JPH0796978A - Container for separately containing liquid, and mixing liquids before use - Google Patents

Abstract

PURPOSE:To provide a container for seperately containing two kinds of chemicals, in which two kinds of unstable chemical are separately contained because they may to deteriorate in the mixed state and before using them, the seal between both liquids is opened while the container is kept closed to mix both liquids and the chemicals can be dripped for use by an appropriate quantity from the front nozzle of the container on the basis of a spoid principle. CONSTITUTION:A container is composed of two chambers A, B. Before using, the upper part 1 of the container is pushed down to break the diaphragm 6 between both chambers. The chemicals in both chambers are mixed together and dripped by appropriate quantity from the front nozzle 11 of the container.

Description

Detailed Description of the Invention

[0001]

[Industrial application] Instable (liquid-liquid) system or [liquid-solid (powder, tablet)] that may be altered in a mixed state
The chemicals of the system are stored separately during storage, mixed or dissolved immediately before use, and the mixed solution is dropped locally at a suitable time for use. The present invention relates to a drug container in which three operations of divided storage, drug mixing, and use can be consistently performed in a single container.

[0002]

Prior to the present invention, when it is necessary to divide and store a drug in this manner, examples shown in FIGS. 5 and 6 are known.

FIG. 5 shows a bag body in which a laminated sheet (aluminum foil-polymer film) is joined to provide both chambers A and B and a medicine is stored in each chamber. When using the A or B chamber with a finger during use, only the relatively weak joint 22 expands and peels off,
Mix while circulating the A and B spaces. In use, this is an example of a container having a structure in which the notch 23 at the medicine outlet is broken and opened.

FIG. 6 shows another known container example in which a liquid A is put in a transparent glass bottle 24. The drug B in the form of granules or tablets is always stored separately in a separate container 26. At the time of use, the stopper 25 of the container is opened, the container 26 in a separate bag is broken, and the granules or tablets B are transferred to the container 24. A type in which the cap 28 at the tip of the lid is removed by mixing and dissolving in this is also known. However, such a type is inconvenient and complicated, there is a possibility that various bacteria may enter, and there is a feeling that the appearance is not clean enough.

[0005]

In the present invention, two liquids can be separately stored in a single container, and mixing of (liquid / liquid) or (liquid / grain) can be performed by an extremely simple operation. It is possible and can be used immediately without changing its container.
An object was to provide a container that can have the three functions of storing, mixing, and using.

[0006]

In order to enable the three functions of the above-mentioned problems of separate storage, convenient mixing of medicines and hygienic use in a single container, the present invention is shown in FIG. The container was developed.

FIG. 1 shows a container consisting of two storage chambers A and B, which are separated by a rupturable partition wall 6. As shown in FIG. 1C, the container is of a shell type, which consists of three parts: an upper part that constitutes chamber A 1, a lower part that constitutes chamber B 3, and an intermediate part 2 that connects the upper part and the lower part. It is a thing. Further, inside the intermediate portion, a partition wall 6 having a liquid-sealing property and capable of being ruptured and an insertion cross body 13 are built in below. The sealing partition is a soft and rupturable material;
(For example, butyl rubber, etc.) is sandwiched between the lower part and the middle part in a gasket shape, and due to the tightening effect of the screw structure of both, separation between chambers A and B and complete prevention of liquid leakage to the outside of the container There is. Due to the effect of this sealing partition, A,
The drugs separately stored in the B chamber can be stably stored for a long period of time.

Next, the operation at the time of use will be described. That is, when the medicine stored in the container is to be used, the upper portion 1 is pushed downward so that the intermediate portion digs deeper, and the concave and convex fitting positions at all times (during storage and storage) [Fig. ] State, push-in position [Fig. 1
・ It will move to the state of (b) (when in use), and it will be set stably by fitting the concavity and convexity. When the upper portion 1 is pushed in, the lower edge simultaneously pushes down the shoulder portion a of the insertion cross body 13, and the tip portion b thereof breaks the sealing partition wall 6, so that the A chamber and the B chamber are in a freely flowable state. Become. As a result, the liquid in chamber A flows into chamber B,
Both are mixed (dissolved in the B chamber in the case of granules or tablets). If the mixing (or dissolution) is insufficient, raise the container,
It is possible to completely mix (or dissolve) by inversion or shaking operation or pressing the side wall of the container to mutually exchange the upper and lower chamber liquids.

When the mixing (dissolving) of the medicines in both chambers A and B is completed, the medicine is ready for use. At the time of use, the medicine drop dropping nozzle 11 at the tip of the upper portion 1 of the container is used. Remove the plug 10 that is installed, and tumbl the container,
When the side peripheral wall of the upper portion is lightly pressed, the chemical liquid drops from the tip of the nozzle. After use, it can be sanitized for a while by plugging.

In the case of the present invention, although the drug container is small as described above, each part of the container is required to have various functions. Therefore, in concrete implementation, in addition to the above-mentioned mechanical requirements, since each component functions such as fitting, liquid sealing, breaking, etc., highly precise processing technology is required in terms of shape. However, they are also required to have different physical properties. From this point of view, the selection of the material for the constituent parts of the container of the present invention is very important. Embodiments of the invention of the present application will be specifically described below in terms of a mechanically required shape surface and a functionally required material selection.

[0011]

FIG. 2 is an enlarged view of the dotted line frame portion of FIG. 1 in order to facilitate the explanation of the function of each portion. Figure 2 below
Will be described. In addition, Figure 2 ・ D shows the state of separate storage
Fig. 2 (e) shows a state in which the partition wall is broken and the sealing is released.
As shown in FIG. 2D, an annular convex portion 8 is provided on the outer peripheral surface of the inner cylinder 1, which is always (when isolated and stored) a concave annular groove (upper stage) 4 provided inside the intermediate portion. Is fitted to.

In use, when the upper portion 1 is pushed down, the annular convex portion 8 slides into the concave annular groove (lower step) 5, is fitted and fixed as shown in FIG. At the same time, the shoulder a of the insertion cross 13 is pushed down, and as a result of the pointed projection at the lower end thereof breaking the partition wall 6, the seal between the chambers A and B is released, free circulation and mutual dissolution are possible. Becomes

Since the upper part 1 of the container is indirect contact with the drug for a long period of time, it is first required to be stable against drugs.
In addition, as described above, this portion has a fixed shape and is required to have appropriate elasticity and slidability in terms of material in order to enable the movement of the fitting position. Adhesive sealability with the inner wall of No. 2 is also required. Further, when the chemical solution after mixing is used, it is necessary to press the side peripheral wall of the upper part 1 to drop the chemical solution, so that appropriate flexibility is required. Various materials
As a result of trial production of the structure, as a material having the above-mentioned characteristics, a material having elasticity such as low density polyethylene (LLDPE) or nylons was suitable.

No flexibility is required for the intermediate portion 2,
Rather, a material that is hard, slidable, and capable of precision molding is desired. For example, polypropylene is suitable.

The lower portion 3 is in contact with the drug even during long-term storage, requires the most stability and barrier property, and it is necessary to confirm the mixed state of the drugs in both chambers A and B inside, and by the screw structure, Because it needs to be closely combined with the middle part,
A hard material that is transparent or translucent (coloring for dimming is also possible) is preferable, and specifically glass, PET, P
BT etc. are selected.

The insert cruciform 13 has a pointed protrusion b on the lower bottom thereof, and from this point, the pressing force of the upper portion 1 is received by the shoulder a, and the lower partition wall 6 for sealing. The mechanical strength is required to transmit the force to break and to break it, as well as the precision forming workability and hardness. As a result of various trials, polypropylene material and polycarbonate were selected.

The joint surface between the intermediate portion 2 and the lower portion 3 is important for preventing liquid leakage to the outside of the container.
Since each is a hard material, a chemical resistant and elastic sealing material (gasket) is used between them. Moreover, since this gasket also serves as the partition wall 6, it is required to have a property that it can be broken by the pointed projections. As a result of repeated tests, a plate-shaped butyl rubber sheet was selected as the material. It is also effective to put a half slit on the upper (or lower) surface near the central part of this partition sheet so that it can be easily broken. Further, an aluminum foil may be added to the rubber gasket 6 in order to further enhance the sealing property between both chambers. The sealing liquid between the upper part 1 and the intermediate part 2 is
Since the material of the upper portion 1 is a flexible and moderately elastic material, it is sufficient to use only the seal formed by the contact between the annular convex portion 9 of the upper portion and the inner peripheral surface of the intermediate portion. .

Nozzle 11 below the liquid drop at the tip of the upper part
High-density polyethylene (HDPE) is used as the material of the plug 10, and as shown in FIG. 4, in order to prevent liquid leakage, a protrusion 12 for fitting and sealing the plug 12 is provided at the center of the plug.

[0019]

According to the present invention, a drug which is unstable when stored in a mixed state for a long time is separated and stored by providing a partition wall between the chambers.
It can be stably stored, and when it is used, the partition wall between both chambers can be easily broken and the seal can be released by simply pressing down a part of the peripheral wall of the container, and both liquids can be freely mixed. . The drug solution after mixing can be dripped locally by removing the stopper 10 attached to the tip of the upper part 1 of the container, inverting it, and gently pinching the peripheral side wall of the container. After temporary use, it can be stored for a while by covering it with a stopper. That is, the container of the present invention enables stable storage, mixing (dissolution), and application of the drug in one container.

[Brief description of drawings]

FIG. 1A is a sectional view of a container according to the present invention, in which two chemicals are separated and stored by a partition wall. (B) is a sectional view of the container showing a state in which the partition wall is broken and the chemical liquid can be mixed. (C) is a side view of the container.

FIG. 2 (d) is a detailed view showing a joined state of each part constituting the container according to the present invention, and is an enlarged cross-sectional view of a portion indicated by a dotted line in FIG. 1 (a) (state where the partition is housed). . (E)
FIG. 3 is an enlarged cross-sectional view of the same portion (unsealed state) of FIG.

FIG. 3 (h) is a detailed view of an insertion cross member of the container of the present invention. FIG. 3L is a sectional view taken along the line AA ′ of FIG.
(Nu) is a top view of FIG.

FIG. 4 is a view of a stopper attached to the tip of the container of the present invention.

FIG. 5A is a schematic top view of a conventionally known drug separation / accommodation container. (B) is a side view of the above.

FIG. 6C is a schematic view of a conventionally known individual container for a medicine, which is a side sectional view of the container for the medicine A. (D)
Shows a separate container for drug B.

[Explanation of symbols]

 1 Upper Part 2 Intermediate Part 3 Lower Part 4 Recessed Fitting Groove (Upper) 5 Recessed Fitting Groove (Lower) 6 Partition (Combined Packing) 7 Lower Part Mounting Screw 8 Fitting Provided on Inner Cylinder Outer Surface of Upper Part 1 Combined convex portion 9 Annular convex portion provided on the outer surface of the inner cylinder of the upper portion 1 10 Plug body 11 Nozzle under the liquid droplet 12 Central projection of the plug body 13 Internal cross body 21 Strong seal portion of the bag for drug packaging 22 Same as above -Left portion 23 Notch for tearing 24 A Container for drug storage 25 Plug for same as above 26 B Container for drug storage a A Shoulder of internal cross body b A pointed protrusion on the bottom of internal cross A A A drug storage chamber B B drug Storage room ↓ Indicates the moving direction of the upper part 1. ─ → Indicates the liquid distribution status.

Claims (3)

[Claims] 1. A container composed of two chambers A and B, which are divided by a partition wall and separate and store separate drugs, respectively. When the drug is used, the pressure applied from the outside of the container causes The two liquids (or liquids and solids) are mixed (or dissolved) in a state where the sealing by the partition wall between AB is released,
A container for separating and storing, mixing, and using, which has a structure in which the mixed liquid is used as it is by dropping it through a hole provided at the tip. 2. A container composed of two chambers, A and B, which are divided by a rupturable partition wall and separate and store separate medicines in each case; when the medicine is used, it is added from the outside of the container. The partition wall between A and B is broken by the applied pressure, and the two liquids (or liquid and solid) are mixed (or dissolved) with the sealing between both chambers released, and the mixed liquid is directly applied to the tip. Separate storage, mixing, and use container with a structure that is used by dropping from the provided hole. 3. It is composed of two chambers, A and B, which are divided by a rupturable partition wall and separate and store separate medicines in each of them; when the medicine is used, the pressure is applied from the outside of the container. , A, B, the partition wall is broken, and the sealing between both chambers is released, the two liquids (or liquid / solid) are mixed (or dissolved), and the mixed liquid is directly supplied from the hole provided at the tip. Separate storage and mixing having a structure to be used by dropping,
A container to be used, wherein a part of the container has a flexible structure,
In use, this is a container for separating, storing, mixing, and using which a suitable amount of drug solution can be dropped in a drop-like manner by pressing this part.