JP4554736B2 - Non-invasive blood analyzer - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a non-invasive blood analyzer that non-invasively measures biological component information.
[0002]
[Prior art]
With a simple device configuration, a transmission image of a blood vessel that fits a part of a living body such as a finger is obtained. Devices that attempt to measure invasively have been devised (for example, International Publication No. WO97 / 24066, International Publication No. WO99 / 00053). In such a non-invasive blood analyzer, blood components and the like have been calculated using a certain function regardless of age, sex, and the like. However, tissue characteristics differ depending on age and sex, and accurate blood component concentrations may not be calculated.
[0003]
[Problems to be solved by the invention]
[0004]
[Problems to be solved by the invention]
The present invention, these circumstances has been made in consideration of, providing a non-invasive blood analyzer capable of obtaining an accurate blood hemoglobin concentrations against gender different subjects.
[0005]
[Means for Solving the Problems]
An input unit for inputting the sex of the subject, a light source unit for irradiating the subject's body with light, a light receiving unit for receiving optical information from the subject's body irradiated with light by the light source unit, By extracting the concentration profile in the direction perpendicular to the blood vessel in the analysis region set based on the optical information received by the light receiving unit, and quantifying the concentration profile extracted by the extracting unit a quantifying unit for calculating the density profile values, the function indicating the correlation between the concentration profile values and blood hemoglobin concentration, a storage unit for storing each for each gender gender, each said storage unit stores of function, using the function corresponding to the subject's sex input by the input unit, the subject from the density profile values calculated by the quantification unit Provided by a calculation unit for calculating the blood hemoglobin concentration, the non-invasive blood analyzer and an output unit for outputting the blood hemoglobin concentration in the subject calculated by the calculation unit.
[0006]
DETAILED DESCRIPTION OF THE INVENTION
In the biopsy device of the present invention, the living body is a mammal that combines humans, and a part of the living body is not a tissue separated from the living body, but a part of the tissue as it is, such as a finger or an ear. Softness is given.
[0007]
The detection unit of the present invention includes a light source unit, a light receiving unit, and a holding unit.
As the light source unit, a semiconductor laser (hereinafter referred to as LD), LED, or halogen light source can be used, and it may be irradiated directly to a part of the living body or through a fiber. The wavelength is preferably in the range of 600 to 950 nm, which penetrates biological tissue and does not absorb water.
[0008]
The light receiving unit can be composed of an optical system such as a lens and a light receiving element such as a photodiode or a CCD. When a CCD is used for the light receiving element, concentration distribution information of the blood vessel portion can be obtained. As the light receiving element, a line sensor or a photodiode array can be used in addition to the CCD.
It is also possible to obtain density distribution information by driving one photodiode in a direction crossing the blood vessel.
[0009]
The optical system of the light receiving unit may be configured using only a TV lens when a CCD is used as the light receiving element.
[0010]
In order to obtain more suitable optical information, the detection unit preferably includes a holding member for holding the light source unit and the light receiving unit with respect to a part of the living body. When a part of the living body is, for example, a finger of a human hand, the holding member may be a member that releasably holds the finger between the light source unit and the light receiving unit. A system in which the finger is inserted into a hole or groove that matches the shape of the finger, or a system in which the finger is sandwiched from both sides by a movable piece can be used.
[0011]
The analysis unit can cause the output unit to display, as an analysis result, information about blood and time-series data of information arbitrarily selected from the obtained optical information of the same person. Information on blood is information on blood and blood flow, specifically blood vessel diameter, blood component concentration (eg, hemoglobin, hematocrit, etc.), blood component concentration ratio (eg, oxygenation rate, etc.), etc. . The analysis unit can use a microcomputer including a CPU, a ROM, a RAM, and an I / O port and a commercially available personal computer in order to analyze optical information.
[0012]
The output unit can use a display device such as a CRT or a liquid crystal display, or a printing device such as a printer.
[0013]
The operation unit can be composed of a keyboard or a numeric keypad that can input subject information (gender, age, etc.), measurement data, and the like. When attribute information such as gender is entered, a function according to the sex of male, female, etc., for example, X: concentration profile value, Y: hemoglobin value, Y = f (X) = aX + b function is calculated. Hemoglobin values corresponding to the attributes of men and women can be obtained. Also, the subject's attribute information (name, gender, date of birth) is temporarily stored in a storage medium such as a PC card, the subject's attribute information is called from the storage medium, and the hemoglobin value is calculated based on a function corresponding to the attribute. It is also possible to calculate blood component information such as
[0014]
【Example】
Hereinafter, the present invention will be described in detail based on embodiments shown in the drawings. This does not limit the invention.
FIG. 1 is a block diagram showing the configuration of a non-invasive blood analyzer used in the present invention, which can measure blood vessel width, blood component concentration and oxygenation rate. In FIG. 1, a detection unit 1 includes a light source unit 11 for illuminating a part of a living body (here, a human finger) that joins blood vessels, and an optical image (here, a transmitted light image) of the illuminated biological part. A light receiving unit 12 for imaging is provided.
[0015]
When the measurement key is pressed after the subject's attribute information or the like is input from the operation unit 35, the light source unit 11 is turned on, and a light-transmitting image is obtained by the light receiving unit 12. The transmission image obtained by the light receiving unit 12 is analyzed by the feature extraction unit 31 via the connectors 7 and 8, the feature point of the living body (finger 16) is calculated, and the feature point stored by the storage unit 32 is compared. The comparison is made by the unit 33, and the analysis region is set by the analysis region setting unit 34.
[0016]
Next, the profile extraction unit 21 creates a concentration profile in a direction perpendicular to the blood vessel in the analysis region, and the concentration profile of the portion is quantified by the quantification unit 22 to a peak height, a half width, or the like.
[0017]
Using this quantified value, based on the function stored in the storage unit 32 according to the subject's attributes, the calculation unit 23 calculates the blood vessel width, blood component concentration (hemoglobin, hematocrit), and oxygenation rate. calculate.
[0018]
These measurement results are stored in the recording unit 25, and the stored data can be displayed as time-series data as a graph or a table by the output unit 24.
[0019]
FIG. 2 is an external perspective view of the apparatus shown in FIG. 1 and shows a state in which the detection unit 1 is placed on the placement unit 4 of the analysis unit. The detection unit 1 includes an arm 5 and a housing 6. A light source unit 11 is built in the arm 5, and a light receiving unit (lens and CCD) is built in the housing 6 to face the arm 5. A finger 16 is held between the arm 5 and the housing 6, and the finger 16 is irradiated with light, and the transmitted light is received by the light receiving unit as a transmitted image. The analysis unit 3 includes a personal computer, and can process information and images related to blood from optical information. An output unit (liquid crystal monitor) 24 for blood related information is connected to the analysis unit 3 by a hinge 10 and can be folded. The operation unit 35 can input subject information and data, and can switch display. The analysis unit 3 has an insertion port 36 for an external storage medium, and an external storage medium can be inserted to record measurement results and the like.
[0020]
FIG. 3 is a diagram showing the relationship between √A / W (concentration profile value) of the non-invasive blood analyzer and the Hgb value (hemoglobin value) of the collected blood measured by the blood analyzer. The X-axis represents √A / W (concentration profile value), the Y-axis represents the blood collection Hgb value, x represents a male subject, and ◯ represents a female subject. If a regression line is created using this plot, Y = f (X) = 34.248X-5.7578 (N = 57) is obtained. Using this function, the Hgb value of the non-invasive blood analyzer was obtained, and a correlation diagram between the Hgb value obtained by measuring the collected blood with the blood analyzer and the Hgb value of the non-invasive blood analyzer is shown in FIG. The X-axis represents the blood collection Hgb value, the Z-axis represents the Hgb value of the non-invasive blood analyzer, x represents a plot of a male subject, and ◯ represents a plot of a female subject. The correlation coefficient at this time was R ² = 0.7038, and the regression line Z = 0.8827X + 1.7106 (N = 57).
[0021]
Similarly, FIG. 5 is a graph showing the relationship between √A / W (concentration profile value) of a non-invasive blood analyzer and the Hgb value obtained by measuring the collected blood with a blood analyzer. FIG. 6 shows a plot of only female subjects. The X axis is √A / W (concentration profile value), and the Y axis is the blood collection Hgb value. The regression line obtained from FIG. 5 is Y = f (X) = 20.051X + 9.8993 (N = 35), and the regression line obtained from FIG. 6 is Y = f (X) = 15.642X + 9.3549 (N = 22). Using these functions for male subjects and functions dedicated to female subjects, the Hgb value of the non-invasive blood analyzer is obtained, and the Hgb value obtained by measuring the collected blood with the blood analyzer and the Hgb value of the non-invasive blood analyzer. The correlation diagram is shown in FIG. The X axis represents the blood collection Hgb value, the Z axis represents the Hgb value of the non-invasive blood analyzer, x represents a male subject, and ◯ represents a female subject. The correlation coefficient at this time was R ² = 0.7742 and the regression line Z = 0.9996X + 0.0932 (N = 57).
[0022]
Thus, the correlation diagram of FIG. 7 using separate functions for male and female subjects has a better correlation coefficient than the correlation diagram of FIG. 4 using a mixed function of male and female subjects. Thus, the coefficient of the regression line is close to 1. That is, it has been found that a more accurate Hgb value can be obtained in the non-invasive blood analyzer by using the function of the separate concentration profile values of the male subject and the female subject.
Moreover, since the characteristics of the tissue differ depending on the age, similarly, it is possible to obtain more accurate biological information by using a function for each age.
[0023]
【The invention's effect】
According to the present invention, in the non-invasive blood analyzer, a plurality of functions indicating the correlation between the concentration profile value corresponding to each attribute (gender and age) and the blood hemoglobin concentration are prepared, and the function is selected from among them. By using this function , a more accurate blood hemoglobin concentration can be obtained.
[Brief description of the drawings]
FIG. 1 is a block diagram showing a configuration of an embodiment of the present invention.
FIG. 2 is a perspective view showing an outer shape of an embodiment of the present invention.
FIG. 3 is a diagram showing a correlation diagram of an embodiment of the present invention.
FIG. 4 is a diagram showing a correlation diagram of an embodiment of the present invention.
FIG. 5 is a diagram showing a correlation diagram of an embodiment of the present invention.
FIG. 6 is a diagram showing a correlation diagram of an embodiment of the present invention.
FIG. 7 is a diagram showing a correlation diagram of an embodiment of the present invention.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Detection part 2 Data processing part 3 Analysis part 11 Light source part 12 Light receiving part 21 Extraction part 22 Quantification part 23 Calculation part 24 Output part 25 Storage part 31 Feature extraction part 32 Storage part 33 Comparison part 34 Analysis area setting part 35 Operation part

Claims (1)

An input unit for inputting the sex of the subject, a light source unit for irradiating the subject's body with light, a light receiving unit for receiving optical information from the subject's body irradiated with light by the light source unit, By extracting the concentration profile in the direction perpendicular to the blood vessel in the analysis region set based on the optical information received by the light receiving unit, and quantifying the concentration profile extracted by the extracting unit a quantifying unit for calculating the density profile values, the function indicating the correlation between the concentration profile values and blood hemoglobin concentration, a storage unit for storing each for each gender gender, each said storage unit stores of function, using the function corresponding to the subject's sex input by the input unit, the subject from the density profile values calculated by the quantification unit A calculation unit for calculating the blood hemoglobin concentration, non-invasive blood analyzer and an output unit for outputting the blood hemoglobin concentration in the subject calculated by the calculation unit.

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