JP4402463B2 - リポペプチド抗生物質のＤａｂ９誘導体およびそれを製造および使用する方法 - Google Patents
リポペプチド抗生物質のＤａｂ９誘導体およびそれを製造および使用する方法 Download PDFInfo
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- JP4402463B2 JP4402463B2 JP2003558038A JP2003558038A JP4402463B2 JP 4402463 B2 JP4402463 B2 JP 4402463B2 JP 2003558038 A JP2003558038 A JP 2003558038A JP 2003558038 A JP2003558038 A JP 2003558038A JP 4402463 B2 JP4402463 B2 JP 4402463B2
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- 231100000057 systemic toxicity Toxicity 0.000 description 1
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- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
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- 231100001274 therapeutic index Toxicity 0.000 description 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 description 1
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- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45371002P | 2002-01-03 | 2002-01-03 | |
| PCT/US2003/000158 WO2003057724A1 (en) | 2002-01-03 | 2003-01-02 | Dab9 DERIVATIVES OF LIPOPEPTIDE ANTIBIOTICS AND METHODS OF MAKING AND USING THE SAME |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005524622A JP2005524622A (ja) | 2005-08-18 |
| JP2005524622A5 JP2005524622A5 (enExample) | 2006-02-16 |
| JP4402463B2 true JP4402463B2 (ja) | 2010-01-20 |
Family
ID=33131662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003558038A Expired - Fee Related JP4402463B2 (ja) | 2002-01-03 | 2003-01-02 | リポペプチド抗生物質のＤａｂ９誘導体およびそれを製造および使用する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7125844B2 (enExample) |
| EP (1) | EP1481005A1 (enExample) |
| JP (1) | JP4402463B2 (enExample) |
| AU (1) | AU2003202878B2 (enExample) |
| CA (1) | CA2471458A1 (enExample) |
| WO (1) | WO2003057724A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1481005A1 (en) * | 2002-01-03 | 2004-12-01 | Micrologix Biotech, Inc. | Dab sp 9 /sp DERIVATIVES OF LIPOPEPTIDE ANTIBIOTICS AND METHODS OF MAKING AND USING THE SAME |
| WO2005000878A2 (en) * | 2003-06-26 | 2005-01-06 | Migenix Inc. | Compositions of lipopeptide antibiotic derivatives and methods of use thereof |
| US7951232B2 (en) * | 2006-02-09 | 2011-05-31 | Elevance Renewable Sciences, Inc. | Surface coating compositions and methods |
| WO2007092633A2 (en) * | 2006-02-09 | 2007-08-16 | Elevance Renewable Sciences, Inc. | Antimicrobial compositions, methods and systems |
| GB0821540D0 (en) | 2008-11-25 | 2008-12-31 | Merlion Pharmaceuticals Pte Ltd | Lipopeptide compounds and their use |
| US9504756B2 (en) * | 2012-05-15 | 2016-11-29 | Seattle Genetics, Inc. | Self-stabilizing linker conjugates |
| CN109562152B (zh) | 2016-08-09 | 2024-04-02 | 西雅图基因公司 | 含有具有改善的生理化学性质的自稳定性接头的药物缀合物 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB923544A (en) | 1959-07-21 | 1963-04-10 | Takeda Pharmaceutical | A new antibiotic-glumamycin |
| US3057779A (en) | 1960-03-14 | 1962-10-09 | American Cyanamid Co | Antibiotic and production thereof |
| US3639582A (en) | 1967-04-14 | 1972-02-01 | Zaidan Hojin Biseibutsu | Antibiotic laspartomycin |
| DE1800363A1 (de) | 1967-10-04 | 1969-07-03 | Shionogi & Co | Tsushimycin und seine Herstellung |
| FR2124060B1 (enExample) | 1971-02-02 | 1974-04-12 | Rhone Poulenc Sa | |
| US4524135A (en) | 1982-05-21 | 1985-06-18 | Eli Lilly And Company | A-21978C cyclic peptides |
| ZA883887B (en) | 1987-06-10 | 1990-02-28 | Lilly Co Eli | Chromatographic purification process |
| US4977083A (en) | 1988-04-11 | 1990-12-11 | Eli Lilly And Company | Processes for preparing A54145 compounds |
| US5039789A (en) | 1988-04-11 | 1991-08-13 | Eli Lilly And Company | A54145 cyclic peptides |
| US4994270A (en) | 1988-04-11 | 1991-02-19 | Eli Lilly And Company | A54145 antibiotics and process for their production |
| US5028590A (en) | 1988-04-11 | 1991-07-02 | Eli Lilly And Company | Derivatives of A54145 cyclic peptides |
| TW455591B (en) | 1993-06-08 | 2001-09-21 | Hoechst Ag | Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof |
| DE4411025A1 (de) | 1994-03-30 | 1995-10-05 | Hoechst Ag | Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US6146872A (en) | 1996-06-13 | 2000-11-14 | Fukisawa Pharmaceutical Co., Ltd. | Cyclic lipopeptide acylase |
| DE19807972A1 (de) | 1998-02-25 | 1999-08-26 | Hoechst Marion Roussel De Gmbh | Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung |
| WO2002005837A1 (en) | 2000-07-17 | 2002-01-24 | Intrabiotics Pharmaceuticals, Inc. | Antimicrobial sulfonamide derivatives of lipopeptide antibiotics |
| US6716962B2 (en) | 2000-07-17 | 2004-04-06 | Micrologix Biotech Inc. | Extractive purification of lipopeptide antibiotics |
| US6750199B2 (en) * | 2000-07-17 | 2004-06-15 | Micrologix Biotech Inc. | Antimicrobial sulfonamide derivatives of lipopeptide antibiotics |
| EP1481005A1 (en) * | 2002-01-03 | 2004-12-01 | Micrologix Biotech, Inc. | Dab sp 9 /sp DERIVATIVES OF LIPOPEPTIDE ANTIBIOTICS AND METHODS OF MAKING AND USING THE SAME |
-
2003
- 2003-01-02 EP EP03701990A patent/EP1481005A1/en not_active Withdrawn
- 2003-01-02 AU AU2003202878A patent/AU2003202878B2/en not_active Ceased
- 2003-01-02 US US10/336,641 patent/US7125844B2/en not_active Expired - Fee Related
- 2003-01-02 JP JP2003558038A patent/JP4402463B2/ja not_active Expired - Fee Related
- 2003-01-02 CA CA002471458A patent/CA2471458A1/en not_active Abandoned
- 2003-01-02 WO PCT/US2003/000158 patent/WO2003057724A1/en not_active Ceased
-
2006
- 2006-10-05 US US11/539,139 patent/US7655623B2/en not_active Expired - Fee Related
-
2010
- 2010-02-01 US US12/697,937 patent/US20100137199A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005524622A (ja) | 2005-08-18 |
| AU2003202878A1 (en) | 2003-07-24 |
| WO2003057724A1 (en) | 2003-07-17 |
| US20100137199A1 (en) | 2010-06-03 |
| AU2003202878B2 (en) | 2008-07-31 |
| US7655623B2 (en) | 2010-02-02 |
| US7125844B2 (en) | 2006-10-24 |
| US20040138107A1 (en) | 2004-07-15 |
| CA2471458A1 (en) | 2003-07-17 |
| US20070167357A1 (en) | 2007-07-19 |
| EP1481005A1 (en) | 2004-12-01 |
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