JP4397813B2 - 時間遅延積分イメージングを使用した微小な動く対象物の光学的断層撮影法 - Google Patents
時間遅延積分イメージングを使用した微小な動く対象物の光学的断層撮影法 Download PDFInfo
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- JP4397813B2 JP4397813B2 JP2004541637A JP2004541637A JP4397813B2 JP 4397813 B2 JP4397813 B2 JP 4397813B2 JP 2004541637 A JP2004541637 A JP 2004541637A JP 2004541637 A JP2004541637 A JP 2004541637A JP 4397813 B2 JP4397813 B2 JP 4397813B2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
- G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
- G01N23/046—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1468—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle
- G01N15/147—Electro-optical investigation, e.g. flow cytometers with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T11/00—2D [Two Dimensional] image generation
- G06T11/003—Reconstruction from projections, e.g. tomography
- G06T11/006—Inverse problem, transformation from projection-space into object-space, e.g. transform methods, back-projection, algebraic methods
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2223/00—Investigating materials by wave or particle radiation
- G01N2223/40—Imaging
- G01N2223/419—Imaging computed tomograph
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Radiology & Medical Imaging (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Description
本出願は、2001年8月10日に出願された同時係属のAlan C.Nelsonの米国特許出願第09/927,151号、現在は「APPARATUS AND METHOD FOR IMAGING SMALL OBJECTS IN A FLOW STREAM USING OPTICAL TOMOGRAPHY」という名称の2003年7月8日に発行された米国特許第6,522,775号の一部継続出願である。 本発明は、一般に光学的断層撮影イメージング・システムに関し、より詳細には、光学的断層撮影法、および時間遅延積分を使用して対象物を画像化する光学的断層撮影法に関する。
各光源は、同じ全般的特性を有することができ、好ましくは、
・小さい円形の点光源に近似させることができる。
・明るく、既知のスペクトル内容を有することができる。
・光源から放射されたフォトンが、5〜10度の小さい円錐角を有する円錐またはすべてのフォトン光線が平行であるペンシル・ビームなど、既知の形状のビームを形成することができる。
・レーザまたは他の高輝度フォトン源の前方の開口
・ピンホールの入口側および出口側での表面プラズモンによるフォトンの集束を利用した開口
・微小な断面を備えた光ファイバ
・フォトン源の前方の短焦点距離レンズ
・蛍光面上の点に照射する電子ビーム(CRTの形式)
・上記の様々な組合せ
Claims (10)
- 目的の動く対象物(1)の画像の断層撮影法による再構成を可能にするための方法であって、
(a)キャピラリ・チューブ(2)内で層流を生じさせるためにシース流体(7)を導入しながら目的の対象物(1)を前記キャピラリ・チューブ(2)内に注入して、前記目的の対象物(1)を層流中で中心に位置決めし一定速度で動かす工程と、
(b)前記層流の周囲に配置された複数の光学的点光源(27)によって、サンプリング中に前記目的の対象物(1)内に焦面が存在しないように前記層流からある距離を置いて前記複数の光学的点光源(27)の反対側に配置された複数の対向する時間遅延積分(TDI)イメージ・センサ(25)と協働して、前記目的の対象物(1)をサンプリングする工程であって、前記目的の対象物(1)が前記複数の光学的点光源(27)と前記反対側の複数のTDIイメージ・センサ(25)の間を流れるときに、前記目的の対象物(1)を通る多数の投影角がサンプリングされる工程と、
(c)行移動速度を前記目的の対象物(1)の流速と同期させた前記反対側の複数のTDIイメージ・センサ(25)によって、複数の投影画像(51)を生成する工程とを含む方法。 - 前記目的の対象物(1)が細胞または細胞核を含む、請求項1に記載の方法。
- 前記複数の光学的点光源(27)が複数の円錐ビーム(35)を生成する、請求項1に記載の方法。
- 目的の動く対象物(1)の画像の断層撮影法による再構成を可能にするための方法であって、
(a)目的の対象物(1)を線形容器(2)中に挿入する工程と、
(b)前記線形容器(2)の周囲に配置された複数の光学的点光源(27)を使用して、サンプリング中に前記目的の対象物(1)内に焦面が存在しないように前記線形容器(2)からある距離を置いて前記複数の光学的点光源(27)の反対側に配置された複数の対向する時間遅延積分(TDI)イメージ・センサ(25)と協働して、前記目的の対象物(1)をサンプリングする工程であって、前記目的の対象物(1)が前記複数の光学的点光源(27)と前記複数の対向する時間遅延積分(TDI)イメージ・センサ(25)との間を動くときに、前記目的の対象物(1)を通る多数の投影角が、前記複数の光学的点光源(27)によって生成された一組の光学的投影ビームによってサンプリングされる工程と、
(c)前記目的の対象物が一度に1つづつ前記光学的投影ビームを通過するように、前記線形容器(2)を一定速度で平行移動させる工程と、
(d)行移動速度を前記対象物の平行移動速度と同期させた前記複数の対向するTDIイメージ・センサ(25)によって、複数の投影画像(51)を生成する工程とを含む方法。 - 前記目的の対象物(1)が細胞または細胞核を含む、請求項4に記載の方法。
- 前記目的の対象物(1)を前記線形容器(2)中に挿入する工程が、複数の細胞をチューブ内に挿入する工程を含む、請求項4に記載の方法。
- 前記一組の光学的投影ビームが一組の円錐ビーム(35)を生成する、請求項4に記載の方法。
- 前記複数の光学的点光源(27)が、ほぼ同軸に配設され前記複数の対向するTDIイメージ・センサ(25)と協働して動作する選択可能な波長の複数の点フォトン源(27)を含む、再構成シリンダ(12)内に配置され、前記複数の対向するTDIイメージ・センサ(25)が、光のスペクトルの選択可能な部分に対して感応性を有し、前記複数の対向するTDIイメージ・センサ(25)が、前記複数の点フォトン源(27)からの光を前記目的の対象物(1)を通過した後で受け取るように配設されている、請求項4に記載の方法。
- 前記複数の光学的点光源(27)が、点光源(27)のリングとして作製され、前記複数のTDIイメージ・センサ(25)が、前記点光源(27)の前記リングの下方の平面に配置されているTDIイメージ・センサ(25)のリングを含む、請求項4に記載の方法。
- 前記目的の対象物(1)を画像化する工程が、少なくとも3つの投影を前記複数のTDIセンサ(25)上でそれぞれ画像化する工程をさらに含む、請求項4に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/260,908 US6591003B2 (en) | 2001-03-28 | 2002-09-30 | Optical tomography of small moving objects using time delay and integration imaging |
PCT/US2003/030063 WO2004031809A2 (en) | 2002-09-30 | 2003-09-24 | Optical tomography of small moving objects using time delay and integration imaging |
Publications (2)
Publication Number | Publication Date |
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JP2006501474A JP2006501474A (ja) | 2006-01-12 |
JP4397813B2 true JP4397813B2 (ja) | 2010-01-13 |
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JP2004541637A Expired - Fee Related JP4397813B2 (ja) | 2002-09-30 | 2003-09-24 | 時間遅延積分イメージングを使用した微小な動く対象物の光学的断層撮影法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6591003B2 (ja) |
EP (1) | EP1554685B1 (ja) |
JP (1) | JP4397813B2 (ja) |
CN (1) | CN1318837C (ja) |
AU (1) | AU2003278889B2 (ja) |
CA (1) | CA2499773C (ja) |
ES (1) | ES2422882T3 (ja) |
HK (1) | HK1080970A1 (ja) |
WO (1) | WO2004031809A2 (ja) |
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- 2003-09-24 JP JP2004541637A patent/JP4397813B2/ja not_active Expired - Fee Related
- 2003-09-24 CA CA2499773A patent/CA2499773C/en not_active Expired - Fee Related
- 2003-09-24 ES ES03770404T patent/ES2422882T3/es not_active Expired - Lifetime
- 2003-09-24 CN CNB038233274A patent/CN1318837C/zh not_active Expired - Fee Related
- 2003-09-24 WO PCT/US2003/030063 patent/WO2004031809A2/en active Application Filing
- 2003-09-24 AU AU2003278889A patent/AU2003278889B2/en not_active Ceased
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Publication number | Publication date |
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HK1080970A1 (en) | 2006-05-04 |
WO2004031809A8 (en) | 2005-08-18 |
CA2499773A1 (en) | 2004-04-15 |
CA2499773C (en) | 2013-07-02 |
JP2006501474A (ja) | 2006-01-12 |
ES2422882T3 (es) | 2013-09-16 |
EP1554685B1 (en) | 2013-04-24 |
US6591003B2 (en) | 2003-07-08 |
AU2003278889A1 (en) | 2004-04-23 |
EP1554685A2 (en) | 2005-07-20 |
WO2004031809A3 (en) | 2004-08-19 |
EP1554685A4 (en) | 2007-07-25 |
CN1685211A (zh) | 2005-10-19 |
CN1318837C (zh) | 2007-05-30 |
WO2004031809A2 (en) | 2004-04-15 |
AU2003278889B2 (en) | 2008-08-21 |
US20030026468A1 (en) | 2003-02-06 |
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