JP2005028041A - Sealing plug for partition bag - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a sealing plug for a partition bag provided with a fail safe means for preventing the situation of letting only a liquid formulation flow out without breaking a partition at the time of using the partition bag. <P>SOLUTION: The sealing plug for sealing the exit part of the generally used partition bag forms a sealing state of sealing the liquid formulation inside a first chemical chamber by being fitted to the base part of the exit part. When a pressure applied from the outside to the partition bag reaches the range of prescribed relation to a partition breaking pressure, the sealing plug is shifted to a distribution state and the liquid formulation inside the first chemical chamber is made to flow out to the exit part. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  In the present invention, one type of liquid preparation and another type of liquid preparation or a solid preparation in the form of powder or granules are accommodated separated by a partition, and the partition is broken by pressurization during use. A liquid preparation containing a predetermined component in a predetermined concentration by mixing one liquid preparation and another liquid preparation or a solid preparation in a powder or granular form, and the solution The present invention relates to a bag with a partition wall (hereinafter referred to as a partition wall bag) through which a medicinal drug flows out.

  The septum bag is mainly used in the medical field, for example, to prepare a liquid preparation for infusion, replacement fluid, or infusion to be used at the treatment site when performing treatment such as infusion, replacement fluid, or drip. ing.

  The partition bag generally has a first drug chamber and a second drug chamber, and the first drug chamber and the second drug chamber are connected to each other by a connecting portion, but a partition is provided at the connecting portion. Accordingly, the plastic bag can store the contents of the first medicine chamber and the contents of the second medicine chamber in an isolated state. The partition wall can be broken by performing an operation such as pressing from the outside during use, and as a result, fluid can be circulated between the first drug chamber and the second drug chamber via the connecting portion. It becomes like this.

  Among medical drugs used by mixing two or more kinds of components, there are some drugs that undergo chemical changes when mixed, and the components change or change over time. Until such a drug is used, it is necessary to separate the one component from the other component, and to use both components dissolved in each other at the time of use. In some cases, a part of the liquid component and the remainder of the liquid component are separated and stored, and may be mixed at the time of use.

  Therefore, for example, if the first type liquid preparation is put in the first drug chamber of the partition bag formed with the partition wall in the communication part and another type of preparation is put in the second drug chamber, the partition wall is broken. The septum bag is very useful because it can be prepared by mixing at least two kinds of preparations when necessary and preparing a medicine containing a predetermined component in a predetermined quantity ratio.

In general, one end of the partition bag, for example, one end of the first drug chamber is provided with an outlet for allowing the prepared drug to flow out. As described above, in a state before the partition wall is broken (hereinafter also referred to as a storage state), the outlet portion is sealed as a port portion having a rubber region in the central portion. After breaking the partition wall (this state is also referred to as “use state” hereinafter), after mixing the two types of preparations through the connecting part, the rubber stopper attached to the outlet part is used for infusion, replacement fluid or infusion. By piercing a needle connected to a tube or catheter of the above, the drug in the septum bag can be used for infusion, replacement fluid, or infusion. Such a partition bag is proposed in, for example, Japanese Patent Laid-Open No. 9-327498.
JP-A-9-327498

  In the conventional partition bag as described above, when performing the operation of breaking the partition wall at the site of treatment, a sufficient force cannot be applied to the bag to break the partition wall. There was a case where only the liquid preparation in the first medicine chamber was allowed to flow out of the bag without mixing the preparations with each other.

  For example, a sodium bicarbonate solution is placed in a first drug chamber as a liquid first component, and a replacement solution is prepared using a septum bag containing a liquid containing sodium chloride, calcium chloride, etc. as a second liquid component in a second drug chamber. In the case of performing the treatment, if the liquid in the first drug chamber and the liquid in the second drug chamber are not mixed and used as a replacement fluid without mixing the liquid in the first drug chamber, hemolysis due to low osmotic pressure is caused, and the patient is severely affected. There have been reports of cases of severe symptoms or even death. This is a kind of medical accident.

  The invention of the present application is an invention made for the purpose of preventing medical accidents that may occur when using the partition bag as described above.

  That is, according to the present invention, the outlet portion of the partition bag can be reliably sealed in the storage state of the partition bag, and the predetermined condition relating to the operation of breaking the partition wall when shifting to the use state. An object of the present invention is to provide a sealing stopper that comes off at the outlet.

  The invention related to the sealing plug of the present application has at least a first drug chamber and a second drug chamber that communicate with each other through a communication portion having a partition inside, and the first drug chamber further has an outlet for allowing the contents to flow out. When the pressure applied from the outside in the state where each medicine is housed in each medicine chamber separated from each other by the partition wall reaches the pressure for breaking the partition wall or the pressure exceeding the pressure, the partition wall breaks and the first medicine chamber is broken. A sealing member that seals the outlet portion of the partition bag that allows fluid to flow between the second medicine chamber and the valve member that can be opened downstream in the flow direction of the fluid from the partition bag toward the outlet portion And is fitted to the base of the outlet portion to form a sealed state in which the liquid preparation in the first drug chamber is sealed, and the pressure applied from the outside to the partition bag is 30 of the partition breaking pressure. % Obtain the, characterized in that the valve member moves the first agent chamber of the liquid formulation opens to the downstream side to the circulatory state to flow out to the outlet portion.

The invention relating to the sealing plug of the present application also includes a valve member that can be opened downstream in the fluid flow direction from the partition bag toward the outlet, and a blocking film member that is disposed upstream in the flow direction of the valve member. And the transition from the sealed state to the distribution state can be made by breaking the barrier film member.
The valve member has a valve body connected to the first annular frame body having an outer dimension and a shape fitted to the outlet base portion by at least one hinge portion, and a blocking film member Is formed by connecting a second annular frame having an outer dimension and shape fitted to the outlet base and a film part disposed on the inner side by a thin part, and has a predetermined thickness with respect to the blocking film member. When pressure is applied, the thin-walled portion breaks and transitions to a distribution state.

  According to the sealing plug of the present invention, when performing an operation of applying a predetermined pressure from the outside to break the partition wall, the pressure applied from the outside to the partition bag is a predetermined value higher than the pressure to break the partition wall. Until the pressure reaches a small pressure, the outlet portion of the partition bag can be securely sealed, and when the pressure applied from the outside exceeds the predetermined pressure value, the outlet portion of the partition bag can be opened. Therefore, the treatment person presses the partition bag, confirms that the sealing plug is in a circulation state, and further confirms that the partition wall is broken and is in a use state. Since the medicine can be used for infusion, infusion, or replacement fluid, it is possible to effectively prevent an accident that two or more kinds of medicines in the septum bag are used for treatment without being mixed.

Hereinafter, each invention of the present application will be described with reference to the drawings showing preferred embodiments thereof.
FIG. 1 is a view schematically showing a partition bag 30 in a state in which the sealing plug 1 of the invention according to this application is fitted. The partition bag 30 is in a state in which the outlet portion 35 is placed on the left side toward the paper surface of FIG. 1, and the first drug chamber 32 communicated by a communication portion 31 located at a substantially central portion in the left-right longitudinal direction. It has two chambers with the second medicine chamber 33.

  The communication unit 31 is an opening through which fluid can flow between the first drug chamber 32 and the second drug chamber 33. In the state shown in FIG. Thus, the fluid is separated from the first medicine chamber 32 and the second medicine chamber 33 so as not to flow. For example, the first drug chamber 32 contains a sodium bicarbonate solution as a liquid first component, and the second drug chamber 33 contains a liquid containing sodium chloride, calcium chloride, etc. as a liquid second component. .

  Since the outlet portion 35 of the partition bag 30 is sealed by attaching the sealing plug 1, the liquid preparation stored in the first drug chamber 32 in the stored state is sealed by the sealing plug 1 and the partition 34. It is contained in the first medicine chamber 32. Regarding the description of the present specification and the drawings, for the convenience of description, the flow direction of the fluid from the first drug chamber 32 toward the outlet portion 35 is used as a reference, and the side close to the first drug chamber 32 (the paper surface in FIG. 2A). The right side) is also referred to as the upstream side, and the side far from the first drug chamber 32 (the left side in FIG. 2A toward the paper surface) is also referred to as the downstream side.

  The outlet portion 35 includes an outlet portion base portion 35a extending with a substantially constant inner diameter in the downstream direction from the first drug chamber 32 located on the upstream side in FIG. 2A, and a downstream end portion of the outlet portion base portion 35a. The outlet tapered portion 35b that extends further downstream while gradually increasing the inner diameter in a tapered shape, and the downstream end of the tapered portion 35b expands to a larger inner diameter, and again toward the downstream with a substantially constant inner diameter. It has the exit part end part 35c extended.

  The partition bag 30 is a flexible plastic bag, and various types and standards are already commercially available for various products. Since the present invention relates to a sealing plug for a partition bag and is not directly related to the material or standard of the partition bag, this specification will mainly describe matters relating to the function of the sealing plug. The partition wall 34 in the communication part 31 is actually formed by heat-sealing a part of the communication part 31. When the first drug chamber 32 of the partition bag 30 in the stored state is pressed from the outside, the pressure is transmitted to the partition wall 34 and the sealing plug 1 by the liquid preparation in the first drug chamber 32.

  When the pressure transmitted to the partition wall 34 exceeds a predetermined value, here, a pressure sufficient to break the partition wall (also referred to as “partition wall breaking pressure” in this specification), the pressure is provided inside the connecting portion 31. The partition wall 34 is broken, and as a result, the fluid can flow between the first drug chamber 32 and the second drug chamber 33 via the communication portion 31. In the case of a general 2 liter partition wall bag, the pressure at which the partition wall 34 breaks is in the range of 5 kPa to 20 kPa, preferably 10 kPa to 15 kPa. However, when a pressure exceeding 15 kPa is instantaneously applied to this bulkhead bag (for example, from a height of about 1 m, which causes the bulkhead bag held in the hand in a standing posture to fall on the floor of the feet) Since it is not preferable that the partition wall 34 breaks when it is dropped, etc., the condition for the partition wall 34 to break is that the pressure of at least 15 kPa is at least 0.2 seconds, preferably 0.5 seconds, more preferably 1.0. It can be added for seconds. However, the pressure when dropping according to the weight of the partition bag and the specific partition breaking pressure vary depending on the type of the partition bag, so the conditions of pressure and time are not limited to those described above.

  FIG. 2 is a view for explaining the basic relationship between the sealing plug 1 and the outlet portion 35 according to the present invention. In the form of FIG. 2, a plastic (for example, polyethylene) port portion having a funnel shape as a whole is employed as the outlet portion 35. A right end portion of the outlet portion 35 communicates with the first drug chamber 32 of the partition bag 30, and a rubber plug body 36 is provided with a rubber region 37 at the central portion thereof at the downstream end portion of the outlet portion 35. Is attached. 2A shows a cross-sectional view of a sealed state in which the closed sealing plug 1 is attached to the outlet portion 35 of the partition bag 30, and FIG. 2B shows the distribution when the sealing plug 1 is opened. It shows a state of transition to the state. In the form shown in FIG. 2, the sealing plug 1 includes a valve member 10 disposed on the relatively downstream side in the flow direction of the fluid from the partition bag toward the outlet portion, and a blocking film disposed on the relatively upstream side. It is formed in combination with the member 20. However, the valve member 10 may be disposed on the relatively upstream side, and the blocking film member 20 may be disposed on the relatively downstream side. In that case, the combination mode of the valve member 10 and the blocking film member 20 may be reversed.

  The valve member 10 and the blocking membrane member 20 have dimensions and shapes in which the right side (upstream side) surface of the valve member 10 and the left side (downstream side) surface of the blocking membrane member 20 are fitted to each other. In addition, the blocking film member 20 can function as the sealing plug 1 in a state of being integrally fitted. In the form shown in FIG. 2, the valve member 10 and the cutoff are provided by providing a concave portion on the outer peripheral portion of the right surface of the valve member 10 and providing a convex portion that fits in the concave portion on the outer peripheral portion of the left surface of the blocking film member 20. The membrane members 20 are combined with each other.

  Various features of the valve member 10 are shown in FIG. FIG. 3A is a front view showing a state in which the valve member 10 shown in FIG. 2A is observed from the downstream side, and FIG. 3C is a view showing the valve member 10 shown in FIG. 2A from the upstream side. It is a rear view which shows the state observed. 3 (d) shows a cross-sectional view taken along the line BB in FIG. 3 (a), and FIG. 3 shows a cross-sectional view taken along the line AA in FIG. 3 (c). This is shown in (b). 3 (d) shows an enlarged view of the part in the circle indicated by reference numeral E in FIG. 3 (d), and FIG. 3 (b) shows an enlarged view of the part in the circle indicated by reference numeral C in FIG. FIG. 3G shows an enlarged view of a portion in a circle shown in FIG. 3F and indicated by a symbol D in FIG.

  As shown in FIG. 3A, the valve member 10 is formed by arranging a first annular frame 11 on the outermost peripheral side and a pair of valve bodies 12 and 12 'on the inner side. In the front view shown in FIG. 3A, one valve body 12 has a substantially semicircular shape, and is positioned in the 12 o'clock direction when the first annular frame 11 is regarded as a clock face. The valve body 12 is connected to the first annular frame 11 by the hinge portion 14. The other valve body 12 'is connected to the first annular frame 11 by a hinge portion 14' positioned in the 6 o'clock direction.

  In the longitudinal sectional view shown in FIG. 3 (b), projecting portions 13 and 13 'projecting downstream are provided at the tips of the valve bodies 12 and 12', respectively. As shown in the longitudinal sectional view of FIG. 3B, the hinge portion 14 is a part of the valve body 12 in the thickness direction, and is provided at a relatively downstream position in the thickness direction. Similarly, 14 ′ is provided at a relatively downstream position in the thickness direction of the valve body 12. Since the hinge parts 14 and 14 'are positioned on the downstream side in the thickness direction of the valve bodies 12 and 12', the valve bodies 12 and 12 'have the hinge parts 14 and 14' as the rotation centers, respectively. Although it can be easily pivoted, it is difficult or substantially impossible to pivot upstream.

  The protrusions 13 and 13 ′ provided to protrude downstream from the distal ends of the valve bodies 12 and 12 ′ are also pressed when the fluid flows from the downstream side to the upstream side, for example. Since the respective tip portions of the projecting portions 13 and 13 ′ are in contact with each other, the valve bodies 12 and 12 ′ can be prevented from rotating upstream with the hinge portions 14 and 14 ′ as the rotation center.

  The first annular frame 11, the valve bodies 12 and 12 ′, the protruding parts 13 and 13 ′, and the hinge parts 14 and 14 ′ can be formed as separate members and then combined to form the valve member 10. Integral molding is preferable because the number of manufacturing steps can be reduced. The valve member 10 can be formed using various plastic materials selected from polyurethane, polyolefin, polyester, silicone, vinyl chloride, acrylic, polycarbonate, polyethylene, polypropylene, polystyrene, nylon, Teflon (registered trademark), The example shown in this embodiment is manufactured using polycarbonate, but is not limited to this as long as it can exhibit the functions described in this specification.

  Various features of the barrier film member 20 are shown in FIG. 4A is a front view showing a state where the blocking film member 20 shown in FIG. 2A is observed from the downstream side, and FIG. 4C is a drawing showing the blocking film member 20 shown in FIG. It is a rear view which shows the state observed from the side. 4 (d) shows a cross-sectional view taken along the line BB in FIG. 4 (a), and FIG. 4 shows a cross-sectional view taken along the line AA in FIG. 4 (c). This is shown in (b). Further, FIG. 4E shows an enlarged view of a portion in a circle indicated by reference numeral C in FIG.

  In the front view shown in FIG. 4A, the blocking film member 20 is formed with the second annular frame 21 disposed on the outermost peripheral side and the circular film portion 22 disposed on the inner side. As shown most clearly in FIG. 4 (e), a thin portion 24 having a thickness smaller than that of the film portion 22 is provided between the second annular frame 21 and the circular film portion 22. Yes. Therefore, the second annular frame 21 and the circular film portion 22 are connected by the thin portion 24. However, the thin portion 24 does not need to be provided on the entire outer periphery of the film portion 22, and as shown in FIG. 4C, the thin portion 24 is not provided at the 12 o'clock and 6 o'clock positions, and is the same as the film portion 22. It can also be a thickness.

  As shown in FIG. 4C, stoppers 23 and 23 'are provided in the direction of 3 o'clock and 9 o'clock on the back side of the second annular frame 21, respectively. As can be understood from FIG. 4B, the stoppers 23 and 23 'support the 3 o'clock and 9 o'clock positions of the circular film portion 22 from the back side. For example, when the sealing plug 1 of the present invention is sterilized and sterilized, fluid (for example, expanded air during high-temperature steam sterilization) may flow from the downstream side to the upstream side. In such a case, if the stoppers 23, 23 ′ are not present, there is a possibility that the membrane portion 22 is excessively pushed toward the upstream side by the fluid flow and the thin portion 24 is broken. Therefore, by providing the stoppers 23 and 23 ', it is possible to prevent the thin portion 24 from being broken when the film portion 22 is excessively pushed toward the upstream side. Further, as shown in FIG. 4C, the thin portion 24 is not only the outer peripheral portion of the film portion 22, but also the central portion in the vertical direction of the thin portion 24, that is, the position at 3 o'clock and 9 o'clock in the thin portion 24. It is also provided at the part connecting. In the rear view shown in FIG. 4 (c), the film part 22 is divided by the thin part 24 at the central part in the vertical direction, so that the upper film part in FIG. The side film part is indicated by reference numeral 22 '.

  When the valve member 10 and the barrier film member 20 as described above are combined with each other, the sealing plug 1 as shown in FIG. 2A can be formed. In this embodiment, the outlet portion 35 is formed using polypropylene, and the dimensions and shape of the outer peripheral side of the first annular frame 11 of the valve member 10 and the second annular frame 21 of the blocking film member 20 are any. However, since it is formed so as to correspond to the size and shape of the inner peripheral side of the outlet portion 35, once the sealing plug 1 is fitted into the outlet portion 35, the sealing plug 1 is firmly secured by the outlet portion 35. And held.

  From the state shown in FIG. 2A, for example, when the first drug chamber 32 of the partition bag 30 placed on the table is strongly pressed by hand, the proximal end of the outlet portion 35 from the first drug chamber 32. A pressure corresponding to the force applied by hand is applied to the part.

  The pressure required to break the partition wall 34 of the partition bag 30 is not uniform because there are various standards depending on the material, contents and manufacturer of the partition bag, but the contents, product standards and manufacturer of the partition bag are not uniform. By specifying, the partition bag can be classified into several standards. Therefore, for the partition bag, which is a specific product of a specific manufacturer, it can be determined in advance by experiments or the like that the partition wall is broken by applying a pressing force. A sealing plug corresponding to the product can be provided.

  Therefore, the sealing plug of the present invention can be set so as to correspond to the pressure at which the partition wall of the partition bag of a specific product of a specific manufacturer breaks (also referred to as a specific partition wall breaking pressure in this specification). . Specifically, the pressure applied from the outside to the partition bag increases from the state of 0 Pa and exceeds at least 30% of the specific partition wall breaking pressure, preferably exceeds 50%, more preferably 70. When entering the range exceeding%, the strength of the thin portion 24 is set so that the thin portion 24 of the blocking film member 20 breaks in the sealing plug 1.

  The conditions under which the thin-walled portion 24 of the barrier film member 20 breaks within the sealing plug 1 are the materials used for the barrier-film member 20, the thickness of the barrier-film member 20, the thin-walled portion 24 and the membrane portion 22, the dimensions of the thin-walled portion 24, and It is thought that it depends on the shape and the like. The conditions under which the thin-walled portion 24 breaks in such a sealing plug 1 are the same as the conditions for breaking the partition wall 34 of the partition bag 30, and after selecting the target partition bag 30, experiments and the like are performed as necessary. Can be obtained.

  FIG. 2B shows a state in which the thin portion 24 of the blocking film member 20 is broken as a result of the fluid pressing the sealing plug 1 from the upstream side with a pressure exceeding a predetermined pressure. The film portions 22 and 22 ′ after the thin-walled portion 24 is broken may remain in a state of being connected to the second annular frame 21 by portions located in the 12 o'clock direction and the 6 o'clock direction, respectively. May be completely separated from the second annular frame 21.

  With respect to the first annular frame 11, the upper valve body 12 is pushed up to the downstream side in a state of being connected to the first annular frame 11 by the hinge portion 14 by the flow of fluid from the upstream side to the downstream side. On the other hand, the lower valve body 12 ′ is pushed down to the downstream side while being connected to the first annular frame 11 by the hinge portion 14 ′. As a result, a portion in which the valve body 12, 12 ′ opens and opens downstream is formed inside the first annular frame body 11, and the film portions 22, 22 ′ are formed inside the second annular frame body 21. Open to the downstream side or separated from the second annular frame 21 to form a portion that opens.

  Therefore, the partition bag 30 can be pressed as described above to bring the sealing plug 1 into a flow state immediately before the partition breaks. When the partition wall 34 is further pressed to break the partition bag 30, Except that the outlet is sealed by the rubber plug 36 fitted to the left end portion of the outlet portion 35, the fluid flows between the first drug chamber 32, the second drug chamber 33, and the outlet portion 35. It will be ready for distribution. In this state, the treatment person (the person who presses the partition wall) sufficiently shakes the partition wall bag or tilts the partition bag up and down a sufficient number of times, so that the solid preparation or liquid preparation contained in the second drug chamber 33 The liquid preparation contained in the first drug chamber 32 can be sufficiently mixed or dissolved to prepare a drug necessary for the treatment.

  Thus, by adopting the sealing plug 1 according to the present invention, the treatment person using the partition bag confirms that the sealing plug 1 is in a distribution state, and further, the partition wall is broken and put into use. It is required to confirm that it has become. Therefore, when the partition bag is used, since the sufficient pressure cannot be applied to the partition bag, the first drug chamber is not noticed by the treatment person even though the partition wall is not broken. Can prevent accidents in which only drugs (particularly liquid preparations) contained in are used for infusion, infusion or replacement.

  The configuration of the sealing plug in the above-described embodiment is to explain the most preferable embodiment of the present invention. The present invention is not limited to this, and is characterized by the matters described in the claims. For example, the sealing membrane member 20 is omitted, and the valve member 10 is provided with a thin portion between the two valve bodies 12 and 12 ′, whereby the sealing plug can be shifted from the sealed state to the flow state. The number of valve bodies provided in the valve member is not limited to two, and various numbers can be adopted as long as the function described in this specification can be exhibited.

  As an example of the partition wall bag, a product sold under the trade name Subrad-BD by Fuso Pharmaceutical Co., Ltd. was used, and the sealing plug of the present invention was manufactured corresponding to this.

  This partition bag has a partition breaking pressure in the range of 8.0 kPa to 15.7 kPa. Therefore, the sealing plug was set to shift from the sealed state to the flowing state at a pressure exceeding 5.6 kPa, which is a pressure value that falls within a range exceeding 70% of the partition wall breaking pressure.

  Actually, the sealing plug is applied to the partition bag of the above-mentioned Subrad-BD (trade name), and the pressure applied to the partition bag is increased while measuring with a pressure gauge, so that the sealing plug is in a flow state from a sealed state. The pressure value to shift to was measured. The measurement was performed on 10 partition walls, and according to the average, when the pressure reached 6.2 kPa, the sealing plug shifted from the sealed state to the distribution state. Further, the average partition wall breaking pressure of the 10-point partition bag was 11.3 kPa.

FIG. 1 is a view schematically showing a partition bag 30 in a state in which a sealing plug is fitted. FIG. 2 is a cross-sectional view showing a state in which a sealing plug is attached to the outlet portion. FIG. 2A shows a sealed state, and FIG. 2B shows a distribution state. FIG. 3 illustrates various features of the valve member. 3 (a) is a front view of the valve member, FIG. 3 (c) is a rear view of the valve member, FIG. 3 (b) is a cross-sectional view taken along the line AA in FIG. 3 (d) is a cross-sectional view taken along the line BB in FIG. 3 (a), FIG. 3 (e) is an enlarged view of a portion in a circle indicated by E in FIG. 3 (d), FIG. FIG. 3 (f) is an enlarged view of a portion in a circle indicated by reference character C in FIG. 3 (b), and FIG. 3 (g) is an enlarged view of a portion in the circle indicated by reference character D in FIG. 3 (b). . FIG. 4 shows various features of the barrier film member 20. 4A is a front view of the barrier film member, FIG. 4C is a rear view of the barrier film member, and FIG. 4D is a cross-sectional view taken along the line BB in FIG. 4A. 4 (b) is a cross-sectional view taken along the line AA in FIG. 4 (c), and FIG. 4 (e) is an enlarged view of a portion in a circle indicated by reference numeral C in FIG. 4 (d). Each is shown.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Sealing plug, 10 ... Valve member, 11 ... Ring frame, 12, 12 '... Valve body, 13 ... Projection part, 14, 14' ... Hinge part, 20 ... Shut-off film member, 21 ... Ring frame, 22, 22 '... membrane part, 23 ... stopper, 24 ... thin wall part, 30 ... partition wall bag, 31 ... communication part, 32 ... first medicine chamber, 33 ... second medicine chamber, 34 ... partition wall, 35 ... outlet part, 35a ... outlet portion base, 35b ... outlet portion tapered portion, 35c ... outlet portion end, 36 ... rubber plug, 37 ... rubber region.

Claims (3)

It has at least a first drug chamber and a second drug chamber that communicate with each other by a communication portion having a partition wall, and the first drug chamber has an outlet for discharging contents, and is separated from each other by the partition wall. When the pressure applied from the outside in the state where each medicine is stored in each medicine chamber reaches the pressure that breaks the partition wall or exceeds the pressure, the partition wall breaks and fluid flows between the first medicine chamber and the second medicine chamber. A sealing plug that seals the outlet of the partition bag that can be circulated,
At least a valve member that can be opened downstream in the flow direction of the fluid from the partition bag toward the outlet,
Forming a sealed state that seals the liquid preparation in the first drug chamber by fitting to the base of the outlet part, when the pressure applied from the outside to the partition bag exceeds 30% of the partition wall breaking pressure, A sealing plug, wherein the valve member opens to the downstream side and shifts to a flow state in which the liquid preparation in the first drug chamber flows out to the outlet.   A combination of a valve member that can be opened downstream in the flow direction of fluid from the partition bag toward the outlet and a blocking film member that is disposed upstream in the flow direction of the valve member, and the blocking film member is broken. The sealing plug according to claim 1, wherein the sealing state is shifted from the sealed state to the distribution state. The valve member has a valve body that is connected to at least one hinge portion with respect to the first annular frame body having an outer dimension and a shape that fits to the outlet base portion,
The barrier film member is formed by connecting the second annular frame body having an outer dimension and a shape fitted to the outlet base portion and the film portion disposed on the inner side by a thin portion,
3. The sealing plug according to claim 1, wherein when a predetermined pressure is applied to the blocking film member, the thin-walled portion breaks and shifts to a flow state.

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