JP2000271105A - Non-invasive blood analyzer - Google Patents
Non-invasive blood analyzerInfo
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- JP2000271105A JP2000271105A JP11078127A JP7812799A JP2000271105A JP 2000271105 A JP2000271105 A JP 2000271105A JP 11078127 A JP11078127 A JP 11078127A JP 7812799 A JP7812799 A JP 7812799A JP 2000271105 A JP2000271105 A JP 2000271105A
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- Prior art keywords
- living body
- analyzing
- subject
- light
- unit
- Prior art date
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Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、無侵襲的に生体成
分情報を計測する無侵襲血液分析装置に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a non-invasive blood analyzer for non-invasively measuring biological component information.
【０００２】[0002]
【従来の技術】簡単な装置構成で指などの生体の一部に
合まれる血管の透過像を得、これを画像解析することに
よって血管サイズやヘモグロビン濃度およびヘマトクリ
ットのような血液成分の濃度を経皮的、非侵襲的に計測
しようとする装置が考案されている（例えば、国際公開
第ＷＯ９７／２４０６６号公報、国際公開第ＷＯ９９／
０００５３号公報）。このような非侵襲血液分析装置で
は、年齢や性別等に関係なく、一定の関数を用いて、血
液成分などの算出を行ってきた。しかしながら、年齢や
性別により、組織の特性が異なり、正確な血液成分濃度
の算出が行えないことがあった。2. Description of the Related Art A transmission image of a blood vessel fitted to a part of a living body such as a finger is obtained with a simple apparatus configuration, and the image is analyzed to determine the blood vessel size, hemoglobin concentration, and blood component concentration such as hematocrit. Devices for percutaneous and non-invasive measurement have been devised (for example, WO 97/24066, WO 99/24066).
00005 publication). In such a noninvasive blood analyzer, blood components and the like have been calculated using a certain function regardless of age, gender, or the like. However, the characteristics of the tissue differ depending on the age and gender, and it may not be possible to calculate the blood component concentration accurately.
【０００３】[0003]
【０００４】この発明は、このような事情を考慮してな
されたもので、無侵襲血液分析装置において性別や年齢
において適切な関数を設け、正確な血液成分濃度を得よ
うとする無侵襲血液分析装置を提供するものである。[0004] The present invention has been made in view of such circumstances, and a noninvasive blood analyzer which provides an appropriate function for sex and age in a noninvasive blood analyzer to obtain an accurate blood component concentration. An apparatus is provided.
【０００５】[0005]
【課題を解決するための手段】検査対象とする生体に光
を供給するための光源部と、光を受けた生体から光学情
報を受光する受光部と、光学情報を解析する解析部と、
解析部により得られた生体情報を出力する出力部と、被
験者の属性等を入力する入力部を備え、解析部には複数
の関数が記憶されており、被験者の属性に応じた関数を
もちいて生体情報を算出し出力部に出力することを特徴
とする。A light source unit for supplying light to a living body to be inspected, a light receiving unit for receiving optical information from the living body receiving the light, an analyzing unit for analyzing the optical information,
An output unit that outputs biological information obtained by the analysis unit, and an input unit that inputs the attributes of the subject and the like are provided. The analysis unit stores a plurality of functions, and uses a function corresponding to the attributes of the subject. It is characterized in that biological information is calculated and output to an output unit.
【０００６】[0006]
【発明の実施の形態】この発明の生体検査用装置におい
て、生体とはヒトを合む哺乳動物であり、生体の一部と
は生体から分離した組織ではなく、生体のありのままの
組織の一部であり、例えば指や耳柔などがあげられる。BEST MODE FOR CARRYING OUT THE INVENTION In the living body examination apparatus of the present invention, a living body is a mammal including a human, and a part of the living body is not a tissue separated from the living body but a part of a tissue as it is. For example, a finger or a soft ear may be used.
【０００７】本発明品の検出部は、光源部と受光部およ
び保持部から構成される。光源部には、半導体レーザ
（以下、ＬＤ）やＬＥＤあるいはハロゲン光源が使用で
き、直接生体の一部に照射してもよいし、ファイバーを
介して照射してもよい。波長としては生体組織を透過
し、水の吸収が大きくない６００〜９５０ｎｍの範囲に
あることが好ましい。The detecting section of the product of the present invention comprises a light source section, a light receiving section, and a holding section. A semiconductor laser (hereinafter, LD), LED, or halogen light source can be used for the light source unit, and the light source unit may directly irradiate a part of the living body or irradiate through a fiber. The wavelength is preferably in the range of 600 to 950 nm, which transmits through the living tissue and does not absorb much water.
【０００８】受光部は、レンズなどの光学系とフォトダ
イオードやＣＣＤなどの受光素子から構成できる。受光
部素子にＣＣＤを用いると、血管部分の濃度分布情報が
得られる。受光素子としては、ＣＣＤの他にラインセン
サーやフォトダイオード・アレイが使用できる。また、
フォトダイオード１個を血管を横切る方向に駆動させて
濃度分布情報を得ることもできる。The light receiving section can be constituted by an optical system such as a lens and a light receiving element such as a photodiode or a CCD. When a CCD is used as the light receiving element, density distribution information of a blood vessel portion can be obtained. As the light receiving element, a line sensor or a photodiode array can be used in addition to the CCD. Also,
The density distribution information can be obtained by driving one photodiode in a direction crossing the blood vessel.
【０００９】受光部の光学系は、受光素子にＣＣＤを用
いる場合、単にＴＶ用レンズだけを用いて構成してもよ
い。In the case where a CCD is used as the light receiving element, the optical system of the light receiving section may be configured using only a TV lens.
【００１０】また、検出部はより好適な光学情報を得る
ために、光源部と受光部を生体の一部に対して保持する
ための保持部材を備えることが好ましい。生体の一部が
例えばヒトの手の指である場合には、保持部材は光源部
と受光部との間にその指を離脱可能に保持するような部
材であればよく、それには、指を指の形状に合わせた穴
や溝に挿入させる方式のものや、指を可動片で両側から
挟む方式のものを用いることができる。[0010] In addition, in order to obtain more preferable optical information, the detecting section preferably includes a holding member for holding the light source section and the light receiving section to a part of the living body. When a part of the living body is a finger of a human hand, for example, the holding member may be a member that detachably holds the finger between the light source unit and the light receiving unit. A type in which the finger is inserted into a hole or groove corresponding to the shape of the finger, or a type in which the finger is sandwiched between the movable pieces from both sides can be used.
【００１１】解析部は、得られた同一人の複数の光学情
報から血液に関する情報および任意に選択された情報の
時系列データを解析結果として出力部に表示させること
ができる。血液に関する情報とは、血液や血流に関する
情報であって、具体的には血管径や血液成分濃度（例え
ば、ヘモグロビン、ヘマトクリット等）、血液成分濃度
比（例えば、酸素化率等）などである。また、解析部
は、光学情報を解析するために、ＣＰＵ、ＲＯＭ、ＲＡ
ＭおよびＩ／Ｏポートからなるマイクロコンピュータ並
びに市販のパーソナルコンピュータを利用できる。[0011] The analysis unit can display on the output unit, as a result of analysis, blood-related information and time-series data of arbitrarily selected information from the obtained plurality of optical information of the same person. The information relating to blood is information relating to blood or blood flow, and specifically includes blood vessel diameter, blood component concentration (eg, hemoglobin, hematocrit, etc.), blood component concentration ratio (eg, oxygenation rate, etc.), and the like. . In addition, the analysis unit includes a CPU, a ROM, and an RA for analyzing optical information.
A microcomputer comprising M and I / O ports and a commercially available personal computer can be used.
【００１２】出力部は、ＣＲＴや液晶ディスプレイなど
の表示装置や、プリンタ等の印字装置を利用できる。The output unit can use a display device such as a CRT or a liquid crystal display, or a printing device such as a printer.
【００１３】操作部は、被験者情報（性別、年齢等）や
測定データ等を入力できるキーボードまたはテンキーか
ら構成することができる。性別等の属性情報を入力する
と、男性、女性等の性別に応じた関数、例えば、X:濃度
プロファイル値、Y:ヘモグロビン値とすると、Y=f(X)=a
X+bの関数が算出され、男性、女性別の属性に応じたヘ
モグロビン値が得られる。また、ＰＣカードなどの記憶
媒体に被験者の属性情報（名前、性別、生年月日）を一
旦記憶させておき、記憶媒体から被験者の属性情報を呼
出し、属性に応じた関数に基づいて、ヘモグロビン値な
どの血液成分情報を算出することも可能である。The operation unit can be composed of a keyboard or numeric keypad capable of inputting subject information (sex, age, etc.) and measurement data. When attribute information such as gender is input, a function corresponding to gender of male, female, etc., for example, X: concentration profile value, Y: hemoglobin value, Y = f (X) = a
The function of X + b is calculated, and the hemoglobin value according to the attribute of each of the male and female is obtained. The subject's attribute information (name, gender, date of birth) is once stored in a storage medium such as a PC card, the subject's attribute information is called from the storage medium, and the hemoglobin value is determined based on a function corresponding to the attribute. It is also possible to calculate blood component information such as.
【００１４】[0014]
【実施例】以下、図面に示す実施例に基づいてこの発明
を詳述する。これによってこの発明が限定されるもので
はない。図１はこの発明に用いられる無侵襲血液分析装
置の構成図を示すブロック図であり、血管幅、血液成分
濃度および酸素化率を計測できる。図１において、検出
部１は、血管を合む生体の一部（ここではヒトの指）を
照明するための光源部１１と、照明された生体部分の光
像（ここでは透過光像）を撮像する受光部１２を備え
る。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail with reference to the embodiments shown in the drawings. This does not limit the present invention. FIG. 1 is a block diagram showing a configuration diagram of a non-invasive blood analyzer used in the present invention, which can measure a blood vessel width, a blood component concentration, and an oxygenation rate. In FIG. 1, a detection unit 1 includes a light source unit 11 for illuminating a part of a living body (here, a human finger) that fits a blood vessel, and a light image (here, a transmitted light image) of the illuminated living body part. A light receiving unit 12 for imaging is provided.
【００１５】操作部３５より被験者の属性情報等が入力
された後、測定キーが押されると、光源部１１が点灯
し、受光部１２によって血管の透過像が得られる。受光
部１２で得られた透過像はコネクタ７，８を介して特徴
抽出部３１で解析され、生体（指１６）の特徴点が算出
され、これと記憶部３２によって記憶された特徴点が比
較部３３によって、比較され、解析領域設定部３４によ
って解析領域が設定される。When the measurement key is pressed after the attribute information of the subject is input from the operation unit 35, the light source unit 11 is turned on, and the light-receiving unit 12 obtains a transmitted image of the blood vessel. The transmission image obtained by the light receiving unit 12 is analyzed by the feature extraction unit 31 via the connectors 7 and 8, the feature points of the living body (finger 16) are calculated, and this is compared with the feature points stored by the storage unit 32. The comparison is performed by the unit 33, and the analysis region is set by the analysis region setting unit 34.
【００１６】次に、プロファイル抽出部２１によって、
解析領域内で血管に垂直な方向の濃度プロファイルが作
成され、その部分の濃度プロファイルが定量化部２２に
よって、ピーク高や半値幅などに定量化される。Next, the profile extracting unit 21
A concentration profile in a direction perpendicular to the blood vessel is created in the analysis region, and the concentration profile of that portion is quantified by the quantification unit 22 into a peak height, a half width, and the like.
【００１７】この定量化された値を使用して、被験者の
属性に応じて記憶部３２に保存してある関数に基づい
て、演算部２３によって血管幅、血液成分濃度（ヘモグ
ロビン、ヘマトクリット）、酸素化率を計算する。Using this quantified value, the blood vessel width, blood component concentration (hemoglobin, hematocrit), oxygen, and the like are calculated by the calculation unit 23 based on the function stored in the storage unit 32 according to the attribute of the subject. Calculate the conversion rate.
【００１８】これらの計測結果は記録部２５に記憶さ
れ、記憶されたデータは出力部２４によって時系列デー
タとしてグラフや表として表示できる。These measurement results are stored in the recording unit 25, and the stored data can be displayed as time series data as a graph or a table by the output unit 24.
【００１９】図２は図ｌに示す装置の外観斜視図であ
り、検出部１を解析部の載置部４に載置した状態を示し
ている。検出部１はアーム５とハウジング６からなり、
アーム５内に光源部１１、アーム５に対向してハウジン
グ６内に受光部（レンズおよびＣＣＤ）を内蔵してい
る。アーム５とハウジング６の間に指１６を保持し、指
１６に光を照射してその透過光を透過像として受光部で
受光するようになっている。解析部３はパーソナルコン
ピュータからなり、光学情報からの血液に関する情報や
画像を処理することができる。血液に関する情報を出力
部（液晶モニター）２４は、ヒンジ１０で解析部３に繋
がっており、折り畳むことができる。操作部３５は被験
者情報やデータ等の入力や、表示の切換ができる。解析
部３には外部記憶媒体の挿入口３６があり、外部記憶媒
体を挿入し、測定結果等を記録できる。FIG. 2 is an external perspective view of the apparatus shown in FIG. 1, showing a state in which the detection unit 1 is mounted on the mounting unit 4 of the analysis unit. The detection unit 1 includes an arm 5 and a housing 6,
A light source unit 11 is provided in the arm 5, and a light receiving unit (lens and CCD) is built in the housing 6 so as to face the arm 5. A finger 16 is held between the arm 5 and the housing 6, and the light is irradiated on the finger 16 and the transmitted light is received by the light receiving unit as a transmitted image. The analysis unit 3 includes a personal computer, and can process information and images related to blood from optical information. The output section (liquid crystal monitor) 24 for blood information is connected to the analysis section 3 by the hinge 10 and can be folded. The operation unit 35 can input subject information, data, and the like, and can switch display. The analysis unit 3 has an insertion port 36 for an external storage medium, and an external storage medium can be inserted therein to record a measurement result and the like.
【００２０】図３は無侵襲血液分析装置の√A/W（濃度
プロファイル値）と採血した血液を血液分析装置で測定
したＨｇｂ値（ヘモグロビン値）との関係を示した図で
ある。Ｘ軸が√A/W（濃度プロファイル値）、Ｙ軸が採
血Ｈｇｂ値であり、×が男性被験者、○が女性被験者を
表している。このプロット図を用いて、回帰直線を作成
すると、Y=f(X)=34.248X-5.7578（N=57）と得られる。
この関数を用いて、無侵襲血液分析装置のＨｇｂ値を求
め、採血した血液を血液分析装置で測定したＨｇｂ値と
無侵襲血液分析装置のＨｇｂ値の相関図を図４に示し
た。Ｘ軸が採血Ｈｇｂ値、Ｚ軸が無侵襲血液分析装置の
Ｈｇｂ値であり、×が男性被験者、○が女性被験者のプ
ロットを示したものである。このときの相関係数はR2=
0.7038であり、回帰直線Z=0.8827X+1.7106（N=57）であ
った。FIG. 3 is a graph showing the relationship between ΔA / W (concentration profile value) of the noninvasive blood analyzer and the Hgb value (hemoglobin value) of the collected blood measured by the blood analyzer. The X axis is ΔA / W (concentration profile value), the Y axis is the blood collection Hgb value, X represents a male subject, and ○ represents a female subject. When a regression line is created using this plot, Y = f (X) = 34.248X-5.7578 (N = 57) is obtained.
Using this function, the Hgb value of the noninvasive blood analyzer was determined, and the correlation diagram between the Hgb value of the collected blood measured by the blood analyzer and the Hgb value of the noninvasive blood analyzer is shown in FIG. The X axis is the blood collection Hgb value, the Z axis is the Hgb value of the non-invasive blood analyzer, X is a plot of a male subject, and ○ is a plot of a female subject. The correlation coefficient at this time is R 2 =
0.7038, and the regression line was Z = 0.8827X + 1.7106 (N = 57).
【００２１】同様に無侵襲血液分析装置の√A/W（濃度
プロファイル値）と採血した血液を血液分析装置で測定
したＨｇｂ値との関係を示した図において、男性被験者
のみをプロットしたものを図５に、女性被験者のみをプ
ロットしたものを図６に示した。Ｘ軸が√A/W（濃度プ
ロファイル値）、Ｙ軸が採血Ｈｇｂ値である。図５から
得られた回帰直線はY=f(X)=20.051X+9.8993（N=35）と
なり、図６から得られた回帰直線はY=f(X)=15.642X+9.3
549（N=22）となる。これらの男性被験者用の関数と女
性被験者専用の関数を用いて、無侵襲血液分析装置のＨ
ｇｂ値を求め、採血した血液を血液分析装置で測定した
Ｈｇｂ値と無侵襲血液分析装置のＨｇｂ値の相関図を図
７に示した。Ｘ軸が採血Ｈｇｂ値、Ｚ軸が無侵襲血液分
析装置のＨｇｂ値であり、×が男性被験者、○が女性被
験者を表している。このときの相関係数はR2=0.7742で
あり、回帰直線Z=0.9996X+0.0932（N=57）であった。Similarly, in the graph showing the relationship between the ΔA / W (concentration profile value) of the noninvasive blood analyzer and the Hgb value of the collected blood measured by the blood analyzer, only the male subjects are plotted. FIG. 5 shows a plot of only female subjects in FIG. The X axis is ΔA / W (concentration profile value), and the Y axis is the blood collection Hgb value. The regression line obtained from FIG. 5 is Y = f (X) = 20.051X + 9.8993 (N = 35), and the regression line obtained from FIG. 6 is Y = f (X) = 15.642X + 9.3.
549 (N = 22). Using these functions for male subjects and those for female subjects, the H
The gb value was determined, and a correlation diagram between the Hgb value obtained by measuring the collected blood with a blood analyzer and the Hgb value of a noninvasive blood analyzer is shown in FIG. The X axis represents the blood collection Hgb value, the Z axis represents the Hgb value of the noninvasive blood analyzer, X represents a male subject, and O represents a female subject. The correlation coefficient at this time was R 2 = 0.7742, and the regression line was Z = 0.9996X + 0.0932 (N = 57).
【００２２】このように、男性被験者と女性被験者の混
ざった関数を用いた図４の相関図に比べ、男性被験者と
女性被験者の別々の関数を用いた図７の相関図の方が、
相関係数が良くなり、回帰直線の係数も１に近づいた。
つまり、男性被験者と女性被験者の別々の濃度プロファ
イル値の関数を使用することにより、無侵襲血液分析装
置において、より正確なＨｇｂ値が得られることが判明
した。また、年齢に応じて、組織の特性が異なることか
ら、同様に、年齢別の関数を用いることにより、より正
確な生体情報を得ることが可能となる。Thus, as compared with the correlation diagram of FIG. 4 using a mixed function of a male subject and a female subject, the correlation diagram of FIG. 7 using separate functions of a male subject and a female subject is
The correlation coefficient improved, and the coefficient of the regression line also approached 1.
In other words, it has been found that by using the functions of the concentration profile values of the male subject and the female subject separately, a more accurate Hgb value can be obtained in the noninvasive blood analyzer. In addition, since the characteristics of the tissue differ depending on the age, similarly, it is possible to obtain more accurate biological information by using the function for each age.
【００２３】[0023]
【発明の効果】この発明によれば、無侵襲血液分析装置
において、性別や年齢別に対応する検量線を用意するこ
とにより、より正確な血液成分情報が得られる。According to the present invention, more accurate blood component information can be obtained in the noninvasive blood analyzer by preparing calibration curves corresponding to gender and age.
【図１】この発明の実施例の構成を示すブロック図であ
る。FIG. 1 is a block diagram showing a configuration of an embodiment of the present invention.
【図２】この発明の実施例の外形を示す斜視図である。FIG. 2 is a perspective view showing an outer shape of the embodiment of the present invention.
【図３】この発明の実施例の相関図を示した図である。FIG. 3 is a diagram showing a correlation diagram of the embodiment of the present invention.
【図４】この発明の実施例の相関図を示した図である。FIG. 4 is a diagram showing a correlation diagram of the embodiment of the present invention.
【図５】この発明の実施例の相関図を示した図である。FIG. 5 is a diagram showing a correlation diagram of the embodiment of the present invention.
【図６】この発明の実施例の相関図を示した図である。FIG. 6 is a diagram showing a correlation diagram of the embodiment of the present invention.
【図７】この発明の実施例の相関図を示した図である。FIG. 7 is a diagram showing a correlation diagram of the embodiment of the present invention.
１ 検出部 ２ データ処理部 ３ 解析部 １１ 光源部 １２ 受光部 ２１ 抽出部 ２２ 定量化部 ２３ 演算部 ２４ 出力部 ２５ 記憶部 ３１ 特徴抽出部 ３２ 記憶部 ３３ 比較部 ３４ 解析領域設定部 ３５ 操作部 DESCRIPTION OF SYMBOLS 1 Detection part 2 Data processing part 3 Analysis part 11 Light source part 12 Light receiving part 21 Extraction part 22 Quantification part 23 Operation part 24 Output part 25 Storage part 31 Feature extraction part 32 Storage part 33 Comparison part 34 Analysis area setting part 35 Operation part
───────────────────────────────────────────────────── フロントページの続き Ｆターム(参考） 2G059 AA03 BB13 CC18 EE01 GG02 JJ17 KK04 MM02 MM09 MM10 MM12 4C038 KK00 KK01 KL07 KM01 KX02 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 2G059 AA03 BB13 CC18 EE01 GG02 JJ17 KK04 MM02 MM09 MM10 MM12 4C038 KK00 KK01 KL07 KM01 KX02
Claims (3)
の光源部と、光を受けた生体から光学情報を受光する受
光部と、光学情報を解析する解析部と、解析部により得
られた生体情報を出力する出力部と、被験者の属性等を
入力する入力部を備え、解析部には複数の関数が記憶さ
れており、被験者の属性に応じた関数をもちいて生体情
報を算出し出力部に出力することを特徴とする無侵襲血
液分析装置。1. A light source unit for supplying light to a living body to be inspected, a light receiving unit for receiving optical information from the living body receiving the light, an analyzing unit for analyzing the optical information, and an analyzing unit. An output unit for outputting biometric information, and an input unit for inputting attributes of the subject are provided.A plurality of functions are stored in the analysis unit, and the biometric information is calculated using a function corresponding to the attributes of the subject. A non-invasive blood analyzer that outputs to an output unit.
特徴とする請求項１記載の無侵襲血液分析装置。2. The non-invasive blood analyzer according to claim 1, wherein the attributes of the subject are genders of males and females.
する請求項１記載の無侵襲血液分析装置。3. The noninvasive blood analyzer according to claim 1, wherein the attribute of the subject is age.
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| JP07812799A JP4554736B2 (en) | 1999-03-23 | 1999-03-23 | Non-invasive blood analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP07812799A JP4554736B2 (en) | 1999-03-23 | 1999-03-23 | Non-invasive blood analyzer |
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| JP2000271105A true JP2000271105A (en) | 2000-10-03 |
| JP4554736B2 JP4554736B2 (en) | 2010-09-29 |
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| JP07812799A Expired - Fee Related JP4554736B2 (en) | 1999-03-23 | 1999-03-23 | Non-invasive blood analyzer |
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| JP (1) | JP4554736B2 (en) |
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| KR100561872B1 (en) | 2004-10-22 | 2006-03-17 | 삼성전자주식회사 | Apparatus and method for analyzing component using microscopic regions |
| JP2009243979A (en) * | 2008-03-28 | 2009-10-22 | Sysmex Corp | Biosample analyzer and computer program |
| JP2014076375A (en) * | 2013-11-27 | 2014-05-01 | Fujifilm Corp | Endoscope system and actuation method for endoscope system |
| US10251538B2 (en) | 2011-07-25 | 2019-04-09 | Fujifilm Corporation | Endoscope system and method for controlling the same |
| CN111603151A (en) * | 2020-06-17 | 2020-09-01 | 中国医学科学院生物医学工程研究所 | Noninvasive blood component detection method and system based on time-frequency joint analysis |
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| WO1997024066A1 (en) * | 1995-12-27 | 1997-07-10 | Toa Medical Electronics Co., Ltd. | Noninvasive blood examination apparatus |
| JPH09182739A (en) * | 1995-12-28 | 1997-07-15 | Matsushita Electric Works Ltd | Measuring apparatus for body fluid component concentration |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100561872B1 (en) | 2004-10-22 | 2006-03-17 | 삼성전자주식회사 | Apparatus and method for analyzing component using microscopic regions |
| JP2009243979A (en) * | 2008-03-28 | 2009-10-22 | Sysmex Corp | Biosample analyzer and computer program |
| US10251538B2 (en) | 2011-07-25 | 2019-04-09 | Fujifilm Corporation | Endoscope system and method for controlling the same |
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| CN111603151A (en) * | 2020-06-17 | 2020-09-01 | 中国医学科学院生物医学工程研究所 | Noninvasive blood component detection method and system based on time-frequency joint analysis |
| CN111603151B (en) * | 2020-06-17 | 2023-05-16 | 深圳智领人工智能健康科技有限公司 | Noninvasive blood component detection method and system based on time-frequency combined analysis |
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| Publication number | Publication date |
|---|---|
| JP4554736B2 (en) | 2010-09-29 |
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