JP4736038B2

JP4736038B2 - Multi-chamber container

Info

Publication number: JP4736038B2
Application number: JP2005336863A
Authority: JP
Inventors: 村松康宏
Original assignee: Ajinomoto Co Inc
Current assignee: Ajinomoto Co Inc
Priority date: 2005-11-22
Filing date: 2005-11-22
Publication date: 2011-07-27
Anticipated expiration: 2025-11-22
Also published as: JP2007136040A

Description

この発明は可撓性（軟質）の合成樹脂フィルムにて形成された薬液バッグ（軟質容器）と薬液バッグに取り付けられる薬剤容器（硬質容器）とを備え、薬剤バック中の薬剤と薬剤容器中の薬剤とを混合して排出するようにした複室容器に関するものである。 The present invention includes a drug solution bag (soft container) formed of a flexible (soft) synthetic resin film and a drug container (hard container) attached to the drug solution bag, and the drug in the drug bag and the drug container The present invention relates to a multi-chamber container in which a medicine is mixed and discharged.

可撓性の合成樹脂フィルムにて形成された薬液バッグと薬液バッグに取り付けられる薬剤容器とを備えた複室容器として特許文献１に記載のものがある。特許文献１の複室容器では、薬剤容器は薬剤を収納する第１の空洞部（薬剤収納部）と、輸液時の排出口となり、輸液時に穿刺される被穿刺部材（シール材）にて閉鎖された第２の空洞部とに区画され、第１及び第２の空洞部は脆弱部を備えた連通規制部により通常は閉鎖され、連通規制部を脆弱部にて折損することにより、第１及び第２の空洞部が薬液バッグに開口されるため、薬剤容器の内部の薬剤は薬液バッグの内部の薬剤と混合され、混合された薬剤が第２の空洞部に開口されるため、被穿刺部材の穿刺により輸液が可能となる。
特開２００５−９５６０４号公報 There exists a thing of patent document 1 as a multi-chamber container provided with the chemical | medical solution bag formed with the flexible synthetic resin film, and the chemical | medical agent container attached to a chemical | medical solution bag. In the multi-chamber container of Patent Document 1, the drug container is a first cavity (medicine storage part) for storing the drug and a discharge port at the time of infusion and is closed by a member to be punctured (sealing material) to be punctured at the time of infusion The first and second cavities are normally closed by a communication restricting portion having a fragile portion, and the communication restricting portion is broken at the fragile portion. Since the second cavity is opened in the drug solution bag, the drug inside the drug container is mixed with the drug inside the drug solution bag, and the mixed drug is opened in the second cavity, so that the puncture target Infusion is possible by puncturing the member.
JP 2005-95604 A

特許文献１に記載の技術では連通規制部によって通常は排出口が閉鎖されているため、連通規制部の折損操作をしない限りは穿刺しても薬剤が流出することはないようになっている。しかしながら、特許文献１の技術では、薬液バッグ中に位置した連通規制部を薬液バッグを構成する合成樹脂フィルムを通して薬液バッグの外部からの操作により折損して排出口の開閉を行っており、操作性が良くないため、所期の操作が行われず、未混合若しくは不十分な混合のまま薬剤の排出が行われる可能性があった。 In the technique described in Patent Document 1, since the discharge port is normally closed by the communication restriction unit, the medicine does not flow out even if puncture is performed unless the breakage operation of the communication restriction unit is performed. However, in the technique of Patent Document 1, the communication restricting portion located in the chemical solution bag is broken by an operation from the outside of the chemical solution bag through the synthetic resin film constituting the chemical solution bag, and the discharge port is opened and closed. Therefore, the intended operation is not performed, and there is a possibility that the drug may be discharged without being mixed or insufficiently mixed.

この発明はかかる従来技術の問題点に鑑みてなされたものであり、薬剤を確実に混合させた上排出を行わせるようにすることを目的とする。 The present invention has been made in view of the problems of the prior art, and an object thereof is to allow the medicine to be mixed and discharged.

この発明になる複室容器は、可撓性の合成樹脂フィルムにて形成された薬液バッグと、薬液バッグに取り付けられ、薬剤収容室、該薬剤収容室を前記薬液バッグの内部空洞へ連通させる上下の連通路及び排出口を形成した薬剤容器と、薬剤容器の前記連通路を通常閉鎖するための閉鎖具と、排出口に設けられ、輸液具により穿刺開口される被穿刺部材とを具備している。閉鎖具は通常時は穿刺しても薬剤収容室に収容した薬剤が排出されないように位置しており、薬剤収容室を上下２箇所において開閉するため複数の開閉部材（弁部材）を備えている。薬液バッグの外部操作部材によるねじ機構を通しての回転−直線移動変換などの直接的操作によって閉鎖具は移動せしめられ、薬液バッグへの連通路が開放に至り、薬液バッグ中の薬液と薬剤収容室中の薬液とが混合せしめられ、同時に穿刺時に薬剤の排出を許容するようにされる。 The multi-chamber container according to the present invention includes a drug solution bag formed of a flexible synthetic resin film, an upper and a lower unit attached to the drug solution bag, and communicates the drug storage chamber and the drug storage chamber to the internal cavity of the drug solution bag. A drug container having a communication path and a discharge port, a closure for normally closing the communication path of the drug container, and a member to be punctured provided in the discharge port and punctured by an infusion device Yes. Closures normal is positioned as drugs be punctured is accommodated in the medicine receiving chamber is not discharged, with a plurality of opening and closing member for opening and closing the medicine accommodating chamber in the vertical two locations (valve member) Yes. The closure is moved by direct operation such as rotation-linear movement conversion through the screw mechanism by the external operation member of the drug solution bag, the communication path to the drug solution bag is opened, and the drug solution in the drug solution bag and the drug storage chamber The drug solution is mixed with each other, and at the same time, discharge of the drug is allowed at the time of puncture.

薬液バッグ外部に位置する操作部材が回転などの移動操作されることにより閉鎖具による連通路の閉鎖状態が解除されるため、薬液バッグ内の薬剤を薬剤収容室内部の薬剤と確実に混合した上で排出口より排出することができるため、未混合若しくは不完全な混合のまま薬剤の排出及び輸液が行われる可能性をより確実に排除することができる。 Since the operating member positioned in the chemical bag outside the closed state of the communication path by the closure is released by being moved operations such as rotation, on the drug in the drug solution bag ensure mixing and drug inside the drug accommodating chamber Therefore, it is possible to more reliably eliminate the possibility that the medicine is discharged and infused with unmixed or incomplete mixing.

外部操作部材のねじ機構を介しての回転操作によりに閉鎖部材を開放位置せしめ、薬剤の混合を確実に行い輸液に供することができる。 The closing member can be opened by rotating the external operating member through the screw mechanism, so that the drug can be reliably mixed and used for infusion.

弁部材を上下２段の部分から構成し、かつ下側の開口部分を絞ることにより、薬剤収容室における薬剤の残留を排除しつつ排出口に対する薬剤の確実な流れを惹起せしめることができる。 By configuring the valve member in two upper and lower portions and narrowing the lower opening, it is possible to cause a reliable flow of the drug to the discharge port while eliminating the remaining of the drug in the drug storage chamber .

以下、図面によってこの発明の実施形態を説明すると、薬液バッグ（軟質容器）１０は上下層を構成するポリエチレンやポリプロピレンなどの合成樹脂フィルム切片を外周部１０Ａにて溶着することにより構成され、その内部空洞１２に輸液製剤などの液状の薬剤が収納されている。薬液バッグ１０の溶着された外周部には薬液バッグ１０を点滴台などに懸架するための開口部１４が形成されている。 Hereinafter, the embodiment of the present invention will be described with reference to the drawings. A chemical solution bag (soft container) 10 is configured by welding synthetic resin film sections such as polyethylene and polypropylene constituting upper and lower layers at an outer peripheral portion 10A, and the inside thereof. A liquid drug such as an infusion preparation is accommodated in the cavity 12. An opening 14 for suspending the chemical solution bag 10 on an infusion stand or the like is formed in the outer peripheral portion where the chemical solution bag 10 is welded.

薬剤容器（硬質容器）１６は微量元素やビタミン剤などの１液化できない混注用の薬剤（液状若しくは粉末若しくは粒状）を収容するためのものであり、薬剤容器１６は独立してその形状を維持するプラスチック成形品として構成され、薬液バッグ１０の外周部１０Ａに溶着・一体化されている。薬剤容器１６中の薬剤は通常は薬液バッグ１０の薬剤とは混合しないように分離保持されており、輸液時に薬液バッグ１０中の薬液に混合・溶解されて使用される。 The drug container (hard container) 16 is for containing a mixed injection drug (liquid, powder, or granular) that cannot be liquefied, such as trace elements and vitamins, and the drug container 16 maintains its shape independently. It is configured as a plastic molded product and is welded and integrated with the outer peripheral portion 10 </ b> A of the chemical solution bag 10. The drug in the drug container 16 is normally separated and held so as not to be mixed with the drug in the drug solution bag 10, and is used by being mixed and dissolved in the drug solution in the drug solution bag 10 at the time of infusion.

図２において、薬剤容器１６は筒状本体１８と、排出口２０と、閉鎖具２２とを備える。筒状本体１８は外周にフランジ部18-1を、内周に環状突起18-2を形成しており、フランジ部18-1を挟んで薬液バッグ１０を構成する上下の合成樹脂フィルム切片の外周部１０Ａが図４に示すように溶着されることで、薬液バッグ１０に対する薬剤容器１６の取り付けが行われている。環状突起18-2によって、筒状本体１８の内部空洞は薬剤収容室２４と排出口２０への接続室２６とに区画される。接続室２６の内周に環状溝26-1が形成され、この環状溝26-1に対して排出口２０の上端の環状突起20-1が嵌合され、環状溝26-1に対する環状突起20-1の嵌合構造により、排出口２０は筒状本体１８に対して回転自在に構成され、この発明の操作具ともなる。排出口２０の回転自在構造のため環状溝とスナップリングとからなる周知の構造を採用することはもとより可能である。排出口２０は下端にフランジ２０Ａを形成しており、このフランジ２０Ａの外側端面にキャップ３０が当接溶着せしめられ、キャップ３０は排出口２０に一体化される。キャップ３０に対しては、穿刺針用のゴム栓３２（被穿刺部材）が密封嵌合され、輸液時に周知のように輸液セットの穿刺針がこのゴム栓に貫通穿刺され、輸液が行われる。 In FIG. 2, the medicine container 16 includes a cylindrical main body 18, a discharge port 20, and a closing tool 22. The cylindrical main body 18 has a flange portion 18-1 on the outer periphery and an annular protrusion 18-2 on the inner periphery, and the outer periphery of the upper and lower synthetic resin film sections constituting the drug solution bag 10 with the flange portion 18-1 interposed therebetween. The part 10A is welded as shown in FIG. 4 so that the medicine container 16 is attached to the medicine bag 10. By the annular protrusion 18-2, the internal cavity of the cylindrical main body 18 is partitioned into a medicine storage chamber 24 and a connection chamber 26 to the discharge port 20. An annular groove 26-1 is formed on the inner periphery of the connection chamber 26, and the annular protrusion 20-1 at the upper end of the discharge port 20 is fitted into the annular groove 26-1, and the annular protrusion 20 with respect to the annular groove 26-1 is fitted. With the -1 fitting structure, the discharge port 20 is configured to be rotatable with respect to the cylindrical main body 18 and is also an operation tool of the present invention. It is possible to adopt a well-known structure composed of an annular groove and a snap ring because of the rotatable structure of the discharge port 20. The discharge port 20 has a flange 20 </ b> A formed at the lower end, and a cap 30 is abutted and welded to the outer end surface of the flange 20 </ b> A, and the cap 30 is integrated with the discharge port 20. A rubber plug 32 for puncture needle (member to be punctured) is hermetically fitted to the cap 30, and the puncture needle of the infusion set is pierced through the rubber plug as is well known at the time of infusion, and infusion is performed.

図３に示すように筒状本体１８の内周の環状突起18-2は複数（４個）の連通孔３４（この発明の連通路の第１部分）を形成し、連通孔３４は外側端は薬液バッグ１０の内部空洞１２に開口し、内側端は筒状本体１８の内周面に開口している。閉鎖具２２は、弁本体３６と、ゴムやセラミックなどのシール素材にて形成された第１及び第２の弁部材（この発明の第１及び第２の閉鎖部材）38, 40とを具備する。弁本体３６は剛性のある合成樹脂一体成形品として構成され、外周に環状溝を形成した第１の拡径部36-1及び第２の拡径部36-2を形成しており、第１の拡径部36-1の環状溝36-1Aに第１の弁部材３８が嵌着され、第２の拡径部36-2の環状溝36-2Aに第２の弁部材３８が嵌着されている。そして、図２に示す通常状態においては、第１の弁部材３８により、連通孔３４が閉鎖され、薬液バッグ１０の内部空洞１２は薬剤収納室２４及び接続室２６に対して閉鎖されており、第２の弁部材４０により筒状本体１８の上側開口端１８Ａ（この発明の連通路の第２部分）が閉鎖され、薬液バッグ１０の内部空洞１２は薬剤収納室２４に対して閉鎖されている。このような弁部材38, 40の密封閉鎖機能に拘わらず、弁部材38, 40は筒状本体１８の内周に沿った長手方向（上下方向）の移動は可能に構成され、弁部材38, 40を後述の開放位置とすることにより薬液バッグ内に収容された薬剤を薬剤容器１６中の薬剤を混合させつつ排出口２０の側に排出させることができる。 As shown in FIG. 3, the annular protrusion 18-2 on the inner periphery of the cylindrical body 18 forms a plurality (four) of communication holes 34 (first portion of the communication path of the present invention). Is opened in the internal cavity 12 of the medical solution bag 10, and the inner end is opened in the inner peripheral surface of the cylindrical main body 18. The closing tool 22 includes a valve main body 36, and first and second valve members (first and second closing members of the present invention) 38, 40 formed of a sealing material such as rubber or ceramic. . The valve main body 36 is configured as a rigid synthetic resin integral molded product, and has a first enlarged diameter portion 36-1 and a second enlarged diameter portion 36-2 formed with an annular groove on the outer periphery. The first valve member 38 is fitted in the annular groove 36-1A of the enlarged diameter portion 36-1, and the second valve member 38 is fitted in the annular groove 36-2A of the second enlarged diameter portion 36-2. Has been. In the normal state shown in FIG. 2, the communication hole 34 is closed by the first valve member 38, and the internal cavity 12 of the drug solution bag 10 is closed with respect to the drug storage chamber 24 and the connection chamber 26. The second valve member 40 closes the upper open end 18A of the cylindrical main body 18 (the second portion of the communication path of the present invention), and the internal cavity 12 of the drug solution bag 10 is closed with respect to the drug storage chamber 24. . Regardless of the sealing and closing function of the valve members 38, 40, the valve members 38, 40 are configured to be movable in the longitudinal direction (vertical direction) along the inner periphery of the cylindrical main body 18. By setting 40 to an open position described later, the medicine stored in the medicine bag can be discharged to the discharge port 20 side while the medicine in the medicine container 16 is mixed.

弁本体３６は図２に示すように下方延長部36-3を一体に形成しており、この下方延長部36-3は図３及び図４に示すように十字断面形状をなしている。他方、筒状本体１８における接続室２６の内周面に弁本体３６の下方延長部36-3に向けて半径方向に突出する直径対立位置した一対の案内部26-2を有しており、この案内部26-2は図４に示すように９０度のコーナー形状をなしており、直径対立位置したこの９０度のコーナー形状の案内部26-2が十字断面形状の下方延長部36-3に係合しており、そのため、弁本体３６は自らの回転運動は阻止しつつ長手方向に直線摺動移動可能となっている。 The valve body 36 is integrally formed with a downward extension 36-3 as shown in FIG. 2 , and the downward extension 36-3 has a cross-sectional shape as shown in FIGS. On the other hand, the cylindrical main body 18 has a pair of guide portions 26-2 which are opposed to each other in diameter and project radially toward the downward extension 36-3 of the valve main body 36 on the inner peripheral surface of the connection chamber 26. As shown in FIG. 4, the guide portion 26-2 has a 90-degree corner shape, and the 90-degree corner-shaped guide portion 26-2 opposed to the diameter is a downward extending portion 36-3 having a cross-sectional shape. Therefore, the valve main body 36 can move linearly in the longitudinal direction while preventing its own rotational movement.

次に、排出口２０の回転により弁本体３６の直線摺動移動を惹起せしめる機構について説明すると、排出口２０の内周面に螺旋溝４２が形成され、他方、弁本体３６の下方延長部36-3は十字断面形状における先端部分が係合部４４を形成しており、この係合部４４が図５に示すように螺旋溝４２に係合することにより、排出口２０の回転により弁本体３６を直線移動せしめるねじ機構が構成される。 Next, the mechanism for causing the linear sliding movement of the valve body 36 by the rotation of the discharge port 20 will be described. A spiral groove 42 is formed on the inner peripheral surface of the discharge port 20, while the downward extension 36 of the valve body 36. -3 has an engagement portion 44 at its tip in the cross-sectional shape, and the engagement portion 44 engages with the spiral groove 42 as shown in FIG. A screw mechanism for linearly moving 36 is configured.

図２に示す通常状態（封止状態）では筒状本体１８の下端側の第１の弁部材３８により連通孔３４が閉鎖され、筒状本体１８の上端側の第２の弁部材４０により筒状本体１８の上端が閉鎖される。そのため、排出口２０は薬液バッグ１０内の空洞１２に収容された薬剤も、薬剤容器１６の薬剤収容室２４に収容された薬剤も排出口２０には導かれることがなく、そのため、輸液セットの穿刺針６０によりゴム栓３２が誤操作により穿刺されたとしても薬剤が間違って排出されことはない。 In the normal state (sealed state) shown in FIG. 2, the communication hole 34 is closed by the first valve member 38 on the lower end side of the cylindrical main body 18, and the second valve member 40 on the upper end side of the cylindrical main body 18 is closed. The upper end of the main body 18 is closed. Therefore, neither the medicine accommodated in the cavity 12 in the chemical solution bag 10 nor the medicine accommodated in the medicine storage chamber 24 of the medicine container 16 is guided to the discharge opening 20 at the discharge port 20, so that the infusion set Even if the rubber stopper 32 is punctured by an erroneous operation by the puncture needle 60, the medicine is not accidentally discharged.

図２の状態から排出口２０を回してゆくと、弁本体３６の側における下方延長部36-3における十字断面形状における先端部分４４が排出口２０の側における螺旋溝４２に螺合しており、しかも弁本体３６が図４の十字断面形状により筒状本体１８に対して周り止めされていることから、弁本体３６は筒状本体１８に沿って直線運動し、図２において上昇せしめることができる。そのため、図６に示すように第１の弁部材３８は筒状本体１８の下端側の連通孔３４を開放するように位置され、第２の弁部材４０は筒状本体１８の上端１８Ａを開放するように位置する。従って、薬剤容器１６内の薬剤は薬液バッグ１０内の薬剤に対して混合されつつ排出口２０に導かれ、輸液ユニットの穿刺針によりゴム栓３２を穿刺することにより混合薬剤の輸液を行うことができる。この際、筒状本体１８の上下を薬液バッグ１０の内部空洞に対して開放することにより薬剤の混合が効率的に行われ、かつ第１の弁体３８により開放される連通孔３４は筒状本体１８の内周における幾分絞られた部位である環状突起18-2を開閉する構造であるため、薬剤収容室２４から排出口２０へ向けての矢印ａのような流路が形成されるため、薬剤収容室２４内の薬剤を隈なく排出口２０まで導くことができ、薬液が薬剤収容室２４に残留してしまうことがない。 When the discharge port 20 is turned from the state of FIG. 2, the tip end portion 44 in the cross-sectional shape of the downward extension 36-3 on the valve body 36 side is screwed into the spiral groove 42 on the discharge port 20 side. Moreover, since the valve main body 36 is prevented from rotating around the cylindrical main body 18 by the cross-sectional shape of FIG. 4, the valve main body 36 moves linearly along the cylindrical main body 18 and can be raised in FIG. it can. Therefore, as shown in FIG. 6, the first valve member 38 is positioned so as to open the communication hole 34 on the lower end side of the cylindrical main body 18, and the second valve member 40 opens the upper end 18 </ b> A of the cylindrical main body 18. Located to do. Therefore, the medicine in the medicine container 16 is guided to the discharge port 20 while being mixed with the medicine in the medicine bag 10 and the mixture medicine is infused by puncturing the rubber plug 32 with the puncture needle of the infusion unit. it can. At this time, the upper and lower sides of the cylindrical main body 18 are opened with respect to the internal cavity of the drug solution bag 10 so that the medicine is efficiently mixed, and the communication hole 34 opened by the first valve body 38 is cylindrical. Since the structure is such that the annular protrusion 18-2 that is a part of the inner periphery of the main body 18 is opened and closed, a flow path as indicated by an arrow a from the medicine storage chamber 24 toward the discharge port 20 is formed. Therefore, the medicine in the medicine storage chamber 24 can be guided to the discharge port 20 without any loss, and the chemical liquid does not remain in the medicine storage room 24.

以上の実施形態においては閉鎖具２２はねじ機構＋摺動案内部とより成る回転運動−直線運動機構により駆動されるものを例にあげたが、この発明はこのような機構に限定されず、外部からの操作具の操作によって閉鎖具を閉鎖状態から開放状態に移動させ、薬液バッグ内の薬剤と薬剤容器中の薬剤とを混合させるものはこの発明に包含されるものである。 In the above embodiment, the closure 22 is driven by a rotational motion-linear motion mechanism comprising a screw mechanism + sliding guide portion, but the present invention is not limited to such a mechanism. What moves a closing tool from a closed state to an open state by operation of the operating tool from the outside, and mixes the medicine in a chemical | medical solution bag and the chemical | medical agent in a chemical | medical agent container is included by this invention.

図７は別実施形態を示し、この実施形態では、筒状部材１１８の内部の薬剤収容室１２４を薬液バッグの内部空洞１２に対して通常は閉鎖する第２の閉鎖部材が破壊可能な膜体１４０にて形成される。膜体１４０はその外周部が筒状部材１１８の端面に接着や溶着等により固定されている。他方、弁本体１３６はその上端136-1が棒状に延びており、膜体１４０と対面している。弁本体１３６の下端は第１の実施形態と同様に排出口１２０に図２と同様なねじ機構により連結され、排出口１２０と一体なキャップ１３０を回すことにより、第１の形態と同様に第１の閉鎖部材としての弁体１３８が直線方向に上昇駆動され、通常は閉鎖している連通孔１３４が図６と同様に開放される。そして、弁体１３８の上昇はその上端136-1が膜体１４０に係合し、膜体１４０は破壊せしめられ、薬液バッグの内部空洞１２は薬剤収容室１２４と連通せしめられる。従って、図６に説明したと同様に薬液バッグ中の薬液と薬剤収容室１２４中の薬剤とは混合せしめられ、排出口１２０に導かれ、キャップ１３０のゴム栓に穿刺された輸液セットに導かれる。 FIG. 7 shows another embodiment, in which the second closure member that normally closes the drug storage chamber 124 inside the cylindrical member 118 with respect to the internal cavity 12 of the drug solution bag can be broken. 140. The outer periphery of the film body 140 is fixed to the end surface of the cylindrical member 118 by adhesion, welding, or the like. On the other hand, the upper end 136-1 of the valve body 136 extends in a rod shape and faces the film body 140. The lower end of the valve main body 136 is connected to the discharge port 120 by the same screw mechanism as in FIG. 2 as in the first embodiment, and the cap 130 integral with the discharge port 120 is turned to turn the first in the same manner as in the first embodiment. The valve body 138 as one closing member is driven to rise in the linear direction, and the normally closed communication hole 134 is opened as in FIG. When the valve body 138 is raised, the upper end 136-1 is engaged with the film body 140, the film body 140 is destroyed, and the internal cavity 12 of the drug solution bag is communicated with the drug storage chamber 124. Accordingly, as described in FIG. 6, the drug solution in the drug solution bag and the drug in the drug storage chamber 124 are mixed, guided to the discharge port 120, and guided to the infusion set punctured by the rubber stopper of the cap 130. .

図８は図７と類似するが更に別の実施形態を示し、筒状部材２１８の上端にこの発明の第２の閉鎖部材としての蓋体２４０を嵌着したものである。蓋体２４０は薬剤収容室１２４を薬液バッグの内部空洞１２に対して閉鎖する。開封時にキャップ２３０を回して行くことにより図２に説明したと同様なねじ機構により弁体２３８は図８において上昇し、弁体２３８の上昇はその上端ピン状部236-1が蓋体２４０に係合し、蓋体２４０は持ち上げられ、最終的には筒状部材２１８から離脱されるに至り、薬液バッグの内部空洞１２は排出口２２０（薬剤収容室２２４）と連通せしめられる。 FIG. 8 is similar to FIG. 7 but shows still another embodiment in which a lid 240 as a second closing member of the present invention is fitted to the upper end of a cylindrical member 218. The lid 240 closes the drug storage chamber 124 with respect to the inner cavity 12 of the drug solution bag. When the cap 230 is rotated at the time of opening, the valve body 238 is raised in FIG. 8 by a screw mechanism similar to that described with reference to FIG. The lid 240 is lifted and finally removed from the cylindrical member 218, and the internal cavity 12 of the drug solution bag is communicated with the discharge port 220 (drug storage chamber 224).

図９は更に別の実施形態を示し、この実施形態ではＯリングにより密封を行っている。筒状部材３１８は薬剤収容室３２４を備えると共に、薬液バッグの内部空洞１２に対する開口部３３４を備える。筒状部材３１８の内部に位置する駆動部材３３６（この発明の第１の閉鎖部材）は図２と同様なねじ機構を介して排出口３２０に連結され、排出口３２０と一体なキャップ３３０を回すことにより駆動部材３３６は図９において上下する。駆動部材３３６には軸方向に離間した部位で一対の環状溝336-1, 336-2が形成され、環状溝336-1, 336-2にＯリング338-1, 338-2が夫々嵌着される。駆動部材３３６は棒状部336Aを介して閉鎖円板３６０（この発明の第２の閉鎖部材）に連結される。そして、閉鎖円板３６０の外周には環状溝360-1が形成され、環状溝360-1にＯリング３４０が嵌着されている。筒状部材３１８はＯリング338-1が摺動する第１部分318-1と、Ｏリング338-2が摺動する第２部分318-2と、Ｏリング３４０が摺動する第３部分318-3とを備える。第２部分318-2はＯリング338-2が摺動する部位より外端側は面一で段付きとはなっていなが、それぞれが第３部分318-3まで延び、長さ方向に延び円周方向に間隔をおいた複数の溝部３６２を形成している。 FIG. 9 shows yet another embodiment, in which sealing is provided by an O-ring. The cylindrical member 318 includes a drug storage chamber 324 and an opening 334 for the internal cavity 12 of the drug solution bag. The driving member 336 (first closing member of the present invention) located inside the cylindrical member 318 is connected to the discharge port 320 via a screw mechanism similar to that in FIG. 2 and rotates the cap 330 integral with the discharge port 320. As a result, the drive member 336 moves up and down in FIG. The drive member 336 is formed with a pair of annular grooves 336-1 and 336-2 at portions spaced apart in the axial direction, and O-rings 338-1 and 338-2 are fitted into the annular grooves 336-1 and 336-2, respectively. Is done. The drive member 336 is connected to the closing disk 360 (the second closing member of the present invention) via the rod-shaped portion 336A. An annular groove 360-1 is formed on the outer periphery of the closed disc 360, and an O-ring 340 is fitted into the annular groove 360-1. The cylindrical member 318 includes a first portion 318-1 on which the O-ring 338-1 slides, a second portion 318-1 on which the O-ring 338-2 slides, and a third portion 318 on which the O-ring 340 slides. -3. The second portion 318-1 is flush with the outer end side of the portion where the O-ring 338-2 slides and is not stepped, but each extends to the third portion 318-3 and extends in the length direction. forming a plurality of grooves 362 spaced circumferentially.

図９（イ）は封止状態を示し、薬液バッグの内部空洞１２に対する開口部３３４は下側Ｏリング338-1により排出口３２０に対する連通を阻止され、上側Ｏリング338-1により薬剤収納室３２４に対する連通を阻止されている。また、最上部のＯリング３４０は薬剤収納室３２４を薬液バッグの内部空洞１２に対し遮断している。従って、輸液セットの穿刺針が穿刺されたとしても薬剤が間違って排出されことはない。 FIG. 9 (a) shows a sealed state, and the opening 334 with respect to the internal cavity 12 of the drug solution bag is blocked from communicating with the discharge port 320 by the lower O-ring 338-1, and the medicine storage chamber by the upper O-ring 338-1. Communication with 324 is blocked. The uppermost O-ring 340 blocks the medicine storage chamber 324 from the internal cavity 12 of the drug solution bag. Therefore, even if the puncture needle of the infusion set is punctured, the medicine is not accidentally discharged.

図９（イ）の状態から排出口１２０を回してゆくと、第１の実施形態と同様の図示しないねじ機構によって駆動部材３３６が図において上昇され、下側のＯリング338-1が第１部分318-1から外れ、中間のＯリング338-2が溝部３６２上に位置され、上側のＯリング３４０が第３部分318-3から外れた（ロ）の開放状態をとるに至る。この状態においては開口部３３４は薬液バッグの内部空洞１２を駆動部材３３６の連通孔336Aを介して排出口３２０に連通させ、薬剤収納室３２４は薬液バッグの内部空洞１２に連通させると共に溝部３６２を介して連通孔336A、ひいては排出口３２０に矢印の経路a, b, cで連通せしめる。そのため、薬液バッグの内部空洞１２に収容された薬液に収納室３２４に収容された薬剤を混合させて排出口３２０に導入することができ、キャップ３３０に設けられるゴム栓に穿刺することにより輸液を開始することができる。 When the discharge port 120 is turned from the state of FIG. 9 (a), the drive member 336 is raised in the drawing by a screw mechanism (not shown) similar to that of the first embodiment, and the lower O-ring 338-1 is the first. The intermediate O-ring 338-2 is disengaged from the portion 318-1, the intermediate O-ring 338-2 is positioned on the groove 362, and the upper O-ring 340 is disengaged from the third portion 318-3 (b). In this state, the opening 334 communicates the internal cavity 12 of the drug solution bag with the discharge port 320 through the communication hole 336A of the drive member 336, and the drug storage chamber 324 communicates with the internal cavity 12 of the drug solution bag and the groove 362. Through the communication hole 336A and eventually through the discharge port 320 through the paths a, b and c indicated by arrows. Therefore, the medicine contained in the storage chamber 324 can be mixed with the medicine contained in the internal cavity 12 of the medicine bag and introduced into the discharge port 320, and the infusion can be performed by puncturing the rubber stopper provided in the cap 330. Can start.

尚、図１の第１実施形態において、突起部18-2を設けず収納室２４の内面と面一とすることができ、この場合、収納室２４の内面に図９の溝部３６２と同様な縦溝を設けることで、弁部材３８が図１から図２の状態にリフトしたときの流路を形成し、薬液を漏れなく排出することができる。 In the first embodiment of FIG. 1, the protrusion 18-2 can be the inner surface flush of the storage room 24 without providing, similarly to the case, the groove portion 362 of FIG. 9 on the inner surface of the storage room 24 By providing such a vertical groove, a flow path when the valve member 38 is lifted from the state shown in FIG. 1 to FIG. 2 can be formed, and the chemical solution can be discharged without leakage.

図１はこの発明の複室容器の概略的平面図である。FIG. 1 is a schematic plan view of a multi-chamber container according to the present invention. 図２は図１の複室容器における薬剤容器の断面図である。2 is a cross-sectional view of the drug container in the multi-chamber container of FIG. 図３は図２のIII−III線に沿った断面図である。3 is a cross-sectional view taken along line III-III in FIG. 図４は図２のIV−IV線に沿った断面図である。FIG. 4 is a cross-sectional view taken along line IV-IV in FIG. 図５は図２のV−V線に沿った断面図である。FIG. 5 is a cross-sectional view taken along line V-V in FIG. 図６は図２と同様であるが閉鎖具の開放状態を示す。FIG. 6 is similar to FIG. 2 but shows the open state of the closure. 図７は第２の閉鎖部材として膜体を使用した別実施形態の概略図である。FIG. 7 is a schematic view of another embodiment using a membrane body as the second closing member. 図８は第２の閉鎖部材として閉鎖蓋を使用した別実施形態の概略図である。FIG. 8 is a schematic view of another embodiment using a closure lid as the second closure member. 図９は開閉手段として弁体の替わりにＯリングを使用した別実施形態の概略図であり、（イ）は閉鎖時、（ロ）は開放時を示す。FIG. 9 is a schematic view of another embodiment in which an O-ring is used as an opening / closing means instead of a valve body. (A) shows a closed state and (B) shows an opened state.

Explanation of symbols

１０…薬液バッグ
１６…薬剤容器
１８…筒状本体
１８Ａ…筒状本体の上端（この発明の連通路の第２部分）
２０…排出口
２２…閉鎖具
２４…薬剤収容室
３４…連通孔（この発明の連通路の第１部分）
３６…弁本体
36-1…弁本体の下方延長部
38, 40…第１及び第２の弁部材
４２…螺旋溝
４４…係合部

DESCRIPTION OF SYMBOLS 10 ... Chemical solution bag 16 ... Drug container 18 ... Cylindrical main body 18A ... Upper end of a cylindrical main body (2nd part of the communicating path of this invention)
DESCRIPTION OF SYMBOLS 20 ... Discharge port 22 ... Closure 24 ... Drug storage chamber 34 ... Communication hole (1st part of the communication path of this invention)
36 ... Valve body
36-1… Lower extension of valve body
38, 40 ... 1st and 2nd valve member 42 ... Spiral groove 44 ... Engagement part

Claims

A drug solution bag formed of synthetic resin film of a flexible, attached to the drug solution bag, medicine accommodating chamber, the medicament container provided with the communication passage and an outlet communicating the drug accommodating chamber to the internal cavity of the medical bag A multi-chamber container for infusion, comprising: a closure for normally closing the communication path of the drug container; and a member to be punctured provided at the discharge port and opened by puncture by the infusion device. The tool is connected to an operating tool located outside the drug solution bag. Normally, the closing tool is positioned so as to prevent the medicine from being discharged to the discharge port regardless of the puncture operation. A multi-chamber container that opens the communication path to the drug solution bag, mixes the drug solution in the drug solution bag and the drug solution in the drug storage chamber , and allows the drug to be discharged at the time of puncturing.

Comprising a drug solution bag formed of synthetic resin film of a flexible, and a drug container attached to the drug solution bag, wherein the medicament container, communicating for communicating the drug accommodating chamber and the drug accommodating the inner cavity of the medical bag A main body having a passage, a discharge port, a member to be punctured provided at the discharge port and opened by an infusion device, and normally the communication channel of the drug container is closed, and at the same time the discharge port regardless of the puncture operation A closing device that prevents the medicine from being discharged, and an operation tool that is located outside the chemical solution bag and that opens the closing tool by rotation. By rotating the closing tool by the operating tool, the communication path by the closing tool is provided. The multi-chamber container is released so that the drug solution in the drug solution bag and the drug solution in the drug storage chamber are mixed together and allowed to discharge the drug by puncture.

Comprising a drug solution bag formed of synthetic resin film of a flexible, and a drug container attached to the drug solution bag, wherein the medicament container, communicating for communicating the drug accommodating chamber and the drug accommodating the inner cavity of the medical bag A main body having a passage, a discharge port provided to be rotatable with respect to the main body, a member to be punctured that is provided in the discharge port and is punctured by an infusion device, and normally the communication passage of the drug container is closed. And at the same time, the closure device is arranged so as to be linearly movable so as to prevent the medicine from being discharged to the discharge port regardless of the puncturing operation, and the discharge port and the closure device are screw-connected to each other from the outside of the discharge port. cooperate as the closure by rotating movement operation of being brought linear movement, which allows the discharge of the drug by simultaneously piercing the allowed to mix the chemical solution of the chemical and chemical-receiving chamber in the drug solution bag is released closing the communication passage Multi-chamber container to be crimped.

The invention according to any one of claims 1 to 3, wherein the communication path includes a first portion located close to the discharge port and a second portion positioned away from the discharge port, and the closure The tool normally closes the first portion of the communication passage to close the internal cavity of the drug solution bag from the medicine storage chamber and the discharge port, and usually the second portion of the communication passage. And a second closing member that shuts off the internal cavity of the drug solution bag from the medicine containing chamber by closing the first sealing member, and the first closing member is positioned so as to open the first portion of the communication passage by the operation. The internal cavity of the medical solution bag communicates with the drug storage chamber and the discharge port, and at the same time, the second closing member is positioned so as to open the second portion of the communication path and stores the internal cavity of the medical solution bag with the drug. multiple chambers communicating against the chamber.

5. The multi-chamber container according to claim 4, wherein an inner diameter of an opening portion of the first portion of the communication passage to the medicine storage chamber is restricted.

5. The multi-chamber container according to claim 4, wherein a communication groove for opening the first portion of the communication path into the medicine storage chamber is formed on the inner peripheral surface of the main body .

5. The multi-chamber container according to claim 4, wherein the first closing member or the second closing member is a valve member.

In the invention of claim 4, the first closure member or the second closure member is multiple chambers that are provided by an O-ring slide moves in a linear direction and the sliding portion.

5. The multi-chamber container according to claim 4, wherein the second closing member is a rupturable membrane member.

5. The multi-chamber container according to claim 4, wherein the second closing member is a detachable lid.