JP4296298B2 - Hay fever drink - Google Patents

Description

  The present invention relates to a hot water extract of cedar leaves effective for the prevention and treatment of hay fever.

  Conventionally, it is known that a hot water extract of cedar leaves is effective for the prevention and treatment of hay fever, especially cedar pollinosis. Regarding the hot water extract of cedar leaves that have been proposed for anti-allergy or cedar pollinosis, Patent Document 1 (orally-administered drugs and foods and drinks having anti-allergic action), Patent Document 2 (Health food made from cedar leaves) ), Patent Document 3 (Internal medicine for desensitization therapy for Japanese cedar pollinosis) and Patent Document 4 (Method for producing cedar leaf extract).

  Among them, the technique of Patent Document 1 is a solution obtained by adding 1000 ml of water to 100 g of fresh cedar leaves or a crushed, ground, dried or dried crushed product, and hot water extraction at 90 to 92 ° C. for 2 hours, or this Is a composite component obtained by concentration under reduced pressure or lyophilization. It is disclosed that this preparation has an antihistamine effect of 29.1 to 37.2% for rats and an antiallergic effect similar to diphenhydramine hydrochloride for guinea pigs. Although there is no test for humans with this preparation, the effect of a single dose is not so high as 29 to 37% according to the results of animal experiments.

  In addition, the technique of Patent Document 2 adds about 2% honey or syrup to a liquid obtained by putting cedar leaves in a pot and boiled in about twice the amount of water of cedar leaves for 5 to 6 hours. It is revealed that 30 people with hay fever have taken about 20 ml once a day for about 3 months, and 24 people (80%) have an allergy prevention effect. Although it is clear that this food has an allergy-preventing effect on humans, the effect is as low as 80% for a long period of about 3 months, and the period of use is too long. There is also a concern that the effectiveness rate may be further reduced.

  The technique of Patent Document 3 is an internal medicine for desensitization therapy obtained by adding about 2800 g of water to about 300 g of any of cedar leaves, cedar pollen, and a mixture of cedar leaves and pollen and heating for 4 hours. This preparation is supposed to be taken about 30 to 40 cc after each meal for about 7 to 10 days, but the allergic reaction inhibitory effect has not been proved at all. Even if there is a certain effect, taking 3 times a day for about 7 to 10 days has a large burden on the number of times and period of taking, there is a high possibility of forgetting to take it on the way, and the effect is reduced. is there.

  The technique of Patent Document 4 is a technique for treating boiling cedar leaves in two stages of 3 to 5 minutes and 3 to 5 hours, but there is no specific description of the antiallergic effect. In addition, there is Patent Document 5 (Preventive or therapeutic agent for cedar pollinosis) as another disclosure of a preventive or therapeutic agent for cedar pollinosis using cedar leaves. This technology uses the compressed oil of cedar leaves as eye drops, transdermal coating agents, and sprays, and is in a different category from the technology of extracting cedar leaves with hot water.

JP-A-9-20671 JP-A-9-107936 JP-A-11-322625 Japanese Patent Laid-Open No. 2001-141 Japanese Patent Application Laid-Open No. 2002-234846

As described above, it is clear that cedar leaves contain anti-allergic components effective for hay fever, and various hot water extraction methods have been disclosed as component extraction methods. There is a drawback in that it is not enough, the number of doses is too many, and the duration of the dose is too long. Furthermore, the products according to these techniques have the disadvantage that the period from taking the medicine to the effect is long and the rapid efficacy is also poor.
As a result of intensive research aimed at obtaining a fast-acting preventive or therapeutic agent for hay fever that exerts an effect by taking a few short-term doses, the present inventors mixed bitter juice with hot water extract of cedar leaves. The inventors have found that it is sufficient to drink, and have completed the present invention.

The present invention is a preventive or therapeutic agent for hay fever characterized by being a mixed solution obtained by adding bitter juice to a hot water extract of cedar leaves.

The preventive or therapeutic agent for hay fever according to the present invention has a rapid effect that various symptoms of hay fever disappear after about 1 hour in a single small dose , and a high effective rate for hay fever is obtained in a short amount of drinking. The recurrence rate is low and the effect is long-lasting.

  The cedar leaves used in the present invention may be fresh green leaves collected from healthy cedar trees that are classified in the genus Sugi, such as Japanese cedar, Enkosugi, Otesugi, Kawasugi, Yawarasugi, Yoshinosugi, Yoresugi, etc. Of these, new leaves are particularly preferred. The cedar leaf may be washed and used as it is, but it may be used in the form of a crushed material or a ground material.

The collected cedar leaves are subjected to hot water extraction. This hot water extraction uses a normal boiling pot and kettle, put cedar leaves in this, and clean water suitable for drinking such as tap water and well water is about 15-40 parts per 1 part by weight of cedar leaves. What is necessary is just to carry out by adding at a ratio of a weight part, Preferably about 20 weight part, and heating at 80-100 degreeC for about 3 to 10 hours, Preferably it is 6 to 7 hours. In addition, since water evaporates due to heating for a long time, it is preferable to replenish the evaporated water in a timely manner, for example, at an appropriate amount.
After the treatment, the supernatant liquid of the cedar leaf treatment liquid that has been hot or naturally cooled is collected, or filtered using cloth or paper to separate the filtrate from the cedar leaf. The resulting liquid is a brown water transparent and bitter, hot water extract with a unique odor mixed with cedar scent.

The hot water extract thus obtained is added and mixed in a ratio of about 0.7 to 10 parts by weight, preferably 0.7 to 5 parts by weight with respect to 100 parts by weight of the present invention. A prophylactic or therapeutic agent for hay fever is obtained. Bitter juice may be added and mixed either while the hot water extract is hot or after it is naturally cooled, but it is fast acting when the amount of bitter juice is less than 0.7 parts by weight with respect to 100 parts by weight of the hot water extract. However, even if the amount exceeds 10 parts by weight, the immediate effect does not change, but the saltiness that is strong against bitterness is added and it is difficult to say that the taste is suitable for drinking.
Alternatively, the bitter juice may be mixed immediately before the end of heating in the hot water extraction step. In this case, there is a loss of bitter juice adhering to the cedar leaf, so that the bitter juice content in the extract is maintained in the range of about 0.7 to 10 parts by weight.
The bitter juice used in this process is a commercially available product used for the production of tofu, etc., and may be in the form of powder, granules, lumps, or liquid, but it is hot or naturally cooled. Mix thoroughly in the liquid. As the bitter juice used in the present invention, those mainly composed of magnesium chloride are particularly suitable. This includes, for example, solid bitter juice mainly composed of MgCl ₂ · 6H ₂ O obtained by further separating bromine from concentrated bitter juice which is mother liquor obtained by separating carnal stone from bitter mother liquor. In addition, the so-called “gully” containing magnesium sulfate as a main component tends to be less effective than bitter juice containing magnesium chloride as a main component in the intended quick effect of the present invention.

  In the present invention, the product obtained by leaving the hot water extract mixed with bitter juice at a temperature of about 0 to 20 ° C. for 6 to 24 hours, preferably 8 to 15 hours is used. Specifically, for example, this liquid may be air-cooled and then refrigerated overnight in a refrigerator having a temperature of 0 to 10 ° C. By this standing treatment, the hot water extract is aged, and the unique strong cedar odor and bitterness are alleviated and the rapid action against hay fever is enhanced.

Next, examples, comparative examples, test examples and comparative test examples of the present invention will be described. However, the examples do not limit the scope of the present invention.
Example 1
100g freshly picked fresh cedar leaves are thoroughly washed, put in a pan, infused with 2kg of tap water, loosely closed, heated using a gas range, and in a timely amount to maintain the amount of water. Maintained at 100 ° C. for 6 hours with water replenishment. After the heating was completed, the supernatant was collected to obtain about 1.6 kg of a hot water extract having a brown color and a strong cedar odor. Before about 1.6 kg of this hot water extract was cooled, 100 g of a bitter granule based on commercially available magnesium chloride was mixed to obtain about 1.7 kg of the product of the present invention.

Example 2
About 1.7 kg of the product of the present invention obtained in Example 1 was naturally cooled and then refrigerated in a refrigerator (10 ° C.) for 8 hours to obtain about 1.7 kg of the product of the present invention.

Example 3
Freshly picked 100g fresh cedar leaves are thoroughly washed and placed in a pan containing 3kg of tap water at 100 ° C, and then refilled with water in a timely amount to maintain the amount of water using a gas range. For 7 hours. Thereafter, the obtained liquid was filtered through a cotton cloth to obtain about 2.7 kg of a brownish brown cedar odor filtrate. After naturally cooling 2.7 kg of the filtrate, 100 g of a bitter powder mainly composed of commercially available magnesium chloride was mixed to obtain about 2.8 kg of the product of the present invention.

Example 4
2.8 kg of the product of the present invention obtained in Example 3 was refrigerated in a refrigerator (10 ° C.) for 15 hours to obtain about 2.7 kg of the product of the present invention.

Example 7
In Example 1, about 3.5 kg of the product of the present invention was obtained in the same manner except that 4 kg of tap water was heated at 80 ° C. for 10 hours, and about 3.2 kg of the obtained supernatant was mixed with 300 g of bitter juice.

Example 8
3.5 kg of the product of the present invention obtained in Example 7 was refrigerated in a refrigerator (5 ° C.) for 24 hours to obtain about 3.5 kg of the product of the present invention.

Example 9
About 100 kg of freshly picked fresh cedar annual leaves were washed well with water, and about 1.7 kg of the product of the present invention was obtained in the same manner as in Example 1 except that the crushed material was crushed with a hammer. The product was naturally cooled and then refrigerated for 8 hours in a refrigerator (10 ° C.) to obtain about 1.7 kg of the product of the present invention.

Example 10
About 100 kg of the product of the present invention was obtained in the same manner as in Example 1, except that about 100 g of freshly harvested fresh cedar 1 year leaves were washed thoroughly with water and ground with a hammer. The product was naturally cooled and then refrigerated for 8 hours in a refrigerator (10 ° C.) to obtain about 1.7 kg of the product of the present invention.

Comparative Example 1
100g freshly picked fresh cedar leaves are thoroughly washed, put into a pan, infused with 2kg of tap water, loosely closed, heated using a gas range, and in a timely amount to maintain the amount of water. Maintained at 100 ° C. for 6 hours with water replenishment. After the heating was completed, the supernatant was collected to obtain about 1.6 kg of a hot water extract having a brown color and a strong cedar odor.

Comparative Example 2
Before about 1.6 kg of the hot water extract obtained in the same manner as in Comparative Example 1 is cooled, 100 g of bitter (gully) granules mainly composed of magnesium sulfate are mixed to obtain about 1.7 kg of the gully mixed extract. Got.

なお、本発明製品飲料は、飲用時に杉臭と苦みが多少気になるが、飲用後に副作用を訴えた者はいない。 Test example 1
The drink of the present invention obtained in Example 2 was drunk to a total of 6 adult boys and 3 girls with cedar pollinosis by the following drinking method, and the effect was tested. As a control, the hot water extract extracted in Comparative Example 1 (a solution in which bitter juice was not mixed by the method of Example 1) was allowed to be drunk by two adult males and three females with cedar pollinosis. Symptoms and effects depend on subjective symptoms reported by the drinker.

Although the product beverage of the present invention is somewhat worried about cedar odor and bitterness during drinking, no one has complained of side effects after drinking.

なお、対照製品は、飲用時に杉臭と苦みが多少気になるが、飲用後に副作用を訴えた者はいない。

The control product is somewhat worried about cedar odor and bitterness when taken, but no one has complained of side effects after drinking.

  It is clear from the results of Test Example 1 that the control product has a lower rate of effect than the product of the present invention, and even those who are effective take two days to achieve the effect, and the recurrence rate of symptoms is high. On the other hand, the product of the present invention has a rapid effect in which significant improvement is observed in itching, redness, runny nose and sneezing, which are symptoms characteristic of hay fever, about 1 hour after drinking.

Test example 2
When 6 subjects who drank for 2 days in Test Example 1 were stopped drinking and the progress was observed, no symptoms appeared for 3 people until 3 months until June when the hay fever season ended. One patient developed symptoms after about 1 month and the other one after 3 weeks, and when they were taken again as before, the symptoms did not recur during the season.

Comparative Test Example 1
The gully mixed extract obtained in Comparative Example 2 was consumed for 1 day for 15 days before breakfast for 12 adult boys and 11 adult girls with cedar pollinosis, but no effect was observed. After that, even if it was continuously taken, there was no effect, and within 7 days, everyone stopped drinking.

Claims (1)

  A ratio of 0.7 to 10 parts by weight of bitter juice containing magnesium chloride as a main component with respect to 100 parts by weight of hot water extract obtained by using 15 to 40 parts by weight of water with respect to 1 part by weight of cedar leaves A preventive or therapeutic agent for hay fever characterized by being a mixed solution added in step 1.