal dialysis have been previously disclosed. For example, even if contamination or infection occurs at the connection site between the dialysate container and the patient catheter, etc., by using a filter at any part of the dialysate injection means (downstream of the contamination occurrence site), It is intended to prevent the infiltration of bacteria into the abdominal cavity and is disclosed in JP-A-57-112873, JP-A-60-249971 and the like.

The above-mentioned prior application is intended to trap bacteria and bacteria with a sterilizing filter mounted on the downstream side even if the flow path is contaminated at the connecting portion. It is a diverted filter. The above was useful as an idea itself,
It was not practically applicable to peritoneal dialysis therapy. This is because there were various problems as follows.

Since infiltration of the dialysate into the filter by self-priming takes a long time, it is desirable to use an apparatus for the purpose of discharging and injecting the fluid. In the current automatic peritoneal dialysis device, not only the inhalation / exhaust of the dialysate, but also the inhalation / exhaust of the stored liquid in the abdominal cavity of the patient uses the diaphragm type inhalation / exhaust means. Then, when the stored liquid flows into the diaphragm and the stored liquid containing the biological component passes through or comes into contact with the filter, the filter is clogged, so that the flow rate is significantly reduced and finally blocked.

When using a plurality of chemical solution bags, the air existing in the next bag flows into the filter infiltrated with the solution from one bag, causing an air lock (clogging, clogging by air). I will end up. In order to prevent the inflow of stored liquid into the filter and contact with biological components,
If the flow path switching means or another flow path is provided, the circuit structure itself must be changed. In addition, the modified circuit cannot be used for the current automatic exchange device. Further, the operation of switching the flow path may be troublesome or the possibility of erroneous operation may increase.

[0011]

SUMMARY OF THE INVENTION Therefore, an object of the present invention is to provide a peritoneal dialysis device (set) having a simpler structure and capable of preventing contamination and infection during dialysate exchange in APD therapy. Desorption (connection / disconnection)
In this case, it is an object of the present invention to provide a peritoneal dialysis device (set) that can prevent bacteria and bacteria from finally entering the abdominal cavity of a patient even if an operation that easily causes contamination and infection is performed, and a means therefor.

[0012]

According to a first aspect of the present invention, one end is connected to a single or a plurality of dialysate storage containers containing fresh dialysate, or is connected to the dialysate storage container. It has a dialysate storage container connecting part (hereinafter also referred to as dialysate side connecting part) provided with a possible connector, and at one end of the other side, a suction / connecting means for connecting with a liquid suction / discharge means.
A peritoneal dialysis circuit having a discharge means side connecting portion (hereinafter, also referred to as a suction side connecting portion) and having a sterilizing filter attached to an intermediate portion of the both end portions, the circuit comprising a sterilizing filter and dialysis. A drain line (for draining the fluid stored in the abdominal cavity of the patient) is provided which has a dialysate line communicating with the fluid storage container and branches between the sterilization filter and the suction side connecting portion. A circuit for an automatic peritoneal dialysis device, characterized in that a flow path opening / closing part capable of opening / closing a flow path by an opening / closing means is provided between the branch part of the drainage line and the sterilization filter.

Further, the present invention can take various embodiments as described below in addition to the above configuration. That is, in one embodiment, the peritoneal dialysis circuit is further divided into an abdominal line connecting to the abdominal cavity of the patient between the suction / drainage means side connecting part and the drain line branch part.

As another embodiment, the peritoneal dialysis circuit is provided with a heating line for heating the dialysate between the dialysate-side connecting portion and the sterilization filter.

In another embodiment, the peritoneal dialysis is provided with a concentration changing line for changing the concentration of the dialysate to be administered to the patient, between the dialysate-side connecting portion and the sterilization filter. Circuit.

[0016] In another embodiment, the peritoneal dialysis circuit has at least the dialysate line and the heating line connected by a manifold. [If there are multiple dialysate containers, there are multiple dialysate lines,
Each dialysate line may be connected by a manifold. ]

Further, as another embodiment, at least the dialysate-side connecting portion, the heating line, the sterilizing filter, the flow path opening / closing portion, the drainage line, and the suction-side connecting portion are assembled in a closed manner. The circuit for peritoneal dialysis described above (which is formed integrally or non-detachably).

Further, as another embodiment, the peritoneal dialysis circuit is provided with the gas sterilization filter having a gas storage portion for storing gas existing in a liquid in an upper portion thereof.

As another embodiment, the sterilization filter is the peritoneal dialysis circuit in which the tubular housing is divided into two chambers by a flat membrane filter.

As another embodiment, the antibacterial filter is the circuit for peritoneal dialysis, which has a water permeability of at least 2.30 ml / min · cm 2. Preferably, the sterilizing filter has a water permeability of 3.5 to 7.5 ml.
The peritoneal dialysis circuit is in the range of / min · cm 2.

As another embodiment, the peritoneal dialysis circuit is the peritoneal dialysis circuit in which the effective pore diameter of the sterilization filter is in the range of 0.22 to 0.45 μm.

A second aspect of the present invention has, at one end, a suction / discharge means-side connecting portion which is connected to a liquid suction / discharge means, and at the other end, fresh dialysate is stored. A dialysate line connected to a single or a plurality of dialysate storage containers, or a dialysate storage container connecting part (hereinafter also referred to as a dialysate side connecting part) having a connector connectable to any one of the dialysate storage containers. , Abdominal line connecting to the patient's abdominal cavity, (for draining fluid stored in the patient's abdominal cavity)
At least three flow paths of the drain line are formed in parallel,
The dialysate line is provided with a flow path opening / closing part for communicating / closing the line and the flow path on the suction / exhaust means side, and in the dialysate line, the flow path opening / closing part and the dialysate side connecting part are provided. A circuit for an automatic peritoneal dialysis device, characterized in that a sterilization filter is provided between the two, and a flow path opening / closing means for opening / closing each flow path is provided in the abdominal cavity line and the drainage line.

Furthermore, the present invention can take various embodiments as described below in addition to the above-mentioned constitution. That is, as one embodiment, at least the above-mentioned three lines (dialysate line, abdominal line, drainage line) and the line including the suction side connection part are closed-incorporated (integrally or non-detachable). The peritoneal dialysis circuit is formed as described above.

Further, as another embodiment, a heating line for heating the dialysate is formed in parallel with the other three lines from the other end, and the heating line is connected to the other three lines.
The above-mentioned circuit for peritoneal dialysis, which is closed-integrated (integrally or non-detachably formed) with two lines.

[0025] As another embodiment, the peritoneal dialysis circuit is the circuit for sterilization, wherein the sterilization filter has a gas storage portion for storing gas existing in a liquid in the upper portion.

As another embodiment, the sterilization filter is the peritoneal dialysis circuit in which the tubular housing is divided into two chambers by a flat membrane filter.

As another embodiment, the sterilization filter is the peritoneal dialysis circuit having a water permeability of at least 2.30 ml / min · cm 2. Preferably, the sterilizing filter has a water permeability of 3.5 to 7.5 ml.
The peritoneal dialysis circuit is in the range of / min · cm 2.

As another embodiment, the peritoneal dialysis circuit has the effective pore diameter of the sterilization filter in the range of 0.22 to 0.45 μm.

[0029]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS A plurality of embodiments of the present invention will be briefly described below with reference to the drawings. FIG. 1 is a schematic diagram showing an example of a circuit 1 for a peritoneal dialysis device of the present invention. This circuit 1
One end of the one is a suction / exhaust means side connecting portion (suction side connecting portion) 1a that is connected to the flexible chamber 2 which is the suction / exhausting means. The flexible chamber 2 is preferably incorporated in the circuit 1 in advance from the viewpoint of preventing contamination.
In addition, the other end of the circuit 1 has a plurality of dialysate bags 3a,
It is a dialysate-side connecting portion 1b connected to 3b and 3c. In this example, the dialysate-side connecting portion 1b is provided with the bag-side connector 1c that can be detachably connected to the container connector 3d that communicates with the dialysate container, but it may be directly connected to each bag.

At the intermediate portion (not in the center) between the suction / exhaust means-side connecting portion and the dialysate-side connecting portion, sterilization for removing bacteria and bacteria from the peritoneal dialysate injected into the abdominal cavity of the patient. The filter 4 is installed. Also,
A drainage line 6 communicating with the drainage bag 5 is branched between the sterilization filter 4 and the suction side connecting portion 1a. Further, a flow path opening / closing section having an opening / closing valve 7 is provided between the branch point of the drainage line 6 and the sterilization filter 4, and each line of the dialysate line 1d and the heating line 9 is connected to the drainage line 6
I am able to shut it off.

Between the branch portion of the drainage line 6 and the suction side connecting portion 1a, the abdominal cavity line 1 which communicates with the abdominal cavity of the patient.
2 is branched. At the tip of the abdominal cavity line 12, a patient-side connector 1 for connecting with a peritoneal catheter 13 or an extension tube (not shown) connected to the peritoneal catheter.
4 is installed.

On the other hand, between the sterilization filter 4 and the bag side connector 1c, if necessary, a heating line 9 for communicating with the heating bag 8 and a concentration changing line for communicating with the dialysate container 10 having a different composition. 11 and the like are branched.

The mechanism for outflowing / inflowing the dialysate by the dialysate circuit 1 of this example will be briefly described. The suction / discharge means illustrated in this example is a flexible chamber 2, and by applying a negative pressure or a positive pressure to the chamber 2, the liquid is sucked into the chamber or discharged from the chamber. To send the liquid.

Then, through each line (drainage line, heating line, dialysate line, etc.) connected to the peritoneal dialysis circuit, it is flexible from each bag (drainage bag, heating bag, dialysate bag). The liquid is sucked into the chamber 2 and injected into a patient's abdominal cavity or another bag (heating bag, drain bag) different from the sucked bag. With this method, the amount of liquid that can be sent at one time cannot exceed the capacity of the chamber 2. Therefore, when the amount of liquid to be sent is large, the expansion and contraction of the chamber are repeated to send the liquid.

Even if a sterilizing filter is used, it becomes meaningless if contamination occurs at the place where the filter and the patient's abdominal cavity are connected. Therefore, as much as possible at the filter downstream side (patient side) of the peritoneal dialysis circuit of the present invention. It is also desirable that each line is built in from the beginning, in other words, integrally formed so that the lines do not need to be attached and detached. In this example, in the circuit on the downstream side (patient side) of the dialysate-side connecting portion 1b, at least the heating line 9, the sterilization filter 4, the opening / closing valve (flow passage opening / closing portion) 7, the drainage line 6, and the flexible line. The constituent elements of the sex chamber 2 and the like are incorporated in advance so that these desorption operations are not necessary at the time of liquid exchange. In other words, it is formed as a closed system to prevent pollution.

Next, a preferable sterilizing filter for use in the present invention will be described. FIG. 3 shows an example of a suitable sterilization filter 4. As in this example, by providing a gas storage portion 41 for storing a gas in the upper portion thereof, a structure in which the liquid passage surface of the filter does not cause airlock due to gas (mixed during liquid circulation) Is desirable.

The sterilization filter 4 has a cylindrical housing 42.
Among them, as shown in FIG. 3, it is divided into two chambers by a flat film filter 43 arranged obliquely. The dialysate first flows into the pre-permeation chamber 45 via the inflow pipe 44, permeates the flat sheet membrane filter 43, then flows into the post-permeation chamber 46, and flows out via the outflow pipe 47. The gas that flows in is lighter than the liquid, and is stored in the upper gas storage portion 41. APD
In therapy, the use of multiple dialysate bags may result in gas contamination of the dialysate,
Before the gas passes through the filter, the gas storage unit 4
Since it is housed in 1, the air lock can be prevented.

The permeation performance of the flat sheet membrane filter 43 is not particularly limited, but one having too low permeability is not preferable because it takes a long time to pass a large amount of dialysate. Therefore, 2.30 ml /
A material having a water permeability of min.cm2 or more is desirable. The filter 43 is a factor that affects the water permeability.
There is a membrane area of. Therefore, in order to improve water permeability, the membrane area of the filter is preferably in the range of 20 to 45 cm 2.

However, even if the water permeability is large, it is meaningless that the sterilization performance of the liver and kidney is deteriorated. Therefore, it is preferable that the effective pore size of the filter 43 is 0.22 to 0.45 μm.

FIG. 2 is a schematic view showing another example of the circuit 1 for peritoneal dialysis apparatus of the present invention. The circuit 1 for peritoneal dialysis shown in FIG. 2 has a suction side connecting portion 1a which is connected to a flexible chamber 2 which is a suction / exhausting means at one end, and a manifold (multi-type) at the other end. The flow paths of the dialysate line 1d, the abdominal cavity line 12, the drainage line 6, and the heating line 9 are connected in parallel via the tube 15 in parallel. Further, the dialysate line 1d, the abdominal cavity line 12, the drainage line 6, and the heating line 9 are respectively provided in the dialysate bag 3
a, 3b, 3c, patient side connector 14, drainage bag 5,
It is connected to the heating bag 8.

The end portion of the dialysate line 1d is the dialysate side connecting portion 1b, and the dialysate bag 3 may be provided with a connector (not shown) which can be connected to an accessory connector. Also,
On-off valves 7a, 7b, 7c and 7d are attached to each of the above lines so as to open and close each flow path. In this example, the open / close valve 7 on the dialysate line is
The part where b is attached is the flow path opening / closing part.

In the present example, in the dialysate line 1d, the sterilization filter 4 is installed between the manifold 15 and the dialysate side connecting portion 1b, and the opening / closing valve 7b is provided between the manifold 15 and the sterilization filter 4. It is provided. In this way, by providing the opening / closing means between the manifold 15 and the sterilization filter 4 to which the liquid from each line may flow, the stored liquid from the abdominal cavity permeates the sterilization filter. Or it prevents contact with the filter. In addition, in this example, the above-mentioned three lines (dialysate line 1d, abdominal cavity line 12, drainage line 6), the line on the suction side connecting portion 1a side, and the heating line 9 are for preventing contamination as described above. From the point of view, the one that is integrated in advance is used.

[0043]

EXAMPLES Below, using the above-mentioned APD circuit,
A procedure for performing the automatic peritoneal dialysis treatment will be briefly described. In the circuit shown in FIG. 1, the operations are performed in the following order. First, the bag-side connector 1c of the dialysis circuit 1 is connected to the plurality of dialysate bags 3. At this time, since the opening / closing means of the conduit attached to each dialysate bag 3 is closed, the dialysate does not flow into the circuit 1.

Next, the patient-side connector 14 is connected to the patient's peritoneal catheter 13 or an extension tube (not shown) connected thereto. At this time as well, since the opening / closing means (not shown) attached to the catheter or the extension tube is closed, the liquid does not flow into the circuit 1. Alternatively, an opening / closing valve (opening / closing means) 7d may be provided in the abdominal cavity line 12 as needed.

After confirming the connection between the circuit 1 and the above two points,
The open / close valve 7b is opened and the open / close valve 7d is closed. A flow path closing clamp (not shown) attached to the dialysate bag 3a is opened to apply a negative pressure to the flexible chamber 2. Then,
The dialysate flows into the chamber 2 from the dialysate bag 3a through the dialysate line 1d and the sterilization filter 4. At this time, each line of the heating line 9, the concentration changing line 11, and the drainage line 6 is closed by a solenoid valve (not shown) loaded in each line.

Next, the solenoid valve loaded in the dialysate line 1d is closed, and the solenoid valve loaded in the heating line 9 is opened. When a positive pressure is applied to the chamber 2 in that state, the dialysate flows from the chamber 2 into the heating bag 8 through the sterilization filter 4 and the heating line 9. The above operation is repeated to transfer the dialysate from the dialysate bag 3a to the heating bag 8, and when the dialysate bag 3a becomes empty, the dialysate is similarly discharged from the next dialysate bag 3b. The heating bag is heated by the heater so that the dialysate is heated to about the body temperature.

While the dialysate is being heated by the heating bag 8, the liquid previously stored in the abdominal cavity of the patient is discharged. After opening / closing means (not shown) of the patient side line and the valve 7d and closing the valve 7b, a negative pressure is applied to the chamber 2 to allow the stored liquid to flow from the patient's abdominal cavity 30 into the chamber 2. Next, the valve 7d is closed and a positive pressure is applied to the chamber 2. Then, the stored liquid stored in the chamber 2 is discharged to the drain bag 5. By repeating this operation, all the stored liquid is transferred from the abdominal cavity of the patient to the drainage bag 5. During the above drainage operation, since the valve 7b is closed, the stored fluid does not come into contact with the sterilization filter 4.

After discharging the stored liquid, the valve 7b is opened and the valve 7d is closed. With the electromagnetic valves installed in the dialysate line 1d, the drainage line 6, and the concentration change line 11 closed and the electromagnetic valve in the heating line 9 opened, a negative pressure is applied to the chamber 2 to set the chamber 2 The dialysate in the heating bag is allowed to flow into the inside. Next, a positive pressure is applied to the chamber 2 with the valve 7b closed and the electromagnetic valve of the drainage line 6 opened. Then, the dialysate in the chamber 2 is transferred to the drain bag 5. In this way, the inside of the chamber 2 (used for draining the patient's stored liquid) is cleaned. In this cleaning operation, the amount of the dialysate cleaning liquid and the number of suction / discharge cycles may be determined according to the degree of necessity of cleaning the chamber 2.

When the washing operation is completed, the operation proceeds to inject the dialysate into the abdominal cavity of the patient. With the electromagnetic valves loaded in the dialysate line 1d, the concentration changing line 11, and the drainage line 6 closed, negative pressure and positive pressure are alternately applied to the chamber 2, and the valves 7b and 7d are alternated. By opening and closing, the dialysate in the heating bag 8 is injected into the abdominal cavity of the patient by the mechanism as described above. When all the operations associated with dialysis are completed, the patient side connector 14 is detached from the patient line 13 and the dialysis circuit 1 is discarded.

When the liquid (reserved liquid and dialysate) is exchanged according to the above procedure, the dialysate and patient stored liquid are aspirated and
Even if the discharge chamber is common, it is possible to prevent clogging of the filter and reduction of the flow rate due to the stored liquid. In this embodiment, the open / close valve 7 (b, d) and the solenoid valve are described separately, but the same operation can be performed even if the open / close valve 7 is replaced with a solenoid valve.

In the circuit shown in FIG. 2, the operation is basically performed by the same procedure as described above. First, the plurality of dialysate bags 3 are connected to the dialysate-side connecting portion 1b of the dialysis circuit 1. Further, the patient line 13 is connected to the patient side connector 14 of the dialysis circuit 1. Next, in order to inject the liquid into the heating line, the valves 7c and 7d are closed and the valves 7a and 7d are closed.
The valve 7b is opened and closed alternately, and negative pressure is alternately applied to the chamber 2.
By applying a positive pressure, the liquid is transferred from the dialysate bag 3 to the heating bag 8. While the temperature of the heating bag is being raised, the patient stored liquid is discharged.

The stored liquid is drained from the patient's abdominal cavity 30 to the drain bag 5, with the valves 7a and 7b closed.
c, the valve 7d is alternately opened and closed, and a negative pressure and a positive pressure are alternately applied to the chamber 2, which is performed. As described above, the suction / discharge of the chamber 2 is repeated until the stored liquid is discharged from the abdominal cavity of the patient.

For cleaning and priming of the circuit 1, the dialysate contained in the heating bag is introduced into the chamber 2 and discharged into the drain bag 5. This cleaning (priming) operation is performed by alternately opening and closing the valves 7a and 7d with the valves 7b and 7c closed, and alternately applying a negative pressure and a positive pressure to the chamber 2.

When the washing (priming) operation is completed,
The procedure proceeds to inject dialysate into the patient's abdominal cavity. This liquid injection operation is performed with the valves 7a and 7d closed while the valves 7b and 7d are closed.
The valve 7c is opened and closed alternately, and negative pressure is alternately applied to the chamber 2.
It is done by applying positive pressure. Also in the circuit and operation procedure of this example, the patient storage liquid does not pass through or come into contact with the sterilization filter 4, so there is no concern of blockage or reduction in flow rate due to it. Then, when the liquid injection operation is completed, the patient side connector 14 is detached from the patient line 13 and the dialysis circuit 1 is discarded.

The circuit for peritoneal dialysis of the present invention has the following advantages. First, a simple structure and mechanism can prevent contamination and infection during dialysate exchange in APD therapy. Second, at the time of detachment (connection / disconnection), even if an operation that may cause contamination or infection is performed, it is possible to finally prevent bacteria or bacteria from entering the abdominal cavity of the patient.

[Brief description of drawings]

FIG. 1 is a schematic view showing one embodiment of a circuit for peritoneal dialysis of the present invention.

FIG. 2 is a schematic view showing another embodiment of the peritoneal dialysis circuit of the present invention.

FIG. 3 is a schematic view of a sterilization filter that can be preferably used in the peritoneal dialysis circuit of the present invention.

[Explanation of symbols]

1. Circuit for peritoneal dialysis machine 1a. Suction side connection 1b. Dialysate side connection 1c. Bag side connector 1d. Dialysate line 2. Flexible chamber 3. Dialysate bag 3a. First dialysate bag 3b. Second dialysate bag 3c. Third dialysate bag 3d. Container connector 4. Sterilization filter 5. Drainage bag 6. Drain line 7. Open / close valve 7a. Open / close valve (heating line) 7b. Open / close valve (dialysis fluid line) 7c. Open / close valve (abdominal line) 7d. Open / close valve (drain line) 8. Heating bag 9. Heating line 10. Dialysate bag (of different fluid composition) 11. Concentration change line 12. Abdominal cavity line 13. Peritoneal catheter (or patient line) 14. Patient side connector 15. Manifold 30. Patient (abdominal cavity) 41. Gas storage 42. Tubular housing 43. Flat membrane filter 44. Inflow pipe 45. Front room 46. Rear room 47. Outflow pipe

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Claims (17)

[Claims] 1. A dialysate container which is connected to one or more dialysate container containing fresh dialysate at one end or provided with a connector connectable to the dialysate container. It has a container connection part (hereinafter also referred to as dialysate side connection part), and at the other one end, suction of liquid
A circuit for peritoneal dialysis, comprising a suction / discharging means-side connecting portion (hereinafter, also referred to as suction-side connecting portion) that is connected to a discharging means, and a sterilization filter is attached to an intermediate portion of the both ends, the circuit comprising: Has a dialysate line that connects the disinfection filter and the dialysate storage container, and branches between the disinfection filter and the suction-side connecting portion (to drain the liquid stored in the abdominal cavity of the patient). An automatic peritoneum, which has a drainage line, and a flow channel opening / closing part capable of opening / closing the flow channel by an opening / closing means is provided between a branch part of the drainage line and the sterilization filter. Circuit for dialysis machine. 2. The circuit for an automatic peritoneal dialysis device according to claim 1, wherein an abdominal line connecting to the abdominal cavity of the patient is further branched between the suction side connecting part and the drain line branch part. 3. The automatic peritoneal dialysis device according to claim 1, wherein a heating line for heating the dialysate is provided between the dialysate-side connecting portion and the sterilization filter. Circuit for. 4. The concentration change line for changing the concentration of dialysate to be administered to a patient is provided between the dialysate-side connecting portion and the sterilization filter. Circuit for automatic peritoneal dialysis machine. 5. The circuit for an automatic peritoneal dialysis device according to claim 3, wherein at least the dialysate line and the heating line are connected by a manifold. 6. At least the dialysate-side connecting portion, the heating line, the sterilizing filter, the flow path opening / closing portion, the drainage line, and the suction-side connecting portion are assembled in a closed manner (integrally or detached). The circuit for an automatic peritoneal dialysis device according to any one of claims 3 to 5, which is formed so as not to be separated. 7. The circuit for an automatic peritoneal dialysis device according to any one of claims 1 to 6, wherein the sterilization filter has a gas storage portion for storing a gas existing in a liquid in an upper portion thereof. 8. The circuit for an automatic peritoneal dialysis device according to claim 7, wherein the sterilization filter is a tubular housing divided into two chambers by a flat membrane filter. 9. The sterilization filter is 2.20 ml / m 2.
The circuit for an automatic peritoneal dialysis device according to claim 7, which has a water permeability of in · cm 2. 10. The effective pore size of the sterilization filter is 0.2.
It is in the range of 2 to 0.45 μm.
The circuit for an automatic peritoneal dialysis device according to any one of 1. 11. One or a plurality of dialysis units, each of which has a suction / drainage means-side connection portion that is connected to a liquid suction / drainage unit at one end, and has fresh dialysate stored at the other end. A dialysate line connected to a dialysate container connecting part (hereinafter also referred to as a dialysate side connecting part) that is connected to a liquid container or has a connector that can be connected to any one of the dialysate containers, and is connected to a patient's abdominal cavity At least three flow paths of an abdominal line and a drain line (for draining the liquid stored in the abdominal cavity of the patient) are formed in parallel, and the dialysate line and the suction / drain means side are connected to the dialysate line. A flow path opening / closing part for communicating / closing the flow path is provided, and in the dialysate line, a sterilization filter is provided between the flow path opening / closing part and the dialysate side connecting part, and the abdominal line, Each of the drain lines Automated peritoneal dialysis system circuit, characterized in that a flow channel opening and closing means for opening and closing the road. 12. At least the above three lines (dialysate line, peritoneal line, drainage line) and a line including a suction side connection part are closed-incorporated (integrally or inseparably). The circuit for an automatic peritoneal dialysis device according to claim 11, which is formed. 13. From the other end, a heating line for heating the dialysate is formed in parallel with the other three lines, and the heating line is closed with the other three lines. The circuit for an automatic peritoneal dialysis device according to claim 11 or 12, which is incorporated (formed integrally or non-detachably formed). 14. The circuit for an automatic peritoneal dialysis device according to any one of claims 11 to 13, wherein the sterilization filter has a gas storage portion for storing a gas existing in a liquid in an upper portion thereof. 15. The circuit for an automatic peritoneal dialysis device according to claim 14, wherein the sterilization filter is a tubular housing divided into two chambers by a flat membrane filter. 16. The sterilizing filter is 2.30 ml /
It has a water permeability of min · cm2.
The circuit for an automatic peritoneal dialysis device according to any one of 4 and 15. 17. The effective pore size of the sterilization filter is 0.2.
The range of 2 to 0.45 μm is preferred.
16. The circuit for an automatic peritoneal dialysis device according to any of 16.