JP4587137B2 - Antibacterial composition - Google Patents
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- JP4587137B2 JP4587137B2 JP2001136717A JP2001136717A JP4587137B2 JP 4587137 B2 JP4587137 B2 JP 4587137B2 JP 2001136717 A JP2001136717 A JP 2001136717A JP 2001136717 A JP2001136717 A JP 2001136717A JP 4587137 B2 JP4587137 B2 JP 4587137B2
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- antibacterial
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Description
【0001】
【発明の属する技術分野】
本発明は、抗菌組成物、特に抗菌性スプレー液に適した抗菌組成物に関するものである。
【0002】
【従来の技術】
従来、低毒性の抗菌剤としてデヒドロ酢酸ナトリウムを主成分とするものは、広く知られている。しかし、その用途の多くは水性インク等で、強い抗菌力を要しないものである。これらの点を改善するため、デヒドロ酢酸ナトリウムにベンツイミダゾール系化合物を添加し、抗菌性の向上を試みた抗菌防黴組成物も知られている(特公昭61−36723号公報、特開昭55−87709号公報)。
【0003】
【発明が解決しようとする課題】
しかしながら、デヒドロ酢酸ナトリウムもチアベンダゾールのごときベンツイミダゾール系化合物も、各々食品添加物として許容される程度に低毒性である利点はあるが、その効力にはおのずから限界がある。またこれらをスプレー液として用いる場合、水難溶性であるチアベンダゾールの溶解が不可欠の要件となる。
【0004】
本発明は、上記のごとき問題点を解決しかつ要件を満たしたもので、比較的安全で、強い抗菌性を有する抗菌組成物を提供することを目的としている。
【0005】
また本発明は、かかる抗菌組成物を主剤とした経時的に安定なスプレー液を提供することを目的としている。
【0006】
【問題を解決するための手段】
上記目的を達成した本発明の抗菌組成物は、抗菌剤がデヒドロ酢酸ナトリウム(DHA−S)と、ピリチオンナトリウムと、チアベンダゾール(TBZ)とから主としてなり、溶媒がアルコール系溶剤と水との混合系からなることを特徴としている。
【0007】
また本発明の抗菌性スプレー液は、上記抗菌組成物を主剤としたことを特徴としており、特に靴内部の抗菌に適している。
【0008】
【発明の実施の形態】
本発明で使用するデヒドロ酢酸ナトリウム、ピリチオンナトリウム、チアベンダゾールは、いずれも抗菌剤として公知の化合物である。しかし、この三者の組合せ、特にピリチオンナトリウムを第3成分として添加することにより、後述する実施例からも明らかなように、広い抗菌スペクトラムと強い抗菌力が得られる。その理由は必ずしも明らかではないが、デヒドロ酢酸ナトリウムは主に防カビ剤としての役割をし、ピリチオンナトリウムは細菌、酵母にも抗菌力を発揮する抗菌防カビ剤であり、チアベンダゾールは防カビ剤として機能する傍ら、前記両化合物の効力促進用の助剤的な効果も奏しているものと推定される。抗菌剤の組成比は用途に応じて適宜選択すればよく特に制限はないが、抗菌力と溶媒可溶性の観点から、溶媒100に対して外割で、0.5〜3%のデヒドロ酢酸ナトリウムと、0.2〜3%のピリチオンナトリウムと、0.1〜0.6%のチアベンダゾールとするのが望ましい。デヒドロ酢酸ナトリウムは、0.5%未満では抗菌性の持続力低下の問題があり、3%を越えると安定性に問題が生じる。またデヒドロ酢酸ナトリウムと同様な効果を示す化合物である安息香酸塩、プロピオン酸塩、ソルビン酸塩をデヒドロ酢酸ナトリウムの代わりに使用することもできるが、効力の面よりデヒドロ酢酸ナトリウムの使用が望ましい。ピリチオンナトリウムは、0.2%未満では抗菌スペクトラムの減少の問題があり、3%を越えると液への着色の問題が生じる。同様にチアベンダゾールも、0.1%未満では、抗菌スペクトラムの減少の問題があり、0.6%をこえると、溶解性の問題が生じる。総じてこれらの組成比では、下限を下回ると強い抗菌力は得られない。また上限を越えると、後述する溶媒との関係で溶媒不溶の分散系となり、特にスプレー液として使用する場合、スプレーノズルを詰まらせる等の問題が生じる。
【0009】
本発明の溶媒には、低級アルキルアルコールと低級脂肪族グリコールと水との混合系を用いる。本発明は、基本的には水系溶媒であるが、低級アルキルアルコールを添加することにより、抗菌力の即効性を促し、低級脂肪族グリコールの添加により液剤の安定性を付与する。低級アルキルアルコールは、特に制限はないが、安全性の観点からエチルアルコール(エタノール)、イソプロピルアルコール(IPA)等の使用が好ましい。また、低級脂肪族グリコールとしては、プロピレングリコール(PG)、1,2−ブタンジオール、1,2−ペンタンジオール、1,2−ヘキサンジオールの使用が望ましい。中でもPGの使用が安定性の面より特に望ましい。溶媒の組成比は、基本的には特に制限はないが、スプレー液として使用する場合は重要であり、20〜60%の低級アルキルアルコールと、10〜30%の低級脂肪族グリコールと、20〜60%の水とするのが望ましい。低級アルキルアルコールが20%未満では、抗菌効力の即効性に問題があり、60%を上回るとアルコール臭や保存性の問題が生じる。低級脂肪族グリコールが10%未満では、安定性に問題があり、30%を越えるとスプレー後の乾燥性、指触感に問題が生じる。前記有機溶媒との相対比で、水が20%未満でも、60%を越える場合でも、抗菌剤の溶解性や液の安定性等に問題が生じる。
【0010】
前記のごとき本発明の組成物は、抗菌性スプレー液に特に適している。スプレー液として要求される要件のうち、乾燥時間の短縮は低級アルキルアルコールで、保存時の安定性は低級脂肪族グリコールで解消されている。とりわけ靴の中は、トリコフィトン属(Trichophyton Sp.)やスポロスリクス シェンキー(Sporothrix schenckii)、カンディダ アルビカンス(Candida albicans)等の表在性真菌症の原因となる菌が生育しやすい危険な環境である。また、靴下などを媒体として家庭内の雑菌、カビなどが多数持ち込まれやすいきわめて不衛生な場所である。例えば、本発明のスプレー液を1回/日程度少量靴の中に散布すると、白癬菌などの増殖も抑制でき、結果的に水虫の治癒効力を発現する。更に、表在性真菌症の予防にも成る。また、黴や雑菌などが原因となる臭いも解消でき、好適な環境となる。
【0011】
【実施例1−2及び比較例1−5の抗菌液の組成】
表1の組成の各実施例及び比較例抗菌液を、次の手順により調整した。まず、室温にてDHA−Sとピリチオンナトリウムを蒸留水に溶解させた。次いでTBZをIPA/エタノール/PG各量の有機溶媒に加え撹拌した。その後、両溶媒を混ぜ合わせ目的物を調整した。
【0012】
【表1】
【0013】
【試験例1】
表1の実施例1〜2及びは比較例1〜2につき、ペーパーディスクを用いたハローテストを行った。ハローテストの手順はAmerican Association Textile Chemists Colorists(AATCC)のAntimicrobial Committee Report記載のAntimicrobial test and Procedureを参考とした。ペーパーディスクには東洋濾紙製の枝肉の抗菌物質検査用(直径10mm)を用い、滅菌シャーレには積水化学製の滅菌シャーレ90(浅型、直径90mm)を用いた。培地にはそれぞれの菌に適応するポテトデキストロース寒天(PDA)、サブロー寒天、オートミール寒天、Malts extract Ager、酵母用寒天(YM Ager)、標準寒天を用いた。ペーパーディスク上への抗菌液の塗布量は一律50μlとした。テスト結果を表2に示す。
【0014】
【表2】
【0015】
表2から明らかなように、本発明の抗菌組成物は、抗菌剤組成の一つを除いた例に比して、各菌に対して幅広く、高い抗菌効果がある。
【0016】
【試験例2】
表1の実施例1及び比較例3〜5につき、スプレー液としての評価テストを行った。各テストの結果を表3に示す。
【0017】
【表3】
【0018】
表3から明らかなように、本発明の抗菌組成物は、溶媒組成の少なくとも一つを欠いた比較例に比して、沈殿の有無、ノズル詰まりの抑制、乾燥時間、噴霧性能等のスプレー液として必要な特性全般において良好な結果を示すものである。
【0019】
【実施例3−4及び比較例6−7の抗菌性エマルション塗料の組成】
表4の組成の各実施例及び比較例抗菌性エマルション塗料を、次の手順により調整した。まず、室温にてDHA−Sとピリチオンナトリウムを蒸留水に溶解させた。次いで、TBZをIPA/エタノール/PGの有機溶媒に加え撹拌した。その後、両溶液とアクリル系樹脂約40%を含む水系エマルション塗料ベースを混ぜ合わせ目的物を調整した。
【0020】
【表4】
【0021】
【試験例3】
表4の実施例3〜4及び比較例6〜7に関しても試験例1と同様に、ペーパーディスクを用いたハローテストを行った。培地にはPDA培地を用いた。結果を表5に示す。
【0022】
【表5】
【0023】
表5から明らかなように、本発明の抗菌剤は、塗膜として残る樹脂中でも高い抗菌性を示すものである。実施例3は実施例4及び比較例6〜7に比して、スペクトラムが広く、且つ高いカビ抵抗性を示す。また、保存菌株だけでなく野生菌株に対しても高い抗菌性を示す。
【0024】
【発明の効果】
本発明の抗菌組成物によれば、次記のごとき利点があり、抗菌防カビ性を必要とする多くの分野に適用できる。またスプレー液では、靴用としてだけでなく手軽な抗菌を求める分野に適応できる。
(1)低毒性で抗菌力が強い。
(2)抗菌スペクトラムがデヒドロ酢酸ナトリウム系としては格段広い。
(3)溶液が経時的に変色しない。
(4)抗菌剤の析出、沈殿がなく、スプレー液として優れている。
(5)塗膜(樹脂)中でも安定した抗菌性を示す。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an antibacterial composition, particularly an antibacterial composition suitable for an antibacterial spray solution.
[0002]
[Prior art]
Conventionally, a low-toxic antibacterial agent based on sodium dehydroacetate is widely known. However, many of its uses are water-based inks and the like, which do not require strong antibacterial power. In order to improve these points, an antibacterial and antifungal composition in which a benzimidazole compound is added to sodium dehydroacetate to try to improve antibacterial properties is also known (Japanese Patent Publication No. 61-36723, Japanese Patent Application Laid-Open No. 55). -87709).
[0003]
[Problems to be solved by the invention]
However, both sodium dehydroacetate and benzimidazole compounds such as thiabendazole have the advantage of low toxicity as acceptable as food additives, but their effectiveness is inherently limited. Moreover, when using these as a spray liquid, melt | dissolution of the thiabendazole which is poorly water-soluble becomes an indispensable requirement.
[0004]
The present invention is intended to solve the above-described problems and satisfy the requirements, and to provide an antibacterial composition that is relatively safe and has strong antibacterial properties.
[0005]
Another object of the present invention is to provide a spray solution that is stable over time using such an antibacterial composition as a main ingredient.
[0006]
[Means for solving problems]
The antibacterial composition of the present invention that achieves the above object is mainly composed of sodium dehydroacetate (DHA-S), sodium pyrithione, and thiabendazole (TBZ), and the solvent is a mixed system of an alcohol solvent and water. It is characterized by consisting of.
[0007]
The antibacterial spray liquid of the present invention is characterized by having the above-mentioned antibacterial composition as a main ingredient, and is particularly suitable for antibacterial activity inside shoes.
[0008]
DETAILED DESCRIPTION OF THE INVENTION
Sodium dehydroacetate, sodium pyrithione and thiabendazole used in the present invention are all known compounds as antibacterial agents. However, by adding these three combinations, particularly pyrithione sodium as the third component, a broad antibacterial spectrum and strong antibacterial activity can be obtained, as will be apparent from the examples described later. The reason is not necessarily clear, but sodium dehydroacetate mainly serves as a fungicide, pyrithione sodium is an antibacterial fungicide that also exerts antibacterial activity against bacteria and yeast, and thiabendazole is a fungicide. While functioning, it is presumed that there is also an auxiliary effect for promoting efficacy of both compounds. The composition ratio of the antibacterial agent is not particularly limited as long as it is appropriately selected depending on the application. 0.2 to 3% sodium pyrithione and 0.1 to 0.6% thiabendazole are desirable. When sodium dehydroacetate is less than 0.5%, there is a problem of a decrease in antibacterial durability, and when it exceeds 3%, there is a problem in stability. In addition, benzoate, propionate, and sorbate, which are compounds having the same effect as sodium dehydroacetate, can be used in place of sodium dehydroacetate, but use of sodium dehydroacetate is desirable from the standpoint of efficacy. When sodium pyrithione is less than 0.2%, there is a problem of a decrease in the antibacterial spectrum, and when it exceeds 3%, there is a problem of coloring the liquid. Similarly, if thiabendazole is less than 0.1%, there is a problem of a decrease in the antibacterial spectrum, and if it exceeds 0.6%, a solubility problem occurs. In general, when these composition ratios are below the lower limit, strong antibacterial activity cannot be obtained. When the upper limit is exceeded, a solvent-insoluble dispersion system is formed in relation to the solvent described later, and particularly when used as a spray solution, problems such as clogging of the spray nozzle occur.
[0009]
As the solvent of the present invention, a mixed system of a lower alkyl alcohol, a lower aliphatic glycol and water is used. Although the present invention is basically an aqueous solvent, the addition of a lower alkyl alcohol promotes the immediate effect of antibacterial activity, and the addition of a lower aliphatic glycol imparts the stability of the liquid agent. The lower alkyl alcohol is not particularly limited, but use of ethyl alcohol (ethanol), isopropyl alcohol (IPA) or the like is preferable from the viewpoint of safety. As the lower aliphatic glycol, it is desirable to use propylene glycol (PG), 1,2-butanediol, 1,2-pentanediol, or 1,2-hexanediol. Among these, use of PG is particularly desirable from the viewpoint of stability. The composition ratio of the solvent is basically not particularly limited, but is important when used as a spray liquid, and is 20 to 60% lower alkyl alcohol, 10 to 30% lower aliphatic glycol, and 20 to 20%. 60% water is desirable. If the lower alkyl alcohol is less than 20%, there is a problem in the immediate effect of the antibacterial effect. If the lower aliphatic glycol is less than 10%, there is a problem in stability, and if it exceeds 30%, problems occur in the drying property after spraying and the touch feeling. Even if the water is less than 20% or more than 60% relative to the organic solvent, problems arise in the solubility of the antibacterial agent and the stability of the liquid.
[0010]
The compositions of the present invention as described above are particularly suitable for antibacterial spray solutions. Among the requirements for spray solutions, shortening of drying time is eliminated with lower alkyl alcohols, and stability during storage is eliminated with lower aliphatic glycols. In particular, in shoes, there is a dangerous environment in which bacteria that cause superficial mycosis such as Trichophyton Sp., Sporothrix schenckii, and Candida albicans are likely to grow. In addition, it is a very unsanitary place where a lot of germs and molds in the home are easily brought in using socks as a medium. For example, when the spray solution of the present invention is sprayed into a small amount of shoes about once / day, the growth of ringworms can be suppressed, and as a result, the healing effect of athlete's foot is exhibited. Furthermore, it also prevents superficial mycosis. In addition, it is possible to eliminate odors caused by sputum and bacteria, which is a suitable environment.
[0011]
Composition of antibacterial solution of Example 1-2 and Comparative Example 1-5
Each Example and Comparative Example antibacterial solution having the composition shown in Table 1 was prepared by the following procedure. First, DHA-S and sodium pyrithione were dissolved in distilled water at room temperature. Subsequently, TBZ was added to each amount of the organic solvent of IPA / ethanol / PG and stirred. Thereafter, both solvents were mixed to prepare the target product.
[0012]
[Table 1]
[0013]
[Test Example 1]
A halo test using a paper disk was performed for Examples 1 and 2 and Comparative Examples 1 and 2 in Table 1. The procedure of the hello test was based on the Antibiotic Test and Procedure described in the American Commitment Report of the American Association Textiles Colorists (AATCC). For the paper disk, Toyo Filter Paper carcass for antibacterial substance test (diameter 10 mm) was used, and for the sterilization dish, Sekisui Chemical sterilization dish 90 (shallow type, diameter 90 mm) was used. As the medium, potato dextrose agar (PDA), Sabouraud agar, oatmeal agar, Malts extract Ager, agar for yeast (YM Ager), and standard agar were used. The application amount of the antibacterial liquid on the paper disk was uniformly 50 μl. The test results are shown in Table 2.
[0014]
[Table 2]
[0015]
As is apparent from Table 2, the antibacterial composition of the present invention has a broad and high antibacterial effect for each bacterium compared to the example except one of the antibacterial agent compositions.
[0016]
[Test Example 2]
About Example 1 of Table 1 and Comparative Examples 3-5, the evaluation test as a spray liquid was done. The results of each test are shown in Table 3.
[0017]
[Table 3]
[0018]
As is apparent from Table 3, the antibacterial composition of the present invention has a spray liquid, such as the presence or absence of precipitation, suppression of nozzle clogging, drying time, and spray performance, as compared with the comparative example lacking at least one of the solvent compositions. As a result, good results are shown in all necessary characteristics.
[0019]
Composition of antibacterial emulsion paint of Example 3-4 and Comparative Example 6-7
Each Example and Comparative Example antibacterial emulsion paint having the composition shown in Table 4 was prepared by the following procedure. First, DHA-S and sodium pyrithione were dissolved in distilled water at room temperature. Subsequently, TBZ was added to an organic solvent of IPA / ethanol / PG and stirred. Thereafter, both solutions and an aqueous emulsion paint base containing about 40% acrylic resin were mixed to prepare a target product.
[0020]
[Table 4]
[0021]
[Test Example 3]
Regarding Examples 3 to 4 and Comparative Examples 6 to 7 in Table 4, as in Test Example 1, a halo test using a paper disk was performed. PDA medium was used as the medium. The results are shown in Table 5.
[0022]
[Table 5]
[0023]
As is clear from Table 5, the antibacterial agent of the present invention exhibits high antibacterial properties even in the resin remaining as a coating film. Example 3 has a broad spectrum and high mold resistance as compared with Example 4 and Comparative Examples 6-7. In addition, it exhibits high antibacterial properties not only against stored strains but also against wild strains.
[0024]
【The invention's effect】
The antibacterial composition of the present invention has the following advantages and can be applied to many fields that require antibacterial and antifungal properties. In addition, spray liquid can be applied not only for shoes but also for fields that require simple antibacterial properties.
(1) Low toxicity and strong antibacterial activity.
(2) The antibacterial spectrum is much wider than that of sodium dehydroacetate.
(3) The solution does not change color over time.
(4) There is no precipitation and precipitation of antibacterial agents, and it is excellent as a spray liquid.
(5) Stable antibacterial properties are exhibited even in a coating film (resin).
Claims (2)
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JP2001136717A JP4587137B2 (en) | 2000-03-31 | 2001-03-29 | Antibacterial composition |
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JP2001136717A JP4587137B2 (en) | 2000-03-31 | 2001-03-29 | Antibacterial composition |
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US20140038933A1 (en) * | 2012-07-31 | 2014-02-06 | Arch Chemicals, Inc. | Composition and Method For Preventing Discoloration of Pyrithione Containing Compositions |
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US20160135465A1 (en) * | 2013-06-20 | 2016-05-19 | Arch Chemicals, Inc. | Building Materials Having Antifungal Properties |
CN112616848A (en) | 2013-11-19 | 2021-04-09 | 奥麒化工股份有限公司 | Enhanced preservatives |
TWI652074B (en) * | 2016-08-09 | 2019-03-01 | 大日本除蟲菊股份有限公司 | Anti-mold agent composition, anti-mold spray product and anti-mildew method |
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JPS5520753A (en) * | 1978-08-02 | 1980-02-14 | Nippon Synthetic Chem Ind Co Ltd:The | Antibacterial and antimold composition |
JPS5587707A (en) * | 1978-12-26 | 1980-07-02 | Nippon Synthetic Chem Ind Co Ltd:The | Anti-bacterial, anti-fungal composition |
JPH09273073A (en) * | 1996-04-01 | 1997-10-21 | Toyobo Co Ltd | Processing of textile product having biological resistance |
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