JP4497778B2 - マルチウェルスキャナおよびその走査方法 - Google Patents

マルチウェルスキャナおよびその走査方法 Download PDF

Info

Publication number
JP4497778B2
JP4497778B2 JP2001530594A JP2001530594A JP4497778B2 JP 4497778 B2 JP4497778 B2 JP 4497778B2 JP 2001530594 A JP2001530594 A JP 2001530594A JP 2001530594 A JP2001530594 A JP 2001530594A JP 4497778 B2 JP4497778 B2 JP 4497778B2
Authority
JP
Japan
Prior art keywords
detector
well
plate
sample
distance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2001530594A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003511702A5 (enExample
JP2003511702A (ja
Inventor
ティー．、 ミン ヴォング、
Original Assignee
ヴァーテックス ファーマシューティカルズ （サンディエゴ）エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/417,246 external-priority patent/US6448089B1/en
Application filed by ヴァーテックス ファーマシューティカルズ （サンディエゴ）エルエルシー filed Critical ヴァーテックス ファーマシューティカルズ （サンディエゴ）エルエルシー
Publication of JP2003511702A publication Critical patent/JP2003511702A/ja
Publication of JP2003511702A5 publication Critical patent/JP2003511702A5/ja
Application granted granted Critical
Publication of JP4497778B2 publication Critical patent/JP4497778B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2001530594A 1999-10-12 2000-10-12 マルチウェルスキャナおよびその走査方法 Expired - Lifetime JP4497778B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/417,246 1999-10-12
US09/417,246 US6448089B1 (en) 1999-10-12 1999-10-12 Multiwell scanner and scanning method
US09/665,546 2000-09-19
US09/665,546 US6586257B1 (en) 1999-10-12 2000-09-19 Multiwell scanner and scanning method
PCT/US2000/028447 WO2001027635A1 (en) 1999-10-12 2000-10-12 Multiwell scanner and scanning method

Publications (3)

Publication Number Publication Date
JP2003511702A JP2003511702A (ja) 2003-03-25
JP2003511702A5 JP2003511702A5 (enExample) 2007-11-22
JP4497778B2 true JP4497778B2 (ja) 2010-07-07

Family

ID=27023661

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001530594A Expired - Lifetime JP4497778B2 (ja) 1999-10-12 2000-10-12 マルチウェルスキャナおよびその走査方法

Country Status (7)

Country Link
US (1) US6586257B1 (enExample)
EP (1) EP1224474A1 (enExample)
JP (1) JP4497778B2 (enExample)
AU (1) AU1333301A (enExample)
CA (1) CA2387502C (enExample)
HK (1) HK1048515A1 (enExample)
WO (1) WO2001027635A1 (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6563581B1 (en) * 2000-07-14 2003-05-13 Applera Corporation Scanning system and method for scanning a plurality of samples
US7666661B2 (en) * 2001-08-27 2010-02-23 Platypus Technologies, Llc Substrates, devices, and methods for quantitative liquid crystal assays
US20030055587A1 (en) * 2001-09-17 2003-03-20 Symyx Technologies, Inc. Rapid throughput surface topographical analysis
KR20030078250A (ko) * 2002-03-28 2003-10-08 대한제당 주식회사 마이크로-웰 플레이트를 이용한 미세체적 반응장치 겸미생물 판별장치 및 그 이용방법
JP2006501860A (ja) * 2002-05-22 2006-01-19 プラティパス テクノロジーズ エルエルシー 細胞をアッセイするための基体、装置および方法
US7803322B2 (en) * 2002-08-14 2010-09-28 Detekt Biomedical, L.L.C. Universal optical imaging and processing system
US7267799B1 (en) 2002-08-14 2007-09-11 Detekt Biomedical, L.L.C. Universal optical imaging and processing system
WO2004055709A2 (en) * 2002-12-13 2004-07-01 Applera Corporation Methods for identifying, viewing, and analyzing syntenic and orthologous genomic regions between two or more species
EP1447454A1 (en) * 2003-02-14 2004-08-18 DR. Chip Biotechnology Incorporation Method and apparatus for detecting pathogens
US6970240B2 (en) * 2003-03-10 2005-11-29 Applera Corporation Combination reader
US7138050B2 (en) * 2003-05-29 2006-11-21 Shimadzu Corporation Fractionating/collecting device of liquid chromatograph
US20050074827A1 (en) * 2003-07-18 2005-04-07 Ute Muh Methods for identifying modulators of quorum-sensing signaling in bacteria
EP1654390B1 (en) 2003-07-25 2009-11-11 Platypus Technologies, LLC Liquid crystal based analyte detection
US20050038776A1 (en) * 2003-08-15 2005-02-17 Ramin Cyrus Information system for biological and life sciences research
EP1670944A4 (en) * 2003-09-19 2012-12-05 Life Technologies Corp MICROPLATES SUITABLE FOR CARRYING OUT NUCLEOTIDE AMPLIFICATION WITH TEMPERATURE CYCLE
US20050221357A1 (en) * 2003-09-19 2005-10-06 Mark Shannon Normalization of gene expression data
US7570443B2 (en) * 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
US20050226771A1 (en) * 2003-09-19 2005-10-13 Lehto Dennis A High speed microplate transfer
US20070015289A1 (en) * 2003-09-19 2007-01-18 Kao H P Dispenser array spotting
US20050233472A1 (en) * 2003-09-19 2005-10-20 Kao H P Spotting high density plate using a banded format
US7718133B2 (en) 2003-10-09 2010-05-18 3M Innovative Properties Company Multilayer processing devices and methods
US7332280B2 (en) * 2003-10-14 2008-02-19 Ronald Levy Classification of patients having diffuse large B-cell lymphoma based upon gene expression
AU2004290432B2 (en) * 2003-11-10 2008-11-20 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
JP2007526911A (ja) 2004-01-22 2007-09-20 ザ ユニバーシティ オブ アクロン 医療装置および治療のためのポリマーｎｏ供与体プレドラッグナノファイバコーティング
US7501301B2 (en) * 2004-03-10 2009-03-10 The Board Of Trustees Of The Leland Stanford Junior University Low cost fabrication of microelectrode arrays for cell-based biosensors and drug discovery methods
DE102004017039A1 (de) * 2004-04-02 2005-11-03 Rwth Aachen Verfahren und Vorrichtung zur Erfassung von Prozessparametern von Reaktionsflüssigkeiten in mehreren geschüttelten Mikroreaktoren
US20060111915A1 (en) * 2004-11-23 2006-05-25 Applera Corporation Hypothesis generation
US8084260B2 (en) * 2004-11-24 2011-12-27 Applied Biosystems, Llc Spectral calibration method and system for multiple instruments
US7858382B2 (en) * 2005-05-27 2010-12-28 Vidar Systems Corporation Sensing apparatus having rotating optical assembly
WO2007025129A2 (en) 2005-08-25 2007-03-01 Platypus Technologies, Llc. Compositions and liquid crystals
US20070098594A1 (en) * 2005-11-03 2007-05-03 Roche Molecular Systems, Inc. Analytical multi-spectral optical detection system
US7528374B2 (en) * 2006-03-03 2009-05-05 Vidar Systems Corporation Sensing apparatus having optical assembly that collimates emitted light for detection
US7842499B2 (en) * 2006-08-07 2010-11-30 Platypus Technologies, Llc Substrates, devices, and methods for cellular assays
US9968935B2 (en) 2007-08-20 2018-05-15 Platypus Technologies, Llc Devices for cell assays
CN101821610B (zh) * 2007-10-30 2012-07-18 爱科来株式会社 试样的分析方法及其装置
US8472683B2 (en) * 2008-05-09 2013-06-25 General Electric Company Motion correction in tomographic images
WO2010031047A2 (en) * 2008-09-15 2010-03-18 Platypus Technologies, Llc Detection of vapor phase compounds by changes in physical properties of a liquid crystal
JP5175749B2 (ja) 2009-01-13 2013-04-03 三洋電機株式会社 搬送装置、制御装置及びプログラム
EP2463643B1 (en) * 2009-08-06 2020-01-15 Universal Bio Research Co., Ltd. Optical fiber measurement device and measurement method using same
US8922858B2 (en) * 2012-01-31 2014-12-30 Corning Incorporated Motion axis control and method for biosensor scanning
US9518977B2 (en) * 2012-10-19 2016-12-13 University Of Washington Through Its Center For Commercialization Microfluidic assay apparatus and methods of use
EP3018470A1 (en) 2014-11-04 2016-05-11 Samsung Electronics Co., Ltd. Method of and apparatus for measuring biometric information
CN109070044B (zh) * 2016-07-21 2021-07-30 宝生物工程（美国)有限公司 使用多孔装置进行的多z平面成像和分配
CN110268108B (zh) 2016-12-12 2022-09-06 埃克切拉生物科学公司 用于使用微毛细管阵列进行筛选的方法和系统
CA3048904A1 (en) 2016-12-30 2018-07-05 xCella Biosciences, Inc. Multi-stage sample recovery system
US12318775B2 (en) 2018-12-06 2025-06-03 xCella Biosciences, Inc. Lateral loading of microcapillary arrays
CN110468027B (zh) * 2019-09-07 2022-04-19 桂林电子科技大学 一种基于同轴双波导光纤的细胞分选微流芯片
CN110591889B (zh) * 2019-09-07 2022-05-17 桂林电子科技大学 一种基于同轴双波导光纤的微流芯片细胞分选器

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4061543A (en) 1976-03-19 1977-12-06 General Electric Company Bioassay for drugs and antibiotics
DE8033450U1 (de) 1980-12-17 1982-07-22 Colgate-Palmolive Co., 10022 New York, N.Y. Laenglicher Behaelter fuer einen Spender fuer pastoeses gut
US4628933A (en) 1985-07-23 1986-12-16 Michelson Robin P Method and apparatus for visual prosthesis
US4677989A (en) 1986-02-06 1987-07-07 Eic Laboratories, Inc. Iridium oxide coated electrodes for neural stimulation
US4969468A (en) 1986-06-17 1990-11-13 Alfred E. Mann Foundation For Scientific Research Electrode array for use in connection with a living body and method of manufacture
US5024223A (en) 1989-08-08 1991-06-18 Chow Alan Y Artificial retina device
WO1991017460A1 (en) 1990-05-08 1991-11-14 Wallac Oy An apparatus for counting liquid scintillation samples
US5569591A (en) 1990-08-03 1996-10-29 University College Of Wales Aberystwyth Analytical or monitoring apparatus and method
DE4207368A1 (de) 1991-08-06 1993-02-11 Biotronik Mess & Therapieg Stimmulationselektrode
US5187096A (en) 1991-08-08 1993-02-16 Rensselaer Polytechnic Institute Cell substrate electrical impedance sensor with multiple electrode array
US5193540A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Structure and method of manufacture of an implantable microstimulator
US5545130A (en) 1992-04-08 1996-08-13 Genetronics, Inc. Flow through electroporation method
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5810725A (en) 1993-04-16 1998-09-22 Matsushita Electric Industrial Co., Ltd. Planar electrode
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5919712A (en) 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5965452A (en) 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US6309601B1 (en) * 1993-11-01 2001-10-30 Nanogen, Inc. Scanning optical detection system
US5563067A (en) 1994-06-13 1996-10-08 Matsushita Electric Industrial Co., Ltd. Cell potential measurement apparatus having a plurality of microelectrodes
US5784152A (en) 1995-03-16 1998-07-21 Bio-Rad Laboratories Tunable excitation and/or tunable detection microplate reader
CA2179364C (en) 1995-06-27 1999-09-28 Klaus W. Berndt Method and apparatus for detecting microorganisms
JP3561891B2 (ja) 1995-08-25 2004-09-02 株式会社三菱化学ヤトロン マイクロプレート遮光手段及び発光測定装置
US5686300A (en) 1995-09-11 1997-11-11 Becton Dickinson And Company Fluorescence detector
WO1997019339A1 (en) 1995-11-17 1997-05-29 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno A photometric measuring system and a holder for such a system
US6010613A (en) 1995-12-08 2000-01-04 Cyto Pulse Sciences, Inc. Method of treating materials with pulsed electrical fields
US5798263A (en) 1996-09-05 1998-08-25 Promega Corporation Apparatus for quantifying dual-luminescent reporter assays
US5957958A (en) 1997-01-15 1999-09-28 Advanced Bionics Corporation Implantable electrode arrays
EP0866123B1 (de) 1997-03-21 2005-03-16 Eppendorf Ag Verfahren und Schaltungsanordnung zur Elektropermeation oder Elektroporation von lebenden Zellen
US5981268A (en) 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
US6071748A (en) 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US6043506A (en) * 1997-08-13 2000-03-28 Bio-Rad Laboratories, Inc. Multi parameter scanner
US6043066A (en) 1997-09-04 2000-03-28 Mangano; Joseph A. Cell separation using electric fields
US6009347A (en) 1998-01-27 1999-12-28 Genetronics, Inc. Electroporation apparatus with connective electrode template
US5935155A (en) 1998-03-13 1999-08-10 John Hopkins University, School Of Medicine Visual prosthesis and method of using same
US6130745A (en) * 1999-01-07 2000-10-10 Biometric Imaging, Inc. Optical autofocus for use with microtiter plates

Also Published As

Publication number Publication date
HK1048515A1 (zh) 2003-04-04
US6586257B1 (en) 2003-07-01
WO2001027635A1 (en) 2001-04-19
WO2001027635A8 (en) 2003-10-23
WO2001027635A9 (en) 2002-08-08
CA2387502A1 (en) 2001-04-19
CA2387502C (en) 2007-09-25
JP2003511702A (ja) 2003-03-25
EP1224474A1 (en) 2002-07-24
AU1333301A (en) 2001-04-23

Similar Documents

Publication Publication Date Title
JP4497778B2 (ja) マルチウェルスキャナおよびその走査方法
US6814933B2 (en) Multiwell scanner and scanning method
US6638483B2 (en) Multiwell scanner and scanning method
JP4391523B2 (ja) 高密度保存およびアッセイプラットフォームを提供するマルチウェルプレート
US6730520B2 (en) Low fluorescence assay platforms and related methods for drug discovery
US6472218B1 (en) Systems and methods for rapidly identifying useful chemicals in liquid samples
US6171780B1 (en) Low fluorescence assay platforms and related methods for drug discovery
US20030104494A1 (en) Assay systems with adjustable fluid communication
WO1999054711A1 (en) Sample-holding devices and systems
US20080207465A1 (en) Assay systems with adjustable fluid communication
EP1004870A1 (en) Liquid barriers for assays

Legal Events

Date Code Title Description
A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20031212

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20031212

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070928

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070928

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090617

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090914

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090924

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091014

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20091021

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091113

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20091120

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091216

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100317

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20100413

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130423

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 4497778

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130423

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140423

Year of fee payment: 4

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250