JP4709120B2 - 成長ホルモン分泌促進用組成物 - Google Patents
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Description
(1)テアニンを有効成分とする成長ホルモン分泌促進組成物や、
(2)テアニン含有量が体重1kg当たり0.5〜5mg/kgであることを特徴とする上記(1)記載の成長ホルモン分泌促進組成物や、
(3)テアニンを有効成分とする血糖値上昇促進組成物や、
(4)テアニン含有量が体重1kg当たり0.5〜5mg/kgであることを特徴とする上記(3)記載の血糖値上昇促進組成物や、
(5)上記(1)若しくは(2)記載の成長ホルモン分泌促進組成物、及び/又は上記(3)若しくは(4)記載の血糖値上昇促進組成物を含有することを特徴とする食品又は飲料や、
(6)テアニンを含有し、成長ホルモン分泌促進及び/又は血糖値上昇促進のために用いられるものである旨の表示を付した食品又は飲料に関する。
)、L−グルタミン酸−γ−メチルアミド、D−グルタミン酸−γ−エチルアミド(D−テアニン )、D−グルタミン酸−γ−メチルアミド等のL−またはD−グルタミン酸−γ−アルキルアミド、L−またはD−グルタミン酸−γ−アルキルアミドを基本構造に含む誘導体(例えばL−またはD−グルタミン酸−γ−アルキルアミドの配糖体など)からなる群から選ばれた1種類の化合物又は2種類以上の化合物からなる混合物を用いることができる。中でも、L−テアニンは、天然物から取得可能であるばかりか、食品添加物として認められており、入手の容易さ及び安全性などからも特に好ましい。
Wistar系雄性ラット(静岡実験動物)を7週齢(約250g)で購入し、1週間予備飼育した後、実験に供した。動物舎は、室温24±0.5℃、湿度55±5%、明暗周期(明期7:00〜19:00)の飼育室内で管理され、水及び餌(MF、オリエンタル酵母社製)を自由に摂取させた。
ペントバルビタール麻酔下でラット脳定位固定装置にラットを固定し、頭骨を露出させた。前頭部及び後頭部の頭蓋骨にアンカービスを埋め込み、ラット脳図譜(G. Paxinos and C. Watson著)に従って海馬上の頭蓋に小穴を開けた。薬物注入カニューレの先端は、ブレグマ(bregma)からP=−5.5、L=±4.5、V=5.0mmに位置していた。両側の海馬に挿入したカニューレとアンカービスは歯科用セメントで頭蓋に固定し、背部皮下に埋め込んだ浸透圧ポンプ(Alzet
2002 Durect社製)は、ビニールチューブで連結した。浸透圧ポンプのfill volumeは214μlでpumping rateは0.5μl/hrであった。
テアニン(伊藤園社製)を生理食塩水に溶解し、ミリポアフィルター(Millex-GS、ミリポア社製)にて濾過した後、浸透圧ポンプに充填した。薬物濃度は、0.1μM、1μM及び10μMであり、対照群として生理食塩水を投与した。
ラット海馬にテアニンの局所投与を開始して第9日目から約36時間にわたって絶食させた。その後、採血して得た血液を分析に供した。
屠殺時の血糖値は、メディセーフチップ(MS-FC25,TERUMO Co.)を装着したメディセーフリーダー(GR-101,TERUMO
Co.)で直接測定した。成長ホルモンはSRL株式会社に依頼し測定した。SRL株式会社で測定されている方法は、非特許文献(石渡尚子ら,ホルモンと臨床,38(6),601-606)にも記載されているが、抗体をアイソトープで標識するimmunoradiometric
assay(IRMA)ものである。
1μM又は10μMのテアニンを海馬に直接投与することにより成長ホルモンの分泌は促進され、特に1μMで顕著であった。また、血糖値についても調べたところ、テアニンを投与することで血糖値を上昇させる効果が認められた。
Claims (4)
- テアニンを有効成分とする成長ホルモン分泌促進組成物。
- テアニン含有量が体重1kg当たり0.5〜5mg/kgであることを特徴とする請求項1記載の成長ホルモン分泌促進組成物。
- テアニンを有効成分とする血糖値上昇促進組成物。
- テアニン含有量が体重1kg当たり0.5〜5mg/kgであることを特徴とする請求項3記載の血糖値上昇促進組成物。
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JP2006287105A JP4709120B2 (ja) | 2006-10-23 | 2006-10-23 | 成長ホルモン分泌促進用組成物 |
PCT/JP2007/000804 WO2008012952A1 (fr) | 2006-07-28 | 2007-07-27 | Composition permettant de stimuler le métabolisme |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2001316256A (ja) * | 2000-04-28 | 2001-11-13 | Taiyo Kagaku Co Ltd | 血流改善用組成物 |
JP2002097136A (ja) * | 2000-07-21 | 2002-04-02 | Taiyo Kagaku Co Ltd | 喫煙欲求抑制組成物 |
JP2002322053A (ja) * | 2001-04-24 | 2002-11-08 | Taiyo Kagaku Co Ltd | 精神集中向上用組成物 |
WO2005107734A1 (ja) * | 2004-05-06 | 2005-11-17 | Taiyokagaku Co., Ltd. | アルコール代謝促進組成物、及びこの組成物を含有する飲食物 |
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JP2001316256A (ja) * | 2000-04-28 | 2001-11-13 | Taiyo Kagaku Co Ltd | 血流改善用組成物 |
JP2002097136A (ja) * | 2000-07-21 | 2002-04-02 | Taiyo Kagaku Co Ltd | 喫煙欲求抑制組成物 |
JP2002322053A (ja) * | 2001-04-24 | 2002-11-08 | Taiyo Kagaku Co Ltd | 精神集中向上用組成物 |
WO2005107734A1 (ja) * | 2004-05-06 | 2005-11-17 | Taiyokagaku Co., Ltd. | アルコール代謝促進組成物、及びこの組成物を含有する飲食物 |
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