JP4510660B2 - Foamable aerosol composition - Google Patents

Description

  The present invention relates to a foamable aerosol composition. Specifically, since the aqueous stock solution and the liquefied gas are in a uniform state, they do not separate even if left for a long time, and they are elastic by discharge and can be applied smoothly like a cream. Relates to a foamable aerosol composition capable of obtaining a smooth foam when the coated surface is washed away with water.

  Conventionally, foamable aerosol compositions consist of an aqueous stock solution and a liquefied petroleum gas containing a surfactant such as a nonionic surfactant. For example, Patent Document 1 discloses a foamable aerosol composition containing a protein hydrolyzate, an anionic surfactant, purified water, and a propellant. According to this foamable aerosol composition, foam having elasticity and excellent drying properties can be obtained. However, since the aqueous stock solution and the liquefied petroleum gas are separated, the product is moved up and down before use. The aqueous stock solution and liquefied petroleum gas had to be made into an emulsion.

  Therefore, Patent Document 2 includes an aqueous stock solution containing a nonionic surfactant having a specific HLB and a hydrocarbon having 3 to 6 carbon atoms, and the aqueous stock solution and hydrocarbon are in a uniform state. A foamable aerosol composition is disclosed. This foamable aerosol composition contains a large amount of a surfactant and a polyhydric alcohol in order to make the aqueous stock solution and hydrocarbon uniform, and it has poor drying properties, and the surfactant remains on the skin. Easy to use and bad to use.

  Further, there are the following Patent Documents 3 and 4 as characteristic foamable aerosol compositions.

  Patent Document 3 discloses a foamy aerosol cleaning composition comprising an acylglutamic acid surfactant, a stock solution containing a hydrating exothermic substance, and a propellant. The foamy aerosol cleaning composition of Patent Document 3 has a warm feeling when used, foams when water is added, and has a smooth feeling after cleaning. However, since water is not contained in the composition, naturally, no consideration is given to making the aqueous stock solution and hydrocarbons in the composition uniform.

  Patent Document 4 discloses a hair cosmetic containing a nonionic surfactant having a HLB in a specific range and a silicone derivative, and having a mass ratio of ethanol and water in a specific range. In Example 6, a foam composition containing N-coconut oil fatty acid acyl-L-glutamate sodium, ethanol, water and liquefied petroleum gas is described. Although this aerosol composition forms foam, since the blending amount of ethanol is small, elastic foam cannot be obtained, and furthermore, a uniform aerosol composition cannot be obtained.

JP 2001-106611 A JP 2003-286130 A JP 2004-292484 A JP 2002-302422 A

  The present invention solves the above-mentioned problems, and since the aqueous stock solution and the liquefied gas are in a uniform state, they do not separate even if left for a long time, and they are elastic and can be applied smoothly and smoothly like cream. It is another object of the present invention to provide a foamable aerosol composition that can be stretched, and can obtain a smooth foam when the coated surface is washed away with water.

  That is, the present invention relates to an aqueous undiluted solution 80 to 98% by weight containing 0.3 to 10% by weight of an amino acid surfactant and 25 to 60% by weight of a monohydric alcohol having 2 to 3 carbon atoms, The present invention relates to a foamable aerosol composition comprising 2 to 20% by weight of a liquefied gas containing 3 to 5 hydrocarbons.

  The amino acid surfactant is preferably an N-acyl amino acid salt.

  It is preferable that the aqueous stock solution contains 0.1 to 10% by weight of a divalent to trivalent alcohol having 2 to 6 carbon atoms.

  The blending weight ratio of the monovalent alcohol having 2 to 3 carbon atoms and the divalent or trivalent alcohol having 2 to 6 carbon atoms is preferably 2.5: 1 to 50: 1.

  According to the aerosol composition of the present invention, since the aqueous stock solution and the liquefied gas are in a uniform state, the operation of shaking the aerosol product before use becomes unnecessary, and it can be used as a stationary aerosol product.

  Since the foam obtained by discharging the aerosol composition of the present invention is elastic, a necessary amount can be picked up with a fingertip and is easily applied to details. Moreover, the foam is easy to spread like a cream and can form a thin layer. Further, when the coated surface is washed away with water, a smooth feeling can be obtained.

  The foamable aerosol composition of the present invention is a liquefaction containing an aqueous stock solution containing a specific amount of an amino acid surfactant and a monohydric alcohol having 2 to 3 carbon atoms and a hydrocarbon having 3 to 5 carbon atoms. The aqueous undiluted solution and the liquefied gas are in a uniform state. The term “homogeneous” as used in the present invention does not completely dissolve like a mixture of water and ethanol, and the liquefied gas is uniformly dispersed in the aqueous stock solution so that it has translucency and is separated. That which is not.

  Here, having translucency means that the transmittance at 25 ° C. is 70 to 99.8%. Preferably it is 75 to 99.5%, more preferably 80 to 99%. When the transmittance is lower than 70%, the separation occurs depending on the storage conditions. The transmittance was measured using a color difference meter CT-210 (Minolta Camera Co., Ltd.) and a transparent polyethylene terephthalate container filled with purified water alone as a reference sample (100%). Value.

  The amino acid-based surfactant used in the present invention makes the aqueous stock solution and the liquefied gas uniform, forms a foam that can be stretched and stretched like a cream, and is applied when washed with water. It is a component for imparting a smooth feeling to the surface.

  Examples of the amino acid surfactants include N-coconut oil fatty acid acyl-L-glutamic acid triethanolamine, N-coconut oil fatty acid acyl-L-glutamic acid potassium, N-coconut oil fatty acid acyl-L-glutamic acid sodium, N -Lauroyl-L-glutamate triethanolamine, N-lauroyl-L-potassium glutamate, N-lauroyl-L-sodium glutamate, N-myristoyl-L-glutamate potassium, N-myristoyl-L-glutamate and N-stearoyl- N-acyl glutamates such as sodium L-glutamate; N-acyl glutamic acids such as N-coconut fatty acid acyl-L-glutamic acid, N-lauroyl-L-glutamic acid and N-stearoyl-L-glutamic acid; N- N- acyl alanine salts such as N- cocoyl -DL- alanine triethanolamine; shea oil fatty acid acyl-glycine potassium and N- cocoyl glycine sodium such as N- acyl glycine salt, and the like.

  In addition, the above-mentioned N-acyl glutamic acid and an alkaline agent such as triethanolamine, diethanolamine, diisopropanolamine, sodium hydroxide and potassium hydroxide are blended in the aqueous stock solution to form N-acyl glutamate in the aqueous stock solution. It may be used.

  Of these, N-acyl amino acid salts such as N-acyl glutamate, N-acyl glycine salt and N-acyl alanine salt are preferred because they are particularly elastic and easily obtain foams that are easy to spread.

  The compounding amount of the amino acid surfactant is 0.3 to 10% by weight in the aqueous stock solution, and preferably 0.5 to 8% by weight. When the blending amount is less than 0.3% by weight, it becomes cloudy or further, the aqueous stock solution and the liquefied gas are separated, so that a uniform aerosol composition cannot be obtained. Furthermore, it is difficult to obtain foam that is elastic and easy to spread like cream. On the other hand, if the blending amount exceeds 10% by weight, since the viscosity of the aerosol composition becomes high, it becomes impossible to discharge the whole amount, and furthermore, the surfactant remains on the skin even after washing with water after use, The feeling of use decreases.

  The monohydric alcohol having 2 to 3 carbon atoms (hereinafter referred to as lower alcohol) used in the present invention is a component for making an aqueous stock solution and a liquefied gas uniform and forming elastic bubbles. It is. Examples of the lower alcohol include ethanol and isopropyl alcohol. Of these, ethanol is preferred because the aqueous stock solution and the liquefied gas are likely to be uniform.

  The blending amount of the lower alcohol is 25 to 60% by weight, preferably 30 to 55% by weight in the aqueous stock solution. If the blending amount is less than 25% by weight, it becomes cloudy or further, the aqueous stock solution and the liquefied gas are separated, so that a uniform aerosol composition cannot be obtained. Furthermore, it is difficult to obtain foam that is elastic and easy to spread like cream. On the other hand, when the blending amount exceeds 60% by weight, it becomes difficult to foam when discharged and becomes liquid.

  Further, even if the aerosol composition is allowed to stand for a long period of time, the aqueous stock solution does not separate from the liquefied gas, and in order to easily maintain a uniform state, the aqueous stock solution has 2 to 3 carbon atoms having 2 to 6 carbon atoms. It is preferable to contain alcohol (hereinafter referred to as polyhydric alcohol).

  Examples of the polyhydric alcohol include ethylene glycol, propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and glycerin. Of these, dihydric alcohols such as ethylene glycol, propylene glycol, and 1,3-butylene glycol are particularly preferred because the effect of making the aqueous stock solution and the liquefied gas uniform can be easily obtained.

  The blending amount of the polyhydric alcohol is preferably 0.1 to 10% by weight, more preferably 1 to 8% by weight in the aqueous stock solution. When the blending amount is less than 0.1% by weight, the aqueous stock solution and the liquefied gas tend to be separated. On the other hand, if the blending amount exceeds 10% by weight, the drying property tends to deteriorate.

  The blending weight ratio of the lower alcohol to the polyhydric alcohol (lower alcohol / polyhydric alcohol) is preferably 2.5: 1 to 50: 1, and more preferably 3: 1 to 20: 1. It is preferable. If the blending weight ratio of the lower alcohol to the polyhydric alcohol is less than 2.5, the aqueous stock solution and the liquefied gas are likely to be separated when left standing for a long time, and a uniform aerosol composition tends to be difficult to obtain. is there. On the other hand, when the blending weight ratio of the lower alcohol exceeds 50, a uniform aerosol composition is easily obtained, but tends to be difficult to foam.

  The aqueous stock solution can be prepared by blending water with the amino acid surfactant, lower alcohol, and polyhydric alcohol used as necessary. The water is not particularly limited, and for example, purified water, ion exchange water, sterilized water, and physiological saline can be used.

  Furthermore, an effective ingredient, an auxiliary ingredient, etc. can be suitably mix | blended with the said aqueous | water-based stock solution according to the use of the aerosol product, the objective, etc.

  Examples of the active ingredient include bactericidal disinfectants / preservatives such as paraoxybenzoic acid ester, sodium benzoate, phenoxyethanol, benzalkonium chloride, chlorhexidine chloride, parachlorometacresol and isopropylmethylphenol, propylene glycol, 1,3- Moisturizers such as butylene glycol, glycerin, collagen, xylitol, sorbitol, hyaluronic acid, sodium lactate, dl-pyrrolidone carboxylate, lecithin and urea, alkylaminoethyl (meth) acrylate / (meth) acrylic acid alkyl ester copolymer , Octylamide acrylate / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer, vinylpyrrolidone / vinyl acetate copolymer, hydroxyethyl acrylate・ Both acrylate / methoxyethyl acrylate copolymer, alkanolamine acrylate, alkyl acrylate copolymer emulsion and alkyl acrylate / styrene copolymer emulsion, etc., paraaminobenzoic acid, paraaminobenzoic acid mono UV absorbers such as glycerin ester, octyl salicylate, phenyl salicylate, isopropyl paramethoxycinnamate and octyl paramethoxycinnamate, glycine, alanine, leucine, serine, tryptophan, cystine, cysteine, methionine, aspartic acid, glutamic acid and arginine Amino acids such as retinol, retinol palmitate, pyridoxine hydrochloride, benzyl nicotinate, nicotinamide, nicotinic acid d, l-α-tocopherol, bi Vitamins such as tamine D2 (ergocaciferol), d, l-α-tocopherol, d, l-α-tocopherol acetate, pantothenic acid and biotin, hormones such as elastoldiol and ethinylestradiol, ascorbic acid, α- Antioxidants such as tocopherol, dibutylhydroxytoluene and butylhydroxyanisole, peony extract, hamamelis extract, rosemary extract, loofah extract, rose extract, lemon extract, aloe extract, ginger root extract, eucalyptus extract, sage extract, tea extract, seaweed Extracts, placenta extract and various extracts such as silk extract, lauryl methacrylate, geranyl crotolate, acetophenone myristate, benzyl acetate, benzyl propionate, benzoic acid Deodorizing and deodorizing agents such as methyl and phenyl acetate, anti-inflammatory analgesics such as methyl salicylate, indomethacin, piroxicam, felbinac and ketoprofen, antipruritic agents such as crotamiton and d-camphor, refreshing agents such as l-menthol and camphor, oxidation Astringents such as zinc, allantoin hydroxyaluminum, tannic acid, citric acid and lactic acid, anti-inflammatory agents such as allantoin, glycyrrhetinic acid, dipotassium glycyrrhizinate and azulene, local anesthetics such as dibucaine hydrochloride, tetracaine hydrochloride and lidocaine hydrochloride, diphenhydramine Antihistamines such as diphenhydramine hydrochloride and chlorfemiramine maleate, whitening agents such as arbutin and kojic acid, N, N-diethyl-m-toluamide (diet), potassium Pest repellents such as acrylic acid diethylamide and dimethyl phthalate, various flavors such as synthetic flavors and natural flavors and the like.

  The compounding amount of the active ingredient is preferably 0.001 to 30% by weight, more preferably 0.005 to 20% by weight in the aqueous stock solution. If the blending amount is less than 0.001% by weight, the concentration of the active ingredient contained in the foam is low and the desired effect tends to be difficult to obtain. On the other hand, if the blending amount exceeds 30% by weight, the concentration of the active ingredient contained in the foam is high, and it becomes easy to apply an excessive amount. Therefore, depending on the active ingredient, the user may be adversely affected.

  Examples of the auxiliary component include surfactants other than amino acid surfactants, water-soluble polymers, oily components, and powders.

  Surfactants other than the amino acid-based surfactant are used for the purpose of making the aqueous stock solution and the liquefied gas easy to be uniform, and improving foamability. Examples of the surfactant include polyglycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene sorbite fatty acid ester, polyoxyethylene Nonionic surfactants such as ethylene glycerin fatty acid ester, polyoxyethylene castor oil / hardened castor oil and polyoxyethylene lanolin alcohol; alkyl sulfate, polyoxyethylene alkyl ether sulfate, alkyl phosphate, polyoxyethylene alkyl Anionic surfactants such as ether phosphates, saponified fatty acids and α-olefin sulfonates; alkyl ammonium salts and alkyls Cationic surfactants such as benzylammonium salts; amphoteric surfactants such as betaine acetate and lecithin; polyoxyethylene / methylpolysiloxane copolymers, polyoxypropylene / methylpolysiloxane copolymers and poly (oxyethylene) -Oxypropylene) -silicone type surfactants such as methylpolysiloxane copolymer; natural type surfactants such as saponin, soybean phospholipid, soybean lysophospholipid solution and surfactin sodium; and the like.

  The blending amount when blending the surfactant is preferably 0.1 to 10% by weight, more preferably 0.5 to 8% by weight in the aqueous stock solution. If the blending amount is less than 0.1% by weight, the blending effect of the surfactant tends to be difficult to obtain. On the other hand, if it exceeds 10% by weight, the feeling of use tends to decrease.

  The water-soluble polymer is used for the purpose of increasing the elasticity of the foam and improving the retention of the foam. Examples of the water-soluble polymer include gelatin, agar, casein, dextrin, pectin, starch, sodium alginate, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, modified potato starch, polyvinyl alcohol, polyvinyl Examples include methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer, sodium polyacrylate and xanthan gum.

  The blending amount of the water-soluble polymer is preferably 0.01 to 10% by weight, more preferably 0.1 to 5% by weight in the aqueous stock solution. If the blending amount is less than 0.01% by weight, the blending effect of the water-soluble polymer tends to be difficult to obtain. On the other hand, if the blending amount exceeds 10% by weight, the viscosity of the aqueous stock solution tends to be too high, and mixing with the liquefied gas and ejection tend to be difficult.

  The oil component is used for the purpose of improving slip and imparting gloss. Examples of the oil component include liquid hydrocarbons such as kerosene, squalane, squalene, liquid paraffin and isoparaffin; isopropyl myristate, cetyl isooctanoate, octyldodecyl myristate, isopropyl palmitate, diethyl phthalate, diethoxyethyl phthalate and Ester oils such as diethoxyethyl succinate; silicone oils such as methylpolysiloxane, decamethyltetrasiloxane, octamethylcyclotetrasiloxane and methylphenylpolysiloxane; camellia oil, corn oil, olive oil, castor oil, safflower oil, jojoba Oils and fats such as coconut oil; higher fatty acids such as oleic acid; higher alcohols such as oleyl alcohol and isostearyl alcohol; Some may be mentioned. The oil component includes higher fatty acids such as lauric acid, myristic acid, palmitic acid and stearic acid; higher alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol and myristyl alcohol; waxes such as beeswax and paraffin wax; The oily component that is solid at room temperature may be used.

  The blending amount of the oil component is preferably 0.01 to 5% by weight, more preferably 0.1 to 3% by weight in the aqueous stock solution. If the blending amount is less than 0.01% by weight, the blending effect of the oil component tends to be difficult to obtain. On the other hand, when the blending amount exceeds 5% by weight, the aerosol composition tends to be easily separated.

  The powder is used for the purpose of improving the sliding of the coated surface and delustering. Examples of the powder include inorganic powders such as talc, corn starch, silica, zinc undecylenate, magnesium silicate, mica, mica titanium, magnesium oxide, zinc oxide, titanium oxide, magnesium carbonate, and calcium carbonate, nylon 6, nylon 66, nylon 12 and the like, organic powders such as polyethylene, polypropylene, polystyrene, polycarbonate, polyester, acrylic resin, fluororesin and silicone resin, and clay minerals such as bentonite and kaolinite.

  The blending amount of the powder is preferably 0.1 to 5% by weight, more preferably 0.3 to 3% by weight in the aqueous stock solution. If the blending amount is less than 0.1% by weight, the blending effect of the powder tends to be difficult to obtain. On the other hand, if the blending amount exceeds 5% by weight, the amount of sedimentation in the aerosol composition increases, and there is a tendency that a shaking operation is required before use, or clogging tends to occur with an aerosol valve or an injection member.

  The aqueous stock solution is mixed with a liquefied gas in an aerosol container to be in a uniform state, and when discharged into the atmosphere, the liquefied gas is vaporized to form bubbles using the aqueous stock solution as a liquid film. The blending amount of the aqueous stock solution is 80 to 98% by weight, preferably 85 to 97% by weight, in the aerosol composition. When the blending amount is less than 80% by weight, it becomes easy to separate from the liquefied gas. On the other hand, if the blending amount exceeds 98% by weight, the foamability is lowered.

  The pH of the aqueous stock solution is preferably 5-9, more preferably 5.2-8.5. When the pH is lower than 5 or higher than 9, the elasticity of the foam is weak, and it tends to be difficult to spread like a cream.

  The liquefied gas used in the present invention is a liquid having a vapor pressure inside the aerosol container, forms a uniform aerosol composition in the aerosol container together with the aqueous stock solution, and vaporizes when discharged into the atmosphere. The volume expands and acts as a foaming agent that makes the aqueous stock solution foamy.

  The liquefied gas contains an aliphatic hydrocarbon having 3 to 5 carbon atoms. Examples of the aliphatic hydrocarbon having 3 to 5 carbon atoms include propane, n-butane, isobutane, n-pentane, isopentane, and mixtures thereof. The blending amount is preferably 50 to 100% by weight in the liquefied gas, and more preferably 60 to 100% by weight. If the blending amount is less than 50% by weight, the foamability tends to be lowered and bubbles are hardly formed, and furthermore, it is difficult to obtain elastic bubbles.

  The liquefied gas may contain, for example, dimethyl ether, tetrafluoroethane, difluoroethane, etc. other than the aliphatic hydrocarbon having 3 to 5 carbon atoms.

  The blending amount of the liquefied gas is 2 to 20% by weight in the aerosol composition, and preferably 3 to 15% by weight. If the blending amount is less than 2% by weight, the foamability tends to be insufficient. On the other hand, when the blending amount exceeds 20% by weight, it becomes easy to separate from the aqueous stock solution.

  As a method for producing the foamable aerosol composition of the present invention, for example, an amino acid surfactant, a lower alcohol, and, if necessary, a polyhydric alcohol, an active ingredient and the like are mixed in water to prepare an aqueous stock solution. The obtained aqueous undiluted solution and liquefied gas are filled into a pressure vessel, and an aerosol valve is fixed to the opening of the pressure vessel. Next, a uniform aerosol composition can be prepared by mixing the aqueous stock solution and the liquefied gas inside the container, for example, by shaking the container.

  The foamable aerosol composition of the present invention can be used as an aerosol product placed on a fixed surface such as a wash basin, for example, because the aqueous stock solution and the liquefied gas are uniform and do not need to be shaken before use. In addition, when foam is spread on the skin, a thin foam layer is formed, and when the applied part is washed away with water, a smooth feeling can be obtained.For washing, face washing, shaving, moisturizing, antipruritic and It can be suitably used for aerosol products for skin such as for astringency. Furthermore, since a relatively large amount of lower alcohol can be blended, it can be suitably used for pharmaceutical aerosol products such as sterilizing, antibacterial, analgesic and anti-inflammatory. It may also be applied to hair aerosol products for styling, treatment and coloring.

Example 1
The following aqueous stock solution was prepared, and the obtained aqueous stock solution and liquefied gas were filled in a pressure resistant container (made of transparent pressure resistant glass, full volume 100 ml), and an aerosol valve was fixed to the opening of the pressure resistant container. The pressure-resistant container was shaken up and down several times to prepare an aerosol composition. The transmittance was 97.5%.

<Aqueous stock solution>
N-lauroyl-L-glutamate sodium (* 1) 2.0
Polyoxyethylene monostearate (20) sorbitan (* 2) 1.5
Polyoxyethylene (4) stearyl ether (* 3) 1.5
Polyoxyethylene (2) stearyl ether (* 4) 1.5
Ethanol 30.0
1,3-butylene glycol 3.0
Purified water 60.5
Total 100.0 (% by weight)
<Aerosol composition>
Aqueous stock solution 95.0
Liquefied gas (* 5) 5.0
Total 100.0 (% by weight)
* 1: Product name Amisoft LS-11 (F), manufactured by Ajinomoto Co., Inc. * 2: Product name NIKKOL TS-10V, manufactured by Nikko Chemicals Co., Ltd. * 3: Product name NIKKOL BS-4, manufactured by Nikko Chemicals Co., Ltd. * 4: Product name NIKKOL BS-2, manufactured by Nikko Chemicals Co., Ltd. * 5: A mixture of butane and propane (butane / propane = 65/35 (weight ratio), vapor pressure at 25 ° C., 0.45 MPa)

Example 2
6.7% by weight of N-coconut oil fatty acid acyl-L-glutamate triethanolamine 30% aqueous solution (trade name: Amisoft CT-12S, manufactured by Ajinomoto Co., Inc.) instead of N-lauroyl-L-glutamate sodium An aqueous undiluted solution and an aerosol composition were prepared in the same manner as in Example 1 except that the pure water was 2.0 wt% and the purified water was changed to 55.8 wt%. The transmittance was 80.5%.

Example 3
Example 1 was used except that N-lauroyl-L-glutamate sodium was used instead of N-coconut oil fatty acid acylglycine potassium (trade name: Amilite GCK-11 (F), manufactured by Ajinomoto Co., Inc.). Aqueous stock solutions and aerosol compositions were prepared. The transmittance was 94.1%.

Example 4
Instead of sodium N-lauroyl-L-glutamate, 6.7% by weight of N-coconut oil fatty acid acyl-DL-alanine triethanolamine 30% aqueous solution (trade name: Amilite ACT-12, manufactured by Ajinomoto Co., Inc.) An aqueous stock solution and an aerosol composition were prepared in the same manner as in Example 1 except that the pure water was 2.0 wt% and the purified water was changed to 55.8 wt%. The transmittance was 98.0%.

Example 5
Instead of sodium N-lauroyl-L-glutamate, N-lauroyl-L-glutamic acid (trade name: Amisoft LA-D, manufactured by Ajinomoto Co., Inc.) was used, and triethanolamine as an alkaline agent had a pH of an aqueous stock solution of 5 An aqueous stock solution and an aerosol composition were prepared in the same manner as in Example 1 except that an appropriate amount was added so as to be .7. The transmittance was 71.2%.

Example 6
The same procedure as in Example 1 except that the blending amount of sodium N-lauroyl-L-glutamate was 5.0% by weight, the blending amount of ethanol was 50% by weight, and the blending amount of purified water was 37.5% by weight. Aqueous stock solutions and aerosol compositions were prepared. The transmittance was 98.0%.

Example 7
An aqueous stock solution and an aerosol composition were prepared in the same manner as in Example 1 except that the blending amount of ethanol was 50 wt% and the blending amount of purified water was 40.5 wt%. The transmittance was 98.6%.

Example 8
Example 1 except that a liquefied gas (a mixture of butane and propane, butane / propane = 85/15 (weight ratio), vapor pressure at 25 ° C. of 0.30 MPa) was used instead of the liquefied gas (* 5). In the same manner, an aqueous stock solution and an aerosol composition were prepared. The transmittance was 96.2%.

Example 9
Instead of the liquefied gas (* 5), liquefied gas (a mixture of butane, propane and dimethyl ether, butane / propane / dimethyl ether = 28/52/20 (weight ratio), vapor pressure at 25 ° C. of 0.50 MPa) was used. Except for the above, an aqueous stock solution and an aerosol composition were prepared in the same manner as in Example 1. The transmittance was 98.1%.

Example 10
Instead of the liquefied gas (* 5), a liquefied gas (a mixture of butane, propane and dimethyl ether, butane / propane / dimethyl ether = 56/14/30 (weight ratio), vapor pressure at 25 ° C., 0.45 MPa) was used. Except for the above, an aqueous stock solution and an aerosol composition were prepared in the same manner as in Example 8. The transmittance was 98.8%.

Example 11
An aqueous stock solution and an aerosol composition were prepared in the same manner as in Example 9, except that 1,3-butylene glycol was not blended and the blending amount of purified water was 63.5% by weight. The transmittance was 95.0%.

Example 12
An aqueous stock solution and an aerosol composition were prepared in the same manner as in Example 1 except that glycerin was used instead of 1,3-butylene glycol. The transmittance was 95.5%.

Comparative Example 1
An aqueous stock solution and an aerosol composition were prepared in the same manner as in Example 1 except that the amount of sodium N-lauroyl-L-glutamate was 0.2% by weight and the amount of purified water was 62.3% by weight. . The transmittance was 66.0%.

Comparative Example 2
An aqueous stock solution and an aerosol composition were prepared in the same manner as in Example 1 except that the amount of sodium N-lauroyl-L-glutamate was 12.0% by weight and the amount of purified water was 50.5% by weight. . The transmission was not measurable.

Comparative Example 3
Implemented except that myristic acid 1.5% by weight and triethanolamine 0.49% by weight in place of sodium N-lauroyl-L-glutamate and the amount of purified water was 60.51% by weight. An aqueous stock solution and an aerosol composition were prepared as in Example 1. The transmission was not measurable.

Comparative Example 4
An aqueous stock solution and an aerosol composition were prepared in the same manner as in Example 1 except that the blending amount of ethanol was 20.0% by weight and the blending amount of purified water was 70.5% by weight. The transmittance was 41.9%.

Comparative Example 5
An aqueous stock solution and an aerosol composition were prepared in the same manner as in Example 1 except that the blending amount of ethanol was 65.0% by weight and the blending amount of purified water was 25.5% by weight. The permeability is 99. It was 8%.

Comparative Example 6
An aqueous stock solution and an aerosol composition were prepared in the same manner as in Example 1 except that the amount of the aqueous stock solution was 70.0% by weight and the amount of the liquefied gas (* 5) was 30.0% by weight. The transmission was not measurable.

Test item 1. PH of aqueous stock solution
The resulting aqueous stock solution was adjusted to 20 ° C. and the pH was measured.

2. Appearance of aerosol composition The obtained aerosol product was stored in a thermostatic water bath adjusted to 25 ° C for 1 hour, and the appearance of the aerosol composition was evaluated. In addition, the permeability of the aerosol composition was determined by keeping the aerosol product filled in a transparent polyethylene terephthalate pressure vessel (full volume 40 ml) in a constant temperature water bath at 25 ° C. for 1 hour, and then measuring the color difference meter CT-210 ( Measurement was performed using Minolta Camera Co., Ltd. In addition, the said transmittance | permeability is a luminous transmittance when the transmittance | permeability when filling only the purified water in the container made from the same polyethylene terephthalate shall be 100%.
Evaluation criteria A: Uniform (colorless and transparent, transmittance 90 to 99%)
○: Uniform (almost transparent, transmittance 80 to 90%)
○ ': Uniform (slightly cloudy, transmittance 70-80%)
X1: Non-uniformity (separated into two layers, permeability measurement impossible)
X2: non-uniform (whole cloudiness, transmittance of 70% or less)
X3: non-uniformity (solidified white, transmittance cannot be measured)

3. Storage stability of aerosol composition The aerosol product was allowed to stand in a room kept at 25 ° C for 1 month, and the appearance of the aerosol composition was evaluated.
Evaluation criteria A: It was transparent and uniform with no change from before storage.
○: Slight turbidity is observed but not separated.
X: The liquefied gas separated in the upper part to form two layers.
-: Solidified state

4). Foam quality 1 g of the aerosol composition was discharged from the aerosol product stored in a thermostatic water bath adjusted to 25 ° C. for 1 hour to the palm of the hand, and the elasticity and the appearance of the foam were evaluated when the foam was tapped with a fingertip.
Evaluation criteria ◎: Elasticity, fine bubbles like cream ○ 1: Elasticity, but one bubble is large ○ 2: Although elasticity is weak, fine bubbles like cream △ 1: There is no elasticity, and one bubble is large (one of the same as the foam of a conventional foamable aerosol composition containing a nonionic surfactant)
△ 2: Sticky foam △ 3: Very coarse, poorly shaped foam ×: No foam

5). Ease of spreading foam 1 g of the aerosol composition was discharged from an aerosol product stored in a thermostatic water bath adjusted to 25 ° C. for 1 hour to the palm of the hand, and the state when the foam was spread with an index finger until it became thin was evaluated.
A: Can be applied smoothly like a cream, and a thin layer of fine foam can be formed without interruption.
○: Can be applied smoothly like a cream, and a thin layer of slightly rough foam is formed.
○ ': The coating could be extended, but the defoaming was slightly faster and the thin layer of foam was interrupted.
X: It is difficult to spread and a thin bubble layer cannot be formed.
-: Since it does not become a bubble, it cannot evaluate.

6). Usability of foam 1 g of aerosol composition was discharged from the aerosol product stored in a thermostatic water bath adjusted to 25 ° C. for 1 hour to the palm of the hand, the foam was spread out with the palm of the hand, and the usability when washed with water was evaluated. .
◯: There was a smooth feeling and a very good feeling was obtained.
(Triangle | delta): There is no smooth feeling and it cannot be said that it is excellent in a usability | use_condition.
X: There is stickiness and it is inferior to a feeling of use.
-: Since it does not become a bubble, it cannot evaluate.

(Example of aerosol product)
Below, the manufacture example of the aerosol product using the foamable aerosol composition of this invention is shown.

Production Example 1 (Aerosol Product for Cleaning)
The following aqueous stock solution was prepared, and the obtained aqueous stock solution and liquefied gas were filled in a pressure resistant container (made of transparent polyethylene terephthalate, full volume 100 ml), and an aerosol valve was fixed to the opening of the pressure resistant container. Subsequently, the pressure-resistant container was shaken up and down several times to prepare an aerosol composition.

<Aqueous stock solution>
N-lauroyl-L-glutamate sodium (* 1) 2.0
Polyoxyethylene monostearate (20) sorbitan (* 2) 1.5
Polyoxyethylene (4) stearyl ether (* 3) 1.5
Polyoxyethylene (2) stearyl ether (* 4) 1.5
95% ethanol 40.0
Concentrated glycerin 1.5
1,3-butylene glycol 1.5
Dipolypropylene glycol-2-milles-10-adibate (* 6) 1.0
Purified water 49.5
Total 100.0 (% by weight)
<Aerosol composition>
Aqueous stock solution 95.0
Liquefied gas (* 5) 5.0
Total 100.0 (% by weight)
* 6: Product name: Chromolyte SCE, made by Croda

Production Example 2 (Aerobic Product for Astringent Cosmetics)
The following aqueous stock solution was prepared, and the obtained aqueous stock solution and liquefied gas were filled in a pressure resistant container (made of transparent polyethylene terephthalate, full volume 100 ml), and an aerosol valve was fixed to the opening of the pressure resistant container. Subsequently, the pressure-resistant container was shaken up and down several times to prepare an aerosol composition.

<Aqueous stock solution>
N-lauroyl-L-glutamate sodium (* 1) 2.0
Polyoxyethylene monostearate (20) sorbitan (* 2) 1.5
Polyoxyethylene (4) stearyl ether (* 3) 1.5
Polyoxyethylene (2) stearyl ether (* 4) 1.5
95% ethanol 30.0
Concentrated glycerin 1.5
1,3-butylene glycol 1.5
Dipolypropylene glycol-2-milles-10-adibate (* 6) 1.0
Hamamelis extract (* 7) 0.05
Rosemary extract (* 8) 0.05
Loofah extract (* 9) 0.05
Purified water 59.35
Total 100.0 (% by weight)
<Aerosol composition>
Aqueous stock solution 95.0
Liquefied gas (* 5) 5.0
Total 100.0 (% by weight)
* 7: Product name Hamelis B, manufactured by Ichimaru Falcos Co., Ltd. * 8: Product name Rosemary E, manufactured by Ichimaru Falcos Co., Ltd. * 9: Product name Hechimari Kidd, manufactured by Ichimaru Falcos Co., Ltd.

Production Example 3 (Anchoral aerosol products)
The following aqueous stock solution was prepared, and the obtained aqueous stock solution and liquefied gas were filled in a pressure resistant container (made of transparent polyethylene terephthalate, full volume 100 ml), and an aerosol valve was fixed to the opening of the pressure resistant container. Subsequently, the pressure-resistant container was shaken up and down several times to prepare an aerosol composition.

<Aqueous stock solution>
N-coconut oil fatty acid acyl-L-glutamic acid triethanolamine solution (* 10)
6.7
Polyoxyethylene monostearate (20) sorbitan (* 2) 1.5
Polyoxyethylene (4) stearyl ether (* 3) 1.5
Polyoxyethylene (2) stearyl ether (* 4) 1.5
95% ethanol 30.0
Concentrated glycerin 1.5
1,3-butylene glycol 1.5
Urea 10.0
Crotamiton 5.0
Diphenhydramine 1.0
Tocopherol acetate 0.5
Dipotassium glycyrrhizinate 0.2
Purified water 39.1
Total 100.0 (% by weight)
<Aerosol composition>
Aqueous stock solution 95.0
Liquefied gas (* 5) 5.0
Total 100.0 (% by weight)
* 10 Product name: Amisoft CT-12S, manufactured by Ajinomoto Co., Inc.

Production Example 4 (Aerobic products for sterilization)
The following aqueous stock solution was prepared, and the obtained aqueous stock solution and liquefied gas were filled in a pressure resistant container (made of transparent polyethylene terephthalate, full volume 100 ml), and an aerosol valve was fixed to the opening of the pressure resistant container. Subsequently, the pressure-resistant container was shaken up and down several times to prepare an aerosol composition.

<Aqueous stock solution>
N-lauroyl-potassium L-glutamate (* 11) 2.0
Polyoxyethylene monostearate (20) sorbitan (* 2) 1.5
Polyoxyethylene (4) stearyl ether (* 3) 1.5
Polyoxyethylene (2) stearyl ether (* 4) 1.5
95% ethanol 50.0
Concentrated glycerin 1.5
1,3-butylene glycol 1.5
Benzalkonium chloride 0.1
Purified water 40.4
Total 100.0 (% by weight)
<Aerosol composition>
Aqueous stock solution 95.0
Liquefied gas (* 5) 5.0
Total 100.0 (% by weight)
* 11 Product name: Amisoft LK-11 (F), manufactured by Ajinomoto Co., Inc.

Production Example 5 (Aerosol product for anti-inflammatory analgesia)
The following aqueous stock solution was prepared, and the obtained aqueous stock solution and liquefied gas were filled in a pressure resistant container (made of transparent polyethylene terephthalate, full volume 100 ml), and an aerosol valve was fixed to the opening of the pressure resistant container. Subsequently, the pressure-resistant container was shaken up and down several times to prepare an aerosol composition.

<Aqueous stock solution>
N-lauroyl-L-glutamate sodium (* 1) 2.0
Polyoxyethylene monostearate (20) sorbitan (* 2) 1.5
Polyoxyethylene (4) stearyl ether (* 3) 1.5
Polyoxyethylene (2) stearyl ether (* 4) 1.5
95% ethanol 40.0
1,3-butylene glycol 3.0
Methyl salicylate 1.0
Glycosalicylate 0.7
Diphenhydramine 1.0
l-Menthol 1.5
Purified water 47.3
Total 100.0 (% by weight)
<Aerosol composition>
Aqueous stock solution 95.0
Liquefied gas (* 5) 5.0
Total 100.0 (% by weight)

Production Example 6 (Aerosol product for shaving)
The following aqueous stock solution was prepared, and the obtained aqueous stock solution and liquefied gas were filled in a pressure resistant container (made of transparent polyethylene terephthalate, full volume 100 ml), and an aerosol valve was fixed to the opening of the pressure resistant container. Subsequently, the pressure-resistant container was shaken up and down several times to prepare an aerosol composition.

<Aqueous stock solution>
Sodium N-lauroyl-L-glutamate (* 1) 3.0
Polyoxyethylene monostearate (20) sorbitan (* 2) 1.5
Polyoxyethylene (4) stearyl ether (* 3) 1.5
Polyoxyethylene (2) stearyl ether (* 4) 1.5
95% ethanol 25.0
Concentrated glycerin 5.0
l-Menthol 0.2
Purified water 62.3
Total 100.0 (% by weight)
<Aerosol composition>
Aqueous stock solution 95.0
Liquefied gas (* 5) 5.0
Total 100.0 (% by weight)

Claims (3)

80-98% by weight of an aqueous stock solution containing 0.3 to 10% by weight of an N-acyl amino acid salt in the aqueous stock solution and 25 to 60% by weight of a monohydric alcohol having 2 to 3 carbon atoms in the aqueous stock solution; A foamable aerosol composition comprising 2 to 20% by weight of a liquefied gas containing 3 to 5 hydrocarbons. The aqueous stock solution, foaming aerosol composition of claim 1 Symbol placement containing 0.1 to 10% by weight of the divalent or trivalent alcohols number 2-6 carbons. Monovalent alcohol the number 2-3 carbons, the ratio by weight of alcohol of the number 2-6 2-3 valence carbon is 2.5: 1 to 50: claim 2 wherein the 1 Foamable aerosol composition.