CN102478580A - Rapid detection method for detecting whole blood coagulation function - Google Patents
Rapid detection method for detecting whole blood coagulation function Download PDFInfo
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- CN102478580A CN102478580A CN2010105617137A CN201010561713A CN102478580A CN 102478580 A CN102478580 A CN 102478580A CN 2010105617137 A CN2010105617137 A CN 2010105617137A CN 201010561713 A CN201010561713 A CN 201010561713A CN 102478580 A CN102478580 A CN 102478580A
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Abstract
A rapid detection method for detecting a whole blood coagulation function detects the coagulation function of blood by means of ultrasonically detecting conditions of rotation (movement) of a metal bar in a whole blood specimen. In the method, plasma is not required to be separated, whole blood is directly sampled in a detecting cup (anti-coagulation or coagulation), a metal-bar-shaped stirrer (capable of being wrapped by other materials) is arranged in the detecting cup, and during detection, a rotating magnet is additionally mounted at the bottom of the detecting cup. Before the blood is coagulated, the stirrer rotates along with the rotating magnet, and after the blood is coagulated, the stirrer stops rotating due to resistance. An ultrasonic detector is additionally mounted on a side surface of the detecting cup, and a blood coagulation condition is judged by means of detecting rotation/fixation of the stirrer in the blood.
Description
One, technical field
The invention belongs to the clinical medical inspection field, belong to the detection method of blood clotting function.
Two, background technology
Blood clotting ability fast detects has crucial clinical meaning, and particularly diagnosis is even more important to acute thrombus diseases.At present, the assay method of blood clotting ability has a lot, but adopts the blood plasma that separates to detect mostly.Existing whole blood test time of setting test or employing manual operations, naked-eye observation, or through adopting the principle of vibrating and feeding back to detect the setting condition in the blood.The manual operations error is big, is difficult to guarantee quality inspection, a kind of detection of mode then domestic rarely found, equipment price is expensive, clinical practice is restricted, and its to detect principle different with the present invention.
Three, summary of the invention
A kind of whole blood solidifies the method for quick of function, is characterized in: whole blood to be detected can add anti-coagulants earlier when blood sampling, then when detecting, adds startup blood sample coagulation processes such as clotting reagent, also can not add anti-coagulants and directly whole blood detected.Its testing process generally comprises: whole blood sample to be detected is put into one detect cup; In detecting cup, add the bar-shaped stirrer of metal; And by the motion of a motion (rotation or other forms) magnetic field drive stirrer, the stirrer velocity of rotation progressively slows at last and stops in the blood clotting process.The side (or top and other positions) of detecting cup installs a ultrasonic detector additional; Utilize ultrasound wave that the motion state of magnetic stirring bar is detected; Through rotation (moving) or stationary state and the stirring rate judgement blood clotting situation that detects stirrer in the blood, obtain the testing result of blood clotting situation.Ultrasonic detector also can be arranged on to detect in the cup and directly contact with blood sample, reduces the obstruct of wall of cup.Testing process requires constant temperature, need control the addition unanimity if need add clotting reagent.
Four, description of drawings
Accompanying drawing is the structural representation that adopts a kind of detector of the inventive method.
Five, embodiment
Below in conjunction with accompanying drawing the present invention is done further description:
Among the figure, 1, ultrasonic detector, 2, ultrasound wave, 3, magnetic stirring apparatus (band constant temperature), 4, stirrer, 5, whole blood sample, 6, detect cup.As shown in the figure; At first whole blood sample to be detected 5 is joined after detector starts and detect in the cup 6; In detecting cup 6, put into the bar-shaped stirrer of metal 4 then; Rotating magnet on the magnetic stirring apparatus 3 drives stirrer 4 and does rotation (or other forms of) motion, and the motion state of 2 pairs of stirrers 4 of ultrasound wave that ultrasonic detector 1 produces detects, thereby obtains the coherent detection result of blood clotting ability.
Claims (6)
1. a whole blood solidifies the method for quick of function; It is characterized in that this method need not separated plasma; Its detection method for will adopt whole blood in put into one and detect cup, in detecting cup, put into the bar-shaped stirrer of metal, detecting on the magnetic stirring apparatus of cup bottom has a rotating magnet; Stirrer is along with rotating magnet moves before blood solidifies; The stirrer velocity of rotation progressively slows at last and stops in the blood clotting process, and the side of detecting cup installs a ultrasonic detector additional, and stirrer rotates in blood through detecting/static and stirring rate judgement blood clotting situation.
2. a kind of whole blood according to claim 1 solidifies the method for quick of function, it is characterized in that whole blood to be detected can add anti-coagulants earlier when blood sampling, then when detecting, adds startup blood sample coagulation processes such as clotting reagent.
3. a kind of whole blood according to claim 1 solidifies the method for quick of function, it is characterized in that the ultrasonic detector installation site can be in sidepiece, top or other positions of detecting cup.
4. a kind of whole blood according to claim 1 solidifies the method for quick of function, it is characterized in that ultrasonic detector can be arranged on to detect in the cup directly to contact the obstruct of minimizing wall of cup with blood sample.
5. a kind of whole blood according to claim 1 solidifies the method for quick of function, it is characterized in that this detection method also can not add direct detection of anti-coagulants whole blood is detected.
6. a kind of whole blood according to claim 1 solidifies the method for quick of function, and it is characterized in that when this detection method detects cup need have constant temperature, guarantees the testing process temperature constant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105617137A CN102478580A (en) | 2010-11-26 | 2010-11-26 | Rapid detection method for detecting whole blood coagulation function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105617137A CN102478580A (en) | 2010-11-26 | 2010-11-26 | Rapid detection method for detecting whole blood coagulation function |
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| CN102478580A true CN102478580A (en) | 2012-05-30 |
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| CN2010105617137A Pending CN102478580A (en) | 2010-11-26 | 2010-11-26 | Rapid detection method for detecting whole blood coagulation function |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105588945A (en) * | 2016-03-17 | 2016-05-18 | 绍兴普施康生物科技有限公司 | Microfluidic blood clotting detection device and detection method thereof |
| CN107132158A (en) * | 2017-06-06 | 2017-09-05 | 中国石油大学(北京) | Hydrate slurry mobility experimental system, method and device |
| CN107462628A (en) * | 2017-09-14 | 2017-12-12 | 重庆南方数控设备有限责任公司 | A kind of thrombus detection device for elasticity and detection method based on magnetic |
| CN107843525A (en) * | 2017-11-27 | 2018-03-27 | 世纪亿康（天津）医疗科技发展有限公司 | Detect specimen cup and its application of coagulation function |
-
2010
- 2010-11-26 CN CN2010105617137A patent/CN102478580A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105588945A (en) * | 2016-03-17 | 2016-05-18 | 绍兴普施康生物科技有限公司 | Microfluidic blood clotting detection device and detection method thereof |
| CN107132158A (en) * | 2017-06-06 | 2017-09-05 | 中国石油大学(北京) | Hydrate slurry mobility experimental system, method and device |
| CN107132158B (en) * | 2017-06-06 | 2024-06-11 | 中国石油大学(北京) | Hydrate slurry fluidity experiment system, method and device |
| CN107462628A (en) * | 2017-09-14 | 2017-12-12 | 重庆南方数控设备有限责任公司 | A kind of thrombus detection device for elasticity and detection method based on magnetic |
| CN107843525A (en) * | 2017-11-27 | 2018-03-27 | 世纪亿康（天津）医疗科技发展有限公司 | Detect specimen cup and its application of coagulation function |
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Address after: 211135 Nanjing, Jiangning, Qilin street, Po Shan Road, No. 7 Applicant after: SINNOWA MEDICAL SCIENCE & TECHNOLOGY CO., LTD. Address before: 211135 Nanjing, Jiangning, Qilin street, Po Shan Road, No. 7 Applicant before: Nanjing Sinnowa Medical Science & Technology Co., Ltd. |
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Free format text: CORRECT: APPLICANT; FROM: NANJING SINNOWA MEDICAL SCIENCE + TECHNOLOGY CO., LTD. TO: JIANGSU SINNOWA MEDICAL SCIENCE + TECHNOLOGY CO., LTD. |
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Application publication date: 20120530 |