JP4733644B2 - 膵臓腺癌の動物モデルおよびその使用 - Google Patents

膵臓腺癌の動物モデルおよびその使用 Download PDF

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JP4733644B2
JP4733644B2 JP2006541469A JP2006541469A JP4733644B2 JP 4733644 B2 JP4733644 B2 JP 4733644B2 JP 2006541469 A JP2006541469 A JP 2006541469A JP 2006541469 A JP2006541469 A JP 2006541469A JP 4733644 B2 JP4733644 B2 JP 4733644B2
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biomarker
cancer
gene
pancreatic adenocarcinoma
expression
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JP2007523631A (ja
JP2007523631A5 (enExample
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ロナルド エー． デフィノー，
ナビール エル−バーディーズィー，
アンドリュー ジェイ． アギレー，
デイビッド エー． テューベッソン，
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Dana Farber Cancer Institute Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
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    • A01K2267/0331—Animal model for proliferative diseases
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12Q2600/136—Screening for pharmacological compounds
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    • C12Q2600/00—Oligonucleotides characterized by their use
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
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  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Environmental Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Husbandry (AREA)
  • Plant Pathology (AREA)
  • Biodiversity & Conservation Biology (AREA)
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JP2006541469A 2003-11-26 2004-11-24 膵臓腺癌の動物モデルおよびその使用 Expired - Fee Related JP4733644B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52546403P 2003-11-26 2003-11-26
US60/525,464 2003-11-26
PCT/US2004/039756 WO2005053512A2 (en) 2003-11-26 2004-11-24 Animal models of pancreatic adenocarcinoma and uses therefor

Publications (3)

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JP2007523631A JP2007523631A (ja) 2007-08-23
JP2007523631A5 JP2007523631A5 (enExample) 2008-01-17
JP4733644B2 true JP4733644B2 (ja) 2011-07-27

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US (1) US20080242742A1 (enExample)
EP (1) EP1718192A4 (enExample)
JP (1) JP4733644B2 (enExample)
CA (1) CA2547355A1 (enExample)
WO (1) WO2005053512A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
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WO2005118869A2 (en) * 2004-05-28 2005-12-15 Dana-Farber Cancer Institute, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
EP2326734B1 (en) * 2008-09-03 2016-11-09 The Johns Hopkins University Pathways underlying pancreatic tumorigenesis and an hereditary pancreatic cancer gene
US8420884B2 (en) * 2008-10-16 2013-04-16 Tufts Medical Center Inc. Models of malignant brain cancer, and therapeutic siRNAs against oncogenic signaling pathways, and methods and kits for uses therefor
US8722964B2 (en) 2009-04-23 2014-05-13 Transposagen Biopharmaceuticals, Inc. Genetically engineered or transgenic rats exhibiting a cancer phenotype due to a disruption of germline tumor suppressor genes
US8563711B2 (en) 2009-06-01 2013-10-22 Sungkyunkwan University Foundation For Corporate Collaboration Nucleic acid aptamer capable of binding specifically to pancreatic cancer cells or tissues and use thereof
WO2010151789A1 (en) * 2009-06-25 2010-12-29 The Regents Of The University Of California Salivary transcriptomic and microbial biomarkers for pancreatic cancer
WO2011002988A1 (en) 2009-07-01 2011-01-06 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for severe combined immunodeficiency (scid)
AU2010282239A1 (en) * 2009-08-14 2012-03-08 Revivicor, Inc. Multi-transgenic pigs for diabetes treatment
CA2825894C (en) * 2011-02-02 2021-11-30 Amgen Inc. Prognosis of cancer using a circulating biomarker
RU2457546C1 (ru) * 2011-03-09 2012-07-27 Учреждение Российской академии медицинских наук Научный центр реконструктивной и восстановительной хирургии Сибирского отделения РАМН (НЦРВХ СО РАМН) Способ моделирования аденокарциномы толстой кишки человека
CA2848162C (en) 2011-09-12 2023-03-14 Creatics Llc Non-invasive methods of detecting target molecules
WO2013184905A1 (en) 2012-06-06 2013-12-12 Myriad Genetics, Inc. Hereditary cancer genes
CA2902841A1 (en) * 2013-03-13 2014-10-02 Creatics Llc Methods and compositions for detecting pancreatic cancer
US10172333B2 (en) 2013-03-15 2019-01-08 Exemplar Genetics, Llc Animal models of cancer
KR101456627B1 (ko) * 2013-04-24 2014-11-03 국립암센터 면역 치료 및 위암 치료제에 대한 효능 및 독성 평가를 위한 마우스 위암 세포주
US20150191744A1 (en) 2013-12-17 2015-07-09 University Of Massachusetts Cas9 effector-mediated regulation of transcription, differentiation and gene editing/labeling
US9986723B2 (en) * 2014-10-22 2018-06-05 The Board Of Regents Of The University Of Texas System Screen and use of therapeutics for pancreatic ductal adenocarcinoma
JP6695586B2 (ja) * 2015-12-17 2020-05-20 国立大学法人北海道大学 膵癌の再発リスクの予測に用いるための診断薬及びキット、並びに予測方法
WO2018230970A1 (ko) 2017-06-14 2018-12-20 서울대학교 산학협력단 돌연변이 마우스 유래 췌장 오거노이드 및 그 용도
US20220033814A1 (en) * 2018-12-03 2022-02-03 Triplet Therapeutics, Inc. Methods for the treatment of trinucleotide repeat expansion disorders associated with mlh1 activity
CN114672517B (zh) * 2020-12-24 2024-01-19 四川大学华西医院 一种全新基因组合模式在小鼠中建立胰腺癌的方法
CN114651786B (zh) * 2022-04-01 2023-05-26 广西医科大学 一种小鼠马尔尼菲篮状菌潜伏再激活模型的构建方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6033862A (en) 1996-10-30 2000-03-07 Tokuyama Corporation Marker and immunological reagent for dialysis-related amyloidosis, diabetes mellitus and diabetes mellitus complications
CA2379819A1 (en) * 1999-07-29 2001-02-08 Dana-Farber Cancer Institute, Inc. Inducible cancer model to study the molecular basis of host tumor cell interactions in vivo
ES2312607T3 (es) * 2001-03-28 2009-03-01 Dana Farber Cancer Inst Inc Identificacion y caracterizacion de genes.
JP2005523012A (ja) * 2002-04-16 2005-08-04 デイナ−ファーバー キャンサー インスティチュート，インコーポレイテッド 癌モデル
EP1670308B9 (en) * 2003-08-28 2012-11-14 Aveo Pharmaceuticals, Inc. Chimeric cancer models

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US20080242742A1 (en) 2008-10-02
JP2007523631A (ja) 2007-08-23
CA2547355A1 (en) 2005-06-16
WO2005053512A2 (en) 2005-06-16
EP1718192A4 (en) 2010-07-14
WO2005053512A3 (en) 2009-05-14
EP1718192A2 (en) 2006-11-08

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