JP4583079B2 - Mold prevention method for pulp sheet - Google Patents
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パルプシートの防カビ方法に関するものである。詳しく述べると、内添された防カビ化合物のパルプへの歩留まり率を向上させ、長期間にわたって防カビ効果が発揮されるパルプシートへの防カビ方法に関するものである。 The present invention relates to a mold prevention method for pulp sheets. More specifically, the present invention relates to a mold prevention method for a pulp sheet that improves the yield ratio of the internally added mold prevention compound to the pulp and exhibits the mold prevention effect over a long period of time.
製紙会社等で生産されるパルプは、直ちに紙となる場合もあるが、生産等の関係で一旦、パルプシートして保管する場合が多い。保管する場合、保管状況によるがパルプにカビ等の微生物が繁殖し、その製品価値が損なわれる。そこで、従来から防カビ剤を使用し、カビ等の微生物の発育を抑制していた。また、防カビ剤の添加方法としては、作業の安全性および作業効率からパルプシートに抄き込む内添法が一般的に採用されている。 Pulp produced by a paper manufacturer or the like may become paper immediately, but is often stored once as a pulp sheet due to production or the like. In the case of storage, depending on the storage conditions, microorganisms such as mold propagate on the pulp, and the product value is impaired. Therefore, conventionally, an antifungal agent has been used to suppress the growth of microorganisms such as mold. Further, as a method for adding a fungicide, an internal addition method in which it is incorporated into a pulp sheet is generally employed in view of work safety and work efficiency.
パルプシートに内添する防カビ剤は、その防カビ効果を充分に発揮させるためには、防カビ剤化合物の良好な防カビ効果と共にパルプシートへの高い歩留まり率が要求される。一般的にパルプスラリーに対する防カビ剤の添加濃度は経済性を考慮すると約０．１〜１．０ｐｐｍである。この添加濃度では、水微溶性の防カビ剤原体は水に溶解してしまい、水側での溶出分が多くパルプへの高い歩留まり率は期待できない。そこで水不溶の防カビ化合物としてテトラクロロイソフタロニトリル（通称ダコニール）を配合した防カビ剤が販売されている。 The antifungal agent internally added to the pulp sheet is required to have a high yield rate to the pulp sheet together with the good antifungal effect of the antifungal compound in order to sufficiently exhibit the antifungal effect. Generally, the concentration of the fungicide added to the pulp slurry is about 0.1 to 1.0 ppm in view of economy. At this added concentration, the water-soluble antifungal agent base is dissolved in water, and the amount of elution on the water side is large, and a high yield rate to the pulp cannot be expected. Therefore, an antifungal agent containing tetrachloroisophthalonitrile (commonly called daconyl) as a water-insoluble antifungal compound is on the market.
しかしながら、テトラクロロイソフタルニトリルは、ＰＲＴＲ法該当物質で環境問題も含め、製紙会社等では、使用しない方向にある。ＰＲＴＲ法非該当物質で良好な防カビ効果を発揮する防カビ剤は存在する。これらは水溶性または水微溶性の防カビ剤であるが、パルプスラリーに対して０．１〜１．０ｐｐｍを添加した場合、薬剤は完全に溶解してしまいパルプへの高い歩留まり率は期待できない。このためパルプに対して長期間防カビ効果を発揮できず、パルプ内添用防カビ剤として使用することが困難である。 However, tetrachloroisophthalonitrile is a substance that is subject to the PRTR Law and is not used by paper manufacturers, including environmental problems. There are anti-fungal agents that exhibit a good anti-fungal effect with non-PRTR substances. These are water-soluble or slightly water-soluble fungicides, but when 0.1 to 1.0 ppm is added to the pulp slurry, the drug is completely dissolved and a high yield rate to the pulp cannot be expected. . For this reason, the fungicidal effect cannot be exhibited for a long time with respect to a pulp, and it is difficult to use it as a fungicide for pulp internal addition.
したがって、本発明の目的は、従来、パルプ内添用防カビ剤として使用が困難であった水微溶性の防カビ剤を用い、パルプへの歩留まり率を向上させ、パルプに対して長期間防カビ効果が発揮されるパルプシートの防カビ方法を提供することにある。 Therefore, the object of the present invention is to use a slightly water-soluble fungicidal agent that has been difficult to use as an anti-mold additive for pulp internally, to improve the yield rate in the pulp and to prevent long-term protection against the pulp. An object of the present invention is to provide a mildewproofing method for a pulp sheet that exhibits a mildew effect.
上記目的は、下記（１）〜（５）により達成される。 The above object is achieved by the following (1) to (5).
（１） 防カビ剤のマイクロカプセルをパルプスラリーに添加してパルプシートを製造することを特徴とするパルプシートの防カビ方法。 (1) An antifungal method for a pulp sheet, which comprises adding a microcapsule of an antifungal agent to a pulp slurry to produce a pulp sheet.
（２） マイクロカプセルを使用したパルプスラリーの濾液をパルプシート製造工程で循環させることを特徴とする前記（１）に記載のパルプシートの防カビ方法。 (2) The pulp sheet mold prevention method as described in (1) above, wherein the pulp slurry filtrate using microcapsules is circulated in the pulp sheet production process.
（３） 該防カビ剤が２−オクチル−４−イソチアゾリン−３−オンである前記（１）または（２）に記載のパルプシートの防カビ方法。 (3) The antifungal method for pulp sheets according to (1) or (2), wherein the antifungal agent is 2-octyl-4-isothiazolin-3-one.
（４） 該防カビ剤のマイクロカプセルをパルプスラリー中に該防カビ剤重量で０．０１〜１ｐｐｍ添加することを特徴とする前記（１）〜（３）のいずれか一つに記載のパルプシートの防カビ方法。 (4) The pulp as described in any one of (1) to (3) above, wherein 0.01 to 1 ppm of the fungicide microcapsule is added to the pulp slurry by the weight of the fungicide. Mold prevention method for sheets.
（５） マイクロカプセル化された２−オクチル−４−イソチアゾリン−３−オンとマイクロカプセル化された３−ヨード−２−プロピニルブチルカーバメートまたはマイクロカプセル化された４，５−ジクロロ−２−オクチル−４−イソチアゾリン−３−オンを混合してまたは別々にパルプスラリーに添加してパルプシートを製造することを特徴とするパルプシートの防カビ方法。 (5) Microencapsulated 2-octyl-4-isothiazolin-3-one and microencapsulated 3-iodo-2-propynylbutylcarbamate or microencapsulated 4,5-dichloro-2-octyl- A pulp sheet mold prevention method, wherein 4-isothiazolin-3-one is mixed or separately added to a pulp slurry to produce a pulp sheet.
以上述べたように、本発明によれば、従来、パルプ内添用防カビ剤として使用が困難であった水微溶性の防カビ剤を用い、パルプの歩留まり率を向上させ、パルプに対して長期間にわたって防カビ効果が発揮できるパルプシートの防カビ方法を得られるのである。 As described above, according to the present invention, conventionally, a mildly water-soluble fungicide that has been difficult to use as an anti-mold additive for pulp is used to improve the yield rate of pulp and It is possible to obtain a mildewproofing method for a pulp sheet that can exhibit a fungicidal effect over a long period of time.
本発明によるパルプシートの防カビ方法は、防カビ剤のマイクロカプセルを、パルプスラリーに添加してパルプシートを製造することにより行なわれるものである。 The method for preventing mold of a pulp sheet according to the present invention is performed by adding a microcapsule of a mold inhibitor to a pulp slurry to produce a pulp sheet.
本発明で用いられるマイクロカプセル化されるべき防カビ剤原体としては、特に制限されるものではないが、２−オクチル−４−イソチアゾリン−３−オン、２，３，５，６−テトラクロロ−４−（メチルスルホニル）ピリジン、４，５−ジクロロ−２−オクチル−４−イソチアゾリン−３−オン、３−ヨード−２−プロピニルブチルカーバメイト、２−ベンズイミダゾールカルバミン酸メチルエステル、メチレンビスチオシアネート、Ｎ−（フルオロジクロロメチルチオ）−フタルイミド、３−メチル−４−クロロフェノール、４−クロロ−３，５−ジメチルフェノール、テトラメチルチウラムジスルフィド等が挙げられ、その１種または２種以上が用いられる。これらの防カビ剤原体のなかで良好な防カビ効果が発揮される２−オクチル−４−イソチアゾリン−３−オンを用いることが望ましい。 The antifungal agent to be microencapsulated for use in the present invention is not particularly limited, but 2-octyl-4-isothiazolin-3-one, 2,3,5,6-tetrachloro -4- (methylsulfonyl) pyridine, 4,5-dichloro-2-octyl-4-isothiazolin-3-one, 3-iodo-2-propynylbutylcarbamate, 2-benzimidazolecarbamic acid methyl ester, methylenebisthiocyanate, N- (fluorodichloromethylthio) -phthalimide, 3-methyl-4-chlorophenol, 4-chloro-3,5-dimethylphenol, tetramethylthiuram disulfide and the like can be mentioned, and one or more of them are used. Of these antifungal agents, it is desirable to use 2-octyl-4-isothiazolin-3-one that exhibits a good antifungal effect.
複数種のマイクロカプセル化防カビ剤の組合わせの例としては、例えばマイクロカプセル化２−オクチル−４−イソチアゾリン−３−オンと、マイクロカプセル化３−ヨード−２−プロピニルブチルカーバメートおよび／またはマイクロカプセル化４，５−ジクロロ−２−オクチル−４−イソチアゾリン−３−オンとの組合わせ等がある。 Examples of combinations of multiple types of microencapsulated fungicides include, for example, microencapsulated 2-octyl-4-isothiazolin-3-one and microencapsulated 3-iodo-2-propynylbutylcarbamate and / or micro And combinations with encapsulated 4,5-dichloro-2-octyl-4-isothiazolin-3-one.
マイクロカプセル化する壁膜剤としては、防カビ剤原体をマイクロカプセル化するものであればよく、特に制限されるものではない。このようなものとして例えば、アクリル酸エステル（例えば、アクリル酸メチル、アクリル酸エチル、アクリル酸イソプロピル、アクリル酸ブチル等）、メタクリル酸エステル（例えば、メタクリル酸メチル、メタクリル酸エチル、メタクリル酸イソプロピル、メタクリル酸ブチル等）、酢酸ビニル、スチレン−ジビニルベンゼン、ポリイソシアネート−ポリオール、イソチアネート、酸クロリド＋ポリオール、有機アミン＋酸アマイド＋水溶性エポキシ化合物、尿素＋ホルムアルデヒドプレポリマー、尿素＋ホルムアルデヒド＋ポリアクリル酸、アミノプラスト樹脂プレポリマー＋界面活性剤、メラミン−ホルムアルデヒドプレポリマー、複素環状アミン＋アルデヒド、ゼラチン−アラビアゴム、ポリ乳酸などがある。 The wall film agent to be microencapsulated is not particularly limited as long as it can microencapsulate the antifungal agent base. For example, acrylic acid esters (eg, methyl acrylate, ethyl acrylate, isopropyl acrylate, butyl acrylate, etc.), methacrylic acid esters (eg, methyl methacrylate, ethyl methacrylate, isopropyl methacrylate, methacrylic acid) Acid butyl, etc.), vinyl acetate, styrene-divinylbenzene, polyisocyanate-polyol, isothiocyanate, acid chloride + polyol, organic amine + acid amide + water-soluble epoxy compound, urea + formaldehyde prepolymer, urea + formaldehyde + polyacrylic acid, Examples include aminoplast resin prepolymer + surfactant, melamine-formaldehyde prepolymer, heterocyclic amine + aldehyde, gelatin-gum arabic, and polylactic acid.
本発明における防カビ剤を含む芯物質と壁膜材の好ましい割合については特に限定されないが、長期間防カビ効果を持続させるためには壁膜材は多いことが好ましいが、速効性を考慮すると壁膜材は少ないことが好ましい。芯物質と壁膜材の好ましい重量比は１：５〜１：０．０１であるが、速効性および持続性を考慮した場合には１：２〜１：０．１であることが好ましい。 The preferred ratio of the core material containing the antifungal agent and the wall film material in the present invention is not particularly limited, but in order to maintain the antifungal effect for a long period of time, it is preferable that the wall film material is large, but considering the rapid effect It is preferable that the wall film material is small. A preferable weight ratio of the core substance to the wall film material is 1: 5 to 1: 0.01, but it is preferably 1: 2 to 1: 0.1 in consideration of quick action and sustainability.
また、本発明のマイクロカプセル化防カビ剤の使用方法としては、特に制限はないが、水または有機溶剤に分散させて製剤化したものを用いるのが好ましい。製剤化する際、増粘剤、防錆剤、界面活性剤、消泡剤、凍結防止剤を用いることができる。これらは、１種で用いてもよいし、２種以上用いてもよい。また、本発明のマイクロカプセル化防カビ剤を２種または、他の防カビ剤を含んでいてもよい。 Further, the method for using the microencapsulated antifungal agent of the present invention is not particularly limited, but it is preferable to use a microcapsule that has been formulated by dispersing in water or an organic solvent. When formulating, a thickener, a rust inhibitor, a surfactant, an antifoaming agent, and an antifreezing agent can be used. These may be used alone or in combination of two or more. Further, the microencapsulated antifungal agent of the present invention may contain two kinds or other antifungal agents.
このようにして得られたマイクロカプセル化防カビ剤は、通常パルプスラリーに有効な量添加し、撹拌後、濾過してパルプシートを作成する。パルプスラリー中のパルプの濃度は、通常０．５〜２．０重量である。また、前記マイクロカプセル化防カビ剤の有効量は、乾燥パルプ当り０．５〜２００ｐｐｍ、好ましくは、１０〜１００ｐｐｍである。すなわち、０．５ｐｐｍ未満では、防カビ効果が不十分であり、一方、２００ｐｐｍを越えると防カビ処理費用がかかりすぎ、現実的ではないからである。また、該パルプスラリー中のマイクロカプセル化防カビ剤の濃度は、重量で０．０１〜１ｐｐｍであり、好ましくは、０．１〜１ｐｐｍである。 The microencapsulated antifungal agent thus obtained is usually added in an effective amount to the pulp slurry, stirred and then filtered to prepare a pulp sheet. The density | concentration of the pulp in a pulp slurry is 0.5 to 2.0 weight normally. The effective amount of the microencapsulated antifungal agent is 0.5 to 200 ppm, preferably 10 to 100 ppm per dry pulp. That is, if the amount is less than 0.5 ppm, the antifungal effect is insufficient, while if it exceeds 200 ppm, the antifungal treatment cost is excessive and is not realistic. Moreover, the density | concentration of the microencapsulation antifungal agent in this pulp slurry is 0.01-1 ppm by weight, Preferably, it is 0.1-1 ppm.
つぎに実施例により本発明をさらに詳細に説明するが、本発明はこれら例によってなんら限定されるものではない。また、実施例に示される製薬有効成分の化合物名と略称を以下に示す。なお、下記例における「％」は、特にことわらない限り「重量％」を意味する。 EXAMPLES Next, although an Example demonstrates this invention further in detail, this invention is not limited at all by these examples. In addition, the compound names and abbreviations of the active pharmaceutical ingredients shown in the examples are shown below. In the following examples, “%” means “% by weight” unless otherwise specified.
２−オクチル−４−イソチアゾリン−３−オン（ＯＩＴ）
３−ヨード−２−プロピニルブチルカーバメート（ＩＰＢＣ）
４，５−ジクロロ−２−オクチル−４−イソチアゾリン−３−オン（ＤＣＯＩＴ）
防カビ剤のマイクロカプセル化
製造例１
スチレン−無水マレイン酸樹脂（モンサント社 スクリプセット ５２０）を５％水溶液に調整し、ｐＨを酢酸にて４．５〜５．０に調整した液１５０ｇにＯＩＴを１５０ｇ加え、平均粒径が１０μｍになるまで撹拌した。得られた乳化物に、メラミン樹脂（住友化学工業株式会社 Ｓｕｍｉｔｅｘ Ｒｅｓｉｎ Ｍ−３）５０％水溶液を５０ｇ滴下し、６５℃で２時間撹拌してメラミン樹脂被膜のマイクロカプセル化したＯＩＴ液を得た。
2-Octyl-4-isothiazolin-3-one (OIT)
3-Iodo-2-propynyl butyl carbamate (IPBC)
4,5-dichloro-2-octyl-4-isothiazolin-3-one (DCOIT)
Microencapsulation of fungicides Production Example 1
Styrene-maleic anhydride resin (Monsanto Corporation Script Set 520) was adjusted to a 5% aqueous solution, 150 g of OIT was added to 150 g of a solution whose pH was adjusted to 4.5 to 5.0 with acetic acid, and the average particle size was adjusted to 10 μm. Stir until. 50 g of 50% aqueous solution of melamine resin (Sumitex Resin M-3) was dropped into the obtained emulsion and stirred at 65 ° C. for 2 hours to obtain an OIT solution in which the melamine resin coating was microencapsulated. .
製造例２
ゼラチン６．６ｇおよびアラビアゴム４．４ｇを水６０ｇに溶解させ、その液にＯＩＴを９０ｇ加えて粒子径が２０μｍになるまで撹拌した。得られた液に水３００ｇを加えて希釈し、１０％の酢酸水溶液によってｐＨを４．０に調整した。
Production Example 2
6.6 g of gelatin and 4.4 g of gum arabic were dissolved in 60 g of water, 90 g of OIT was added to the solution, and the mixture was stirred until the particle size became 20 μm. The obtained liquid was diluted with 300 g of water, and the pH was adjusted to 4.0 with a 10% aqueous acetic acid solution.
その液を１０℃まで冷却した後、ホルマリン２．７５ｇを投入し、さらに１０％炭酸ナトリウム水溶液でｐＨを８．８まで上昇させた。室温に戻して２時間撹拌し、ゼラチン−アラビアゴム皮膜のマイクロカプセル化したＯＩＴ液を得た。 After cooling the solution to 10 ° C., 2.75 g of formalin was added, and the pH was further increased to 8.8 with a 10% aqueous sodium carbonate solution. After returning to room temperature and stirring for 2 hours, an OIT solution in which a gelatin-gum arabic film was encapsulated was obtained.
製造例３
スチレン−無水マレイン酸樹脂（モンサント社 スクリプセット ５２０）を５％水溶液に調整し、ｐＨを酢酸にて４．５〜５．０に調整した液１５０ｇにＩＰＢＣ １０％溶液を９３ｇ加え、平均粒径が１０μｍになるまで撹拌した。得られた乳化物に、メラミン樹脂（住友化学工業株式会社 Ｓｕｍｉｔｅｘ Ｒｅｓｉｎ Ｍ−３）５０％水溶液を５０ｇ滴下し、６５℃で２時間撹拌してメラミン樹脂被膜のマイクロカプセル化したＩＰＢＣ液を得た。
Production Example 3
A styrene-maleic anhydride resin (Monsanto Corporation Script Set 520) was adjusted to a 5% aqueous solution, and 93 g of an IPBC 10% solution was added to 150 g of a solution whose pH was adjusted to 4.5 to 5.0 with an acetic acid. The mixture was stirred until 10 μm. 50 g of a 50% aqueous solution of melamine resin (Sumitex Resin M-3) was dropped into the obtained emulsion and stirred at 65 ° C. for 2 hours to obtain an IPBC solution in which the melamine resin coating was microencapsulated. .
製造例４
スチレン−無水マレイン酸樹脂（モンサント社 スクリプセット５２０）を５％水溶液に調整し、ｐＨを酢酸にて４．５〜５．０に調整した液１５０ｇにＤＣＯＩＴ（ローム・アンド・ハース・ジャパン株式会社 ＫＡＴＨＯＮ ２８７ＰＸＥ）を５０ｇ加え、平均粒径が１０μｍになるまで撹拌した。得られた乳化物に、メラミン樹脂（住友化学工業株式会社 Ｓｕｍｉｔｅｘ Ｒｅｓｉｎ Ｍ−３）５０％水溶液を５０ｇ滴下し、６５℃で２時間撹拌してメラミン樹脂被膜のマイクロカプセル化したＤＣＯＩＴ液を得た。
Production Example 4
A styrene-maleic anhydride resin (Monsanto Corporation Script Set 520) was adjusted to a 5% aqueous solution, and the pH was adjusted to 4.5 to 5.0 with acetic acid to 150 g of DCOIT (Rohm and Haas Japan Co., Ltd.) 50 g of KATHON 287PXE) was added and stirred until the average particle size was 10 μm. 50 g of a 50% aqueous solution of melamine resin (Sumitex Resin M-3) was dropped into the obtained emulsion and stirred at 65 ° C. for 2 hours to obtain a DCOIT liquid in which the melamine resin coating was microencapsulated. .
試験例１
パルプスラリーに対する歩留まり率の測定
１％のパルプスラリーにマイクロカプセル化した防カビ剤と比較対象としてマイクロカプセル化していない防カビ剤を絶乾パルプあたり有効成分濃度が３０ｐｐｍになるようにそれぞれ添加した。撹拌後、濾過してパルプシートを作成した。そのパルプシートから有効成分を抽出し、液体高速クロマトグラフにより有効成分濃度を求め歩留まり率を測定した。結果を表１に示す
Test example 1
Measurement of Yield Ratio for Pulp Slurry Antifungal agent microencapsulated in 1% pulp slurry and antifungal agent not microencapsulated as a comparison target were added so that the active ingredient concentration was 30 ppm per absolutely dry pulp. After stirring, it was filtered to prepare a pulp sheet. The active ingredient was extracted from the pulp sheet, the active ingredient concentration was determined by liquid high-speed chromatograph, and the yield rate was measured. The results are shown in Table 1.
表１の結果からは、マイクロカプセル化した防カビ剤と、比較対象としたのマイクロカプセル化していない防カビ剤と比較してパルプシートに対する歩留まり率が高いことが認められた。 From the results shown in Table 1, it was confirmed that the yield rate with respect to the pulp sheet was higher than that of the microencapsulated antifungal agent and the antifungal agent that was not microencapsulated.
試験例２
パルプスラリー濾液循環試験
１％のパルプスラリーに、マイクロカプセル化ＯＩＴ（製造例１）を絶乾パルプあたり有効成分濃度が５０ｐｐｍになるように添加した。該スラリーを撹拌後、濾過し、パルプシートを作成した。パルプシート作成時に発生した濾液を用いて新たに１％パルプスラリーを調整し、マイクロカプセル化ＯＩＴを絶乾パルプあたり５０ｐｐｍになるように添加した。該スラリーを撹拌後、濾過し、パルプシートを作成した。この濾過循環工程を６回繰り返し各工程で作成したパルプシートから有効成分を抽出し、液体高速クロマトグラフにより有効成分濃度を求め歩留まり率を測定した。結果を表２
に示す
Test example 2
Pulp Slurry Filtrate Cycling Test Microcapsulated OIT (Production Example 1) was added to 1% pulp slurry so that the active ingredient concentration per absolutely dry pulp was 50 ppm. The slurry was stirred and then filtered to prepare a pulp sheet. A 1% pulp slurry was newly prepared using the filtrate generated at the time of pulp sheet preparation, and microencapsulated OIT was added to 50 ppm per absolutely dry pulp. The slurry was stirred and then filtered to prepare a pulp sheet. This filtration and circulation process was repeated 6 times, the active ingredients were extracted from the pulp sheet prepared in each process, the active ingredient concentration was determined by liquid high-speed chromatograph, and the yield rate was measured. Table 2 shows the results.
Shown in
表２の結果から、パルプシート作成時に発生する濾液を循環させることによって、パルプシートに対する歩留まり率が飛躍的に上昇することが認められた。 From the results shown in Table 2, it was recognized that the yield rate with respect to the pulp sheet was dramatically increased by circulating the filtrate generated at the time of producing the pulp sheet.
試験例３
防カビ試験
１％パルプスラリーにマイクロカプセル化ＯＩＴ（製造例１）を絶乾パルプ当り、それぞれ有効成分濃度が３０、４０および５０ｐｐｍになるように添加した。該スラリーを撹拌後、濾過し、パルプシートを作成した。作成したパルプシートを予めシャーレに固化滅菌させておいたＪＩＳ Ｚ ２９１１の無機寒天培地に貼り付け、その後、供試菌（Ａｓｐｌｕｇｌｕｓ ｎｉｇｅｒ）の胞子懸濁液をマイクロスプレーで塗布した。２８±２℃で培養し、経過日数毎にカビの発育状態を観察した。また、比較対象としてマイクロカプセル化しないＯＩＴおよびＴＰＮも同様に試験をした。結果を表３に示す。
Test example 3
Anti-fungal test Microcapsulated OIT (Production Example 1) was added to 1% pulp slurry so that the active ingredient concentration was 30, 40, and 50 ppm per dry pulp, respectively. The slurry was stirred and then filtered to prepare a pulp sheet. The prepared pulp sheet was affixed to an inorganic agar medium of JIS Z 2911 that had been solidified and sterilized in a petri dish in advance, and then a spore suspension of the test bacteria (Aspulus niger) was applied by microspray. The cells were cultured at 28 ± 2 ° C., and the growth state of the mold was observed every elapsed day. In addition, OIT and TPN that were not microencapsulated were also tested in a similar manner. The results are shown in Table 3.
表３より明らかなように、マイクロカプセル化したＯＩＴが他の防カビ剤原体と比較し、高い防カビ効果認められる。 As apparent from Table 3, the microencapsulated OIT has a higher antifungal effect than other antifungal agents.
試験例４
薬剤相乗効果試験
１％パルプスラリーに、マイクロカプセル化ＯＩＴ（ＭＣＯＩＴ（製造例１））、マイクロカプセル化ＤＣＯＩＴ（ＭＣＤＣＯＩＴ（製造例４））およびマイクロカプセル化ＩＰＢＣ（ＭＣＩＰＢＣ（製造例３））を、それぞれ絶乾パルプ当り有効成分濃度が計２０ｐｐｍになるように添加した。該スラリーを撹拌後、濾過し、パルプシートを作成した。作成したパルプシートを予めシャーレに固化滅菌させておいたＪＩＳ Ｚ ２９１１の無機寒天培地に貼り付け、その後、供試菌（Ａｓｐｌｕｇｌｕｓ ｎｉｇｅｒ）の胞子懸濁液をマイクロスプレーで塗布した。２８±２℃で培養し、経過日数毎にカビの発育状態を観察した。結果を表４に示す。
Test example 4
Drug synergistic effect test To 1% pulp slurry, microencapsulated OIT (MCOIT (Production Example 1)), microencapsulated DCOIT (MCDCOIT (Production Example 4)) and microencapsulated IPBC (MCIPBC (Production Example 3)), Each was added so that the active ingredient concentration per absolute dry pulp was 20 ppm in total. The slurry was stirred and then filtered to prepare a pulp sheet. The prepared pulp sheet was affixed to an inorganic agar medium of JIS Z 2911 that had been solidified and sterilized in a petri dish in advance, and then a spore suspension of the test bacteria (Aspulus niger) was applied by microspray. The cells were cultured at 28 ± 2 ° C., and the growth state of the mold was observed every elapsed day. The results are shown in Table 4.
表４から明らかなように、ＭＣＯＩＴは、他のマイクロカプセル化防カビ剤（例えば、ＭＣＩＰＢＣ、ＭＣＤＣＯＩＴ等）との併用により相乗効果を発揮し、高い防カビ効果が認められる。 As is apparent from Table 4, MCOIT exhibits a synergistic effect when used in combination with other microencapsulated antifungal agents (for example, MCIPBC, MCDCOIT, etc.), and a high antifungal effect is observed.
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| JP2003055117A (en) * | 2001-08-16 | 2003-02-26 | Katayama Chem Works Co Ltd | Rot/fungus-proofing method for wet pulp and rot/fungus- proofing composition therefor |
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| JPH05320002A (en) * | 1992-05-19 | 1993-12-03 | Kureha Chem Ind Co Ltd | Microcapsulated natimicrobial agent |
| JPH0782109A (en) * | 1993-09-16 | 1995-03-28 | Toppan Moore Co Ltd | Antibacterial agent encapsulated in microcapsule |
| JP2003055117A (en) * | 2001-08-16 | 2003-02-26 | Katayama Chem Works Co Ltd | Rot/fungus-proofing method for wet pulp and rot/fungus- proofing composition therefor |
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