JP4707815B2 - Halogen gas-releasing drug packaging bag and packaging halogen gas-releasing drug - Google Patents

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to a packaging bag for packaging a drug having a characteristic that a halogen gas such as chlorine gas is released under a certain condition, and a package for stably sealing and enclosing such a halogen gas-releasing drug and the halogen-releasing drug. The present invention relates to a packaging halogen gas releasing drug comprising a bag.
[0002]
[Prior art]
Patients with severe kidney disease need to continue dialysis on a regular basis for a long time, for example, about 3 times a week. Since the influence on the limbs is too large, an AV shunt is formed at a position that has relatively little influence on daily life, such as the extremities, and a catheter is placed on the blood vessel that has been exposed to the skin by forming the AV shunt. The distal end portion of the circulatory system of the artificial dialysis apparatus is joined to the distal end portion inserted and led out of the body of the catheter to reduce the burden on the artificial dialysis patient. In such a case, the contact portion between the catheter and the skin that is led out is likely to be inflamed or suppurated by various bacteria. In addition, when forming an artificial anus due to colorectal cancer, etc., when a drain is joined to the large intestine and the tip of this drain is led out of the body, the drained part and the contact part of the skin are also in contact with bacteria. Inflammation easily occurs, and inflammation due to various bacteria tends to develop into suppuration in these parts.
[0003]
In the case where the tubular body is led out from the body, not limited to the above-mentioned kidney disease, artificial anus, etc., the prevention of inflammation or suppuration at the joint portion between the skin and the tubular body led out is as described above. It is very important for patients with chronic diseases.
Despite having such a chronic disease, there are many people who are active as well as healthy people and are active in their respective fields. In patients with chronic diseases in which the tubular body is led out of the body, it is important to live a normal life in the same manner as a healthy person in order to perform as well as a healthy person.
[0004]
In patients with such chronic diseases, the contact between the tubular body and the skin that is led out of the body to the outside of the body is regularly disinfected, and this part is covered with gauze that has few germs, so that normal life can be achieved. Is less likely to be a significant burden. However, it is necessary to take a bath even if it has a tube that is led out from the body to the outside of the body, and in this case, the contact portion between the skin and the tube contacts the hot water bath. Bath water is not necessarily clean in terms of bacteriology, and the contact between the skin and the tube may be inflamed after such bathing.
[0005]
Therefore, when a person having a lead-out tube from the body takes a bath, a method is adopted in which a disinfectant is introduced into the hot water in the bathtub to sterilize the hot water in the bathtub and prevent infection.
As such a bactericidal agent, a halogen-releasing agent having such a stability that a gas having a bactericidal property such as chlorine gas is released by being poured into hot water is used.
[0006]
By the way, the volume of such a bathtub is standardized to some extent, and therefore the amount of hot water stored in the bathtub is unlikely to be significantly different. It is also preferable to adjust the concentration of the halide that is allowed to be released from the halogen-releasing agent as described above and exist in the hot water to a certain concentration with a certain width.
Considering this form of use, the patient's bathtub is usually the same by packaging the halogen-releasing drug into small quantities to be used at one time, so a constant halide concentration is always maintained. It becomes possible to form a hot water bath.
[0007]
In general, halogen-free drugs have low light stability, and therefore, a light-impermeable film or the like can be considered as a packaging material used for packaging halogen-free drugs. In order to make the film light-opaque, it is most efficient to use a resin film having a vapor-deposited layer of metal such as aluminum or a resin film having a layer made of metal foil as a packaging material. From such a viewpoint, the present inventor also hermetically wraps a halogen-free drug using a resin film having a layer formed of an aluminum vapor-deposited resin film and a metal foil, and the package containing the halogen-free drug has a very short time. As a result, a part of this packaging bag is ruptured. Therefore, a metal-deposited resin film or a resin film having a layer made of a metal foil is excellent in light-shielding properties, but is used as a sealed bag for halogen-free drugs. I can't do it.
[0008]
OBJECT OF THE INVENTION
An object of the present invention is to provide a sealed bag for safely packaging a halogen gas-releasing drug having a characteristic of slightly releasing halogen gas at room temperature.
Another object of the present invention is to provide a halogen gas-releasing chemical solution that is subdivided into a single use amount and safely sealed and packaged.
[0009]
Summary of the Invention
The packaging bag for halogen gas-releasing drug of the present invention is a packaging bag for containing and sealing a halogen gas-releasing drug, and the packaging bag is formed from a laminate having an unstretched polypropylene layer and a stretched polypropylene layer. The average thickness of the laminate is in the range of 50 to 100 μm, and the ratio of the average thickness of the unstretched polypropylene layer and the stretched polypropylene layer in the laminate is 5: 4 to 2: 1. In the range, an unstretched polypropylene layer is disposed inside the packaging bag, Further, in order to print the necessary items of the packaging halogen gas-releasing agent on the surface of the laminate, a light-shielding inorganic ink containing a white inorganic pigment that forms a printing base layer is coated, thereby printing organic ink. Has been made possible to mitigate and effectively prevent fading from being caused by halogen gas. It is characterized by being.
[0010]
Further, the packaging halogen gas-releasing drug of the present invention is a packaging halogen gas-releasing drug comprising a halogen gas-releasing drug and a packaging bag containing and sealing the halogen gas-releasing drug, the packaging bag being , Formed from a laminate having an unstretched polypropylene layer and a stretched polypropylene layer, the average thickness of the laminate is in the range of 50 to 100 μm, and the unstretched polypropylene layer and the stretched polypropylene layer in the laminate The ratio of the average thickness is in the range of 5: 4 to 2: 1, and an unstretched polypropylene layer is disposed inside the packaging bag.
[0011]
The packaging bag of the present invention is a packaging bag for dividing and safely packaging a halogen gas-releasing agent having a characteristic of liberating halogen gas although it is very little at normal temperature. That is, when the halogen gas-releasing agent as described above is sealed, it is decomposed into a halogen gas, which is very little by little. Such halogen gas increases the internal pressure in the packaging bag, and in the worst case, the halogen gas-releasing agent is removed. The packaging bag to be included may burst. The liberation of halogen gas in such chemicals is promoted by light, heat, etc., particularly by light. Therefore, the amount of the free halogen gas can be reduced by sealing and packaging using a packaging material having a highly light-shielding metal deposition layer. Reduction can be achieved. For example, when a halogen gas-releasing agent is packaged using a plastic film having an aluminum vapor deposition layer, the halogen gas liberation reaction due to light can be effectively suppressed. However, the halogen gas releasing reaction in the halogen gas releasing agent as described above is promoted by light, and the effect of promoting the halogen gas releasing reaction by light can be suppressed by shielding the light, but The liberation itself cannot be stopped. On the contrary, when the metal vapor deposition layer and the halogen gas-releasing agent come into contact with each other, the liberation reaction of the halogen gas from the halogen gas-releasing agent is remarkably accelerated. Accordingly, when the halogen gas-releasing agent is hermetically stored, it is necessary to coat the surface of the metal vapor-deposited layer with a resin film so that the halogen gas-releasing agent is not in direct contact with the metal vapor-deposited layer. However, the film having the metal vapor deposition layer in this way has a very high gas barrier property due to the presence of the metal vapor deposition layer, and the halogen gas is released from the packaging bag formed of the packaging material having the metal vapor deposition layer. When the sex medicine is sealed and stored, the gas in the packaging bag is not released out of the packaging bag. The packaging bag inevitably contains air, and further contains halogen gas generated by decomposition of the halogen gas-releasing drug. And the partial pressure of this halogen gas becomes high with progress of time, and if the internal pressure in a packaging bag exceeds the intensity | strength of a packaging bag, a packaging bag will burst.
[0012]
According to the study by the present inventors, it has been found that a packaging material having a light-shielding metal vapor-deposited layer or a metal foil layer is not suitable for packaging in which a halogen gas-releasing agent is subdivided for the reasons described above.
Furthermore, a halogen gas-releasing agent that has a bactericidal effect when placed in a hot water bath is effective unless it is a compound that has a halogen atom stability (instability) that releases halogen gas little by little over time. Cannot be expected to be effective. Therefore, when the halogen gas-releasing drug is divided and sealed and packaged, it is virtually impossible to avoid the gas pressure in the packaging bag from increasing with time. In this way, in the packaged halogen gas-releasing drug, which is divided and sealed and packaged in this way, when the internal pressure of the packaging bag increases to some extent, the packaging bag is reduced so that the pressure is reduced. It has been found that it is necessary to form a packaging bag using a packaging material capable of releasing the gas inside.
[0013]
From the relationship between the stability of the halogen gas-releasing drug to be packaged, the internal pressure in the packaging bag caused by the halogen gas generated from the halogen gas-releasing drug, and the gas permeability of the packaging material, When a packaging bag formed using a polypropylene-laminated packaging material reaches a certain pressure due to the halogen gas generated from the halogen gas-releasing drug, the inside of the packaging bag It was found that gas can be released efficiently to prevent the packaging bag from bursting.
[0014]
DETAILED DESCRIPTION OF THE INVENTION
Next, the packaging bag for halogen gas-releasing drug and the packaging halogen gas-releasing drug of the present invention will be specifically described with reference to the drawings.
FIG. 1 is a cross-sectional view schematically showing an example of a cross section of a laminate forming the packaging bag of the present invention. FIG. 2 is a perspective view schematically showing an example of the packaging bag of the present invention. 3 is a cross-sectional view taken along the line AA of the packaging bag shown in FIG. FIG. 4 is a partially cutaway perspective view schematically showing an example of the packaged halogen gas releasing drug of the present invention. 1-4, the common number is attached | subjected to the common member.
[0015]
FIG. 1 shows a cross-sectional view of a packaging material (laminate) 10 that forms a packaging bag of a halogen gas-releasing drug of the present invention.
As shown in FIG. 1, the packaging material 10 used in the present invention is a laminate having an unstretched polypropylene layer 12 and a stretched polypropylene layer 14. The thickness of the laminate 10 is usually in the range of 50 to 100 μm, preferably 60 to 80 μm. The package of the present invention contains a halogen gas-releasing agent inside, and the halogen gas-releasing agent is gradually decomposed to generate halogen gas even at room temperature, so that the internal pressure in the packaging bag is increased and packaging is performed by this internal pressure. In order to prevent the bag from rupturing, it is preferable to use a laminate having the thickness as described above, and when a laminate having a thickness exceeding the above range is used, the cost increases and the packaging bag is used. It becomes difficult to tear open. Moreover, this laminated body 10 is normally laminated | stacked without interposing layers, such as an adhesive bond layer, between the unstretched polypropylene layer 12 and the stretched polypropylene layer 14. FIG. In the present invention, the laminated body 10 is used to form a packaging bag with the unstretched polypropylene layer 12 on the inside, but when forming this packaging bag, it is formed into a bag shape by thermocompression bonding at the edge, The surface 15 of the unstretched polypropylene layer 12 is preferably surface-treated so as to be heat-sealable.
[0016]
The unstretched polypropylene layer 12 forming this laminate 10 is a polymer having a repeating unit derived from propylene usually of 80 mol% or more, preferably 90 mol% or more, and may be a propylene homopolymer. However, it may be a copolymer having repeating units derived from ethylene and / or repeating units derived from other α-olefins in an amount of usually 20 mol% or less, preferably 10 mol% or less. .
[0017]
Like the unstretched polypropylene layer 12, the stretched propylene 14 which is the other polypropylene layer forming the laminate 10 is usually 80 mol% or more, preferably 90 mol% or more of repeating units derived from propylene. A propylene homopolymer, usually in an amount of not more than 20 mol%, preferably not more than 10 mol%, from repeating units derived from ethylene and / or other α-olefins. It may be a copolymer having derived repeating units. The polypropylene forming the stretched polypropylene layer is obtained by stretching the above-described polypropylene. Polypropylene stretching includes uniaxial stretching and biaxial stretching. In the present invention, either a uniaxially stretched film or a biaxially stretched film can be used. However, it is preferable to use a uniaxially stretched film in consideration of tear openability of the formed packaging bag. As this stretched film, a stretched film having a stretch ratio in the range of 110 to 500%, preferably 110 to 300%, particularly preferably 120 to 250%, with a stretch ratio representing the length of the original fabric as 100%. Can be preferably used.
[0018]
The laminate 10 can be formed by pressing the unstretched film 12 and the stretched film 14 under heating as described above.
In the present invention, it is necessary that the ratio of the average thickness of the unstretched polypropylene layer 12 and the stretched polypropylene layer 14 in the formed laminate is in the range of 5: 4 to 2: 1. By making the ratio of the average thickness in the range of 10: 7 to 8: 5, an effect particularly excellent in reducing the internal pressure in the packaging bag is shown.
[0019]
As shown in FIGS. 2 and 3, the packaging bag 20 of the halogen gas-releasing drug of the present invention is formed by stacking the above laminate 10, preferably, the laminate 10 with the unstretched polypropylene layer 12 inside, It can be formed into a bag shape by folding and heat-sealing the two edge portions 22 and 24. When two laminated bodies 10 are overlapped, the three sides are heat-sealed. In addition, one edge part 25a in the packaging bag 20 formed in this way forms the open part 25 without heat-sealing in order to fill the halogen gas-releasing drug.
[0020]
As described above, the two edge portions 22 and 24 are usually heat-sealed heat seal bars heated to a temperature of 190 to 250 ° C., preferably 185 to 220 ° C. It can heat-seal by contact | abutting to 24 normally for 0.1 to 5 second, Preferably 0.5 to 1 second and thermocompression-bonding. In addition, the width | variety of the heat seal part at this time is 2-8 mm normally, Preferably it is 3-6 mm. By setting the heat seal width in the above range, even if the internal pressure in the packaging bag increases, the heat seal portion does not peel and the internal gas does not leak.
[0021]
Moreover, it is preferable that the notch 26 is formed in the edge part 22 heat-sealed of the package body 20 in the longitudinal direction. The notch 26 is preferably formed so as to cut the packaging bag along the stretching direction of the stretched polypropylene film 14 forming the packaging bag 20. Therefore, the forming direction of the notch 26 is usually substantially the same direction as the stretching direction of the stretched polypropylene film.
[0022]
The packaging bag 20 formed from the laminate 10 with the unstretched polypropylene layer 12 thus formed on the inside and the stretched propylene layer 14 on the outside has a gas barrier property that can prevent free circulation of air, It does not have such a good gas barrier property, and when a pressure is applied to the gas in the packaging bag, the gas in the inside passes through the laminate 10 and is released until a predetermined internal pressure is reached. .
[0023]
The packaging halogen gas-releasing drug 30 of the present invention is formed by filling the packaging bag as described above with the halogen gas-releasing drug 40 and sealing it.
Here, the halogen gas releasing agent may be liquid or solid, and examples of such halogen gas releasing agent include sodium dichloroisocyanurate, sodium trichloroisocyanurate, potassium dichloroisocyanurate and the following. Examples include compounds (solid compounds) such as sodium chlorite. The halogen gas-releasing agents can be used alone or in combination.
[0024]
In particular, when the packaged halogen gas-releasing drug of the present invention is used for sterilization of a hot water bath when taking a tube out of the body from the body, sodium dichloroisocyanurate, sodium trichloroisocyanurate, etc. It is preferable to use a solid compound. In particular, in the present invention, it is preferable to use a compound having a characteristic of liberating chlorine gas as the halogen gas, and sodium dichloroisocyanurate is particularly preferable because of its stability. Such a halogen gas-releasing agent 40 may be liquid or solid, but when the halogen gas-releasing agent 40 is solid, the halogen gas-releasing agent 40 is a powder. It may be in the form of granules, or it may be shaped into a desired shape like a tablet. That is, it is preferable that the halogen gas-releasing drug 40 has a form suitable for normally dissolving in a hot water when it is dissolved and releasing a sterilizing halogen gas into the hot water. For example, by making granules having an average particle diameter of 0.01 to 3 mm, preferably 0.05 to 2 mm, the halogen gas-releasing drug is dispersed in hot water very quickly. Further, in order to keep the halogen gas released by a certain amount for a certain time, it may be shaped into a tablet. In this way, the halogen gas-releasing drug shaped into a tablet shape can have its disintegration time, that is, the time for supplying the halogen gas, by selecting the size of the tablet and the excipient for shaping into the tablet. It is possible to adjust.
[0025]
The volume of the bathtub used in a general household is about 100 to 300 liters. When the packaged halogen gas-releasing agent of the present invention is dissolved in hot water in such a bath, the concentration of halide contained in the hot water in this water tank is usually 0.1 to 100 ppm, preferably 0.8. It is preferable that the packaging is divided into one packaging bag so as to fall within the range of 5 to 5 ppm. The amount stored in one packaging bag of halogen gas-releasing drug calculated from the capacity of an average bathtub for household use is usually, for example, when the halogen gas-releasing drug solution is sodium dichloroisocyanurate. Is about 100 to 1000 mg, preferably about 500 mg ± 100 mg. Therefore, the packaging of the present invention is not carried out by weighing every use, but by subdividing a predetermined amount of halogen gas-releasing drug that is light in advance according to the volume of the bathtub and enclosing it in a packaging bag. The packaging bag of the halogen gas-releasing drug can be opened from the notch portion, and the entire amount can be poured into hot water in the bath and dissolved.
[0026]
FIG. 4 is a perspective view in which a packaging bag of the packaging halogen gas-releasing drug 30 of the present invention is partially cut away. The packaging halogen gas-releasing drug 30 is filled in the packaging bag 20 with an amount of halogen gas-releasing drug calculated in advance from the halogen gas concentration in the hot water from the opening 25 of the packaging bag 20 as shown in FIG. The opening 25 of the packaging bag 20 is heat-sealed to seal the halogen gas-releasing drug in the packaging bag 20. At this stage, most of the gas in the packaging bag 20 is air. The packaged halogen gas-releasing drug sealed with the halogen-gas-releasing drug put in the packaging bag 20 in this way is decomposed over time even though the halogen-gas-releasing drug 40 is little, so that the halogen gas in the sealed packaging bag is decomposed. The amount increases and gradually expands. When the pressure inside the packaging bag is increased by the halogen gas separated due to the halogen gas-releasing agent, the molecular diameter is small, but the one that permeates the laminate forming the packaging bag and is released to the outside of the packaging bag It is estimated to be. Normally, it is considered that nitrogen and oxygen, which are air forming gases in the packaging bag, are permeated and released. Accordingly, when the packaging bag is inflated, there is almost no halogen gas release and generally no halogen gas odor. Then, it is presumed that the halogen gas is gradually discharged when the nitrogen and oxygen, which are air forming components, are completely released.
[0027]
The package halogen gas-releasing agent 30 is generally printed on the outer surface thereof with necessary information such as the name, application, capacity, and usage of the packaging halogen-gas-releasing agent. Because it is a transparent film with a slight white tinge, it is preferable that printing to identify the product is inconspicuous, and halogen gas-releasing agents are preferably not exposed to direct sunlight as much as possible. It is preferable to form the printing base layer 32 by applying a compatible ink. When the printing underlayer 32 contains an organic dye or an organic pigment, it is discolored by the halogen gas that has passed through the laminate, particularly chlorine gas, so that it is not affected by the permeating gas. It is preferably formed using an ink containing a white inorganic pigment such as titanium. In the conventional laminated film, printing was performed between the laminated films to improve the scratch resistance of the ink, but in the packaging bag of the present invention, a coating film is formed on the outer surface of the packaging bag formed from the laminated body. As a result, the color fading action of the ink caused by chlorine gas or the like can be reduced. When printing is performed using an ink containing an organic pigment or a dye after applying such a white pigment, it is possible to effectively prevent the matter printed with the colored ink on the surface from being faded by the halogen gas.
[0028]
In addition, although the packaging bag of this invention may be formed in this packaging bag front surface of the printing lower layer 32 by an inorganic white inorganic pigment as mentioned above, the part which does not form the printing foundation layer 23 in a part of packaging bag 34 is preferably provided. Even if the discharge of the gas such as the halogen gas by the printing foundation layer 32 is obstructed by forming the portion 34 that does not form the printing foundation layer, the portion 34 that does not have the printing foundation layer 32 is used. The gas in the packaging bag can be released without any trouble. Moreover, since the transparency for packaging materials is lost in the portion where the printing foundation layer 32 is formed, the state in the packaging bag cannot be observed from this portion, but the printing foundation layer 32 is not formed as described above. By making the portion 34, the state inside the packaging bag can be observed from the portion 34 that does not form the printing base layer.
[0029]
As described above, the packaged halogen gas-releasing drug of the present invention has a halogen gas-releasing drug in an amount to be used at one time and is sealed in a predetermined packaging bag, and needs to be calibrated and used every time it is used. Not very convenient. In addition, the packaging bag used in the present invention uses a laminate made of unstretched polypropylene and stretched propylene, which has not so good gas barrier properties, so that the halogen gas-releasing drug decomposes over time. When the internal pressure in the packaging bag increases, it is assumed that, for example, the gas passes through the wall surface of the laminate according to the molecular diameter of the gas inside and is released to the outside. No rupture.
[0030]
In addition, it uses a polypropylene-stretched film and an unstretched film, and does not use any special materials, and it is possible to adopt a conventional packaging bag method that uses packaging materials. It is possible to use a packaging bag for storing a halogen gas-releasing drug and a packaging halogen gas-releasing drug at a very low cost.
[0031]
The packaging bag for halogen gas-releasing drug and the packaging halogen-gas-releasing drug of the present invention have the above-described configuration, but the present invention can be further modified.
That is, in the present invention, in the laminate forming the package, the unstretched polypropylene layer forming the inner layer is relatively softer than the stretched polypropylene layer, and the gas barrier property is lower than that of the unstretched polypropylene layer. Indicates. On the other hand, the stretched polypropylene forming the outer layer is relatively harder than the unstretched polypropylene layer and has better gas barrier properties than the unstretched polypropylene layer. Moreover, both are the same (co) polymers.
[0032]
It is considered that the packaging bag and the packaging halogen gas-releasing drug of the present invention can be purified by using a laminate in which resin films having such characteristics are combined.
For example,
A combination of stretched polyethylene film and unstretched polyethylene film,
Combination of stretched polyester film and unstretched polyester film,
A combination of stretched polyamide film and unstretched polyamide film,
Combination of stretched polyacrylamide film and unstretched polyacrylamide film,
A combination of stretched polyvinyl chloride film and unstretched polyvinyl chloride film,
A combination of stretched polyether film and unstretched polyether film,
A combination of a stretched polyacrylonitrile film and an unstretched polyacrylonitrile film,
A combination of stretched hydrocarbon polymer film and unstretched hydrocarbon polymer film,
A combination of stretched polystyrene film and unstretched polystyrene film,
Combination of stretched polysulfone film and unstretched hydrocarbon polysulfone film,
Examples thereof include a combination of a stretched poly (ethylene / vinyl acetate) copolymer (EVA) film and an unstretched poly (ethylene / vinyl acetate) copolymer (EVA) film.
[0033]
That is, when a packaging bag sealed at 25 ° C. is stored under 40 ° C., the halogen gas permeability is 0.01 to 0.1 μg / cm inside the packaging bag. ² An inner layer made of a resin film having relatively good gas permeability and flexibility within the range of day is disposed, and halogen gas permeability is 0.001 to 0.01 μg / cm on the outside. ² ・ Packaging bags are formed by halogen gas generated from halogen gas-releasing chemicals by forming a packaging bag using a laminate in which a relatively hard resin film having a relatively high gas permeability in the range of day is arranged. When the internal pressure becomes a certain value or more, a packaging bag having such a characteristic that the internal gas is discharged to the outside little by little can be formed. And the average thickness of the laminated body at that time is usually in the range of 10 to 300 μm, preferably 50 to 100 μm, as in the case of the laminated body using the above-mentioned polypropylene, and the outer thickness in this laminated body. The ratio of the average thickness of the layer to the inner layer is usually in the range of 10: 9 to 3: 1, preferably in the range of 5: 4 to 2: 1.
[0034]
When a packaging bag having the above-described configuration is filled with a halogen gas-releasing agent and sealed, generally between the pressure in the packaging bag and atmospheric pressure within a few days after filling and sealing, depending on the type of filling. A clear difference occurs and the pressure inside the packaging bag is higher than atmospheric pressure. When the pressure in the packaging bag becomes higher than the atmospheric pressure in this way, the gas in the packaging bag (nitrogen gas constituting the air, oxygen, halogen gas generated by decomposition of halogen-free chemicals, etc.) It is estimated that a small amount from the wall surface of the packaging bag begins to be released into the atmosphere depending on the molecular diameter. In the packaging bag of the present invention, the amount of gas released increases as the internal pressure increases, and the pressure in the packaging bag does not become so high as to rupture the packaging bag. Therefore, by using the packaging bag of the present invention, even if the halogen gas-releasing drug is sealed in this packaging bag, the packaging bag does not rupture due to an increase in internal pressure caused by the liberated halogen gas. In addition, this packaging bag is formed from a laminate of resin films as described above, and this laminate has water resistance, and the pressure in the packaging bag is always higher than atmospheric pressure. Air containing moisture in the atmosphere does not enter the packaging bag from the wall surface of the packaging bag. Therefore, even if the halogen gas-releasing drug filled in the packaging bag of the present invention is a substance having, for example, deliquescence, moisture outside the packaging bag is removed from the wall surface of the packaging bag of the present invention. Since it cannot enter, it can be effectively prevented that the deliquescent medicine in the packaging bag absorbs moisture and impairs the original form such as powder or granules.
[0035]
The packaging bag of the present invention is a medicine for disinfecting hot water at the time of bathing a person who has led out a tubular body (tubular object) from the body, such as an artificial dialysis patient or a person having an artificial anus, a pool, etc. It can be suitably used for hermetically preserving a drug having a characteristic of releasing halogen gas little by little over time, such as a drug used for disinfecting a liquid. Similarly, it can also be used as a packaging bag for hermetically storing a drug having the property of releasing a gas other than halogen gas, such as active oxygen, little by little over time, such as a denture cleaning agent. it can.
[0036]
【The invention's effect】
The packaging bag of the halogen gas-releasing drug of the present invention has an unstretched polypropylene layer and a stretched polypropylene layer, an average thickness of 50 to 100 μm, and an average thickness ratio of each layer of 5: 4 to 2: 1. It is formed from a laminate, and an unstretched polypropylene layer is disposed inside the packaging bag. The packaging bag of the present invention having such a configuration does not have so good gas barrier properties. On the other hand, the halogen-gas-releasing agent that is filled and sealed in this packaging bag has the property of releasing halogen gas at room temperature, but it is hermetically sealed in a packaging bag with good gas barrier properties. Then, the internal gas pressure in the packaging bag gradually increases over time, and this packaging bag bursts. However, when the internal gas pressure exceeds a certain level, the packaging bag of the present invention has a gas permeability such as a molecular diameter. Accordingly, the gas in the packaging bag is released from the wall surface of the packaging bag, and the internal pressure in the packaging bag does not exceed a certain pressure. Accordingly, even if the packaging bag of the present invention is filled with a halogen gas-releasing agent and sealed, the packaging bag will not rupture due to an increase in gas pressure in the packaging bag caused by the released halogen gas. Also, if the packaging bag is filled with a halogen gas-releasing agent and sealed, the pressure inside the packaging bag is higher than atmospheric pressure due to the liberated halogen gas, and the laminate constituting the packaging bag is hydrophobic. Have Further, since the internal pressure becomes high, there is little possibility that moisture in the atmosphere enters the packaging bag.
[0037]
Therefore, by using the packaging bag of the present invention, the halogen gas-releasing drug can be divided into small portions and can be safely sealed and stored little by little.
The packaging halogen gas-releasing drug of the present invention is sealed by filling the packaging bag as described above with the amount of halogen gas-releasing drug to be used at one time. It can be stored safely without being ruptured due to an increase in internal pressure caused by halogen gas, and the halogen gas-releasing agent is subdivided by the amount used at one time in consideration of its use. Is very easy to use. Moreover, since the packaging bag used here uses the stretched film, the tear opening from a notch can be performed easily.
[0038]
In addition, since the amount of the medicine to be used at a time is stably sealed in the packaging bag, it is very easy to carry this medicine. It is very useful for people who use drugs regularly.
[Brief description of the drawings]
FIG. 1 is a cross-sectional view schematically showing an example of a cross section of a laminate forming a packaging bag of the present invention.
FIG. 2 is a perspective view schematically showing an example of the packaging bag of the present invention.
FIG. 3 is a cross-sectional view taken along line AA of the packaging bag shown in FIG.
FIG. 4 is a partially cutaway perspective view schematically showing an example of the packaged halogen gas releasing drug of the present invention.
[Explanation of symbols]
10 ... Packaging material (laminate)
12 ... Unstretched polypropylene layer
14 ... Stretched polypropylene layer
15 ... surface of unstretched polypropylene layer
20 ... Packing bag
22 ... Edge
24 ... Edge
25a ... one edge
25 ... Open part
26 ... Notch
30 ... Packaging halogen gas-releasing drug
32 ... Printing base layer
34 .. the portion where the printing base layer is not formed
40 ... Halogen gas-releasing drug

Claims (7)

A packaging bag for containing and sealing a halogen gas-releasing agent, wherein the packaging bag is formed of a laminate having an unstretched polypropylene layer and a stretched polypropylene layer, and the average thickness of the laminate is 50. The ratio of the average thickness of the unstretched polypropylene layer and the stretched polypropylene layer in the laminate is in the range of 5: 4 to 2: 1 and is unstretched inside the packaging bag. A polypropylene layer is disposed, and further, a light-shielding inorganic ink containing a white inorganic pigment for forming a printing base layer is applied to print the necessary items of the packaging halogen gas-releasing agent on the surface of the laminate. A packaging bag for halogen gas-releasing drug, characterized in that the organic ink for printing can be mitigated and effectively prevented from being faded by halogen gas.   2. The packaging bag for halogen gas-releasing drug according to claim 1, wherein a notch is formed along an extending direction of the stretched polypropylene at an edge of the packaging bag for the halogen gas-releasing drug.   The packaging bag of the halogen gas-releasing drug is formed into a bag shape by heat-sealing the peripheral portion of the laminate in which the laminate of the unstretched polypropylene layer and the stretched polypropylene layer is overlapped so that the unstretched polypropylene is located inside. The packaging bag for halogen gas-releasing drug according to claim 1, wherein   2. The packaging bag for halogen gas-releasing drug according to claim 1, wherein a light-shielding paint is applied to the surface of the packaging bag for the halogen gas-releasing drug. A packaged halogen gas-releasing agent comprising a halogen-gas-releasing agent and a packaging bag for containing and sealing the halogen-gas-releasing agent, wherein the packaging bag has an unstretched polypropylene layer and a stretched polypropylene layer The average thickness of the laminate is in the range of 50 to 100 μm, and the ratio of the average thickness of the unstretched polypropylene layer and the stretched polypropylene layer in the laminate is 5: 4 to 2 : 1; unstretched polypropylene layer on the inner side of the packaging bag is disposed, further, to print the necessary information packaging halogen gas free drug on the surface of the laminate, the printing underlayer By coating the light-shielding inorganic ink containing the white inorganic pigment to be formed, it is possible to mitigate and effectively prevent the printing organic ink from being faded by the halogen gas. Packaging halogen gas free drug, characterized by being Uninasa.   6. The halogen gas-releasing agent is at least one compound selected from the group consisting of sodium dichloroisocyanurate, sodium trichloroisocyanurate, potassium dichloroisocyanurate and sodium hypochlorite. The packaged halogen gas-releasing agent according to Item. When the halogen gas-releasing drug is dissolved in a predetermined volume of water in a water tank, the halide concentration contained in the water in the water tank is such that the halide concentration is in the range of 0.5 to 1000 ppm. 6. The packaged halogen gas-releasing drug according to claim 5, which is independently sealed and packaged.

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