JP4683727B2 - 線維芽細胞様またはマクロファージ様細胞の形質導入のための手段と方法 - Google Patents
線維芽細胞様またはマクロファージ様細胞の形質導入のための手段と方法 Download PDFInfo
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- JP4683727B2 JP4683727B2 JP2000602796A JP2000602796A JP4683727B2 JP 4683727 B2 JP4683727 B2 JP 4683727B2 JP 2000602796 A JP2000602796 A JP 2000602796A JP 2000602796 A JP2000602796 A JP 2000602796A JP 4683727 B2 JP4683727 B2 JP 4683727B2
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
- C12N9/1211—Thymidine kinase (2.7.1.21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10351—Methods of production or purification of viral material
- C12N2710/10352—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99200624.7 | 1999-03-04 | ||
EP99200624 | 1999-03-04 | ||
PCT/NL2000/000133 WO2000052186A1 (en) | 1999-03-04 | 2000-03-03 | Means and methods for fibroblast-like or macrophage-like cell transduction |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2002537816A JP2002537816A (ja) | 2002-11-12 |
JP2002537816A5 JP2002537816A5 (de) | 2011-02-24 |
JP4683727B2 true JP4683727B2 (ja) | 2011-05-18 |
Family
ID=8239945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000602796A Expired - Fee Related JP4683727B2 (ja) | 1999-03-04 | 2000-03-03 | 線維芽細胞様またはマクロファージ様細胞の形質導入のための手段と方法 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1159438B1 (de) |
JP (1) | JP4683727B2 (de) |
AT (1) | ATE403006T1 (de) |
AU (1) | AU776067B2 (de) |
CA (1) | CA2364499C (de) |
DE (1) | DE60039683D1 (de) |
WO (1) | WO2000052186A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
US6869936B1 (en) | 1999-03-04 | 2005-03-22 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
AU777041B2 (en) * | 1999-05-17 | 2004-09-30 | Crucell Holland B.V. | Adenovirus derived gene delivery vehicles comprising at least one element of adenovirus type 35 |
US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
EP1067188A1 (de) * | 1999-07-08 | 2001-01-10 | Introgene B.V. | Infektion mit chimärischen Adenoviren der Zellen die für den Adenoviren Serotyp 5 Coxsacki Adenoviren Rezeptor (CAR) negativ sind |
AU9434801A (en) * | 2000-08-10 | 2002-02-18 | Crucell Holland Bv | Gene delivery vectors with cell type specificity for primary human chondrocytes |
WO2002024730A2 (en) * | 2000-09-20 | 2002-03-28 | Crucell Holland B.V. | Transduction of dendritic cells using adenoviral vectors |
EP1195440A1 (de) * | 2000-10-06 | 2002-04-10 | Introgene B.V. | Genverabreichung-Vektoren für Stammzellen |
WO2002029073A2 (en) * | 2000-10-06 | 2002-04-11 | Crucell Holland B.V. | Gene delivery vectors for stem cells |
US6905678B2 (en) * | 2001-07-07 | 2005-06-14 | Crucell Holland B.V. | Gene delivery vectors with cell type specificity for mesenchymal stem cells |
EP1279738A1 (de) * | 2001-07-06 | 2003-01-29 | Crucell Holland B.V. | Für mesenchymale Stammzellen spezifische Gen-Transfer-Vektoren |
ATE405663T1 (de) | 2002-04-25 | 2008-09-15 | Crucell Holland Bv | Stabile adenovirale vektoren und methoden für deren vermehrung |
US20080153083A1 (en) | 2003-10-23 | 2008-06-26 | Crucell Holland B.V. | Settings for recombinant adenoviral-based vaccines |
EP1553983A2 (de) | 2002-10-23 | 2005-07-20 | Crucell Holland B.V. | Einstellung für rekombinante adenovirus-basierte impfstoffe |
WO2004055187A1 (en) | 2002-12-17 | 2004-07-01 | Crucell Holland B.V. | Recombinant viral-based malaria vaccines |
WO2014153204A1 (en) | 2013-03-14 | 2014-09-25 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
EP3359175B1 (de) | 2015-10-05 | 2020-09-16 | Salk Institute for Biological Studies | Synthetische adenoviren mit tropismus gegen geschädigtes gewebe zur förderung der wundheilung und geweberegeneration |
JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
KR20180112024A (ko) | 2016-02-23 | 2018-10-11 | 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
CN110062630A (zh) | 2016-12-12 | 2019-07-26 | 萨克生物研究学院 | 肿瘤靶向合成腺病毒及其用途 |
WO2018125970A1 (en) * | 2016-12-30 | 2018-07-05 | Salk Institute For Biological Studies | Synthetic adenoviruses targeting bone tissue and uses thereof |
WO2018218240A1 (en) | 2017-05-26 | 2018-11-29 | Epicentrx, Inc. | Recombinant adenoviruses carrying transgenes |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997000326A1 (en) * | 1995-06-15 | 1997-01-03 | Introgene B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
JPH11500315A (ja) * | 1995-02-21 | 1999-01-12 | ジェンベク、インコーポレイティッド | キメラアデノウイルスファイバータンパク質およびその使用方法 |
JP2000157289A (ja) * | 1998-11-20 | 2000-06-13 | Introgene Bv | 平滑筋細胞および/または内皮細胞への組織向性を与えられた遺伝子送達ベクタ― |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2723697B1 (fr) * | 1994-08-17 | 1996-09-20 | Rhone Poulenc Rorer Sa | Methode de traitement de la restenose par la therapie genique |
ATE382694T1 (de) * | 1995-11-28 | 2008-01-15 | Genvec Inc | Vektoren und methoden zum gentransfer in zellen |
US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
EP1020529B1 (de) * | 1998-11-20 | 2005-06-01 | Crucell Holland B.V. | Genverabreichende Vektoren mit Gewebetropismus für glatte Muskelzellen und/oder Endothelzellen |
-
2000
- 2000-03-03 EP EP00908116A patent/EP1159438B1/de not_active Expired - Lifetime
- 2000-03-03 CA CA002364499A patent/CA2364499C/en not_active Expired - Fee Related
- 2000-03-03 JP JP2000602796A patent/JP4683727B2/ja not_active Expired - Fee Related
- 2000-03-03 DE DE60039683T patent/DE60039683D1/de not_active Expired - Lifetime
- 2000-03-03 WO PCT/NL2000/000133 patent/WO2000052186A1/en active Search and Examination
- 2000-03-03 AT AT00908116T patent/ATE403006T1/de not_active IP Right Cessation
- 2000-03-03 AU AU29488/00A patent/AU776067B2/en not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11500315A (ja) * | 1995-02-21 | 1999-01-12 | ジェンベク、インコーポレイティッド | キメラアデノウイルスファイバータンパク質およびその使用方法 |
WO1997000326A1 (en) * | 1995-06-15 | 1997-01-03 | Introgene B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
JP2000157289A (ja) * | 1998-11-20 | 2000-06-13 | Introgene Bv | 平滑筋細胞および/または内皮細胞への組織向性を与えられた遺伝子送達ベクタ― |
Also Published As
Publication number | Publication date |
---|---|
CA2364499C (en) | 2008-12-23 |
CA2364499A1 (en) | 2000-09-08 |
DE60039683D1 (de) | 2008-09-11 |
EP1159438B1 (de) | 2008-07-30 |
JP2002537816A (ja) | 2002-11-12 |
EP1159438A1 (de) | 2001-12-05 |
AU2948800A (en) | 2000-09-21 |
ATE403006T1 (de) | 2008-08-15 |
WO2000052186A1 (en) | 2000-09-08 |
AU776067B2 (en) | 2004-08-26 |
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US7968087B2 (en) | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells | |
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