JP4594539B2 - Stirring method - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a method of stirring a solvent and a powdery solute using ultrasonic waves.
[0002]
[Prior art]
Conventionally, as a method of stirring a powdered solute in a solvent and dissolving the solute in the solvent, for example, a wing member made of a magnetic material is put in a container together with the solvent and the solute, and a rotating magnetic field is applied from the outside of the container. There is a known method in which the wing member is rotated inside the container and stirred.
[0003]
By the way, when the solute is a powder, for example, moisture in the air is absorbed, and particles may be bonded to each other to form a lump. However, if the solute contains a lump and is stirred in a solvent, it takes a long time until the lump is completely dissolved even if the wing member is rotated.
[0004]
In order to solve such a problem, it is necessary to crush the solute mass, but as a method, put a container containing a solvent and a solute in a water tank that can act from the outside, There is known a method in which an ultrasonic wave is applied to a solute mass in a solvent to cause the ultrasonic wave to act on the solute mass in a solvent to crush the solute mass.
[0005]
[Problems to be solved by the invention]
Ultrasound is designed to concentrate in the middle of the aquarium when propagated into the aquarium. However, when a container is placed in the water tank, the location where the ultrasonic waves are reflected by the container and the ultrasonic waves concentrate in the water tank changes. In addition, since the location where the ultrasonic waves concentrate varies depending on various conditions such as the situation where the container is placed in the water tank, it is extremely difficult to predict the location where the ultrasonic waves concentrate, and the concentration location moves frequently. On the other hand, when a container containing a solvent and a solute is held by a robot arm and put into a water tank, the position to put the container is set in advance by the robot arm operation program. Time ultrasonic waves were propagated to the container, and then the container was pulled out of the water tank. In such a conventional method, the location where the container is placed and the location where the ultrasonic wave is concentrated do not coincide with each other. In this case, the ultrasonic wave does not sufficiently act on the solute mass in the solvent. The inconvenience arises that the mass is not completely crushed.
[0006]
Here, using a robot arm, it is conceivable to move the container to a location where the ultrasound is concentrated at that time, but for that purpose, the location where the ultrasound is concentrated is detected, and based on the detected result It is necessary to control the robot arm. However, such a method requires high technology, and the apparatus becomes expensive and cannot be employed.
[0007]
Alternatively, a method of changing the frequency of the ultrasonic wave so that the ultrasonic wave is concentrated at the place where the container is placed is considered, but again the point where the ultrasonic wave is concentrated is detected and the frequency is adjusted based on the detected result Therefore, advanced technology is required and cannot be adopted.
[0008]
Therefore, in view of the above problems, the present invention reliably and easily applies ultrasonic waves to a solute mass in a solvent when a container containing a solvent and a solute is placed in a water tank in which ultrasonic waves act using a robot arm. It is an object of the present invention to provide a method that can act to pulverize a lump and dissolve a solute in a short time.
[0009]
[Means for Solving the Problems]
In order to solve the above problems, the stirring method according to the present invention is to hold a container containing a solvent and a powdery solute with a robot arm and place it in a water tank where ultrasonic waves act, and apply ultrasonic waves to the solute mass. in the stirring method was to grind the該塊and is, together with the ultrasonic wave sequentially moving a plurality of locations in the tub to the container while acting on the water tank, when the sequentially moving, the predetermined time container at each location It is characterized by being stopped .
[0010]
According to the present invention, since the container is moved to a plurality of locations in the water tank in which the ultrasonic waves are propagated, the container is always passed through the location where the ultrasonic waves are concentrated regardless of the location in the water tank. And ultrasonic waves can be applied to the solute mass in the container.
[0012]
DETAILED DESCRIPTION OF THE INVENTION
The stirring method according to the present invention is used, for example, when a sample is arbitrarily extracted from a produced chemical to inspect whether the active ingredient satisfies a predetermined content of the powdery chemical.
[0013]
As a method for measuring the content of an active ingredient by sampling inspection for a powdered medicine, there is a method in which the chemical is dissolved in a solvent and the amount of the active ingredient contained in the solution is measured by liquid chromatography. In order to dissolve the chemical in the solvent, the wing member made of magnetic material is put in the container together with the solvent and the chemical, and the wing member is rotated inside the container by applying a rotating magnetic field from the outside of the container. If the drug contains lumps of drug particles bonded together, it takes a long time to completely dissolve the drug in the solvent.
[0014]
However, when sampling inspection is performed on chemicals produced in large quantities, the number of samples increases and it is necessary to perform inspection quickly. On the other hand, since the content of the active ingredient of the medicine is measured by measuring the amount of the active ingredient in the solution, an accurate result cannot be obtained if the medicine lump is completely dissolved. In such a case, before stirring with the wing member or the like, if the lump of the solute chemical is pulverized using the stirring method according to the present invention, the wing member is later rotated and stirred for a short time. Can completely dissolve the chemical in the solvent.
[0015]
Referring to FIG. 1, a container 1 contains a chemical, that is, a solute 1 a and a solvent 1 b, and the container 1 is held by a robot arm 2. The robot arm 2 is controlled by a computer program so that the grasped container 1 is placed in the center of the water tank 3. The water tank 3 is made of stainless steel, and water 3 a is stretched in the water tank 3. An ultrasonic oscillator 3 b is provided below the water tank 3, and an ultrasonic wave 3 d oscillated by the ultrasonic oscillator 3 b acts in the water tank 3.
[0016]
Referring to FIG. 2, after putting the container 1 in the water tank 3, the robot arm 2 slowly moves to one side while holding the container 1 and stops temporarily, and then slowly returns to the center and temporarily stops. After that, it is controlled to move slowly to the other and stop, and finally return to the center and stop. Therefore, according to the movement of the robot arm 2, the container 1 first moves to the left in the water tank 3 as shown in A, stops on the left side in the water tank 3 for a certain period of time, and then moves to the right as shown in B. Stop at the center of the tank 3 for a certain period of time, then move further to the right as in C, stop at the right side of the tank 3 for a certain period of time, and finally move to the left as D and move inside the tank 3 Stop for a certain time in the center.
[0017]
Thus, since the container 1 moves right and left in the water tank 3, it always passes through the location (3e in the figure) where the ultrasonic waves in the water tank 3 are concentrated, and at that time, the ultrasonic waves 3d pass through the water 3a in the water tank 3. It acts on the mass of the solute 1a in the container 1 to pulverize the mass of the solute 1a.
[0018]
【The invention's effect】
As is clear from the above description, the present invention can always pass the container through the ultrasonic concentration point when the container containing the solvent and the solute is put into the water tank in which the ultrasonic wave acts using the robot arm. Therefore, ultrasonic waves can be reliably and easily applied to the solute mass in the solvent to grind the mass and dissolve the solute in a short time.
[Brief description of the drawings]
FIG. 1 is a diagram showing a premise for carrying out the present invention. FIG. 2 is a diagram showing an embodiment of the present invention.
1 Container 1a Solute 1b Solvent 2 Robot arm 3 Water tank 3e Where ultrasonic waves concentrate

Claims (1)

In a stirring method in which a container containing a solvent and a powdery solute is held by a robot arm and placed in a water tank in which ultrasonic waves act, and ultrasonic waves are applied to the solute mass to crush the mass. A stirring method, wherein the container is sequentially moved to a plurality of locations in the water tank while acting on the water tank, and the container is stopped at each location for a certain time when the container is sequentially moved .

Images