JP4598527B2 - 一貫した供給を提供する定量吸入器のための計量弁 - Google Patents
一貫した供給を提供する定量吸入器のための計量弁 Download PDFInfo
- Publication number
- JP4598527B2 JP4598527B2 JP2004534632A JP2004534632A JP4598527B2 JP 4598527 B2 JP4598527 B2 JP 4598527B2 JP 2004534632 A JP2004534632 A JP 2004534632A JP 2004534632 A JP2004534632 A JP 2004534632A JP 4598527 B2 JP4598527 B2 JP 4598527B2
- Authority
- JP
- Japan
- Prior art keywords
- metering
- valve
- valve stem
- formulation
- mandrel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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- 239000012530 fluid Substances 0.000 claims description 17
- 239000000203 mixture Substances 0.000 description 94
- 238000009472 formulation Methods 0.000 description 82
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- 238000007789 sealing Methods 0.000 description 24
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- VXNZUUAINFGPBY-UHFFFAOYSA-N 1-Butene Chemical compound CCC=C VXNZUUAINFGPBY-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
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- VHOQXEIFYTTXJU-UHFFFAOYSA-N Isobutylene-isoprene copolymer Chemical compound CC(C)=C.CC(=C)C=C VHOQXEIFYTTXJU-UHFFFAOYSA-N 0.000 description 2
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 2
- 239000004977 Liquid-crystal polymers (LCPs) Substances 0.000 description 2
- 239000004696 Poly ether ether ketone Substances 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 239000004974 Thermotropic liquid crystal Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
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- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 239000000395 magnesium oxide Substances 0.000 description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229920002530 polyetherether ketone Polymers 0.000 description 2
- 229920000306 polymethylpentene Polymers 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 230000003797 telogen phase Effects 0.000 description 2
- 229920002397 thermoplastic olefin Polymers 0.000 description 2
- YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 1
- BQCIDUSAKPWEOX-UHFFFAOYSA-N 1,1-Difluoroethene Chemical compound FC(F)=C BQCIDUSAKPWEOX-UHFFFAOYSA-N 0.000 description 1
- IPJGAEWUPXWFPL-UHFFFAOYSA-N 1-[3-(2,5-dioxopyrrol-1-yl)phenyl]pyrrole-2,5-dione Chemical compound O=C1C=CC(=O)N1C1=CC=CC(N2C(C=CC2=O)=O)=C1 IPJGAEWUPXWFPL-UHFFFAOYSA-N 0.000 description 1
- 229920000049 Carbon (fiber) Polymers 0.000 description 1
- 229920001634 Copolyester Polymers 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 229920000265 Polyparaphenylene Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000004917 carbon fiber Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 150000001993 dienes Chemical class 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920000840 ethylene tetrafluoroethylene copolymer Polymers 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 229920005555 halobutyl Polymers 0.000 description 1
- GXNDYZPMZKJDSS-UHFFFAOYSA-N hex-1-ene Chemical compound CCCCC=C.CCCCC=C GXNDYZPMZKJDSS-UHFFFAOYSA-N 0.000 description 1
- 229920000554 ionomer Polymers 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229920006343 melt-processible rubber Polymers 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910001510 metal chloride Inorganic materials 0.000 description 1
- 229910001507 metal halide Inorganic materials 0.000 description 1
- 150000005309 metal halides Chemical class 0.000 description 1
- 229940071648 metered dose inhaler Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002557 mineral fiber Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- IQOICMOMHUBJCM-UHFFFAOYSA-N oct-1-ene Chemical compound CCCCCCC=C.CCCCCCC=C IQOICMOMHUBJCM-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920006149 polyester-amide block copolymer Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001021 polysulfide Polymers 0.000 description 1
- 239000005077 polysulfide Substances 0.000 description 1
- 150000008117 polysulfides Polymers 0.000 description 1
- 229920003225 polyurethane elastomer Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229920000131 polyvinylidene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 229920003031 santoprene Polymers 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 229920001935 styrene-ethylene-butadiene-styrene Polymers 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 230000008646 thermal stress Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 229920006344 thermoplastic copolyester Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
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- 210000001215 vagina Anatomy 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
- B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
- B65D83/52—Metering valves; Metering devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Mechanical Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Nozzles (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40863702P | 2002-09-06 | 2002-09-06 | |
| GBGB0315791.4A GB0315791D0 (en) | 2003-07-07 | 2003-07-07 | Two component molded valve stems |
| PCT/US2003/027829 WO2004022143A2 (en) | 2002-09-06 | 2003-09-04 | Metering valve for a metered dose inhaler providing consistent delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006500980A JP2006500980A (ja) | 2006-01-12 |
| JP2006500980A5 JP2006500980A5 (enExample) | 2006-09-28 |
| JP4598527B2 true JP4598527B2 (ja) | 2010-12-15 |
Family
ID=31980038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004534632A Expired - Fee Related JP4598527B2 (ja) | 2002-09-06 | 2003-09-04 | 一貫した供給を提供する定量吸入器のための計量弁 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1554002B1 (enExample) |
| JP (1) | JP4598527B2 (enExample) |
| AU (1) | AU2003270338B2 (enExample) |
| CA (1) | CA2497646A1 (enExample) |
| WO (1) | WO2004022143A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0302812D0 (en) | 2003-02-07 | 2003-03-12 | Wickham Mark D | Metering valves for dispensers |
| DE102004034626A1 (de) * | 2004-06-17 | 2006-01-12 | Seaquist Perfect Dispensing Gmbh | Dosierventil und Vorrichtung zur Abgabe einer vorzugsweise kosmetischen Flüssigkeit |
| GB2417024B (en) | 2004-08-11 | 2007-01-03 | Bespak Plc | Improvements in metering valves for dispensers |
| DE102006012302A1 (de) | 2006-03-15 | 2007-09-27 | Seaquist Perfect Dispensing Gmbh | Abgabevorrichtung |
| EP1998832B1 (en) | 2006-03-24 | 2014-10-22 | 3M Innovative Properties Company | Method for assessing the suitability of metered dose inhaler actuators |
| US8763865B2 (en) | 2007-01-31 | 2014-07-01 | I.P.S. Research And Development B.V. | Metering device for dispensing a dose of pressurized fluid |
| DE102007049614B4 (de) | 2007-03-15 | 2015-03-05 | Aptar Dortmund Gmbh | Abgabevorrichtung |
| EP2144653B1 (en) | 2007-05-10 | 2018-11-28 | 3M Innovative Properties Company | Manufacture of metered dose valve components |
| FR2937019B1 (fr) * | 2008-10-15 | 2012-06-08 | Rexam Pharma La Verpilliere | Dispositif de distribution de liquide muni d'un organe d'etancheite ayant une partie elastomere |
| AU2011242686A1 (en) * | 2010-04-20 | 2012-11-15 | Capnia, Inc. | Compressed gas cylinder with an integral valve |
| DE102011080970B4 (de) * | 2011-08-15 | 2020-01-09 | Elringklinger Ag | Dichtung zum Abdichten eines Dichtspalts und Verfahren zum Herstellen einer solchen Dichtung |
| FR2996827B1 (fr) | 2012-10-12 | 2014-10-31 | Rexam Healthcare La Verpillier | Valve doseuse de distribution d'un aerosol |
| FR2993250B1 (fr) * | 2012-10-12 | 2014-08-01 | Rexam Healthcare La Verpillier | Valve doseuse de distribution d'un aerosol |
| GB2526821B (en) | 2014-06-03 | 2016-04-27 | The Salford Valve Company | Valve assembly |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1225163A (fr) * | 1959-03-07 | 1960-06-29 | Valois Sa | Valve doseuse pour vaporisateurs à gaz sous pression |
| US3229851A (en) * | 1964-03-25 | 1966-01-18 | Casco Products Corp | Valve and pressure indicator for pressurized containers |
| FR1461685A (fr) * | 1965-10-29 | 1966-02-25 | Idees | Perfectionnement aux valves doseuses fonctionnant sous l'action d'un gaz comprimé |
| GB1336379A (en) * | 1971-05-19 | 1973-11-07 | Neotechnic Eng Ltd | Valve assemblies for pressurised aerosol-dispensing containers |
| FR2300950A1 (fr) * | 1975-02-12 | 1976-09-10 | Valois Sa | Valve doseuse du type aerosol |
| US4362257A (en) * | 1980-05-05 | 1982-12-07 | Ethyl Products Company | Pressure fillable dispensing device |
| US4819834A (en) * | 1986-09-09 | 1989-04-11 | Minnesota Mining And Manufacturing Company | Apparatus and methods for delivering a predetermined amount of a pressurized fluid |
| FR2740527B1 (fr) * | 1995-10-31 | 1998-01-02 | Valois | Tige de soupape a faibles frottements |
-
2003
- 2003-09-04 AU AU2003270338A patent/AU2003270338B2/en not_active Ceased
- 2003-09-04 JP JP2004534632A patent/JP4598527B2/ja not_active Expired - Fee Related
- 2003-09-04 CA CA002497646A patent/CA2497646A1/en not_active Abandoned
- 2003-09-04 WO PCT/US2003/027829 patent/WO2004022143A2/en not_active Ceased
- 2003-09-04 EP EP03752024A patent/EP1554002B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2497646A1 (en) | 2004-03-18 |
| AU2003270338B2 (en) | 2008-09-25 |
| EP1554002B1 (en) | 2012-03-21 |
| WO2004022143A3 (en) | 2004-08-19 |
| AU2003270338A1 (en) | 2004-03-29 |
| WO2004022143A2 (en) | 2004-03-18 |
| JP2006500980A (ja) | 2006-01-12 |
| EP1554002A2 (en) | 2005-07-20 |
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