JP4632676B2 - Spatial disinfection composition and spatial disinfection method - Google Patents

Spatial disinfection composition and spatial disinfection method Download PDF

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JP4632676B2
JP4632676B2 JP2004045791A JP2004045791A JP4632676B2 JP 4632676 B2 JP4632676 B2 JP 4632676B2 JP 2004045791 A JP2004045791 A JP 2004045791A JP 2004045791 A JP2004045791 A JP 2004045791A JP 4632676 B2 JP4632676 B2 JP 4632676B2
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靖之 長谷川
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Kobayashi Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/14—Disinfection, sterilisation or deodorisation of air using sprayed or atomised substances including air-liquid contact processes

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  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)

Description

本発明は、簡便に使用でき、浮遊菌に対して優れた殺菌作用を発揮する空間殺菌用組成物に関する。また、本発明は、空間殺菌方法に関する。   The present invention relates to a composition for space sterilization that can be used conveniently and exhibits an excellent bactericidal action against airborne bacteria. The present invention also relates to a space sterilization method.

産業活動や日常生活を営む空間の衛生状態は、人間の健康に影響を及ぼすため、常に良好であることが求められる。特に、トイレ、玄関、台所、居室等の居住空間や、病院、飲食店、製薬工場、食品加工工場等の施設内の空間、或いは車、航空機、電車等の車両内の空間では、高い衛生状態を保持することが望まれている。   The hygienic condition of the space that conducts industrial activities and daily life has an impact on human health and is therefore required to be always good. High hygiene especially in living spaces such as toilets, entrances, kitchens, living rooms, spaces in hospitals, restaurants, pharmaceutical factories, food processing factories, etc., or spaces in vehicles such as cars, airplanes, and trains It is desirable to keep

近年、空間内の衛生状態を良好に保つ手段として、各種の殺菌成分で空間内を殺菌する方法が提案されている。例えば、特定湿度条件下で空間内にオゾンガスを空間内に流入させる方法（特許文献１参照）や、次亜塩素酸を含む薬液を空間内に噴霧する方法（特許文献２参照）等が報告されている。しかしながら、前者の方法では、オゾンガスを空間内に流入させるための専用装置が必要であり、空間内の殺菌を簡便に行うことができないという欠点がある。また、後者の方法では、浮遊菌に対する殺菌効果が不十分であるという問題点がある。   In recent years, methods for sterilizing the interior of the space with various sterilizing components have been proposed as means for maintaining good sanitary conditions in the space. For example, a method of flowing ozone gas into the space under a specific humidity condition (see Patent Document 1), a method of spraying a chemical solution containing hypochlorous acid into the space (see Patent Document 2), and the like have been reported. ing. However, the former method requires a dedicated device for allowing ozone gas to flow into the space, and has a drawback that sterilization in the space cannot be easily performed. Further, the latter method has a problem that the bactericidal effect against airborne bacteria is insufficient.

このような従来技術を背景として、簡便な方法で使用でき、しかも浮遊菌に対して優れた殺菌作用を発揮する空間殺菌剤の開発が望まれていた。   Against the background of such a conventional technique, it has been desired to develop a space disinfectant that can be used in a simple manner and that exhibits an excellent disinfecting action against airborne bacteria.

ところで、従来、塩化ベンザルコニウム、塩化ベンゼトニウム並びにエタノールには、殺菌作用があることが知られており、殺菌成分として各種の製品に配合して使用されている。しかしながら、これらの成分の殺菌作用を増強させる方法、特に空間浮遊菌に対する殺菌作用を増強させる方法については、これまで報告されていない。
特開平５−１４８１１４号公報 特開平１１−１６９４４１号公報 By the way, conventionally, benzalkonium chloride, benzethonium chloride and ethanol are known to have a bactericidal action and are used in various products as a bactericidal component. However, a method for enhancing the bactericidal action of these components, particularly a method for enhancing the bactericidal action against space-borne bacteria has not been reported so far.
JP-A-5-148114 JP-A-11-169441

本発明の目的は、上記従来技術の課題を解決することである。詳細には、本発明は簡便に使用でき、浮遊菌に対して優れた殺菌作用を発揮する空間殺菌用組成物を提供することを目的とする。また、本発明は、当該空間殺菌用組成物を用いて空間を殺菌する方法を提供することを目的とする。   The object of the present invention is to solve the above-mentioned problems of the prior art. Specifically, an object of the present invention is to provide a composition for space sterilization that can be used easily and exhibits an excellent sterilizing action against airborne bacteria. Moreover, an object of this invention is to provide the method of disinfecting space using the said composition for space disinfection.

本発明者等は、上記課題を解決すべく鋭意検討したところ、塩化ベンザルコニウム及び／又は塩化ベンゼトニウムと共に、エタノール、水及びジメチルエーテルを含有する組成物は、殺菌作用が相乗的に増強されており、特に空間内の浮遊菌に対して優れた殺菌作用を発揮することを見出した。本発明は、かかる知見に基づいて、更に検討を重ねることによって完成したものである。   As a result of intensive studies to solve the above-mentioned problems, the present inventors have synergistically enhanced the bactericidal action of a composition containing ethanol, water and dimethyl ether together with benzalkonium chloride and / or benzethonium chloride. In particular, it has been found that it exhibits excellent bactericidal action against airborne bacteria in the space. The present invention has been completed by further studies based on this finding.

即ち、本発明は、下記に掲げる空間殺菌用組成物である：
項１． （Ａ）塩化ベンザルコニウム及び塩化ベンゼトニウムよりなる群から選択される少なくとも１種、（Ｂ）エタノール、（Ｃ）水、及び（Ｄ）ジメチルエーテルを含有する空間殺菌用組成物。
項２． （Ａ）成分０．０１〜０．８重量％、（Ｂ）成分８〜６４重量％、（Ｃ）成分３．２〜４７．９９重量％、及び（Ｄ）成分２０〜８０重量％の割合で含有する、項１に記載の空間殺菌用組成物。
項３． （Ａ）成分０．０５〜０．８重量％、（Ｂ）成分１５〜６０重量％、（Ｃ）成分５〜４０重量％、及び（Ｄ）成分２５〜７０重量％の割合で含有する、項１又は２に記載の空間殺菌用組成物。
項４． （Ａ）成分０．１〜０．８重量％、（Ｂ）成分２０〜５０重量％、（Ｃ）成分１０〜３０重量％、及び（Ｄ）成分３０〜６０重量％の割合で含有する、項１乃至３のいずれかに記載の空間殺菌用組成物。 That is, the present invention is the composition for space sterilization listed below:
Item 1. (A) A composition for space sterilization containing at least one selected from the group consisting of benzalkonium chloride and benzethonium chloride, (B) ethanol, (C) water, and (D) dimethyl ether.
Item 2. (A) 0.01-0.8 wt% of component, (B) 8-8 wt% of component, (C) 3.2-47.9 wt% of component, and (D) 20-20 wt% of component Item 2. The composition for space sterilization according to Item 1, which is contained in Item 1.
Item 3. (A) 0.05 to 0.8% by weight of component, (B) 15 to 60% by weight of component, (C) 5 to 40% by weight of component, and (D) 25 to 70% by weight of component, Item 3. A composition for space sterilization according to item 1 or 2.
Item 4. (A) 0.1 to 0.8% by weight of component, (B) 20 to 50% by weight of component, (C) 10 to 30% by weight of component, and (D) 30 to 60% by weight of component, Item 4. The composition for space sterilization according to any one of Items 1 to 3.

また、本発明は、下記に掲げる空間殺菌方法である：
項５． 項１乃至４のいずれかに記載の空間殺菌用組成物を空間内に拡散させることを特徴とする、空間内の殺菌方法。 Moreover, this invention is the space sterilization method hung up below:
Item 5. Item 5. A method for sterilizing space, wherein the composition for space sterilization according to any one of Items 1 to 4 is diffused into the space.

以下、本発明を詳細に説明する。本発明の空間殺菌用組成物は、（Ａ）塩化ベンザルコニウム及び塩化ベンゼトニウムよりなる群から選択される少なくとも１種、（Ｂ）エタノール、（Ｃ）水、及び（Ｄ）ジメチルエーテルを含有することを特徴とするものである。   Hereinafter, the present invention will be described in detail. The composition for space sterilization of the present invention contains (A) at least one selected from the group consisting of benzalkonium chloride and benzethonium chloride, (B) ethanol, (C) water, and (D) dimethyl ether. It is characterized by.

（Ａ）成分として、塩化ベンザルコニウム及び塩化ベンゼトニウムの内、いずれか少なくとも１種を使用する。好ましくは塩化ベンザルコニウムである。本発明の空間殺菌用組成物中の（Ａ）成分の配合割合としては、（Ａ）成分の総量で、通常０．０１〜０．８重量％、好ましくは０．０５〜０．８重量％、更に好ましくは０．１〜０．８重量％が例示される。かかる範囲よりも高い割合で（Ａ）成分を使用しても優れた殺菌作用が発揮できるため、（Ａ）成分を上記割合よりも多く含有することを妨げるものではないが、本発明の空間殺菌用組成物では、各成分の相互作用により殺菌作用が相乗的に高められるため、上記割合で（Ａ）成分を含有していれば、優れた殺菌作用を発揮することができる。   As the component (A), at least one of benzalkonium chloride and benzethonium chloride is used. Preferred is benzalkonium chloride. As a mixture ratio of the component (A) in the composition for space sterilization of the present invention, the total amount of the component (A) is usually 0.01 to 0.8% by weight, preferably 0.05 to 0.8% by weight. More preferably, it is 0.1 to 0.8% by weight. Even if the component (A) is used in a proportion higher than the above range, an excellent bactericidal action can be exerted. Therefore, it does not preclude containing the component (A) in a larger amount than the above proportion, but the space sterilization of the present invention In the composition for use, since the bactericidal action is synergistically enhanced by the interaction of each component, an excellent bactericidal action can be exhibited if the component (A) is contained in the above proportion.

（Ｂ）であるエタノールは、空間殺菌用組成物中に、通常８〜６４重量％、好ましくは１５〜６０重量％、更に好ましくは２０〜５０重量％の割合で配合される。   Ethanol as (B) is usually blended in the composition for space sterilization at a ratio of 8 to 64% by weight, preferably 15 to 60% by weight, and more preferably 20 to 50% by weight.

（Ｃ）成分である水は、空間殺菌用組成物中に、通常３．２〜４７．９９重量％、好ましくは５〜４０重量％、更に好ましくは１０〜３０重量％の割合で配合される。   (C) The water which is a component is normally mix | blended in the composition for space sterilization in the ratio of 3.2-47.9 weight%, Preferably it is 5-40 weight%, More preferably, it is 10-30 weight%. .

（Ｄ）成分であるジエチルエーテルは、空間殺菌用組成物中に、通常２０〜８０重量％重量％、好ましくは２５〜７０重量％、更に好ましくは３０〜６０重量％の割合で配合される。   The diethyl ether which is (D) component is normally mix | blended in the composition for space disinfection in the ratio of 20-80 weight% weight%, Preferably 25-70 weight%, More preferably, 30-60 weight%.

また、本発明の空間殺菌用組成物は、上記（Ａ）〜（Ｄ）成分の各配合割合を充足し、更に（Ｂ）成分１重量部に対して、（Ｃ）成分が例えば０．２５〜１．５重量部、好ましくは０．４〜１．２重量部、更に好ましくは０．６〜１．０重量部となる割合を満たしていれば、一層殺菌作用が増強され、優れた殺菌効果が奏される。   Moreover, the composition for space sterilization of this invention satisfies each compounding ratio of said (A)-(D) component, and also (C) component is 0.25, for example with respect to 1 weight part of (B) component. -1.5 parts by weight, preferably 0.4-1.2 parts by weight, more preferably 0.6-1.0 parts by weight An effect is produced.

また、本発明の空間殺菌用組成物は、上記（Ａ）〜（Ｄ）成分の各配合割合を充足し、更に（Ａ）、（Ｂ）及び（Ｃ）成分の総重量１重量部に対して、（Ｄ）成分が、例えば０．２５〜４重量部、好ましくは０．４〜２重量部、更に好ましくは０．５〜１重量部となる割合を満たしていれば、より一層優れた殺菌効果が奏される。   Moreover, the composition for space sterilization of this invention satisfies each compounding ratio of said (A)-(D) component, and also with respect to 1 weight part of total weight of (A), (B) and (C) component. In addition, if the component (D) satisfies a ratio of, for example, 0.25 to 4 parts by weight, preferably 0.4 to 2 parts by weight, and more preferably 0.5 to 1 part by weight, further excellent Bactericidal effect is produced.

本発明の空間殺菌用組成物が有する格別の殺菌作用は、上記（Ａ）〜（Ｄ）成分の内のいずれか一つの成分でも欠いている組成物では得られず、上記（Ａ）〜（Ｄ）成分が組成物中で一体となって共存することによって奏されるものである。   The special bactericidal action possessed by the composition for space sterilization of the present invention cannot be obtained with a composition lacking any one of the above components (A) to (D). The component D) is produced by the coexistence in the composition.

また、上記（Ｄ）成分は、上記格別の効果に寄与するだけでなく、容器に充填された当該空間殺菌用組成物をエアゾール状で噴霧又は噴射して空間内に分散させる際の噴射剤としての役割をも果たしている。即ち、本発明の空間殺菌用組成物は、必須成分として上記（Ｄ）成分を含有することによって、エアゾールの形態を備えている。   In addition, the component (D) not only contributes to the above-mentioned special effects, but also as a propellant when the composition for space sterilization filled in the container is sprayed or sprayed in an aerosol form and dispersed in the space. Also plays a role. That is, the composition for space sterilization of the present invention has an aerosol form by containing the component (D) as an essential component.

本発明の空間殺菌組成物には、上記（Ａ）〜（Ｄ）成分に加えて、他の殺菌成分や消毒成分を含有していてもよい。また、前述するように、上記（Ｄ）成分が、組成物をエアゾール状にする噴射剤としての役割も果たしているため、本発明の空間殺菌用組成物には、他の噴射剤成分を配合しなくてもよいが、本発明の効果に悪影響を及ぼさない限り、液化石油ガス（例えば、エタン、プロパン、エチレン、イソブタン、ノルマルブタン、プロピレン等）、窒素ガス、炭酸ガス、フロンガス等の噴射剤成分を更に含んでいてもよい。   In addition to the components (A) to (D), the space sterilizing composition of the present invention may contain other sterilizing components and disinfecting components. Further, as described above, since the component (D) also plays a role as a propellant that makes the composition into an aerosol form, the composition for space sterilization of the present invention contains other propellant components. The propellant component such as liquefied petroleum gas (for example, ethane, propane, ethylene, isobutane, normal butane, propylene, etc.), nitrogen gas, carbon dioxide gas, chlorofluorocarbon gas, etc. May further be included.

また、本発明の空間殺菌用組成物には、上記（Ａ）〜（Ｄ）成分の他に、本発明の効果を妨げないことを限度として、界面活性剤、ｐＨ調整剤、緩衝剤、香料、消臭剤、他の有機溶剤等が更に配合されていてもよい。   In addition to the above components (A) to (D), the composition for space sterilization of the present invention is not limited to the effects of the present invention, but includes a surfactant, a pH adjuster, a buffer, and a fragrance. Further, a deodorant, other organic solvent, etc. may be further blended.

本発明の空間殺菌用組成物の調製方法は、特に制限されず、例えば、上記（Ａ）〜（Ｄ）成分及び必要に応じて他成分を混合して耐圧性容器に充填する方法や、上記（Ａ）〜（Ｃ）成分及び必要に応じて他成分（噴射成剤分以外）を混合してこれを耐圧性容器に充填し、次いで当該容器内に上記（Ｄ）成分及び必要に応じて他の噴射剤成分を加圧充填する方法等を挙げることができる。上記耐圧性容器としては、本発明の空間殺菌用組成物を充填し収容するのに耐え得る強度を備えていればよく、例えば、エアゾール組成物を収容する容器として、通常使用されている缶、瓶又は樹脂製の容器が挙げられる。   The method for preparing the composition for space sterilization of the present invention is not particularly limited. For example, the above-described methods (A) to (D) and other components as necessary are mixed and filled in a pressure-resistant container, Components (A) to (C) and other components (other than the propellant component) are mixed and filled in a pressure-resistant container, and then the component (D) and, if necessary, the container. Examples thereof include a method of pressurizing and filling other propellant components. As said pressure-resistant container, what is necessary is just to have the intensity | strength which can endure filling and accommodating the composition for space sterilization of this invention, for example, the can normally used as a container which accommodates an aerosol composition, A bottle or a resin container may be mentioned.

本発明の空間殺菌用組成物は、空間内に拡散されることにより使用され、該空間を殺菌することができる。本発明の空間殺菌用組成物は、エアゾール形態の組成物であるので、収容された容器から、殺菌対象の空間内に噴霧又は噴射されることにより、該空間殺菌用組成物が空間内に霧状で拡散される。   The composition for space sterilization of the present invention is used by being diffused into a space and can sterilize the space. Since the composition for space sterilization of the present invention is a composition in the form of an aerosol, the composition for space sterilization is fogged into the space by being sprayed or injected into the space to be sterilized from the contained container. Diffused in the form.

本発明の空間殺菌用組成物が空間内に拡散される際の霧状粒子の粒子径については、特に制限されない。   The particle diameter of the atomized particles when the composition for space sterilization of the present invention is diffused into the space is not particularly limited.

本発明の空間殺菌用組成物を空間内に拡散させる量については、該組成物の種類や粒子径、殺菌対象となる空間の種類等によって異なり、一律に規定することはできないが、殺菌対象の空間１ｍ3あたり、該空間殺菌用組成物が通常１００〜６０００ｍｇ、好ましくは３００〜４０００ｍｇ、更に好ましくは５００〜２０００ｍｇとなる量を挙げることができる。 The amount of the composition for space sterilization of the present invention to be diffused in the space varies depending on the type and particle diameter of the composition, the type of space to be sterilized, etc., and cannot be uniformly defined. The amount that the composition for space sterilization is usually 100 to 6000 mg, preferably 300 to 4000 mg, more preferably 500 to 2000 mg per 1 m 3 of space.

空間殺菌用組成物の噴霧・噴射状態は、容器内の圧力や容器のバルブの噴射孔径等を適宜設定することにより調整できる。   The spraying / injecting state of the composition for space sterilization can be adjusted by appropriately setting the pressure in the container, the diameter of the injection hole of the valve of the container, and the like.

本発明の空間殺菌用組成物は、屋内空間又は屋外空間の別を問わず、空間内の浮遊菌を低減乃至死滅させる目的で使用される。本発明の効果をより効果的に発揮させるという観点から、適用対象となる空間は屋内空間であることが望ましい。   The composition for space sterilization of the present invention is used for the purpose of reducing or killing floating bacteria in the space regardless of whether it is indoor space or outdoor space. From the viewpoint of more effectively exerting the effects of the present invention, it is desirable that the space to be applied is an indoor space.

本発明の空間殺菌用組成物の好適な適用対象空間の一例として、トイレ、玄関、台所、居室等の居住空間；病院、飲食店、製薬工場、食品加工工場等の施設内の空間；車、航空機、電車等の車両内の空間等が例示される。   As an example of a suitable application target space of the composition for space sterilization of the present invention, a living space such as a toilet, an entrance, a kitchen, a living room; a space in a facility such as a hospital, a restaurant, a pharmaceutical factory, a food processing factory; a car, Examples include spaces in vehicles such as airplanes and trains.

また、本発明の空間殺菌用組成物は、空間内に浮遊している菌に対して、優れた殺菌作用を発揮するが、該空間殺菌用組成物が空間内に拡散されることによって、同時に、該空間の壁、天井、床に付着している菌に対しても、殺菌作用を発揮する。   In addition, the composition for space sterilization of the present invention exerts an excellent sterilizing action against bacteria floating in the space, but at the same time, the composition for space sterilization diffuses in the space. It also exerts a bactericidal action against bacteria attached to the walls, ceiling, and floor of the space.

本発明の空間殺菌用組成物は、細菌、ウイルス、カビ等を含む広範な微生物に対して殺菌作用を発揮できる。特に、空間には、例えば、Acremonium sp、Cladosporium cladosporioides、Aspergillus versicolor等の微生物が浮遊していることが知られており、本発明の空間殺菌用組成物は、これらの空間浮遊微生物に対して優れた殺菌効果を奏する。 The composition for space sterilization of the present invention can exert a bactericidal action against a wide range of microorganisms including bacteria, viruses, molds and the like. In particular, it is known that microorganisms such as Acremonium sp, Cladosporium cladosporioides , Aspergillus versicolor, etc. are suspended in the space. Has a sterilizing effect.

また、他の観点から、本発明は、上記（Ａ）成分、（Ｂ）成分及び（Ｃ）成分を含有し、殺菌作用を有する組成物に、上記（Ｄ）成分を配合することにより、該組成物の殺菌作用を増強すること、特に空間内の浮遊菌に対する殺菌作用を増強することができる。従って、本発明は、更に、以下に示す殺菌作用の増強方法を提供する。なお、下記発明において、使用する各成分、その配合割合、各成分の配合方法、殺菌対象空間、殺菌対象の菌等については、上記殺菌剤組成物の場合と同様である。
（１） （Ａ）塩化ベンザルコニウム及び塩化ベンゼトニウムよりなる群から選択される少なくとも１種、（Ｂ）エタノール、及び（Ｃ）水を含有する殺菌剤組成物に、（Ｄ）ジメチルエーテルを配合することを特徴とする、上記殺菌剤組成物の殺菌作用の増強方法。
（２） 最終濃度が、（Ａ）成分０．０１〜０．８重量％、（Ｂ）成分８〜６４重量％、（Ｃ）成分３．２〜４７．９９重量％、及び（Ｄ）成分２０〜８０重量％となるように、（Ａ）、（Ｂ）及び（Ｃ）成分を含有する殺菌剤組成物に（Ｄ）成分を配合する、（１）記載の殺菌作用の増強方法。
（３） 殺菌剤組成物中に、（Ｃ）成分が（Ｂ）成分１重量部に対して０．２５〜１．５重量部となる割合で含有されている、（１）又は（２）に記載の殺菌作用の増強方法。
（４） （Ａ）、（Ｂ）及び（Ｃ）成分の総重量１重量部に対して、（Ｄ）成分を０．２５〜４重量部の割合で配合する、（１）乃至（３）のいずれかに記載の殺菌作用の増強方法。
（５） 増強対象となる殺菌作用が、空間内の浮遊菌に対する殺菌作用である、（１）乃至（４）のいずれかに記載の殺菌作用の増強方法。 From another point of view, the present invention contains the component (A), the component (B), and the component (C), and blends the component (D) with a composition having a bactericidal action. The bactericidal action of the composition can be enhanced, particularly the bactericidal action against airborne bacteria in the space can be enhanced. Therefore, the present invention further provides a method for enhancing the bactericidal action described below. In addition, in the following invention, about each component to be used, its blending ratio, the blending method of each component, the space to be sterilized, the fungus to be sterilized, and the like, it is the same as in the case of the above bactericidal composition.
(1) (A) At least one selected from the group consisting of benzalkonium chloride and benzethonium chloride, (B) ethanol, and (C) water, and (D) dimethyl ether is added to the disinfectant composition. A method for enhancing the bactericidal action of the bactericidal agent composition.
(2) The final concentration is 0.01 to 0.8% by weight of component (A), 8 to 64% by weight of component (B), 3.2 to 47.9% by weight of component (C), and component (D). The method for enhancing the bactericidal action according to (1), wherein the component (D) is blended with the bactericide composition containing the components (A), (B) and (C) so as to be 20 to 80% by weight.
(3) In the disinfectant composition, the component (C) is contained in a ratio of 0.25 to 1.5 parts by weight with respect to 1 part by weight of the component (B), (1) or (2) The method for enhancing the bactericidal action as described in 1.
(4) (1) thru | or (3) which mix | blend (D) component in the ratio of 0.25-4 weight part with respect to 1 weight part of total weight of (A), (B) and (C) component. The method for enhancing a bactericidal action according to any one of the above.
(5) The method for enhancing a bactericidal action according to any one of (1) to (4), wherein the bactericidal action to be enhanced is a bactericidal action against airborne bacteria in the space.

本発明の空間殺菌用組成物によれば、空間内に浮遊する細菌に対する殺菌作用が顕著に高められているので、空間内の細菌を効果的に死滅させて、空間を衛生的に保つことができる。   According to the composition for space sterilization of the present invention, since the sterilization action against bacteria floating in the space is remarkably enhanced, it is possible to effectively kill the bacteria in the space and keep the space hygienic. it can.

また、本発明の空間殺菌用組成物は、人体に対する安全性も備えているので、屋内空間において問題なく使用できる。   Moreover, since the composition for space sterilization of this invention is also equipped with the safety | security with respect to a human body, it can be used without a problem in indoor space.

更に、本発明の空間殺菌用組成物は、エアゾール形態の組成物であり、容器内から吐出されて空間内に霧状に拡散するので、特段の装置を用いることなく、簡便に使用できる。   Furthermore, the composition for space sterilization of the present invention is a composition in the form of an aerosol, and since it is discharged from the container and diffused in the form of a mist in the space, it can be used conveniently without using a special device.

そして更に、本発明の空間殺菌用組成物は、易揮発性であるので、該組成物を空間内に拡散した後に、水滴が壁、床又は天井に残留することがない。そのため、本発明の空間殺菌用組成物によれば、極めて簡便な方法で空間内の衛生状態を良好に保つことができる。   Furthermore, since the composition for space sterilization of the present invention is easily volatile, water droplets do not remain on the wall, floor or ceiling after the composition is diffused into the space. Therefore, according to the composition for space sterilization of the present invention, the sanitary condition in the space can be kept good by an extremely simple method.

以下、実施例を挙げて本発明を更に詳しく説明するが、本発明は以下の実施例等により何ら限定されるものではない。なお、以下の実施例において、表中の成分の欄の数値の単位は重量％である。   EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in more detail, this invention is not limited at all by the following examples. In the following examples, the unit of numerical values in the component column in the table is% by weight.

実施例１−１１
所定量の塩化ベンザルコニウム、エタノール及び蒸留水を混合して、これを耐圧容器に充填し、更に所定量のジメチルエーテル（ＤＭＥ）を該容器に充填することによって、表１に示す処方の空間殺菌用組成物（実施例１−９）を製造した。 Example 1-11
A predetermined amount of benzalkonium chloride, ethanol and distilled water are mixed, filled in a pressure-resistant container, and further filled with a predetermined amount of dimethyl ether (DME), whereby the space sterilization of the formulation shown in Table 1 is performed. Composition (Example 1-9) was prepared.

得られた空間殺菌用組成物の空間内浮遊細菌に対する殺菌作用を以下の方法で評価した。
＜殺菌作用評価方法＞
１． １０００Ｌの密閉空間内の浮遊細菌数を測定する。
２． 次いで、その空間に空間殺菌用組成物を２秒間噴射（噴射量１g）して、１分間静置した。
３． 再度、空間内の浮遊細菌数を測定する。
４． 下記式に従って、空間殺菌用組成物の殺菌率を算出する。 The following method evaluated the bactericidal action with respect to the airborne bacteria of the space sterilization composition obtained.
<Bactericidal action evaluation method>
1. The number of airborne bacteria in a 1000 L sealed space is measured.
2. Next, the composition for space sterilization was sprayed into the space for 2 seconds (injection amount 1 g) and left to stand for 1 minute.
3. Again, measure the number of airborne bacteria in the space.
4). The sterilization rate of the composition for space sterilization is calculated according to the following formula.

Figure 0004632676
なお、浮遊細菌の測定は、エアサンプラー（Biotest社製RCS High Flow）に一般細菌用培地（Biotest社製 アガーストリップTC）を装着して、上記密閉空間の中央下部にエアサンプラーを設置し、５００Lのエアーをサンプリングした後、該培地を３０℃恒温槽に３日間置いて、生育菌数を計測することにより行った。
Figure 0004632676
 For the measurement of airborne bacteria, an air sampler (RCS High Flow manufactured by Biotest) is attached to a medium for general bacteria (Agar Strip TC manufactured by Biotest), and an air sampler is installed at the lower center of the sealed space. After sampling the air, the medium was placed in a constant temperature bath at 30 ° C. for 3 days, and the number of growing bacteria was counted.

また、比較のため、表２に示す空間殺菌用組成物（比較例１−４）についても、同様の方法で調製して、空間内浮遊細菌に対する殺菌作用を評価した。なお、表２中のLPGは、プロパンガスを意味する。   For comparison, the composition for space sterilization (Comparative Example 1-4) shown in Table 2 was also prepared in the same manner, and the bactericidal action against the floating bacteria in the space was evaluated. Note that LPG in Table 2 means propane gas.

得られた結果を表１及び２に併せて示す。この結果、塩化ベンザルコニウム、エタノール、水及びジメチルエーテルの４成分を組み合わせて空間殺菌用組成物を調製することによって、空間に浮遊する菌に対する殺菌効果が顕著に高められることが確認された。特に、塩化ベンザルコニウム、エタノール及び水からなる組成物の殺菌作用が、ジメチルエーテルにより著しく高められることが確認された。   The obtained result is combined with Table 1 and 2, and is shown. As a result, it was confirmed that the bactericidal effect against bacteria floating in the space was remarkably enhanced by preparing a composition for space sterilization by combining four components of benzalkonium chloride, ethanol, water and dimethyl ether. In particular, it was confirmed that the bactericidal action of a composition comprising benzalkonium chloride, ethanol and water can be significantly enhanced by dimethyl ether.

Figure 0004632676
Figure 0004632676

Figure 0004632676
実施例１０−１３
表３に示す組成の空間殺菌用組成物を調製し、その殺菌作用について評価した。なお、調製方法及び殺菌作用の評価方法は、上記実施例１−９場合と同様である。
Figure 0004632676
 Examples 10-13
Space sterilization compositions having the compositions shown in Table 3 were prepared and evaluated for their bactericidal action. In addition, the preparation method and the evaluation method of a bactericidal action are the same as that of the said Example 1-9.

得られた結果を表３に併せて示す。この結果、実施例１０−１３の空間殺菌用組成物についても、優れた殺菌作用があることが確認された。   The obtained results are also shown in Table 3. As a result, it was confirmed that the composition for space sterilization of Examples 10-13 also had an excellent sterilizing action.

Figure 0004632676
実施例１４−１７
表４に示す組成の空間殺菌用組成物を調製した（実施例１４−１７）。
Figure 0004632676
 Examples 14-17
The composition for space disinfection of the composition shown in Table 4 was prepared (Examples 14-17).

Figure 0004632676
Figure 0004632676

Claims (3)

（Ａ）塩化ベンザルコニウム及び塩化ベンゼトニウムよりなる群から選択される少なくとも１種、（Ｂ）エタノール、（Ｃ）水、及び（Ｄ）ジメチルエーテルを含有する空間殺菌用組成物。 (A) A composition for space sterilization containing at least one selected from the group consisting of benzalkonium chloride and benzethonium chloride, (B) ethanol, (C) water, and (D) dimethyl ether. （Ａ）成分０．０１〜０．８重量％、（Ｂ）成分８〜６４重量％、（Ｃ）成分３．２〜４７．９９重量％、及び（Ｄ）成分２０〜８０重量％の割合で含有する、請求項１に記載の空間殺菌用組成物。 (A) 0.01-0.8 wt% of component, (B) 8-8 wt% of component, (C) 3.2-47.9 wt% of component, and (D) 20-20 wt% of component The composition for space sterilization according to claim 1, comprising: 請求項１又は２に記載の空間殺菌用組成物を空間内に拡散させることを特徴とする、空間内の殺菌方法。

A method for sterilizing a space, wherein the composition for space sterilization according to claim 1 or 2 is diffused into the space.

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