JP4781060B2 - Syringe pump - Google Patents

Description

  The present invention relates to a syringe pump for discharging a sample in a syringe.

  A syringe pump 100 as shown in FIG. 6 is known as a syringe pump used for an experiment using a sample such as a chemical solution.

  The syringe pump 100 includes a main body 102 including a holding unit 130 that holds a syringe 106 having a piston 170, a pressing body 105 that presses the piston 170 in the axial direction, a motor 120 that drives the pressing body 105, and a motor. The control part 121 which controls the action | operation of 120, the moving terminal part 111 fixed to the press body 105, the fixed terminal part 110 fixed to the main body 102, and contacts the moving terminal part 111, the moving terminal part 111, and a fixed terminal A detection unit 109 that detects that the unit 110 has come into contact with the unit 110.

  According to such a syringe pump 100, first, a desired amount of sample is accommodated in the syringe 106. Next, the motor 120 is operated to drive the pressing body 105. As a result, the piston 170 is pressed in the axial direction by the pressing body 105, and the sample is discharged from the syringe 106. Thereafter, the moving terminal portion 111 approaches the fixed terminal portion 110 as the pressing body 105 moves. When the moving terminal unit 111 and the fixed terminal unit 110 come into contact with each other, the detection unit 109 detects this contact. The control unit 121 stops the operation of the motor 120 based on the detection by the detection unit 109. Thus, the discharge of the sample from the syringe 106 is stopped.

  However, in the syringe pump 100 as described above, the moving terminal portion 111 and the fixed terminal portion 110 are fixed to the pressing body 105 and the main body 102, respectively, and the discharge of the sample does not stop unless both are in contact with each other. When the amount of discharge was set, it had to be performed when the sample was stored in the syringe 106. Therefore, it is difficult to finely adjust the discharge amount.

  Further, the stroke when the piston 170 is pushed to the tip of the syringe 106 with the syringe 106 held by the holding unit 130 differs depending on the size of the syringe 106 and the like. However, since the moving distance of the pressing body 105 cannot be adjusted for the above-described reason, for example, when the moving distance of the pressing body 105 is shorter than the stroke of the piston 170, all the sample in the syringe 106 is discharged. I can't. On the other hand, if the sample is long, the pressing body 105 continues to press the piston 170 even after all of the sample is discharged, and thus the syringe 106 may be damaged.

  The present invention has been made to solve the above problems, and an object of the present invention is to provide a syringe pump capable of accurately and easily discharging a desired amount while preventing the syringe from being damaged.

  The object of the present invention is to provide a main body having a holding part for holding a syringe having a piston, a pressing body for pressing the piston in the axial direction, a driving means for driving the pressing body, and an operation of the driving means. Control means for controlling, a stroke adjusting rod attached to the pressing body so as to be movable in the axial direction of the piston, a terminal portion fixed to the main body and contacting the tip of the stroke adjusting rod, A detection unit configured to detect that a tip of a stroke adjusting rod and the terminal portion are in contact with each other, and the control unit is achieved by a syringe pump that stops the operation of the driving unit based on detection of the detection unit. .

  Further, it is preferable that the stroke adjusting rod is inserted into a through hole formed in the pressing body and fixed by a fixing screw screwed into the pressing body so as to be substantially orthogonal to the through hole.

  Further, the object of the present invention is to provide a main body having a holding portion for holding a syringe having a piston, a pressing body that presses the piston in the axial direction, a driving unit that drives the pressing body, and the driving unit. Control means for controlling the operation of the piston, a stroke adjusting rod attached to the main body so as to be movable in the axial direction of the piston, a terminal portion fixed to the pressing body and contacting the tip of the stroke adjusting rod And a detecting means for detecting that the tip of the stroke adjusting rod and the terminal portion are in contact with each other, and the control means is achieved by a syringe pump that stops the operation of the driving means based on the detection of the detecting means. Is done.

  Each of the syringe pumps further includes an input unit for instructing the operation of the drive unit, and the control unit is configured to control the drive unit based on an input from the input unit at an operating speed in a normal operation state. It is preferable to operate at a high speed.

  According to the syringe pump of the present invention, a desired amount can be accurately and easily discharged while preventing the syringe from being damaged.

  Hereinafter, actual forms of the present invention will be described with reference to the accompanying drawings. FIG. 1 is a side sectional view of a syringe pump 1 according to an embodiment of the present invention, FIG. 2 is a top view of the syringe pump 1, and FIG. 3 is a partial side view of the syringe pump 1.

  As shown in FIG. 1, the syringe pump 1 includes a casing-shaped main body 2, a syringe 6 held by a holding portion 93 provided in the main body 2, and a pressure that presses a piston 70 of the syringe 6 in the axial direction. A body 5 and a motor 20 for driving the pressing body 5 are provided. The syringe pump 1 also includes a detection unit 9, an input unit 7 that instructs the operation of the motor 20, and a control unit 21 that controls the operation of the motor 20.

  The main body 2 includes a spacer 33 and a holding portion 93 installed on the spacer 33 in the upper part. The spacer 33 secures the installation height of the holding portion 93 and insulates the holding portion 93 from the main body 2 and is formed of an insulating material. The holding part 93 includes a syringe holder 34 and a clamp 36. The syringe holder 34 is made of a metal having excellent electrical conductivity, and the terminal portion 8 is constituted by a side wall surface. Further, as shown in FIG. 3, a V-shaped notch 30 for holding the syringe 6 is formed on the side wall surface of the syringe holder 34. A screw receiver 37 is erected on the bottom surface of the syringe holder 34, and a fixing bolt 35 is screwed to the screw receiver 37. A clamp 36 and a coil spring 38 are installed between the bolt head of the fixing bolt 35 and the syringe holder 34. The clamp 36 covers the upper portion of the notch 30 in order to fix the syringe 6 between the notch 30.

  As shown in FIG. 2, a slit 28 extending in the axial direction of the syringe 6 is formed on the upper surface of the main body 2, and the pressing body 5 is inserted into the slit 28.

  A support plate 27 and a holding base 22 are installed inside the main body 2. A motor 20 is attached to the support plate 27, and a shaft coupling 31 that engages with a flange portion 32 described later is attached to the shaft of the motor 20. In the present embodiment, the motor 20 uses a pulse motor, and has a configuration in which the rotation speed can be set to a desired value by controlling the pulse to be applied.

  The holding table 22 has side walls 40 and 40, and shaft holes 23 and 23 are formed in the side walls 40 and 40. A rotary screw shaft 24 is inserted into the shaft holes 23, 23, and both ends of the rotary screw shaft 24 are rotatably supported by bearings 25, 25 fixed to the side walls 40, 40. The rotating screw shaft 24 is threaded on the outer peripheral surface, and a flange 32 is provided on one end side. The flange portion 32 is engaged with the shaft coupling 31, whereby the shaft of the motor 20 and the rotating screw shaft 24 are connected, and the rotation of the motor 20 can be transmitted to the rotating screw shaft 24. A guide bar 39 for guiding the pressing body 5 is provided between the side walls 40 and 40 in parallel with the axial direction of the syringe 6.

  The syringe 6 can be a known one that discharges the sample accommodated therein from the tip when the piston 70 is pressed, and is held in the notch 30 of the syringe holder 34 as shown in FIG. It is fixed by a clamp 36. The piston 70 has an end face 88 on one end side in the axial direction.

  The pressing body 5 has a pressing surface 91 that contacts the end surface of the piston 70. FIG. 4 is a detailed view of the pressing body 5. As shown in FIG. 4, the pressing body 5 includes a pressing portion 51 positioned above the main body 2, a slide portion 52 positioned inside the main body 2, and a narrowed portion 53 inserted into the slit 28. 28 is configured to be slidable along the line 28.

  A screw hole 62 is formed in the pressing portion 51 at a substantially right angle to the axial direction of the syringe 6, and a connection bolt 57 is screwed into the screw hole 62.

  A guide hole 58 is formed in the slide portion 52, and a guide rod 39 is inserted into the guide hole 58. The inside of the slide portion 52 communicates with the screw hole 62 through the communication hole 63. In addition, a connecting body 50 and a support spring 54 that supports the connecting body 50 are installed inside the slide portion 52.

  The connecting body 50 is provided with a pressing rod 55, and the pressing rod 55 is inserted into the communication hole 63, and the tip projects from the lower surface of the screw hole 62. In addition, a connection hole 56 is formed in the connection body 50, and the rotating screw shaft 24 is inserted into the connection hole 56. The connection hole 56 is threaded in the lower half of the inner peripheral surface, and is configured to be screwed with the rotary screw shaft 24 when the connection body 50 is pressed upward by the support spring 54. Further, when the connection body 50 is pressed downward by the connection bolt 57 via the pressing rod 55, the connection between the connection hole 56 and the rotary screw shaft 24 is released.

  In the syringe pump 1 of the present embodiment, as shown in FIG. 2, a scale 42 is provided on the upper surface of the main body 2 along the axial direction of the syringe 6. The scale 42 has a scale, and sets the discharge amount of the sample from the syringe 6 according to the distance from the terminal portion 8 to the scale. The scale of the scale 42 preferably corresponds to the length of the syringe 6.

  As shown in FIG. 4, the pressing portion 51 is formed with a through hole 61 that penetrates the syringe 6 in the axial direction. A metal stroke adjusting rod 60 is slidably inserted into the through hole 61, and the distance d between the tip of the stroke adjusting rod 60 and the terminal portion 8 can be adjusted according to the scale of the scale 42. (See FIG. 2). A fixing screw 60 a is screwed into the pressing portion 51 so as to be substantially orthogonal to the through hole 61, and the stroke adjusting rod 60 can be fixed to the pressing portion 51 by the fixing screw 60 a.

  The detection unit 9 is connected to a circuit 95 that closes when the terminal unit 8 and the tip of the stroke adjusting rod 60 come into contact with each other, and detects the energization of the circuit 95. In the present embodiment, the circuit 95 includes the syringe holder 34, the stroke adjusting rod 60, the pressing body 5, the rotating screw shaft 24, the bearing 25, the holding base 22, the main body 2, and the support plate 27.

  As shown in FIG. 2, the input unit 7 is fixed to the main body 2 by a fixing screw 81 and includes a start button 85, a stop button 86, a control button 84, a setting dial 83, and a conversion table 82. The input unit 7 is connected to the control unit 21 by a cable or the like (not shown), and is configured to be able to instruct the operation of the motor 20 by operating the buttons and dial. The control button 84 instructs the motor 20 to operate at a speed higher than the operating speed in the normal operating state. The setting dial 83 sets the rotation speed of the motor 20. The conversion table 82 obtains the flow rate of the sample from the syringe 6 per unit time and the operating time of the motor 20 from the capacity of the syringe 6 and the value of the setting dial 83, that is, the rotation speed of the motor 20.

  The control unit 21 controls the operation of the motor 20 based on an instruction input by the input unit 7 or detection of energization by the detection unit 9.

  Next, a method for discharging a sample using the syringe pump 1 configured as described above will be described.

  First, the connection bolt 57 is screwed into the screw hole 62. As a result, the pressing rod 55 and the connection body 50 are pressed downward against the support spring 54, and the connection between the connection hole 56 of the connection body 50 and the rotary screw shaft 24 is released. In this way, the pressing body 5 can slide independently of the rotary screw shaft 24.

  Subsequently, the syringe 6 containing the sample is installed in the notch 30 and the fixing bolt 35 is screwed against the coil spring 38. Thereby, the syringe 6 is pressed by the clamp 36 and fixed to the syringe holder 34.

  Next, the pressing body 5 is slid along the rotating screw shaft 24. Thus, the pressing surface 91 is brought into contact with the end surface 88 of the piston 70. Thereafter, the connection bolt 57 is loosened. Thereby, the connection body 50 is pressed upward by the support spring 54, and the connection hole 56 and the rotary screw shaft 24 are screwed together. Thus, the pressing body 5 comes to slide according to the rotation of the rotary screw shaft 24.

  Thereafter, the stroke adjusting rod 60 is slid in the axial direction of the syringe 6, and the tip is adjusted to a desired scale of the scale 42. Further, the fixing screw 60 a is screwed into the pressing portion 51 to fix the stroke adjusting rod 60 to the pressing body 5. Thereby, the distance d between the terminal portion 8 and the tip of the stroke adjusting rod 60 is set. Thus, the moving distance of the pressing body 5 is set, and the discharge amount of the sample from the syringe 6 is set. For example, when the capacity of the syringe 6 is 10 ml, the length is 10 cm, and the distance d is set to 3 cm, the discharge amount of the sample is 3 ml. Further, the setting dial 83 is turned to set the rotation speed of the motor 20.

  Thereafter, the start button 85 is pressed to operate the motor 20. The rotation screw shaft 24 is rotated by the rotation of the motor 20, and the pressing body 5 slides along the rotation screw shaft 24 according to the rotation of the rotation screw shaft 24. The sliding pressing body 5 is guided in the axial direction of the syringe 6 by the guide rod 39 and presses the piston 70. In this way, the sample is discharged from the syringe 6. Thereafter, as the pressing body 5 slides, the tip of the stroke adjusting rod 60 approaches the terminal portion 8. When the tip of the stroke adjusting rod 60 contacts the terminal portion 8, the circuit 95 is closed and energized. At this time, the detection unit 9 detects energization. The control unit 21 stops the operation of the motor 20 based on the detection by the detection unit 9. Thereby, the pressing body 5 stops when moving the distance d, and the discharge of the sample from the syringe 6 stops. In this way, an amount of sample set by the distance d is discharged from the syringe 6.

  As described above, by adjusting the distance d between the terminal portion 8 and the tip of the stroke adjusting rod 60, the movement amount of the pressing body 5 is adjusted to set the discharge amount, so that a desired discharge amount can be easily set. can do. Further, since the discharge amount is set by the stroke adjusting rod 60 and the discharge is stopped when the terminal portion 8 and the tip of the stroke adjusting rod 60 come into contact with each other, the desired amount can be discharged accurately. Moreover, since the operation of the motor 20 is stopped when the set amount is discharged, the syringe 6 can be prevented from being damaged.

  When the sample is discharged again after the motor 20 is stopped, the tip of the stroke adjusting rod 60 is aligned with a desired scale of the scale 42 in the same procedure as described above, and the motor 20 is operated. Thus, since a desired discharge amount can be set, the sample in the syringe 6 can be divided and discharged.

  In this embodiment, when air bubbles are mixed in the sample accommodated in the syringe 6, the control button 84 is pushed when the connection hole 56 and the rotary screw shaft 24 are screwed together. Thereby, the motor 20 operates at a speed higher than the operating speed in the normal operating state, and the pressing body 5 continuously presses the piston 70. In this way, bubbles are removed from the inside of the syringe 6. At this time, it is preferable to tilt the main body 2 so that the tip of the syringe 6 faces obliquely upward. Thus, since the piston 70 is pressed based on the operation of the motor 20, the bubbles can be easily removed from the syringe 6. Further, since the motor 20 is operated faster than the normal operation speed, the bubbles can be quickly removed.

  As mentioned above, although one Embodiment of this invention was explained in full detail, the specific aspect of this invention is not limited to the said embodiment.

  The terminal portion 8 and the stroke adjusting rod 60 can adjust the distance d between the terminal portion 8 and the tip of the stroke adjusting rod 60, and the tip of the stroke adjusting rod 60 contacts the terminal portion 8 as the pressing body 5 slides. If it is the structure to do, the installation position will not be specifically limited. For example, in the present embodiment, the terminal portion 8 is configured by the side wall surface of the syringe holder 34, but may be provided separately from the syringe holder 34. In this case, as shown in FIG. 5, the terminal portion 8 may be installed on the spacer 33, and a portion in contact with the stroke adjusting rod 60 may be exposed.

  In the present embodiment, the stroke adjusting rod 60 is inserted into the through hole 61 of the pressing portion 51, but may be configured to be screwed into the pressing portion 51. According to such a configuration, the stroke adjusting rod 60 is screwed into the pressing portion 51, and the tip is adjusted to a desired scale of the scale 42. Thus, the moving distance of the pressing body 5 is set, and the discharge amount of the sample from the syringe 6 is set.

  In the present embodiment, the terminal portion 8 is fixed to the main body 2 and the stroke adjusting rod 60 is attached to the pressing body 5. However, the terminal portion 8 is fixed to the pressing body 5 and the stroke adjusting rod 60 is fixed to the main body 2. The structure attached to may be sufficient. In this case, as shown in FIG. 7, the terminal portion 8 is constituted by a pressing surface 91 of the pressing body 5. The scale 42 is provided on the pressing body 5 and extends along the axial direction of the syringe 6. The main body 2 is provided with an attachment portion 75, and the stroke adjusting rod 60 is inserted into the attachment portion 75 so as to be slidable in the axial direction of the syringe 6. Thereby, the distance d between the tip of the stroke adjusting rod 60 and the terminal portion 8 can be adjusted according to the scale of the scale 42.

  Further, as long as the input unit 7 is connected to the control unit 21, the installation position is not particularly limited, and the input unit 7 may be installed at a position away from the main body 2. According to such a configuration, since the main body 2 and the input unit 7 are separated from each other, for example, the main body 2 is installed in an environmental test chamber where the temperature or the like is set, and the input unit 7 is installed outside the environmental test chamber. Experiment. Therefore, since the input unit 7 is not operated in the environmental test chamber, the experiment can be performed without disturbing the temperature or the like in the environmental test chamber. Further, the main body 2 can be installed near the sample supply destination. Thereby, the distance which liquid-feeds a sample from the syringe 6 can be shortened, and a dead volume can be made small.

  The number of syringes 6 can be changed as appropriate. In this case, a plurality of notches 30 are formed on the side wall surface of the syringe holder 34.

  Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to this embodiment.

  The sample was discharged from the syringe 6 using the syringe pump 1 shown in FIG. As test conditions of this example, the discharge amount of the sample was 5 ml, and the flow rate of the sample per unit time was 50 μl / min. The syringe 6 used had a total volume of 10 ml and a length of 60 mm. Further, the motor 20 has a configuration in which the rotation speed can be set in 16 steps.

  FIG. 8 is a detailed view of the scale 42. The scale 42 is engraved with a scale that divides the length of 60 mm into 10 equal parts. That is, when the scale value is 1.0, the distance from the terminal portion 8 is 60 mm, and when the scale value is 0.5, the distance is 30 mm.

  In the present embodiment, as shown in FIG. 8, the tip of the stroke adjusting rod 60 is aligned with the scale 0.5 of the scale 42. Thereby, the distance d was set to 30 mm, and the discharge amount of the sample from the syringe 6 was set to 10 ml × 0.5 (= 30 mm / 60 mm) = 5 ml.

  FIG. 9 is a detailed view of the conversion table 82. In this embodiment, the value of the setting dial 83 is set to 11, and the rotation speed of the motor 20 is set. Thereby, as shown in FIG. 9, the flow rate of the sample per unit time was set to 50 μl / min from the total volume of the syringe 6 and the value of the setting dial 83. Further, the operating time of the motor 20 at this time was set to 200 minutes × 0.5 = 100 minutes.

  With the above settings, the pressing body 5 stopped by moving 30 mm in 100 minutes. As a result, 5 ml of the sample was discharged at a flow rate of 50 μl / min.

  Thus, by setting the discharge amount with the stroke adjusting rod 60, a desired amount of sample can be discharged accurately.

It is side surface sectional drawing of the syringe pump which concerns on one Embodiment of this invention. It is a top view of the syringe pump shown in FIG. It is a partial side view of the syringe pump shown in FIG. It is detail drawing of a press body. It is side surface sectional drawing of the syringe pump which concerns on other embodiment. It is side surface sectional drawing of the conventional syringe pump. It is a top view of the syringe pump which concerns on other embodiment. It is a detailed view of a scale. It is a detailed view of a conversion table.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Syringe pump 2 Main body 5 Pressing body 6 Syringe 7 Input part 8 Terminal part 9 Detection part 20 Motor 21 Control part 24 Rotating screw shaft 34 Syringe holder 84 Control button

Claims (4)

A main body having a holding part for holding a syringe having a piston;
A pressing body for pressing the piston in the axial direction;
Driving means for driving the pressing body;
Control means for controlling the operation of the drive means;
A stroke adjusting rod attached to the pressing body so as to be movable in the axial direction of the piston;
A terminal portion fixed to the main body and contacting a tip of the stroke adjusting rod;
Detecting means for detecting that the tip of the stroke adjusting rod and the terminal portion are in contact with each other;
The control means is a syringe pump that stops the operation of the drive means based on the detection of the detection means ,
A rotating screw shaft extending along the axial direction of the piston;
The pressing body includes a connection body having a connection hole, an elastic member that supports the connection body, and a connection body pressing unit that can press the connection body against the elastic member.
In the connection hole, a screw is formed and the rotating screw shaft is inserted,
The rotating screw shaft and the connection hole are screwed together when the connecting body pressing means is not pressing the connecting body, and are released when the connecting body pressing means presses the connecting body,
The pressing body is a syringe pump that slides by rotation of the rotating screw shaft .   The stroke adjusting rod is inserted into a through hole formed in the pressing body, and fixed by a fixing screw screwed into the pressing body so as to be substantially orthogonal to the through hole. Syringe pump. A main body having a holding part for holding a syringe having a piston;
A pressing body for pressing the piston in the axial direction;
Driving means for driving the pressing body;
Control means for controlling the operation of the drive means;
A stroke adjusting rod attached to the main body so as to be movable in the axial direction of the piston;
A terminal portion fixed to the pressing body and in contact with the tip of the stroke adjusting rod;
Detecting means for detecting that the tip of the stroke adjusting rod and the terminal portion are in contact with each other;
The control means is a syringe pump that stops the operation of the drive means based on the detection of the detection means ,
A rotating screw shaft extending along the axial direction of the piston;
The pressing body includes a connection body having a connection hole, an elastic member that supports the connection body, and a connection body pressing unit that can press the connection body against the elastic member.
In the connection hole, a screw is formed and the rotating screw shaft is inserted,
The rotating screw shaft and the connection hole are screwed together when the connecting body pressing means is not pressing the connecting body, and are released when the connecting body pressing means presses the connecting body,
The pressing body is a syringe pump that slides by rotation of the rotating screw shaft . An input unit for instructing the operation of the driving means;
The syringe pump according to any one of claims 1 to 3, wherein the control unit operates the driving unit at a speed higher than an operation speed in a normal operation state based on an input from the input unit.

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