JP4397396B2 - レーザ光イオン化装置への直接液体注入口 - Google Patents
レーザ光イオン化装置への直接液体注入口 Download PDFInfo
- Publication number
- JP4397396B2 JP4397396B2 JP2006514270A JP2006514270A JP4397396B2 JP 4397396 B2 JP4397396 B2 JP 4397396B2 JP 2006514270 A JP2006514270 A JP 2006514270A JP 2006514270 A JP2006514270 A JP 2006514270A JP 4397396 B2 JP4397396 B2 JP 4397396B2
- Authority
- JP
- Japan
- Prior art keywords
- photoionization
- sample
- area
- analyte
- liquid sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000007788 liquid Substances 0.000 title claims description 29
- 238000000034 method Methods 0.000 claims description 22
- 239000012491 analyte Substances 0.000 claims description 20
- 150000002500 ions Chemical class 0.000 claims description 12
- 238000004949 mass spectrometry Methods 0.000 claims description 8
- 238000004458 analytical method Methods 0.000 claims description 5
- 230000001678 irradiating effect Effects 0.000 claims description 4
- 230000005494 condensation Effects 0.000 claims description 2
- 238000009833 condensation Methods 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims description 2
- 230000003247 decreasing effect Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 description 32
- 238000001514 detection method Methods 0.000 description 9
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- 238000001816 cooling Methods 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- 239000012472 biological sample Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 238000004811 liquid chromatography Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 238000013375 chromatographic separation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000001307 laser spectroscopy Methods 0.000 description 1
- 239000002071 nanotube Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000001269 time-of-flight mass spectrometry Methods 0.000 description 1
Images
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
- H01J49/162—Direct photo-ionisation, e.g. single photon or multi-photon ionisation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
- H01J49/0445—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for introducing as a spray, a jet or an aerosol
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46716203P | 2003-04-29 | 2003-04-29 | |
| PCT/US2004/013821 WO2004097891A2 (en) | 2003-04-29 | 2004-04-29 | Direct liquid injection inlet to a laser photoionization apparatus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006525528A JP2006525528A (ja) | 2006-11-09 |
| JP2006525528A5 JP2006525528A5 (enExample) | 2007-07-19 |
| JP4397396B2 true JP4397396B2 (ja) | 2010-01-13 |
Family
ID=33418440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006514270A Expired - Fee Related JP4397396B2 (ja) | 2003-04-29 | 2004-04-29 | レーザ光イオン化装置への直接液体注入口 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US7095016B2 (enExample) |
| JP (1) | JP4397396B2 (enExample) |
| WO (1) | WO2004097891A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1672674A1 (de) * | 2004-12-17 | 2006-06-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Untersuchungsverfahren und -system zur Hochdurchsatzmassenanalyse |
| EP2017875A1 (en) * | 2007-07-16 | 2009-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method and apparatus for providing a sample for a subsequent analysis |
| EP2230702A1 (en) | 2009-03-19 | 2010-09-22 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Modified surface |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4358302A (en) | 1980-11-24 | 1982-11-09 | The University Of Rochester | Apparatus for separation of gas borne particles |
| US5285064A (en) | 1987-03-06 | 1994-02-08 | Extrel Corporation | Method and apparatus for introduction of liquid effluent into mass spectrometer and other gas-phase or particle detectors |
| US6653626B2 (en) | 1994-07-11 | 2003-11-25 | Agilent Technologies, Inc. | Ion sampling for APPI mass spectrometry |
| US5917185A (en) * | 1997-06-26 | 1999-06-29 | Iowa State University Research Foundation, Inc. | Laser vaporization/ionization interface for coupling microscale separation techniques with mass spectrometry |
| US6140639A (en) * | 1998-05-29 | 2000-10-31 | Vanderbilt University | System and method for on-line coupling of liquid capillary separations with matrix-assisted laser desorption/ionization mass spectrometry |
| ATE386335T1 (de) | 1999-10-29 | 2008-03-15 | Mds Inc Through Its Mds Sciex | Atmosphärendruckphotoionisation : ein neues ionisationsverfahren für flüssigchromatographie- massenspekrometrie |
| EP1193730A1 (en) * | 2000-09-27 | 2002-04-03 | Eidgenössische Technische Hochschule Zürich | Atmospheric-pressure ionization device and method for analysis of a sample |
| US6858841B2 (en) * | 2002-02-22 | 2005-02-22 | Agilent Technologies, Inc. | Target support and method for ion production enhancement |
| US6646257B1 (en) * | 2002-09-18 | 2003-11-11 | Agilent Technologies, Inc. | Multimode ionization source |
-
2004
- 2004-04-29 US US10/836,644 patent/US7095016B2/en not_active Expired - Fee Related
- 2004-04-29 WO PCT/US2004/013821 patent/WO2004097891A2/en not_active Ceased
- 2004-04-29 JP JP2006514270A patent/JP4397396B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006525528A (ja) | 2006-11-09 |
| WO2004097891A2 (en) | 2004-11-11 |
| US20040222373A1 (en) | 2004-11-11 |
| WO2004097891A3 (en) | 2005-03-17 |
| US7095016B2 (en) | 2006-08-22 |
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