JP4480973B2 - Body fat reduction promoter - Google Patents

Description

  The present invention relates to a body fat reduction promoter characterized by containing L-carnitine and a lotus germ extract.

  Body fat refers to subcutaneous fat that accumulates under the skin and visceral fat that accumulates around the viscera. Accumulation of body fat is a cause of not only obesity but also lifestyle-related diseases such as diabetes, hyperlipidemia and hypertension, and is a serious problem. Therefore, reducing body fat is very important in preventing and treating these diseases.

  Dietary restriction and exercise are effective in reducing body fat, but it is extremely difficult to manage. On the other hand, there is a method of reducing body fat with a drug, but safety is a problem and it is not preferable to use it on a daily basis. The sympathomimetic drug ephedrine has a risk of cardiac arrest, and mazindol and sibutramine, which have an effect of suppressing appetite, have side effects such as headache and dry mouth. Therefore, a body fat reduction promoter that can be used on a daily basis and exhibits a safe and sufficient effect has been sought and has been developed in various fields.

  For example, a lipolysis promoter containing a citrus plant as an active ingredient (see Patent Document 1), a lipolysis promoter containing a thrips plant as an active ingredient (see Patent Document 2), and a fat containing a pepper plant as an active ingredient Decomposition accelerator (see Patent Document 3), lipolysis accelerator (see Patent Document 4) containing at least one component selected from the group consisting of yellow cocoon extract and yellow continuous extract as an active ingredient, and effective hawthorn fruit component Food / beverage products that promote the burning of fat as ingredients (see Patent Document 5), lipolysis accelerators (see Patent Document 6), which comprise plants of orange leaf, orange flower, dandelion leaves and kalamas root as active ingredients, constituent acyl Body fat containing, as an active ingredient, an oil containing 5% by weight or more of diglyceride and / or monoglyceride having a ω3 unsaturated acyl group content of 15% by weight or more And the like baked accelerator (see patent document 7). However, their effects were not sufficient.

  L-carnitine is an indispensable substance when taking in fatty acids into mitochondria for energy. Since L-carnitine is a substance involved in lipid metabolism, it has hitherto been said to have an effect of reducing body fat, but the effect is not sufficient in practice. In addition, the lotus germ extract alone has been reported to have a collagen production promoting effect, a skin fibroblast proliferation promoting effect (Patent Document 8), and an epidermal metabolism activation effect (Patent Document 9). Has not been reported.

JP-A-8-81382 JP-A-8-301780 JP-A-8-245410 Japanese Patent Laid-Open No. 9-95452 JP-A-10-215811 JP-A-11-228431 JP 2001-64672 A JP 2002-29980 A JP 2002-68993 A

  In view of such circumstances, the present inventors have intensively studied to obtain a further excellent body fat reduction promoter, and as a result, combining L-carnitine and lotus germ extract is a significant body fat. The inventors have found that a reduction promoting effect is exhibited, and have completed the present invention.

  That is, the present invention is a body fat reduction promoter characterized by containing L-carnitine and a lotus germ extract.

  The L-carnitine of the present invention is a substance that is not only biosynthesized from the essential amino acids lysine and methionine in the body but also contained in beef, pork, mutton, etc., and is ingested on a daily basis. In pharmaceuticals, the use of L-carnitine chloride, which is a chloride, is recognized and is considered a highly safe component. For use in the present invention, those synthesized chemically or enzymatically, those produced by microorganisms, those obtained from natural products, and the like can be used. L-carnitine may be in the form of a salt. Salts of L-carnitine include metal salts such as sodium, potassium, calcium, magnesium, zinc, ammonium, hydrochloric acid, sulfuric acid, phosphoric acid, acetic acid, propionic acid, lactic acid, tartaric acid, citric acid, succinic acid, maleic acid, etc. . These can be used alone or in combination.

  The lotus germ of the present invention is an extremely safe food since the lotus seed containing the lotus germ has been edible as so-called “lotus seed” before the Heian period. For use in the present invention, a lotus of the genus Lotus (Nelumbo nuifera Gaertn.), N. lutea Pers. Seed germs can be used. Examples of products that are distributed as crude drugs include lotus wicks, lotus wicks, and cargo bells. These can be purchased and used. Various parts of lotus are used for medicinal purposes, and each has a different medicinal effect. For example, lotus leaves of lotus genus have anti-diarrhea, hemostasis, fruits (lotus meat) and stamens (lotus) are tonic, and germs (lotus wick, lotus wick, bunko) have different medicinal effects. It has been known. In addition, a large amount of starch and saccharide raffinose are known as fruit components, whereas leaves contain alkaloids such as loemerin and luciferin, and germs contain different alkaloids such as methyl coliparin and rotsin. It is known that

  The lotus germ extract in the present invention can be obtained as an extract by extracting the germ contained in the lotus seed with water or a hydrophilic organic solvent such as methanol, ethanol, propanol, acetone, or a mixed solvent thereof. it can. It can also be obtained in the form of a concentrated solution obtained by concentrating the extract or a dried powder.

  The dose or intake of the lotus germ extract and L-carnitine in the present invention varies depending on the form, symptoms, age, weight, etc., but L-carnitine is 5 to 5000 mg / day, preferably 50 to 2000 mg / day, More preferably, it is 100-1000 mg / day, and the lotus germ extract is 0.1-1000 mg / day, preferably 1-500 mg / day, more preferably 10-200 mg / day in terms of dry lotus germ.

  The body fat reduction promoter of the present invention can be used as a pharmaceutical or a food. Examples of pharmaceutical forms include powders, tablets, granules, capsules, troches, liquids for internal use, suspensions, syrups and the like. As the form of food, in addition to the above-mentioned pharmaceutical form, confectionery such as biscuits, cookies, candy and chocolate, seasonings such as vinegar, soy sauce and dressing, meat products such as ham, bacon and sausage, kamaboko, rice It can be made into fish paste products such as pies, beverages such as fruit juice beverages, soft drinks, alcoholic beverages, bread, noodles, jams and the like. These medicines and foods can be ingested in an amount of 0.1 to 1000 mg / day in terms of L-carnitine 5 to 5000 mg / day and lotus germ extract converted to dried lotus germ, but the intake is adjusted Tablets, granules, capsules, troches, liquids for internal use, and beverages are more preferable. In the production of pharmaceuticals and foods, they are usually used in the technical fields of pharmaceuticals and foods such as excipients, binders, lubricants, flavoring agents, stabilizers, vitamins, minerals, and fragrances as necessary. Adjuvants can be used.

  The body fat reduction promoter characterized by containing the extract of L-carnitine and lotus germ of the present invention has a significant body fat reduction effect.

  Next, examples are given as the best mode for carrying out the present invention, but the present invention is not limited to these. In the examples, (%) indicates weight (%).

Tablet <Prescription> Compounding amount (%)
1. L-carnitine 10.0
2. Lotus water dry water extract (equivalent to an equal amount of dry lotus germ) 1.0
3. Caffeine 1.0
4). Reduced maltose starch syrup 85.0
5). Sucrose fatty acid ester 3.0
<Manufacturing method>
An appropriate amount of 70% ethanol is added to components 1 to 4, kneaded, extruded and granulated, and dried to obtain granules. Ingredient 5 is added and tableted to give 500 mg tablets. By taking 6 tablets per day, an extract of lotus germ corresponding to 300 mg / day of L-carnitine and 30 mg / day of dried lotus germ can be ingested.

Lozenges <Prescription> Formulation amount (%)
1. L-carnitine 20.0
2. Lotus water dry water extract (equivalent to an equal amount of dried lotus germ) 5.0
3. Lactose 40.0
4). Cornstarch 32.0
5). Sucrose fatty acid ester 3.0
<Manufacturing method>
An appropriate amount of 70% ethanol is added to components 1 to 4, kneaded, extruded and granulated, and dried to obtain granules. Ingredient 5 is added and tableted to obtain 1000 mg of lozenge. By taking 3 lozenges a day, it is possible to take an extract of lotus germ corresponding to 600 mg / day of L-carnitine and 150 mg / day of dried lotus germ.

Granules <Prescription> Compounding amount (%)
1. L-carnitine 10.0
2. Lotus water dry water extract (equivalent to an equal amount of dried lotus germ) 2.0
3. Reduced maltose starch syrup 30.0
4). Cellulose 58.0
<Manufacturing method>
An appropriate amount of 70% ethanol is added to components 1 to 4, kneaded, extruded and granulated, and dried to obtain granules. The granule can ingest an extract of lotus germ corresponding to 600 mg / day of L-carnitine and 120 mg / day of dried lotus germ by ingesting 2000 mg at a time three times a day.

Capsule <Prescription> Content (%)
1. L-carnitine 10.0
2. Lotus ethanol extract of dried lotus germ (equivalent to 5 times the amount of dried lotus germ) 2.0
3. Coenzyme Q10 0.2
4). Cellulose 87.8
<Manufacturing method>
Ingredients 1-4 are mixed and 250 mg is filled into No. 2 hard capsule to obtain a capsule. By taking 6 capsules per day, the capsule can take in an extract of lotus germ corresponding to 150 mg / day of L-carnitine and 150 mg / day of dried lotus germ.

Beverage <Prescription> Blending amount (%)
1. L-carnitine 1.0
2. 30% ethanol extract of lotus germ (equivalent to equivalent amount of dried lotus germ) 0.5
3. 10% Coenzyme Q10 aqueous solution formulation 1.0
4). Caffeine 0.1
5). Sucrose 6.0
6). Citric acid 0.7
7). Perfume appropriate amount 8. Bring the total amount to 100 with purified water.
<Manufacturing method>
Add ingredients 1-7 to ingredient 8, dissolve with stirring, filter, heat sterilize and fill into a 30 mL glass bottle. The beverage can ingest an extract of lotus germ corresponding to 300 mg / day of L-carnitine and 150 mg / day of dried lotus germ by ingesting once a day.

Comparative example Beverage
Compounding amount (%)
<Prescription> Comparative Example 1 Comparative Example 2 Comparative Example 3
1. L-carnitine 0.0 1.0 0.0
2. 30% ethanol extract of lotus germ 0.0 0.0 0.5
(Equivalent amount of dried lotus germ)
3. 10% Coenzyme Q10 aqueous solution formulation 1.0 1.0 1.0
4). Caffeine 0.1 0.1 0.1
5). Sucrose 6.0 6.0 6.0
6). Citric acid 0.7 0.7 0.7
7). Perfume appropriate amount appropriate amount appropriate amount Bring the total amount to 100 with purified water.
<Manufacturing method>
Add ingredients 1-7 to ingredient 8, dissolve with stirring, filter, heat sterilize and fill into a 30 mL glass bottle.

  Ten 10-week-old Wistar male rats were divided into 4 groups of 8 rats in each group, and a diet having the composition shown in Table 1 was given for 2 weeks. The body fat percentage was measured with a body fat measuring apparatus for small animals (EM-SCAN SA-2 Central Science Trade). The obtained results are shown in Table 2.

  From the results of Table 2, it can be seen that the test group 2 of the diet containing L-carnitine and the diet containing the extract of the lotus germ were compared with the test group 1 given the diet not containing the extract of L-carnitine and the lotus germ. The decrease in body fat percentage in test group 3 is slight. On the other hand, it can be seen that the test group 4 fed the diet containing the extract of L-carnitine and the lotus germ significantly reduced body fat.

  Three healthy men aged 25 to 40 and two women (A, B, C, D, E) were allowed to consume the beverage of Example 5 once a day for 8 weeks without changing their diet, and BMI [ Body Mass Index: body weight kg / (height m × height m)], body fat percentage, and waist size were measured. The results are shown in Table 4.

  From the results in Table 3, it can be seen that when the body fat reduction promoter of the present invention is ingested, the body fat percentage decreases without changing the diet, and accordingly, BMI and waist size decrease.

The body fat reduction promoter containing L-carnitine and lotus germ extract can also be applied to the prevention and treatment of lifestyle-related diseases caused by excessive body fat.

Claims (2)

A body fat reduction promoter comprising L-carnitine and a lotus germ extract. The body fat reduction promoter according to claim 1, wherein L-carnitine is in a form that can be ingested in an amount of 5-5000 mg / day and a lotus germ extract converted to dried lotus germ in an amount of 0.1-1000 mg / day.