JP4571408B2 - 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン - Google Patents

癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン Download PDF

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JP4571408B2
JP4571408B2 JP2003557380A JP2003557380A JP4571408B2 JP 4571408 B2 JP4571408 B2 JP 4571408B2 JP 2003557380 A JP2003557380 A JP 2003557380A JP 2003557380 A JP2003557380 A JP 2003557380A JP 4571408 B2 JP4571408 B2 JP 4571408B2
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cancer
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cells
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JP2005527487A (ja
JP2005527487A5 (US07981874-20110719-C00313.png
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ラルフ エー． ジンガロ
エミール エル． フライライヒ
ヘイチス デュケイル
アゴプ カンタルジャン
スルジャン ベルストフセク
メリンダ ソテロ−レルマ
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University of Texas System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/72—Aliphatic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2003557380A 2002-01-07 2003-01-07 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン Expired - Lifetime JP4571408B2 (ja)

Applications Claiming Priority (2)

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US34649202P 2002-01-07 2002-01-07
PCT/US2003/000281 WO2003057012A2 (en) 2002-01-07 2003-01-07 S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Related Child Applications (1)

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JP2009279362A Division JP5603593B2 (ja) 2002-01-07 2009-12-09 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン

Publications (3)

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JP2005527487A JP2005527487A (ja) 2005-09-15
JP2005527487A5 JP2005527487A5 (US07981874-20110719-C00313.png) 2006-08-17
JP4571408B2 true JP4571408B2 (ja) 2010-10-27

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JP2003557380A Expired - Lifetime JP4571408B2 (ja) 2002-01-07 2003-01-07 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン
JP2009279362A Expired - Fee Related JP5603593B2 (ja) 2002-01-07 2009-12-09 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン
JP2013172071A Pending JP2013237701A (ja) 2002-01-07 2013-08-22 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン
JP2015051753A Pending JP2015120745A (ja) 2002-01-07 2015-03-16 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン

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JP2009279362A Expired - Fee Related JP5603593B2 (ja) 2002-01-07 2009-12-09 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン
JP2013172071A Pending JP2013237701A (ja) 2002-01-07 2013-08-22 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン
JP2015051753A Pending JP2015120745A (ja) 2002-01-07 2015-03-16 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン

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US (4) US6911471B2 (US07981874-20110719-C00313.png)
EP (3) EP2462932A1 (US07981874-20110719-C00313.png)
JP (4) JP4571408B2 (US07981874-20110719-C00313.png)
AU (1) AU2003207455B2 (US07981874-20110719-C00313.png)
CA (1) CA2472633C (US07981874-20110719-C00313.png)
WO (1) WO2003057012A2 (US07981874-20110719-C00313.png)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4571408B2 (ja) * 2002-01-07 2010-10-27 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン
AU2011204901B2 (en) * 2004-07-16 2013-09-12 Board Of Regents, The University Of Texas System Compounds and methods for treatment of cancer
TWI411431B (zh) * 2004-07-16 2013-10-11 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
EP2394702B1 (en) * 2005-07-29 2014-12-31 Ziopharm Oncology, Inc. Compounds and methods for the treatment of cancer
WO2007082104A2 (en) * 2006-01-13 2007-07-19 The Texas A & M University System Compounds and methods for the treatment of cancer
TW200829261A (en) * 2006-09-29 2008-07-16 Ziopharm Oncology Inc Method for controlling angiogenesis in animals
JP5301449B2 (ja) * 2006-11-01 2013-09-25 ニューサウス イノベイションズ ピーティーワイ リミテッド 有機アルセノキシド化合物およびその使用
KR20100100835A (ko) * 2007-11-02 2010-09-15 지오팜 온콜로지 인코포레이티드 유기 비소제와의 병용 요법
CN104592302A (zh) * 2007-12-12 2015-05-06 日本苏爱康制药有限公司 用于治疗癌症的化合物和方法
BRPI0912175A2 (pt) * 2008-05-28 2015-10-06 Basf Se métodos para diagnosticar indução de enzima do fígado, para determinar se um composto é capaz de induzir indução de enzima do fígado em um indivíduo, e para identificar uma substância para tratar indução de enzima do fígado
EP2321012B1 (en) 2008-08-20 2018-10-10 Solasia Pharma K.K. Organoarsenic compounds and methods for the treatment of cancer
CA2800260C (en) * 2010-04-19 2013-07-09 Sri International Compositions and method for the treatment of multiple myeloma
CN105899486A (zh) * 2013-12-05 2016-08-24 日本苏爱康制药有限公司 用于治疗癌症的化合物和方法
CN112941027B (zh) * 2021-03-19 2021-11-02 苏州大学 二甲基亚胂酸致人角质形成细胞恶性转化细胞株及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2349729A (en) * 1940-08-24 1944-05-23 Parke Davis & Co Therapeutic arsenic preparation
US2701812A (en) * 1951-06-26 1955-02-08 Dainippon Pharmaceutical Co Diarylarsenious acid derivatives and the preparation thereof
DE3229565A1 (de) * 1982-08-07 1984-02-16 Etschenberg, Eugen, Dr., 5000 Köln Arsenhaltige nucleoside
FR2640269B1 (fr) * 1988-12-13 1991-03-15 Maes Ludo Composes organometalliques, leurs modes de preparation et compositions pharmaceutiques les contenant
US6875451B2 (en) 1997-10-15 2005-04-05 Polarx Biopharmaceuticals Inc. Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds
PL343868A1 (en) 1997-11-10 2001-09-10 Sloan Kettering Inst Cancer Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol
CN1233476A (zh) * 1998-04-24 1999-11-03 陆道培 治疗急性白血病的药物及其制备方法
EP1002537A1 (en) 1998-10-30 2000-05-24 Assistance Publique, Hopitaux De Paris Use of melarsoprol for the manufacture of a medicament for treating B-cell lymphoproliferative diseases, such as multiple myeloma
US6191123B1 (en) 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
AUPQ296799A0 (en) * 1999-09-20 1999-10-14 Unisearch Limited A cell-membrane impermeable trivalent organoarsenical derivative and use thereof
DE60118172T2 (de) 2000-04-26 2007-03-08 Oregon Health Sciences University, Portland Verabreichung von einer chemoschützenden verbindung,welche eine thiolgruppe enthält
AUPR379801A0 (en) 2001-03-19 2001-04-12 Unisearch Limited Use of a substantially cell membrane impermeable compound for treating arthritis
AUPR598901A0 (en) 2001-06-28 2001-07-19 Unisearch Limited Inhibition of angiogenesis by targeting protein tyrosine phosphatases
CA2417008A1 (en) 2001-07-06 2003-01-16 Cochlear Limited Configuration of implanted devices
JP4571408B2 (ja) * 2002-01-07 2010-10-27 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 癌治療薬としての、ｓ−ジメチルアルシノ−チオコハク酸、ｓ−ジメチルアルシノ−２−チオ安息香酸、ｓ−（ジメチルアルシノ）グルタチオン
ES2330519T3 (es) 2002-11-07 2009-12-11 Newsouth Innovations Pty Limited Inducion de la transicion de permeabilidad mitocondrial.
TWI411431B (zh) 2004-07-16 2013-10-11 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
JP5301449B2 (ja) 2006-11-01 2013-09-25 ニューサウス イノベイションズ ピーティーワイ リミテッド 有機アルセノキシド化合物およびその使用

Also Published As

Publication number Publication date
WO2003057012A8 (en) 2004-04-01
AU2003207455B2 (en) 2007-09-20
JP2013237701A (ja) 2013-11-28
JP2005527487A (ja) 2005-09-15
EP2462932A1 (en) 2012-06-13
JP2015120745A (ja) 2015-07-02
US6995188B2 (en) 2006-02-07
AU2003207455A1 (en) 2003-07-24
US20040034095A1 (en) 2004-02-19
US20050131062A1 (en) 2005-06-16
EP1474128A4 (en) 2006-05-03
US20080090904A1 (en) 2008-04-17
EP2420229A1 (en) 2012-02-22
AU2003207455A2 (en) 2003-07-24
EP1474128A2 (en) 2004-11-10
WO2003057012A2 (en) 2003-07-17
JP2010090149A (ja) 2010-04-22
US7619000B2 (en) 2009-11-17
EP1474128B1 (en) 2016-06-01
JP5603593B2 (ja) 2014-10-08
US20060189687A1 (en) 2006-08-24
CA2472633C (en) 2014-07-08
CA2472633A1 (en) 2003-07-17
US6911471B2 (en) 2005-06-28
WO2003057012A3 (en) 2004-07-08

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