JP4614457B2 - Topical skin disease - Google Patents

Description

  TECHNICAL FIELD The present invention relates to an external preparation used for the treatment of skin diseases in small animals such as dogs and cats and large animals such as horse cattle, and the external preparation relates to soaps and lotions and creams mainly using herbal extracts and fruit extracts. Is.

Prior arts for topical animal skin diseases include JP-A-6-179625 (Patent Document 1), JP-A-10-139677 (Patent Document 2), JP-A-2001-321016 (Patent Document 3), JP-A-2002- No. 154975 (Patent Document 4), Japanese Patent Application Laid-Open No. 2002-363065 (Patent Document 5) and the like can be seen.
Of these patent documents, Patent Document 5 is related to the applicant of the present application. However, each patent document mainly relates to a therapeutic agent for external use mainly made of medicinal herbs, and has shown its therapeutic effect. is there.
However, in order to obtain a stable therapeutic agent, it is recognized that no consideration has been given to the concentration of ingredients extracted from the main raw materials and the preparation technique.
JP-A-6-179625 Japanese Patent Laid-Open No. 10-139677 JP 2001-321016 A JP 2002-154975 A Japanese Patent Laid-Open No. 2002-363065

  The problem to be solved by the present invention is that the conditions for extracting the main component from the herb are used in the case of using the same or similar to the main ingredient medicinal herb or fruit described in the prior literature as the main ingredient for treatment. It is intended to be an external preparation with a stable therapeutic effect by adding an organic solvent and glycerin and mixing them.

  In order to solve the above-mentioned problems, the applicant of the present application carefully examines and arranges the main raw materials in Patent Document 5 related to the applicant and summarizes them into the required raw materials. In this process, the alcoholic leachate of fruit, glycerin and aromatic fruit liquid are added to achieve the purpose.

  Specifically, the above means for achieving the purpose are medicinal herbs of mugwort, horsetail, green tea leaves and dokudami, fruits are wild grapes, and aromatic fruit oils are orange oil and lemon oil. In order to suspend the extracts of the above four kinds of herbs in water, shochu pickled liquor and glycerin with an alcohol degree of around 35 ° in the field grapes are used.

These medicinal herbs are boiled with a constant volume of water and used as a specific volume of medicinal component extract, and the soy pickles of field grapes also have the above specific volume .

The mixing ratio of the above-mentioned external preparations of the present invention consisting of the herbal extract, glycerin and aromatic fruit liquid is 3 for each of the 4 types of herbal extracts, 1 in the field grape shochu pickled liquid, and the aromatic fruit oil content. Orange oil 3, lemon oil 0.3 and glycerin 5.
Among the above, the extract of cedar, tea leaves and dokudami can be reduced to 2 depending on the symptoms of the affected area of the patient.

When the main stock solution mixed with the above main components is used as a lotion, that is, affected area washing water or lotion, it is mixed with water at a ratio of 30% by volume, and when it is used as a cream lotion, the main stock solution 3, cream 5, Mix in the proportion of water 2 and in the case of soap, mix in the proportion of the main ingredient stock solution 3, soap material 4, and water 3.
Since the main stock solution is alkaline, natural water that is not acidic is used. In addition, lotions and soaping means may be performed by general techniques in the industry.

  In Patent Document 5 relating to the applicant's application, the effects of the invention are shown in (Table 1). That is, the therapeutic effect of dogs is 3-4 months for serious injuries, 1-1.5 months for slander, 1 month for minor injuries, 4.5 months for the longest day, and 10 days for the shortest day. In the treatment according to the present invention, the above results have been shortened by at least 10%.

As an example of the above effect, the history of the dog (male 1 year old, weight 7 kg, hybrid) before using the external preparation of the present invention is as follows:
On July 4, 2003, a red rash-like thing appeared on the nasal mirror. In addition, since the area around the eyes was drowned, I visited a nearby doctor (Hospital A). Pruritus appears in the limbs and the whole body, and when she visited the clinic again on the 25th, antibiotics were administered based on the judgment of allergy. The pruritus worsened, and the scratched part (mainly the extremities) bleeds and swells, and hair loss begins. Therefore, pyoderma was judged, and antibiotics, itching and steroids were given, but the symptoms worsened, and most of the whole body had fallen by mid-August. The appetite declined because of itching, and the nutritional status became extremely poor. Feels ineffective for internal treatment at Hospital B, replaces Hospital C, and is prescribed as antibiotics, acaricides, and shampoos. I went to the store on December 5, 2003 because of howling, escape, and abnormal behavior began at night.

The course of treatment using the external preparation of the present invention started on December 5, 2003. Lotion, cream lotion and soap were used.
(Current disease)
Extensive systemic hair loss, flushing, papules, bloody crusts, bleeding from scratches. Particularly noticeable are the bilateral side, the rear drive, both thigh trailing edges / anus, tail, and extremities, and has strong licking. Extensive hair loss and patchy pigmentation are seen from the thigh trailing edge to the joint. From the nasal mirror to the nasal bridge, the papules and scratches result in the presence of wrinkles and strong inflammation. Nutritional condition is poor, thin and restless.
(Progress)
From the day after the start of external therapy, the pruritus is reduced and the behavior becomes calm. On December 19th (2 weeks after the start of treatment), hair loss did not heal, but inflammation had subsided. Most of the whole body's hair recovered from the first month of treatment. The nutritional status improved, and the nasal mirror remained slightly inflamed, but it was completely cured on February 15. My weight was 17kg.

  When the treatment course by the use of the above external preparation of the present invention is shown in photographs, FIGS. 1 and 2 show the symptoms of the dog on December 8, 2003, and FIGS. 3 and 4 show the results on January 16, 2004. 5 and 6 show the symptoms on February 15, 2004.

  The preparation examples of the preparation for external use of the present invention will be described in detail. 500 g each of mugwort, horsetail, green tea leaves and dokudami dried in the shade are boiled together with 6 liters of water to 400 cc to obtain individual extracts. When using raw dokudami, weigh 1.5kg. For the field grapes, use a solution of 500g in a shochu with an alcohol content of 35 ° (preferably 3 years). Orange oil and lemon oil are extracts obtained by drying each skin, crushing it, placing it in a container, steaming it with steam and moistening it, and then squeezing it through a dehydrator.

  For the preparation of the above, 30cc mugwort extract and 20cc each extract of sugina, green tea leaves, and dokudami are mixed in 650cc water, add 50cc glycerin and 10cc wild grape shochu liquor, and mix well. Add 30cc and 2cc of lemon oil to make main ingredients. This is the main ingredient of lotion, cream lotion and soap.

A photograph showing the symptoms of the dog on December 8, 2003. The photograph which showed the symptom of the other side of FIG. A photograph showing the symptoms of the January 16, 2004 dog. The enlarged photograph of FIG. A photograph showing the dog's healing status on February 15, 2004. The enlarged photograph of FIG.

Claims (3)

  500g each of dried mugwort, dried horsetail, dried green tea leaves and dried dokudami is boiled in 6 liters of water to make each component extract as 400cc, each component extract is 3 unit capacity, 1 unit volume of field grape shochu pickled solution A skin disease preparation for external use in which 5 unit volumes of glycerin, 3 units volume of orange oil of aromatic fruit oil components and 0.3 unit volume of lemon oil are mixed and used as a main stock solution.   The external preparation for skin diseases in which the main stock solution according to claim 1 is mixed with 30% of water to make a lotion.   A skin disease external preparation comprising 30% of the main stock solution according to claim 1 mixed with a cream lotion or soap material.